Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424331
(CHEMBL2314497)Show InChI InChI=1S/C16H17FN6/c17-11-3-1-10(2-4-11)13-9-12-14(20-13)21-16(18)22-15(12)23-7-5-19-6-8-23/h1-4,9,19H,5-8H2,(H3,18,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50304501
(6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...)Show InChI InChI=1S/C9H16N6/c1-14-2-4-15(5-3-14)8-6-7(10)12-9(11)13-8/h6H,2-5H2,1H3,(H4,10,11,12,13) | PDB
Reactome pathway
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CHEMBL
PC cid
PC sid
UniChem
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Similars
| Article
PubMed
| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424324
(CHEMBL2314761)Show SMILES N[C@H]1CCN(C1)c1nc(N)nc2[nH]c(cc12)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C16H17FN6/c17-10-3-1-9(2-4-10)13-7-12-14(20-13)21-16(19)22-15(12)23-6-5-11(18)8-23/h1-4,7,11H,5-6,8,18H2,(H3,19,20,21,22)/t11-/m0/s1 | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
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PubMed
| 980 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50304501
(6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...)Show InChI InChI=1S/C9H16N6/c1-14-2-4-15(5-3-14)8-6-7(10)12-9(11)13-8/h6H,2-5H2,1H3,(H4,10,11,12,13) | PDB
Reactome pathway
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PC sid
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PubMed
| 1.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424340
(CHEMBL2314772)Show InChI InChI=1S/C16H18N6/c17-16-20-14-12(15(21-16)22-8-6-18-7-9-22)10-13(19-14)11-4-2-1-3-5-11/h1-5,10,18H,6-9H2,(H3,17,19,20,21) | PDB
Reactome pathway
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PC sid
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Similars
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PubMed
| 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424327
(CHEMBL2314501)Show InChI InChI=1S/C18H22N6/c1-23-8-5-9-24(11-10-23)17-14-12-15(13-6-3-2-4-7-13)20-16(14)21-18(19)22-17/h2-4,6-7,12H,5,8-11H2,1H3,(H3,19,20,21,22) | PDB
Reactome pathway
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PC sid
UniChem
Similars
| Article
PubMed
| 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424325
(CHEMBL2314760)Show SMILES N[C@@H]1CCN(C1)c1nc(N)nc2[nH]c(cc12)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C16H17FN6/c17-10-3-1-9(2-4-10)13-7-12-14(20-13)21-16(19)22-15(12)23-6-5-11(18)8-23/h1-4,7,11H,5-6,8,18H2,(H3,19,20,21,22)/t11-/m1/s1 | PDB
Reactome pathway
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PC sid
UniChem
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PubMed
| 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424338
(CHEMBL2314774)Show SMILES CN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C17H19FN6/c1-23-6-8-24(9-7-23)16-13-10-14(11-2-4-12(18)5-3-11)20-15(13)21-17(19)22-16/h2-5,10H,6-9H2,1H3,(H3,19,20,21,22) | PDB
Reactome pathway
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PC sid
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PubMed
| 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424341
(CHEMBL2314771)Show InChI InChI=1S/C11H16N6/c1-7-6-8-9(14-7)15-11(12)16-10(8)17-4-2-13-3-5-17/h6,13H,2-5H2,1H3,(H3,12,14,15,16) | PDB
Reactome pathway
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UniChem
Similars
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PubMed
| 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424326
(CHEMBL2314759)Show SMILES CN1CCCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C18H21FN6/c1-24-7-2-8-25(10-9-24)17-14-11-15(12-3-5-13(19)6-4-12)21-16(14)22-18(20)23-17/h3-6,11H,2,7-10H2,1H3,(H3,20,21,22,23) | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 2.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424337
(CHEMBL2314775)Show SMILES CN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H19ClN6/c1-23-6-8-24(9-7-23)16-13-10-14(11-2-4-12(18)5-3-11)20-15(13)21-17(19)22-16/h2-5,10H,6-9H2,1H3,(H3,19,20,21,22) | PDB
Reactome pathway
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PubMed
| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424336
(CHEMBL2314776)Show SMILES COc1ccc(cc1)-c1cc2c(nc(N)nc2[nH]1)N1CCN(C)CC1 Show InChI InChI=1S/C18H22N6O/c1-23-7-9-24(10-8-23)17-14-11-15(20-16(14)21-18(19)22-17)12-3-5-13(25-2)6-4-12/h3-6,11H,7-10H2,1-2H3,(H3,19,20,21,22) | PDB
Reactome pathway
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PubMed
| 3.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424335
(CHEMBL2314777)Show SMILES CN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(C)cc1 Show InChI InChI=1S/C18H22N6/c1-12-3-5-13(6-4-12)15-11-14-16(20-15)21-18(19)22-17(14)24-9-7-23(2)8-10-24/h3-6,11H,7-10H2,1-2H3,(H3,19,20,21,22) | PDB
Reactome pathway
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PC sid
UniChem
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PubMed
| 3.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424330
(CHEMBL2314498)Show SMILES CCN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C18H21FN6/c1-2-24-7-9-25(10-8-24)17-14-11-15(12-3-5-13(19)6-4-12)21-16(14)22-18(20)23-17/h3-6,11H,2,7-10H2,1H3,(H3,20,21,22,23) | PDB
Reactome pathway
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PC sid
UniChem
Similars
| Article
PubMed
| 4.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424339
(CHEMBL2314773)Show InChI InChI=1S/C17H20N6/c1-22-7-9-23(10-8-22)16-13-11-14(12-5-3-2-4-6-12)19-15(13)20-17(18)21-16/h2-6,11H,7-10H2,1H3,(H3,18,19,20,21) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424323
(CHEMBL2314762)Show SMILES Nc1nc(N[C@H]2CCNC2)c2cc([nH]c2n1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C16H17FN6/c17-10-3-1-9(2-4-10)13-7-12-14(20-11-5-6-19-8-11)22-16(18)23-15(12)21-13/h1-4,7,11,19H,5-6,8H2,(H4,18,20,21,22,23)/t11-/m0/s1 | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 5.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424334
(CHEMBL2314494)Show SMILES CN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C18H19N7/c1-24-6-8-25(9-7-24)17-14-10-15(21-16(14)22-18(20)23-17)13-4-2-12(11-19)3-5-13/h2-5,10H,6-9H2,1H3,(H3,20,21,22,23) | PDB
Reactome pathway
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UniChem
Similars
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PubMed
| 7.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424320
(CHEMBL2314765)Show InChI InChI=1S/C14H22N6/c1-2-3-7-19-8-4-11-12(19)17-14(15)18-13(11)20-9-5-16-6-10-20/h4,8,16H,2-3,5-7,9-10H2,1H3,(H2,15,17,18) | PDB
Reactome pathway
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UniChem
Similars
| Article
PubMed
| 8.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424328
(CHEMBL2314500)Show InChI InChI=1S/C12H18N6/c1-17-5-2-6-18(8-7-17)11-9-3-4-14-10(9)15-12(13)16-11/h3-4H,2,5-8H2,1H3,(H3,13,14,15,16) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424333
(CHEMBL2314495)Show SMILES CN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C17H19BrN6/c1-23-6-8-24(9-7-23)16-13-10-14(11-2-4-12(18)5-3-11)20-15(13)21-17(19)22-16/h2-5,10H,6-9H2,1H3,(H3,19,20,21,22) | PDB
Reactome pathway
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AffyNet
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424322
(CHEMBL2314763)Show SMILES CN(C)c1nc(N2CCN(C)CC2)c2cc([nH]c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H23FN6/c1-24(2)19-22-17-15(18(23-19)26-10-8-25(3)9-11-26)12-16(21-17)13-4-6-14(20)7-5-13/h4-7,12H,8-11H2,1-3H3,(H,21,22,23) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424319
(CHEMBL2314766)Show InChI InChI=1S/C17H20N6/c18-17-20-15(22-10-7-19-8-11-22)14-6-9-23(16(14)21-17)12-13-4-2-1-3-5-13/h1-6,9,19H,7-8,10-12H2,(H2,18,20,21) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 2.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424332
(CHEMBL2314496)Show SMILES CN1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H18Cl2N6/c1-24-4-6-25(7-5-24)16-11-9-14(21-15(11)22-17(20)23-16)10-2-3-12(18)13(19)8-10/h2-3,8-9H,4-7H2,1H3,(H3,20,21,22,23) | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 3.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424321
(CHEMBL2314764)Show InChI InChI=1S/C11H16N6/c1-16-5-2-8-9(16)14-11(12)15-10(8)17-6-3-13-4-7-17/h2,5,13H,3-4,6-7H2,1H3,(H2,12,14,15) | PDB
Reactome pathway
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UniChem
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PubMed
| 3.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424318
(CHEMBL2314767)Show InChI InChI=1S/C17H19FN6/c1-23-14(11-2-4-12(18)5-3-11)10-13-15(23)21-17(19)22-16(13)24-8-6-20-7-9-24/h2-5,10,20H,6-9H2,1H3,(H2,19,21,22) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424342
(CHEMBL2314770)Show InChI InChI=1S/C10H14N6/c11-10-14-8-7(1-2-13-8)9(15-10)16-5-3-12-4-6-16/h1-2,12H,3-6H2,(H3,11,13,14,15) | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 4.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424329
(CHEMBL2314499)Show SMILES CC(C)N1CCN(CC1)c1nc(N)nc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C19H23FN6/c1-12(2)25-7-9-26(10-8-25)18-15-11-16(13-3-5-14(20)6-4-13)22-17(15)23-19(21)24-18/h3-6,11-12H,7-10H2,1-2H3,(H3,21,22,23,24) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424317
(CHEMBL2314768)Show SMILES CN1CCN(CC1)c1nc(N)nc2n(C)c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C18H21FN6/c1-23-7-9-25(10-8-23)17-14-11-15(12-3-5-13(19)6-4-12)24(2)16(14)21-18(20)22-17/h3-6,11H,7-10H2,1-2H3,(H2,20,21,22) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.79E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50424331
(CHEMBL2314497)Show InChI InChI=1S/C16H17FN6/c17-11-3-1-10(2-4-11)13-9-12-14(20-13)21-16(18)22-15(12)23-7-5-19-6-8-23/h1-4,9,19H,5-8H2,(H3,18,20,21,22) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
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PubMed
| 8.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50424316
(CHEMBL2314769)Show SMILES CNc1nc(N2CCN(C)CC2)c2cc(-c3ccc(F)cc3)n(C)c2n1 Show InChI InChI=1S/C19H23FN6/c1-21-19-22-17-15(18(23-19)26-10-8-24(2)9-11-26)12-16(25(17)3)13-4-6-14(20)7-5-13/h4-7,12H,8-11H2,1-3H3,(H,21,22,23) | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven
Curated by ChEMBL
| Assay Description
Displacement of [3H]Histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai/o and Gbeta1gamma |
Bioorg Med Chem Lett 23: 132-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.139
BindingDB Entry DOI: 10.7270/Q28P61TF |
More data for this
Ligand-Target Pair | |
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