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PubMed code 23265875

Compile data set for download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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n/an/a 3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426734
PNG
(CHEMBL2322142)
Show SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)12-8-16-13-9-17-14-11(18(12)13)6-7-15-14/h6-10,15H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426732
PNG
(CHEMBL2322134)
Show SMILES C1CCC(CC1)c1ncc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)14-17-9-11-8-16-13-12(18(11)14)6-7-15-13/h6-10,15H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426733
PNG
(CHEMBL2322143)
Show SMILES C1CCC(CC1)c1ccc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C15H17N3/c1-2-4-11(5-3-1)13-7-6-12-10-17-15-14(18(12)13)8-9-16-15/h6-11,16H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426733
PNG
(CHEMBL2322143)
Show SMILES C1CCC(CC1)c1ccc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C15H17N3/c1-2-4-11(5-3-1)13-7-6-12-10-17-15-14(18(12)13)8-9-16-15/h6-11,16H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426734
PNG
(CHEMBL2322142)
Show SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)12-8-16-13-9-17-14-11(18(12)13)6-7-15-14/h6-10,15H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426733
PNG
(CHEMBL2322143)
Show SMILES C1CCC(CC1)c1ccc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C15H17N3/c1-2-4-11(5-3-1)13-7-6-12-10-17-15-14(18(12)13)8-9-16-15/h6-11,16H,1-5H2
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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n/an/a 200n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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n/an/a 220n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426734
PNG
(CHEMBL2322142)
Show SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)12-8-16-13-9-17-14-11(18(12)13)6-7-15-14/h6-10,15H,1-5H2
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n/an/a 240n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426732
PNG
(CHEMBL2322134)
Show SMILES C1CCC(CC1)c1ncc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)14-17-9-11-8-16-13-12(18(11)14)6-7-15-13/h6-10,15H,1-5H2
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n/an/a 270n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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n/an/a 300n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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n/an/a 340n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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n/an/a 440n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50426740
PNG
(CHEMBL2322140)
Show SMILES C1CCC(CC1)N1CCCc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H21N3/c1-2-6-13(7-3-1)19-10-4-5-12-11-18-16-14(15(12)19)8-9-17-16/h8-9,11,13H,1-7,10H2,(H,17,18)
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n/an/a 530n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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n/an/a 570n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426733
PNG
(CHEMBL2322143)
Show SMILES C1CCC(CC1)c1ccc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C15H17N3/c1-2-4-11(5-3-1)13-7-6-12-10-17-15-14(18(12)13)8-9-16-15/h6-11,16H,1-5H2
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n/an/a 600n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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n/an/a 640n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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n/an/a 720n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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n/an/a 740n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426732
PNG
(CHEMBL2322134)
Show SMILES C1CCC(CC1)c1ncc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)14-17-9-11-8-16-13-12(18(11)14)6-7-15-13/h6-10,15H,1-5H2
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n/an/a 890n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426732
PNG
(CHEMBL2322134)
Show SMILES C1CCC(CC1)c1ncc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)14-17-9-11-8-16-13-12(18(11)14)6-7-15-13/h6-10,15H,1-5H2
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n/an/a 910n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426734
PNG
(CHEMBL2322142)
Show SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)12-8-16-13-9-17-14-11(18(12)13)6-7-15-14/h6-10,15H,1-5H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426740
PNG
(CHEMBL2322140)
Show SMILES C1CCC(CC1)N1CCCc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H21N3/c1-2-6-13(7-3-1)19-10-4-5-12-11-18-16-14(15(12)19)8-9-17-16/h8-9,11,13H,1-7,10H2,(H,17,18)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM50426733
PNG
(CHEMBL2322143)
Show SMILES C1CCC(CC1)c1ccc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C15H17N3/c1-2-4-11(5-3-1)13-7-6-12-10-17-15-14(18(12)13)8-9-16-15/h6-11,16H,1-5H2
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n/an/a 4.80E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy tranfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy tranfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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n/an/a 1.14E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy tranfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/a 1.53E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/a 1.80E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/a 2.73E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50426740
PNG
(CHEMBL2322140)
Show SMILES C1CCC(CC1)N1CCCc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H21N3/c1-2-6-13(7-3-1)19-10-4-5-12-11-18-16-14(15(12)19)8-9-17-16/h8-9,11,13H,1-7,10H2,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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n/an/an/an/a 170n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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n/an/an/an/a 180n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426734
PNG
(CHEMBL2322142)
Show SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)12-8-16-13-9-17-14-11(18(12)13)6-7-15-14/h6-10,15H,1-5H2
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n/an/an/an/a 150n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50393756
PNG
(CHEMBL2159198)
Show SMILES Cc1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H18N4/c1-10-18-13-9-17-15-12(7-8-16-15)14(13)19(10)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,16,17)
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n/an/an/an/a 6.60E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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n/an/an/an/a 890n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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n/an/an/an/a 430n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426732
PNG
(CHEMBL2322134)
Show SMILES C1CCC(CC1)c1ncc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)14-17-9-11-8-16-13-12(18(11)14)6-7-15-13/h6-10,15H,1-5H2
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n/an/an/an/a 2.80E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426739
PNG
(CHEMBL2322135)
Show SMILES C1CCC(CC1)c1n[nH]c2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)17-18-13/h6-9H,1-5H2,(H,15,16)(H,17,18)
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n/an/an/an/a 4.20E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426732
PNG
(CHEMBL2322134)
Show SMILES C1CCC(CC1)c1ncc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)14-17-9-11-8-16-13-12(18(11)14)6-7-15-13/h6-10,15H,1-5H2
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n/an/an/an/a 370n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426738
PNG
(CHEMBL2322136)
Show SMILES Cn1nc(C2CCCCC2)c2c3cc[nH]c3ncc12
Show InChI InChI=1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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n/an/an/an/a 970n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/an/an/a 350n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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n/an/an/an/a 210n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426734
PNG
(CHEMBL2322142)
Show SMILES C1CCC(CC1)c1cnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)12-8-16-13-9-17-14-11(18(12)13)6-7-15-14/h6-10,15H,1-5H2
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n/an/an/an/a 4.80E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426735
PNG
(CHEMBL2322141)
Show SMILES C1CCC(CC1)c1nnc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C13H15N5/c1-2-4-9(5-3-1)13-17-16-11-8-15-12-10(18(11)13)6-7-14-12/h6-9,14H,1-5H2
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n/an/an/an/a 1.58E+4n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426733
PNG
(CHEMBL2322143)
Show SMILES C1CCC(CC1)c1ccc2cnc3[nH]ccc3n12
Show InChI InChI=1S/C15H17N3/c1-2-4-11(5-3-1)13-7-6-12-10-17-15-14(18(12)13)8-9-16-15/h6-11,16H,1-5H2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426736
PNG
(CHEMBL2322139)
Show SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C15H15F3N4/c16-15(17,18)14-21-11-8-20-13-10(6-7-19-13)12(11)22(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,19,20)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426731
PNG
(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-...)
Show SMILES C1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N4/c1-2-4-10(5-3-1)18-9-17-12-8-16-14-11(13(12)18)6-7-15-14/h6-10H,1-5H2,(H,15,16)
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n/an/an/an/a 9.80E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426737
PNG
(CHEMBL2322137)
Show SMILES C1CCC(CC1)c1noc2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15N3O/c1-2-4-9(5-3-1)13-12-10-6-7-15-14(10)16-8-11(12)18-17-13/h6-9H,1-5H2,(H,15,16)
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n/an/an/an/a 1.60E+3n/an/an/an/a



Abbott Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation


Bioorg Med Chem Lett 23: 693-8 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.108
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%