Found 9 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50231755
(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)Show InChI InChI=1S/C19H17NO/c1-19(2)13-12-17-16(18(19)21)11-10-15(20-17)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Modulation of mGluR5 (unknown origin) |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50429062
(CHEMBL2335279)Show InChI InChI=1S/C18H13NO/c1-20-18-9-5-8-17-16(18)13-12-15(19-17)11-10-14-6-3-2-4-7-14/h2-9,12-13H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FDSS6000 assay |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50429061
(CHEMBL2335285)Show InChI InChI=1S/C17H12N2O/c1-20-17-6-2-5-16-15(17)10-9-14(19-16)8-7-13-4-3-11-18-12-13/h2-6,9-12H,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FDSS6000 assay |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50429059
(CHEMBL2335295)Show InChI InChI=1S/C16H9BrN2/c17-15-5-3-6-16-14(15)10-9-13(19-16)8-7-12-4-1-2-11-18-12/h1-6,9-11H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FDSS6000 assay |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50429060
(CHEMBL2335291)Show InChI InChI=1S/C16H10N2/c1-2-7-16-13(5-1)8-9-15(18-16)11-10-14-6-3-4-12-17-14/h1-9,12H | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FDSS6000 assay |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50429060
(CHEMBL2335291)Show InChI InChI=1S/C16H10N2/c1-2-7-16-13(5-1)8-9-15(18-16)11-10-14-6-3-4-12-17-14/h1-9,12H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50429059
(CHEMBL2335295)Show InChI InChI=1S/C16H9BrN2/c17-15-5-3-6-16-14(15)10-9-13(19-16)8-7-12-4-1-2-11-18-12/h1-6,9-11H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50429062
(CHEMBL2335279)Show InChI InChI=1S/C18H13NO/c1-20-18-9-5-8-17-16(18)13-12-15(19-17)11-10-14-6-3-2-4-7-14/h2-9,12-13H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50429061
(CHEMBL2335285)Show InChI InChI=1S/C17H12N2O/c1-20-17-6-2-5-16-15(17)10-9-14(19-16)8-7-13-4-3-11-18-12-13/h2-6,9-12H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Science Institute
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 23: 1472-6 (2013)
Article DOI: 10.1016/j.bmcl.2012.12.056 BindingDB Entry DOI: 10.7270/Q2DR2WVN |
More data for this Ligand-Target Pair | |