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PubMed code 23414088

Compile data set for download or QSAR
Found 102 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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 3.40n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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 13n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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 17n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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 35n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/m1/s1
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 37n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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 96n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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 123n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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 140n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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 144n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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 185n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426291
PNG
(CHEMBL2312681)
Show SMILES N[C@@H](C[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(14(20)21)8-11(13(18)19)6-7-17-15(22)23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,22)(H,18,19)(H,20,21)/t11-,12+/m1/s1
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 217n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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 239n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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 282n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
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 330n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to full length rat GluA3

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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 331n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426288
PNG
(CHEMBL2312684)
Show SMILES NCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H14N2O4/c8-2-1-4(6(10)11)3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1
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 340n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426291
PNG
(CHEMBL2312681)
Show SMILES N[C@@H](C[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(14(20)21)8-11(13(18)19)6-7-17-15(22)23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,22)(H,18,19)(H,20,21)/t11-,12+/m1/s1
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 340n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426297
PNG
(CHEMBL2312680)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NNc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H19N3O5/c15-11(14(21)22)8-9(13(19)20)6-7-12(18)17-16-10-4-2-1-3-5-10/h1-5,9,11,16H,6-8,15H2,(H,17,18)(H,19,20)(H,21,22)/t9-,11+/m1/s1
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 382n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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 413n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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 494n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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 500n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to full length rat GluA3

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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 560n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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 583n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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 700n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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 820n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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 900n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA3-LBD (GluK3-S1S2)

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426286
PNG
(CHEMBL2312686)
Show SMILES OC(=O)[C@@H]1CCCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c10-7(11)5-2-1-3-9-6(4-5)8(12)13/h5-6,9H,1-4H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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 906n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426288
PNG
(CHEMBL2312684)
Show SMILES NCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H14N2O4/c8-2-1-4(6(10)11)3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1
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 1.46E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426286
PNG
(CHEMBL2312686)
Show SMILES OC(=O)[C@@H]1CCCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c10-7(11)5-2-1-3-9-6(4-5)8(12)13/h5-6,9H,1-4H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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 2.81E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426291
PNG
(CHEMBL2312681)
Show SMILES N[C@@H](C[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(14(20)21)8-11(13(18)19)6-7-17-15(22)23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,22)(H,18,19)(H,20,21)/t11-,12+/m1/s1
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 3.04E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426298
PNG
(CHEMBL2312401)
Show SMILES CC(C)(C)ONC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O6/c1-12(2,3)20-14-9(15)5-4-7(10(16)17)6-8(13)11(18)19/h7-8H,4-6,13H2,1-3H3,(H,14,15)(H,16,17)(H,18,19)/t7-,8+/m1/s1
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 3.18E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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 3.27E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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 3.29E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
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 4.20E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA3-LBD (GluK3-S1S2)

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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 4.66E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/m1/s1
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 5.39E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50426287
PNG
(CHEMBL2312685)
Show SMILES NCCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H16N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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 5.53E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426297
PNG
(CHEMBL2312680)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NNc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H19N3O5/c15-11(14(21)22)8-9(13(19)20)6-7-12(18)17-16-10-4-2-1-3-5-10/h1-5,9,11,16H,6-8,15H2,(H,17,18)(H,19,20)(H,21,22)/t9-,11+/m1/s1
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 5.66E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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 5.78E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r|
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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 6.30E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA2-LBD (GluR2-S1S2J)

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 3


(RAT)		BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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 7.40E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA3-LBD (GluK3-S1S2)

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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 8.05E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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 8.65E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426287
PNG
(CHEMBL2312685)
Show SMILES NCCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H16N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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 1.02E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426288
PNG
(CHEMBL2312684)
Show SMILES NCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H14N2O4/c8-2-1-4(6(10)11)3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1
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 1.09E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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 1.42E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426286
PNG
(CHEMBL2312686)
Show SMILES OC(=O)[C@@H]1CCCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c10-7(11)5-2-1-3-9-6(4-5)8(12)13/h5-6,9H,1-4H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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 2.18E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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 2.84E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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 3.09E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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 3.46E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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 4.08E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50426298
PNG
(CHEMBL2312401)
Show SMILES CC(C)(C)ONC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O6/c1-12(2,3)20-14-9(15)5-4-7(10(16)17)6-8(13)11(18)19/h7-8H,4-6,13H2,1-3H3,(H,14,15)(H,16,17)(H,18,19)/t7-,8+/m1/s1
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 4.45E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/m1/s1
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 4.92E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426297
PNG
(CHEMBL2312680)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NNc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H19N3O5/c15-11(14(21)22)8-9(13(19)20)6-7-12(18)17-16-10-4-2-1-3-5-10/h1-5,9,11,16H,6-8,15H2,(H,17,18)(H,19,20)(H,21,22)/t9-,11+/m1/s1
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 5.33E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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 5.62E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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 5.65E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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 7.11E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426287
PNG
(CHEMBL2312685)
Show SMILES NCCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H16N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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 8.31E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426297
PNG
(CHEMBL2312680)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NNc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H19N3O5/c15-11(14(21)22)8-9(13(19)20)6-7-12(18)17-16-10-4-2-1-3-5-10/h1-5,9,11,16H,6-8,15H2,(H,17,18)(H,19,20)(H,21,22)/t9-,11+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50426298
PNG
(CHEMBL2312401)
Show SMILES CC(C)(C)ONC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O6/c1-12(2,3)20-14-9(15)5-4-7(10(16)17)6-8(13)11(18)19/h7-8H,4-6,13H2,1-3H3,(H,14,15)(H,16,17)(H,18,19)/t7-,8+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426298
PNG
(CHEMBL2312401)
Show SMILES CC(C)(C)ONC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O6/c1-12(2,3)20-14-9(15)5-4-7(10(16)17)6-8(13)11(18)19/h7-8H,4-6,13H2,1-3H3,(H,14,15)(H,16,17)(H,18,19)/t7-,8+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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 1.26E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Binding affinity to rat GluA2-LBD (GluR2-S1S2J)

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426291
PNG
(CHEMBL2312681)
Show SMILES N[C@@H](C[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(14(20)21)8-11(13(18)19)6-7-17-15(22)23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,22)(H,18,19)(H,20,21)/t11-,12+/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426291
PNG
(CHEMBL2312681)
Show SMILES N[C@@H](C[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(14(20)21)8-11(13(18)19)6-7-17-15(22)23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,22)(H,18,19)(H,20,21)/t11-,12+/m1/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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n/an/a 2.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426286
PNG
(CHEMBL2312686)
Show SMILES OC(=O)[C@@H]1CCCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c10-7(11)5-2-1-3-9-6(4-5)8(12)13/h5-6,9H,1-4H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426286
PNG
(CHEMBL2312686)
Show SMILES OC(=O)[C@@H]1CCCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c10-7(11)5-2-1-3-9-6(4-5)8(12)13/h5-6,9H,1-4H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426286
PNG
(CHEMBL2312686)
Show SMILES OC(=O)[C@@H]1CCCN[C@@H](C1)C(O)=O |r|
Show InChI InChI=1S/C8H13NO4/c10-7(11)5-2-1-3-9-6(4-5)8(12)13/h5-6,9H,1-4H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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n/an/a 3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426295
PNG
(CHEMBL2312397)
Show SMILES N[C@@H](C[C@@H](CCC(=O)Nc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c15-11(14(20)21)8-9(13(18)19)6-7-12(17)16-10-4-2-1-3-5-10/h1-5,9,11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t9-,11+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426291
PNG
(CHEMBL2312681)
Show SMILES N[C@@H](C[C@@H](CCNC(=O)OCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(14(20)21)8-11(13(18)19)6-7-17-15(22)23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,22)(H,18,19)(H,20,21)/t11-,12+/m1/s1
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n/an/a 3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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n/an/a 7.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426288
PNG
(CHEMBL2312684)
Show SMILES NCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H14N2O4/c8-2-1-4(6(10)11)3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426287
PNG
(CHEMBL2312685)
Show SMILES NCCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H16N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))		BDBM50426287
PNG
(CHEMBL2312685)
Show SMILES NCCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H16N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426292
PNG
(CHEMBL2312402)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NOCc1ccccc1)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C15H20N2O6/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-23-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426288
PNG
(CHEMBL2312684)
Show SMILES NCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H14N2O4/c8-2-1-4(6(10)11)3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426288
PNG
(CHEMBL2312684)
Show SMILES NCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C7H14N2O4/c8-2-1-4(6(10)11)3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426287
PNG
(CHEMBL2312685)
Show SMILES NCCC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C8H16N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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n/an/a>3.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))		BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r|
Show InChI InChI=1S/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/m1/s1
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n/an/a>3.00E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay

J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%