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PubMed code 23416002

Compile data set for download or QSAR
Found 126 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430377
PNG
(CHEMBL2333898)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430355
PNG
(CHEMBL2333899)
Show SMILES FC(F)(F)c1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C22H18F3N5O/c23-22(24,25)15-4-1-12(2-5-15)17-10-26-11-18(17)20-29-19-6-3-13(14-8-27-28-9-14)7-16(19)21(31)30-20/h1-9,17-18,26H,10-11H2,(H,27,28)(H,29,30,31)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430356
PNG
(CHEMBL2333897)
Show SMILES Fc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18FN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430339
PNG
(CHEMBL2333879)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430346
PNG
(CHEMBL2333886)
Show SMILES C[N+]1(C)C[C@H]([C@@H](C1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1)c1ccccc1 |r|
Show InChI InChI=1S/C23H23N5O/c1-28(2)13-19(15-6-4-3-5-7-15)20(14-28)22-26-21-9-8-16(17-11-24-25-12-17)10-18(21)23(29)27-22/h3-12,19-20H,13-14H2,1-2H3,(H-,24,25,26,27,29)/p+1/t19-,20+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430372
PNG
(CHEMBL2334294)
Show SMILES N[C@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430349
PNG
(CHEMBL2333883)
Show SMILES NCCC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C21H19ClN6O2/c22-15-4-1-12(2-5-15)19(27-18(29)7-8-23)20-26-17-6-3-13(14-10-24-25-11-14)9-16(17)21(30)28-20/h1-6,9-11,19H,7-8,23H2,(H,24,25)(H,27,29)(H,26,28,30)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430331
PNG
(CHEMBL2334290)
Show SMILES Nc1nccc(n1)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C22H20N6O/c23-22-25-9-8-18(27-22)14-6-7-19-15(10-14)21(29)28-20(26-19)17-12-24-11-16(17)13-4-2-1-3-5-13/h1-10,16-17,24H,11-12H2,(H2,23,25,27)(H,26,28,29)/t16-,17+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430373
PNG
(CHEMBL2334293)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430375
PNG
(CHEMBL2334291)
Show SMILES Cc1[nH]ncc1-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C22H21N5O/c1-13-17(12-24-27-13)15-7-8-20-16(9-15)22(28)26-21(25-20)19-11-23-10-18(19)14-5-3-2-4-6-14/h2-9,12,18-19,23H,10-11H2,1H3,(H,24,27)(H,25,26,28)/t18-,19+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430364
PNG
(CHEMBL2333912)
Show SMILES N[C@H](Cc1ccc(F)c(F)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H15F2N5O/c20-14-3-1-10(5-15(14)21)6-16(22)18-25-17-4-2-11(12-8-23-24-9-12)7-13(17)19(27)26-18/h1-5,7-9,16H,6,22H2,(H,23,24)(H,25,26,27)/t16-/m1/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430369
PNG
(CHEMBL2333907)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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n/an/a 8n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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n/an/a 8n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430358
PNG
(CHEMBL2333895)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1ccc(Cl)cc1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-2-4-13(20)5-3-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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n/an/a 9n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430360
PNG
(CHEMBL2333893)
Show SMILES NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-4-1-10(2-5-13)16(20)17-23-15-6-3-11(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a 10n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430362
PNG
(CHEMBL2333914)
Show SMILES N[C@H](Cc1cccc(F)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-3-1-2-11(6-14)7-16(21)18-24-17-5-4-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430335
PNG
(CHEMBL2334286)
Show SMILES N[C@@H](Cc1ccccc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H17N5O/c20-16(8-12-4-2-1-3-5-12)18-23-17-7-6-13(14-10-21-22-11-14)9-15(17)19(25)24-18/h1-7,9-11,16H,8,20H2,(H,21,22)(H,23,24,25)/t16-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a 13n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430363
PNG
(CHEMBL2333913)
Show SMILES N[C@H](Cc1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-3-1-2-11(6-14)7-16(21)18-24-17-5-4-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430350
PNG
(CHEMBL2333904)
Show SMILES CCN[C@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H20ClN5O/c1-2-23-19(9-13-3-6-16(22)7-4-13)20-26-18-8-5-14(15-11-24-25-12-15)10-17(18)21(28)27-20/h3-8,10-12,19,23H,2,9H2,1H3,(H,24,25)(H,26,27,28)/t19-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a 15n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430361
PNG
(CHEMBL2334284)
Show SMILES N[C@H](Cc1cccc(c1)C(F)(F)F)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H16F3N5O/c21-20(22,23)14-3-1-2-11(6-14)7-16(24)18-27-17-5-4-12(13-9-25-26-10-13)8-15(17)19(29)28-18/h1-6,8-10,16H,7,24H2,(H,25,26)(H,27,28,29)/t16-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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n/an/a 18n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430366
PNG
(CHEMBL2333910)
Show SMILES CCOc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C21H21N5O2/c1-2-28-16-6-3-13(4-7-16)9-18(22)20-25-19-8-5-14(15-11-23-24-12-15)10-17(19)21(27)26-20/h3-8,10-12,18H,2,9,22H2,1H3,(H,23,24)(H,25,26,27)/t18-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430347
PNG
(CHEMBL2333885)
Show SMILES NCc1cccc(c1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-7-4-16(5-8-20)23(32-25(34)18-3-1-2-15(10-18)12-28)24-31-22-9-6-17(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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n/an/a 20n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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n/an/a 22n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430332
PNG
(CHEMBL2334289)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1ccncc1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H20N4O/c28-23-18-12-17(15-8-10-24-11-9-15)6-7-21(18)26-22(27-23)20-14-25-13-19(20)16-4-2-1-3-5-16/h1-12,19-20,25H,13-14H2,(H,26,27,28)/t19-,20+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430341
PNG
(CHEMBL2333891)
Show SMILES CN(CCO)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H](N)Cc1cccc(F)c1 |r|
Show InChI InChI=1S/C22H23FN6O/c1-29(7-8-30)22-18-11-15(16-12-25-26-13-16)5-6-20(18)27-21(28-22)19(24)10-14-3-2-4-17(23)9-14/h2-6,9,11-13,19,30H,7-8,10,24H2,1H3,(H,25,26)/t19-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430343
PNG
(CHEMBL2333889)
Show SMILES CN(CCO)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@H](N)Cc1cccc(F)c1 |r|
Show InChI InChI=1S/C22H23FN6O/c1-29(7-8-30)22-18-11-15(16-12-25-26-13-16)5-6-20(18)27-21(28-22)19(24)10-14-3-2-4-17(23)9-14/h2-6,9,11-13,19,30H,7-8,10,24H2,1H3,(H,25,26)/t19-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430365
PNG
(CHEMBL2333911)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1OC |r|
Show InChI InChI=1S/C21H21N5O3/c1-28-18-6-3-12(8-19(18)29-2)7-16(22)20-25-17-5-4-13(14-10-23-24-11-14)9-15(17)21(27)26-20/h3-6,8-11,16H,7,22H2,1-2H3,(H,23,24)(H,25,26,27)/t16-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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n/an/a 43n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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n/an/a 48n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430352
PNG
(CHEMBL2333902)
Show SMILES Fc1ccccc1[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C28H24FN5O/c29-25-9-5-4-8-21(25)23-16-34(15-18-6-2-1-3-7-18)17-24(23)27-32-26-11-10-19(20-13-30-31-14-20)12-22(26)28(35)33-27/h1-14,23-24H,15-17H2,(H,30,31)(H,32,33,35)/t23-,24+/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430336
PNG
(CHEMBL2334285)
Show SMILES N[C@@H](Cc1ccccc1)c1nc2ccc(cc2c(=O)[nH]1)-c1ccncc1 |r|
Show InChI InChI=1S/C21H18N4O/c22-18(12-14-4-2-1-3-5-14)20-24-19-7-6-16(13-17(19)21(26)25-20)15-8-10-23-11-9-15/h1-11,13,18H,12,22H2,(H,24,25,26)/t18-/m0/s1
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n/an/a 52n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430340
PNG
(CHEMBL2333892)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H](N)Cc1cccc(F)c1 |r|
Show InChI InChI=1S/C21H21FN6/c1-28(2)21-17-10-14(15-11-24-25-12-15)6-7-19(17)26-20(27-21)18(23)9-13-4-3-5-16(22)8-13/h3-8,10-12,18H,9,23H2,1-2H3,(H,24,25)/t18-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430338
PNG
(CHEMBL2333880)
Show SMILES Fc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc(N2CCC2)c2cc(ccc2n1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C24H23FN6/c25-18-5-2-15(3-6-18)20-13-26-14-21(20)23-29-22-7-4-16(17-11-27-28-12-17)10-19(22)24(30-23)31-8-1-9-31/h2-7,10-12,20-21,26H,1,8-9,13-14H2,(H,27,28)/t20-,21+/m0/s1
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n/an/a 71n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430354
PNG
(CHEMBL2333900)
Show SMILES COc1ccc(cc1)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C29H27N5O2/c1-36-23-10-7-20(8-11-23)25-17-34(16-19-5-3-2-4-6-19)18-26(25)28-32-27-12-9-21(22-14-30-31-15-22)13-24(27)29(35)33-28/h2-15,25-26H,16-18H2,1H3,(H,30,31)(H,32,33,35)/t25-,26+/m0/s1
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n/an/a 88n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430334
PNG
(CHEMBL2334287)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1C
Show InChI InChI=1S/C20H19N5O2/c1-11-16(10-22-25-11)13-5-8-17-15(9-13)20(26)24-19(23-17)18(21)12-3-6-14(27-2)7-4-12/h3-10,18H,21H2,1-2H3,(H,22,25)(H,23,24,26)
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n/an/a 98n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430342
PNG
(CHEMBL2333890)
Show SMILES CN(CCCO)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@H](N)Cc1cccc(F)c1 |r|
Show InChI InChI=1S/C23H25FN6O/c1-30(8-3-9-31)23-19-12-16(17-13-26-27-14-17)6-7-21(19)28-22(29-23)20(25)11-15-4-2-5-18(24)10-15/h2,4-7,10,12-14,20,31H,3,8-9,11,25H2,1H3,(H,26,27)/t20-/m1/s1
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n/an/a 159n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430353
PNG
(CHEMBL2333901)
Show SMILES Fc1cccc(c1)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C28H24FN5O/c29-22-8-4-7-20(11-22)24-16-34(15-18-5-2-1-3-6-18)17-25(24)27-32-26-10-9-19(21-13-30-31-14-21)12-23(26)28(35)33-27/h1-14,24-25H,15-17H2,(H,30,31)(H,32,33,35)/t24-,25+/m0/s1
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n/an/a 225n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430351
PNG
(CHEMBL2333903)
Show SMILES Clc1ccc(C[C@@H](NC(=O)Cc2cccnc2)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C26H21ClN6O2/c27-20-6-3-16(4-7-20)10-23(31-24(34)11-17-2-1-9-28-13-17)25-32-22-8-5-18(19-14-29-30-15-19)12-21(22)26(35)33-25/h1-9,12-15,23H,10-11H2,(H,29,30)(H,31,34)(H,32,33,35)/t23-/m1/s1
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n/an/a 239n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430337
PNG
(CHEMBL2333881)
Show SMILES CN(C)CCNc1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccc(F)cc1 |r|
Show InChI InChI=1S/C25H28FN7/c1-33(2)10-9-28-24-20-11-17(18-12-29-30-13-18)5-8-23(20)31-25(32-24)22-15-27-14-21(22)16-3-6-19(26)7-4-16/h3-8,11-13,21-22,27H,9-10,14-15H2,1-2H3,(H,29,30)(H,28,31,32)/t21-,22+/m0/s1
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n/an/a 371n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50430344
PNG
(CHEMBL2333888)
Show SMILES CN(C)CCN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@H](N)Cc1cccc(F)c1 |r|
Show InChI InChI=1S/C24H28FN7/c1-31(2)9-10-32(3)24-20-13-17(18-14-27-28-15-18)7-8-22(20)29-23(30-24)21(26)12-16-5-4-6-19(25)11-16/h4-8,11,13-15,21H,9-10,12,26H2,1-3H3,(H,27,28)/t21-/m1/s1
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n/an/a 627n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430339
PNG
(CHEMBL2333879)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430373
PNG
(CHEMBL2334293)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430339
PNG
(CHEMBL2333879)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430377
PNG
(CHEMBL2333898)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430377
PNG
(CHEMBL2333898)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430373
PNG
(CHEMBL2334293)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430376
PNG
(CHEMBL2333882)
Show SMILES CN(C)CC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C22H21ClN6O2/c1-29(2)12-19(30)27-20(13-3-6-16(23)7-4-13)21-26-18-8-5-14(15-10-24-25-11-15)9-17(18)22(31)28-21/h3-11,20H,12H2,1-2H3,(H,24,25)(H,27,30)(H,26,28,31)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430376
PNG
(CHEMBL2333882)
Show SMILES CN(C)CC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C22H21ClN6O2/c1-29(2)12-19(30)27-20(13-3-6-16(23)7-4-13)21-26-18-8-5-14(15-10-24-25-11-15)9-17(18)22(31)28-21/h3-11,20H,12H2,1-2H3,(H,24,25)(H,27,30)(H,26,28,31)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430376
PNG
(CHEMBL2333882)
Show SMILES CN(C)CC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C22H21ClN6O2/c1-29(2)12-19(30)27-20(13-3-6-16(23)7-4-13)21-26-18-8-5-14(15-10-24-25-11-15)9-17(18)22(31)28-21/h3-11,20H,12H2,1-2H3,(H,24,25)(H,27,30)(H,26,28,31)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430339
PNG
(CHEMBL2333879)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430373
PNG
(CHEMBL2334293)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430376
PNG
(CHEMBL2333882)
Show SMILES CN(C)CC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C22H21ClN6O2/c1-29(2)12-19(30)27-20(13-3-6-16(23)7-4-13)21-26-18-8-5-14(15-10-24-25-11-15)9-17(18)22(31)28-21/h3-11,20H,12H2,1-2H3,(H,24,25)(H,27,30)(H,26,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430373
PNG
(CHEMBL2334293)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430339
PNG
(CHEMBL2333879)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430377
PNG
(CHEMBL2333898)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430359
PNG
(CHEMBL2333894)
Show SMILES NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430367
PNG
(CHEMBL2333909)
Show SMILES COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 |r|
Show InChI InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430370
PNG
(CHEMBL2333906)
Show SMILES N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430373
PNG
(CHEMBL2334293)
Show SMILES N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK2 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430368
PNG
(CHEMBL2333908)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430374
PNG
(CHEMBL2334292)
Show SMILES O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430377
PNG
(CHEMBL2333898)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430371
PNG
(CHEMBL2333905)
Show SMILES N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1
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Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430376
PNG
(CHEMBL2333882)
Show SMILES CN(C)CC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C22H21ClN6O2/c1-29(2)12-19(30)27-20(13-3-6-16(23)7-4-13)21-26-18-8-5-14(15-10-24-25-11-15)9-17(18)22(31)28-21/h3-11,20H,12H2,1-2H3,(H,24,25)(H,27,30)(H,26,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK3 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430348
PNG
(CHEMBL2333884)
Show SMILES NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha


(Homo sapiens (Human))
BDBM50430357
PNG
(CHEMBL2333896)
Show SMILES COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1
Show InChI InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MRCKalpha (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430339
PNG
(CHEMBL2333879)
Show SMILES CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430345
PNG
(CHEMBL2333887)
Show SMILES COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430377
PNG
(CHEMBL2333898)
Show SMILES Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 |r|
Show InChI InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50430333
PNG
(CHEMBL2334288)
Show SMILES COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JNK1 (unknown origin)


Bioorg Med Chem Lett 23: 1592-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.109
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%