Found 3 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50432802
(CHEMBL2376052)Show SMILES CN(C)CCCNCCC(=O)Nc1ccc(cc1)C(=O)Nc1cc(Cl)ccc1-c1nc(NCCCN(C)C)c2ccccc2n1 Show InChI InChI=1S/C34H43ClN8O2/c1-42(2)21-7-18-36-20-17-31(44)38-26-14-11-24(12-15-26)34(45)40-30-23-25(35)13-16-28(30)33-39-29-10-6-5-9-27(29)32(41-33)37-19-8-22-43(3)4/h5-6,9-16,23,36H,7-8,17-22H2,1-4H3,(H,38,44)(H,40,45)(H,37,39,41) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human HL60 cell extract by TRAP-LIG assay |
Eur J Med Chem 63: 1-13 (2013)
Article DOI: 10.1016/j.ejmech.2013.01.051
BindingDB Entry DOI: 10.7270/Q2BP045H |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50432803
(CHEMBL2376047)Show SMILES CN(C)CCCNCCC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1-c1nc(NCCCN(C)C)c2ccccc2n1 Show InChI InChI=1S/C34H44N8O2/c1-41(2)23-9-20-35-22-19-31(43)37-26-17-15-25(16-18-26)34(44)39-30-14-8-6-12-28(30)33-38-29-13-7-5-11-27(29)32(40-33)36-21-10-24-42(3)4/h5-8,11-18,35H,9-10,19-24H2,1-4H3,(H,37,43)(H,39,44)(H,36,38,40) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human HL60 cell extract by TRAP-LIG assay |
Eur J Med Chem 63: 1-13 (2013)
Article DOI: 10.1016/j.ejmech.2013.01.051
BindingDB Entry DOI: 10.7270/Q2BP045H |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50432804
(CHEMBL2376061)Show SMILES CN(C)CCCNCCC(=O)Nc1ccccc1-c1nc(NCCCN(C)C)c2ccccc2n1 Show InChI InChI=1S/C27H39N7O/c1-33(2)19-9-16-28-18-15-25(35)30-23-13-7-6-12-22(23)27-31-24-14-8-5-11-21(24)26(32-27)29-17-10-20-34(3)4/h5-8,11-14,28H,9-10,15-20H2,1-4H3,(H,30,35)(H,29,31,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of telomerase in human HL60 cell extract by TRAP-LIG assay |
Eur J Med Chem 63: 1-13 (2013)
Article DOI: 10.1016/j.ejmech.2013.01.051
BindingDB Entry DOI: 10.7270/Q2BP045H |
More data for this
Ligand-Target Pair | |
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