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PubMed code 23499504

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432958
PNG
(CHEMBL2377727)
Show SMILES Cc1cc(C)nc(NC(=O)N(CCC(c2ccccc2)c2ccccc2)CCN2CCOCC2)c1
Show InChI InChI=1S/C29H36N4O2/c1-23-21-24(2)30-28(22-23)31-29(34)33(16-15-32-17-19-35-20-18-32)14-13-27(25-9-5-3-6-10-25)26-11-7-4-8-12-26/h3-12,21-22,27H,13-20H2,1-2H3,(H,30,31,34)
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n/an/an/an/a 80n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432971
PNG
(CHEMBL2377745)
Show SMILES FC(F)(F)Oc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H31F3N4O3S/c31-30(32,33)40-24-11-12-26-27(21-24)41-28(34-26)35-29(38)37(16-15-36-17-19-39-20-18-36)14-13-25(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-12,21,25H,13-20H2,(H,34,35,38)
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n/an/an/an/a 90n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432966
PNG
(CHEMBL2375383)
Show SMILES OC(=O)c1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H32N4O4S/c35-28(36)24-11-12-26-27(21-24)39-29(31-26)32-30(37)34(16-15-33-17-19-38-20-18-33)14-13-25(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-12,21,25H,13-20H2,(H,35,36)(H,31,32,37)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432950
PNG
(CHEMBL2377735)
Show SMILES O=C(Nc1nc2ccccc2s1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C29H32N4O2S/c34-29(31-28-30-26-13-7-8-14-27(26)36-28)33(18-17-32-19-21-35-22-20-32)16-15-25(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-14,25H,15-22H2,(H,30,31,34)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432952
PNG
(CHEMBL2377733)
Show SMILES Cc1noc(NC(=O)N(CCC(c2ccccc2)c2ccccc2)CCN2CCOCC2)c1C
Show InChI InChI=1S/C27H34N4O3/c1-21-22(2)29-34-26(21)28-27(32)31(16-15-30-17-19-33-20-18-30)14-13-25(23-9-5-3-6-10-23)24-11-7-4-8-12-24/h3-12,25H,13-20H2,1-2H3,(H,28,32)
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n/an/an/an/a 1.70E+3n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432963
PNG
(CHEMBL2377752)
Show SMILES CS(=O)(=O)c1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H34N4O4S2/c1-40(36,37)25-12-13-27-28(22-25)39-29(31-27)32-30(35)34(17-16-33-18-20-38-21-19-33)15-14-26(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-13,22,26H,14-21H2,1H3,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432968
PNG
(CHEMBL2377748)
Show SMILES CS(=O)(=O)Nc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H35N5O4S2/c1-41(37,38)33-25-12-13-27-28(22-25)40-29(31-27)32-30(36)35(17-16-34-18-20-39-21-19-34)15-14-26(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-13,22,26,33H,14-21H2,1H3,(H,31,32,36)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432948
PNG
(CHEMBL2377737)
Show SMILES Cn1c(NC(=O)N(CCC(c2ccccc2)c2ccccc2)CCN2CCOCC2)nc2ccccc12
Show InChI InChI=1S/C30H35N5O2/c1-33-28-15-9-8-14-27(28)31-29(33)32-30(36)35(19-18-34-20-22-37-23-21-34)17-16-26(24-10-4-2-5-11-24)25-12-6-3-7-13-25/h2-15,26H,16-23H2,1H3,(H,31,32,36)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432949
PNG
(CHEMBL2377736)
Show SMILES O=C(Nc1nc2ccccc2[nH]1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C29H33N5O2/c35-29(32-28-30-26-13-7-8-14-27(26)31-28)34(18-17-33-19-21-36-22-20-33)16-15-25(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-14,25H,15-22H2,(H2,30,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432957
PNG
(CHEMBL2377728)
Show SMILES O=C(Nc1cnccn1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C26H31N5O2/c32-26(29-25-21-27-12-13-28-25)31(16-15-30-17-19-33-20-18-30)14-11-24(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-10,12-13,21,24H,11,14-20H2,(H,28,29,32)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432973
PNG
(CHEMBL2377743)
Show SMILES CS(=O)(=O)Nc1ccc2sc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc2c1
Show InChI InChI=1S/C30H35N5O4S2/c1-41(37,38)33-25-12-13-28-27(22-25)31-29(40-28)32-30(36)35(17-16-34-18-20-39-21-19-34)15-14-26(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-13,22,26,33H,14-21H2,1H3,(H,31,32,36)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432976
PNG
(CHEMBL2377740)
Show SMILES Clc1cccc2sc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc12
Show InChI InChI=1S/C29H31ClN4O2S/c30-25-12-7-13-26-27(25)31-28(37-26)32-29(35)34(17-16-33-18-20-36-21-19-33)15-14-24(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,24H,14-21H2,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432953
PNG
(CHEMBL2377732)
Show SMILES Cc1cc(NC(=O)N(CCC(c2ccccc2)c2ccccc2)CCN2CCOCC2)no1
Show InChI InChI=1S/C26H32N4O3/c1-21-20-25(28-33-21)27-26(31)30(15-14-29-16-18-32-19-17-29)13-12-24(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-11,20,24H,12-19H2,1H3,(H,27,28,31)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432961
PNG
(CHEMBL2375386)
Show SMILES Fc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C29H31FN4O2S/c30-24-11-12-26-27(21-24)37-28(31-26)32-29(35)34(16-15-33-17-19-36-20-18-33)14-13-25(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-12,21,25H,13-20H2,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432962
PNG
(CHEMBL2375385)
Show SMILES CCOc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C31H36N4O3S/c1-2-38-26-13-14-28-29(23-26)39-30(32-28)33-31(36)35(18-17-34-19-21-37-22-20-34)16-15-27(24-9-5-3-6-10-24)25-11-7-4-8-12-25/h3-14,23,27H,2,15-22H2,1H3,(H,32,33,36)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432965
PNG
(CHEMBL2377750)
Show SMILES CCOC(=O)c1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C32H36N4O4S/c1-2-40-30(37)26-13-14-28-29(23-26)41-31(33-28)34-32(38)36(18-17-35-19-21-39-22-20-35)16-15-27(24-9-5-3-6-10-24)25-11-7-4-8-12-25/h3-14,23,27H,2,15-22H2,1H3,(H,33,34,38)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432974
PNG
(CHEMBL2377742)
Show SMILES Cc1cccc2sc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc12
Show InChI InChI=1S/C30H34N4O2S/c1-23-9-8-14-27-28(23)31-29(37-27)32-30(35)34(18-17-33-19-21-36-22-20-33)16-15-26(24-10-4-2-5-11-24)25-12-6-3-7-13-25/h2-14,26H,15-22H2,1H3,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432977
PNG
(CHEMBL2377739)
Show SMILES Clc1ccc2oc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc2c1
Show InChI InChI=1S/C29H31ClN4O3/c30-24-11-12-27-26(21-24)31-28(37-27)32-29(35)34(16-15-33-17-19-36-20-18-33)14-13-25(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-12,21,25H,13-20H2,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432972
PNG
(CHEMBL2377744)
Show SMILES COc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H34N4O3S/c1-36-25-12-13-27-28(22-25)38-29(31-27)32-30(35)34(17-16-33-18-20-37-21-19-33)15-14-26(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-13,22,26H,14-21H2,1H3,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432975
PNG
(CHEMBL2377741)
Show SMILES COc1cccc2sc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)nc12
Show InChI InChI=1S/C30H34N4O3S/c1-36-26-13-8-14-27-28(26)31-29(38-27)32-30(35)34(18-17-33-19-21-37-22-20-33)16-15-25(23-9-4-2-5-10-23)24-11-6-3-7-12-24/h2-14,25H,15-22H2,1H3,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432978
PNG
(CHEMBL2377738)
Show SMILES O=C(Nc1nc2ccccc2n1Cc1ccccc1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C36H39N5O2/c42-36(38-35-37-33-18-10-11-19-34(33)41(35)28-29-12-4-1-5-13-29)40(23-22-39-24-26-43-27-25-39)21-20-32(30-14-6-2-7-15-30)31-16-8-3-9-17-31/h1-19,32H,20-28H2,(H,37,38,42)
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n/an/an/an/a 300n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432959
PNG
(CHEMBL2377726)
Show SMILES O=C(Nc1cccnc1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C27H32N4O2/c32-27(29-25-12-7-14-28-22-25)31(17-16-30-18-20-33-21-19-30)15-13-26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-12,14,22,26H,13,15-21H2,(H,29,32)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432970
PNG
(CHEMBL2377746)
Show SMILES Clc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C29H31ClN4O2S/c30-24-11-12-26-27(21-24)37-28(31-26)32-29(35)34(16-15-33-17-19-36-20-18-33)14-13-25(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-12,21,25H,13-20H2,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432951
PNG
(CHEMBL2377734)
Show SMILES COC(=O)c1sccc1NC(=O)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C28H33N3O4S/c1-34-27(32)26-25(13-21-36-26)29-28(33)31(16-15-30-17-19-35-20-18-30)14-12-24(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-11,13,21,24H,12,14-20H2,1H3,(H,29,33)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432954
PNG
(CHEMBL2377731)
Show SMILES O=C(Nc1nccs1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C25H30N4O2S/c30-25(27-24-26-12-20-32-24)29(15-14-28-16-18-31-19-17-28)13-11-23(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-10,12,20,23H,11,13-19H2,(H,26,27,30)
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n/an/an/an/a 300n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432964
PNG
(CHEMBL2377751)
Show SMILES CN(C)CCNC(=O)c1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C34H42N6O3S/c1-38(2)18-16-35-32(41)28-13-14-30-31(25-28)44-33(36-30)37-34(42)40(20-19-39-21-23-43-24-22-39)17-15-29(26-9-5-3-6-10-26)27-11-7-4-8-12-27/h3-14,25,29H,15-24H2,1-2H3,(H,35,41)(H,36,37,42)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432967
PNG
(CHEMBL2377749)
Show SMILES Cc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H34N4O2S/c1-23-12-13-27-28(22-23)37-29(31-27)32-30(35)34(17-16-33-18-20-36-21-19-33)15-14-26(24-8-4-2-5-9-24)25-10-6-3-7-11-25/h2-13,22,26H,14-21H2,1H3,(H,31,32,35)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432969
PNG
(CHEMBL2377747)
Show SMILES OCc1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Show InChI InChI=1S/C30H34N4O3S/c35-22-23-11-12-27-28(21-23)38-29(31-27)32-30(36)34(16-15-33-17-19-37-20-18-33)14-13-26(24-7-3-1-4-8-24)25-9-5-2-6-10-25/h1-12,21,26,35H,13-20,22H2,(H,31,32,36)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432955
PNG
(CHEMBL2377730)
Show SMILES O=C(Nc1nccc(n1)-c1nccs1)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
Show InChI InChI=1S/C29H32N6O2S/c36-29(33-28-31-13-11-26(32-28)27-30-14-22-38-27)35(17-16-34-18-20-37-21-19-34)15-12-25(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-11,13-14,22,25H,12,15-21H2,(H,31,32,33,36)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432956
PNG
(CHEMBL2377729)
Show SMILES COc1cc(C)nc(NC(=O)N(CCC(c2ccccc2)c2ccccc2)CCN2CCOCC2)n1
Show InChI InChI=1S/C28H35N5O3/c1-22-21-26(35-2)30-27(29-22)31-28(34)33(16-15-32-17-19-36-20-18-32)14-13-25(23-9-5-3-6-10-23)24-11-7-4-8-12-24/h3-12,21,25H,13-20H2,1-2H3,(H,29,30,31,34)
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Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50432960
PNG
(KRN-568 | NPS-R-568 | Norcalcin | R-568 | TECALCET...)
Show SMILES COc1cccc(c1)[C@@H](C)NCCCc1ccccc1Cl
Show InChI InChI=1S/C18H22ClNO/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3/t14-/m1/s1
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n/an/an/an/a 80n/an/an/an/a



Galapagos SASU

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...


Bioorg Med Chem Lett 23: 2455-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.077
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%