Found 15 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50125265
(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433667
(CHEMBL2380965)Show SMILES CN(C)CCN(C)Cc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C37H39F4N7OS/c1-45(2)19-20-46(3)22-33-43-44-34(48(33)21-25-7-11-27(12-8-25)28-13-15-29(16-14-28)37(39,40)41)23-47-32-6-4-5-31(32)35(49)42-36(47)50-24-26-9-17-30(38)18-10-26/h7-18H,4-6,19-24H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433665
(CHEMBL2380967)Show SMILES CN(CCN1CCCC1)Cc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C39H41F4N7OS/c1-47(21-22-48-19-2-3-20-48)24-35-45-46-36(50(35)23-27-7-11-29(12-8-27)30-13-15-31(16-14-30)39(41,42)43)25-49-34-6-4-5-33(34)37(51)44-38(49)52-26-28-9-17-32(40)18-10-28/h7-18H,2-6,19-26H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433661
(CHEMBL2380954)Show SMILES CCN(CC)CCN(C)C(C)c1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C40H45F4N7OS/c1-5-49(6-2)23-22-48(4)27(3)37-47-46-36(51(37)24-28-10-14-30(15-11-28)31-16-18-32(19-17-31)40(42,43)44)25-50-35-9-7-8-34(35)38(52)45-39(50)53-26-29-12-20-33(41)21-13-29/h10-21,27H,5-9,22-26H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433658
(CHEMBL2380957)Show SMILES CCN(CC)CCCCc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C39H42F4N6OS/c1-3-47(4-2)23-6-5-10-35-45-46-36(49(35)24-27-11-15-29(16-12-27)30-17-19-31(20-18-30)39(41,42)43)25-48-34-9-7-8-33(34)37(50)44-38(48)51-26-28-13-21-32(40)22-14-28/h11-22H,3-10,23-26H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433664
(CHEMBL2380968)Show SMILES CN(C)CCCN(C)Cc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C38H41F4N7OS/c1-46(2)20-5-21-47(3)23-34-44-45-35(49(34)22-26-8-12-28(13-9-26)29-14-16-30(17-15-29)38(40,41)42)24-48-33-7-4-6-32(33)36(50)43-37(48)51-25-27-10-18-31(39)19-11-27/h8-19H,4-7,20-25H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433666
(CHEMBL2380966)Show SMILES CN(CCN1CCCCC1)Cc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C40H43F4N7OS/c1-48(22-23-49-20-3-2-4-21-49)25-36-46-47-37(51(36)24-28-8-12-30(13-9-28)31-14-16-32(17-15-31)40(42,43)44)26-50-35-7-5-6-34(35)38(52)45-39(50)53-27-29-10-18-33(41)19-11-29/h8-19H,2-7,20-27H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433660
(CHEMBL2380955)Show SMILES CC(N(C)CCN(C)C)c1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C38H41F4N7OS/c1-25(47(4)21-20-46(2)3)35-45-44-34(49(35)22-26-8-12-28(13-9-26)29-14-16-30(17-15-29)38(40,41)42)23-48-33-7-5-6-32(33)36(50)43-37(48)51-24-27-10-18-31(39)19-11-27/h8-19,25H,5-7,20-24H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433656
(CHEMBL2380959)Show SMILES Fc1ccc(CSc2nc(=O)c3CCCc3n2Cc2nnc(CCCN3CCCC3)n2Cc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C38H38F4N6OS/c39-31-18-10-27(11-19-31)25-50-37-43-36(49)32-5-3-6-33(32)47(37)24-35-45-44-34(7-4-22-46-20-1-2-21-46)48(35)23-26-8-12-28(13-9-26)29-14-16-30(17-15-29)38(40,41)42/h8-19H,1-7,20-25H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433659
(CHEMBL2380956)Show SMILES CC(N(C)CCCN(C)C)c1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C39H43F4N7OS/c1-26(48(4)22-6-21-47(2)3)36-46-45-35(50(36)23-27-9-13-29(14-10-27)30-15-17-31(18-16-30)39(41,42)43)24-49-34-8-5-7-33(34)37(51)44-38(49)52-25-28-11-19-32(40)20-12-28/h9-20,26H,5-8,21-25H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433668
(CHEMBL2380963)Show SMILES CCN(CC)CCN(C)Cc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C39H43F4N7OS/c1-4-48(5-2)22-21-47(3)24-35-45-46-36(50(35)23-27-9-13-29(14-10-27)30-15-17-31(18-16-30)39(41,42)43)25-49-34-8-6-7-33(34)37(51)44-38(49)52-26-28-11-19-32(40)20-12-28/h9-20H,4-8,21-26H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433655
(CHEMBL2380960)Show SMILES Fc1ccc(CSc2nc(=O)c3CCCc3n2Cc2nnc(CCCN3CCCCC3)n2Cc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C39H40F4N6OS/c40-32-19-11-28(12-20-32)26-51-38-44-37(50)33-6-4-7-34(33)48(38)25-36-46-45-35(8-5-23-47-21-2-1-3-22-47)49(36)24-27-9-13-29(14-10-27)30-15-17-31(18-16-30)39(41,42)43/h9-20H,1-8,21-26H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433657
(CHEMBL2380958)Show SMILES CCN(CC)CCCc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C38H40F4N6OS/c1-3-46(4-2)22-6-9-34-44-45-35(48(34)23-26-10-14-28(15-11-26)29-16-18-30(19-17-29)38(40,41)42)24-47-33-8-5-7-32(33)36(49)43-37(47)50-25-27-12-20-31(39)21-13-27/h10-21H,3-9,22-25H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433663
(CHEMBL2380859)Show SMILES CN(C)[C@@H]1CCN(Cc2nnc(Cn3c4CCCc4c(=O)nc3SCc3ccc(F)cc3)n2Cc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)C1 |r| Show InChI InChI=1S/C38H39F4N7OS/c1-46(2)31-18-19-47(21-31)22-34-44-45-35(49(34)20-25-6-10-27(11-7-25)28-12-14-29(15-13-28)38(40,41)42)23-48-33-5-3-4-32(33)36(50)43-37(48)51-24-26-8-16-30(39)17-9-26/h6-17,31H,3-5,18-24H2,1-2H3/t31-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
Platelet-activating factor acetylhydrolase
(Homo sapiens (Human)) | BDBM50433662
(CHEMBL2380952)Show SMILES CCN(CC)CCN(C)Cc1cnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C40H44F4N6OS/c1-4-48(5-2)22-21-47(3)25-34-23-45-37(49(34)24-28-9-13-30(14-10-28)31-15-17-32(18-16-31)40(42,43)44)26-50-36-8-6-7-35(36)38(51)46-39(50)52-27-29-11-19-33(41)20-12-29/h9-20,23H,4-8,21-22,24-27H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins b... |
Bioorg Med Chem Lett 23: 2897-901 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.062
BindingDB Entry DOI: 10.7270/Q2KW5HFS |
More data for this
Ligand-Target Pair | |
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