Found 4 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50435303
(CHEMBL2391167)Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)c2cc(F)ccc2C)c(C)c1 Show InChI InChI=1S/C24H30FN3O/c1-16-6-7-19(25)14-22(16)24(29)26-23-9-8-20(13-17(23)2)27-12-10-21(15-27)28-11-4-5-18(28)3/h6-9,13-14,18,21H,4-5,10-12,15H2,1-3H3,(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi US
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor |
Bioorg Med Chem Lett 23: 3421-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.081
BindingDB Entry DOI: 10.7270/Q2HH6MGF |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50435304
(CHEMBL2391166)Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)c2ccccc2F)c(C)c1 Show InChI InChI=1S/C23H28FN3O/c1-16-14-18(26-13-11-19(15-26)27-12-5-6-17(27)2)9-10-22(16)25-23(28)20-7-3-4-8-21(20)24/h3-4,7-10,14,17,19H,5-6,11-13,15H2,1-2H3,(H,25,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi US
Curated by ChEMBL
| Assay Description
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor |
Bioorg Med Chem Lett 23: 3421-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.081
BindingDB Entry DOI: 10.7270/Q2HH6MGF |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM50435303
(CHEMBL2391167)Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)c2cc(F)ccc2C)c(C)c1 Show InChI InChI=1S/C24H30FN3O/c1-16-6-7-19(25)14-22(16)24(29)26-23-9-8-20(13-17(23)2)27-12-10-21(15-27)28-11-4-5-18(28)3/h6-9,13-14,18,21H,4-5,10-12,15H2,1-3H3,(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi US
Curated by ChEMBL
| Assay Description
Binding affinity to human histamine H1 receptor |
Bioorg Med Chem Lett 23: 3421-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.081
BindingDB Entry DOI: 10.7270/Q2HH6MGF |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM50435304
(CHEMBL2391166)Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)c2ccccc2F)c(C)c1 Show InChI InChI=1S/C23H28FN3O/c1-16-14-18(26-13-11-19(15-26)27-12-5-6-17(27)2)9-10-22(16)25-23(28)20-7-3-4-8-21(20)24/h3-4,7-10,14,17,19H,5-6,11-13,15H2,1-2H3,(H,25,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi US
Curated by ChEMBL
| Assay Description
Binding affinity to human histamine H1 receptor |
Bioorg Med Chem Lett 23: 3421-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.081
BindingDB Entry DOI: 10.7270/Q2HH6MGF |
More data for this
Ligand-Target Pair | |
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