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Articleid 237

Compile data set for download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3443
PNG
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 60n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3433
PNG
(1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(3.23,1.45,;3.23,2.99,;4.56,3.76,;4.56,5.3,;3.23,6.07,;1.89,5.3,;.56,6.07,;1.89,3.76,;.56,2.99,;-.77,3.76,;-2.11,2.99,;-3.44,3.76,;-4.78,2.99,;-4.78,1.45,;-6.11,.68,;-3.44,.68,;-2.11,1.45,;-.77,.68,;.56,1.45,;1.89,.68,;1.89,-.86,;.56,-1.63,;3.23,-1.63,;4.56,-.86,;5.89,-1.63,;4.56,.68,;5.89,-.09,)|
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-12(2)15(11)14-9-13-10-22-18(21)24-16(13)23-17(14)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 110n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4826
PNG
(1-[2-amino-6-(2,3,6-trichlorophenyl)pyrido[2,3-d]p...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)ccc(Cl)c1Cl |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;3.58,1.94,;3.58,.4,;4.91,2.71,;4.91,4.25,;3.58,5.02,;3.58,6.56,;2.24,4.25,;.91,5.02,)|
Show InChI InChI=1S/C18H17Cl3N6O/c1-18(2,3)27-17(28)26-15-9(12-10(19)4-5-11(20)13(12)21)6-8-7-23-16(22)25-14(8)24-15/h4-7H,1-3H3,(H4,22,23,24,25,26,27,28)
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n/an/a 110n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4829
PNG
(1-[2-amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(F)cccc1F |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;2.24,4.25,;.91,5.02,;3.58,5.02,;4.91,4.25,;4.91,2.71,;3.58,1.94,;3.58,.4,)|
Show InChI InChI=1S/C18H18F2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 110n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl |(4.56,-3.94,;3.23,-3.17,;1.89,-3.94,;3.23,-4.71,;3.23,-1.63,;1.89,-.86,;.56,-1.63,;1.89,.68,;.56,1.45,;-.77,.68,;-2.11,1.45,;-3.44,.68,;-4.78,1.45,;-6.11,.68,;-4.78,2.99,;-3.44,3.76,;-2.11,2.99,;-.77,3.76,;.56,2.99,;1.89,3.76,;1.89,5.3,;.56,6.07,;3.23,6.07,;4.56,5.3,;4.56,3.76,;3.23,2.99,;3.23,1.45,)|
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 140n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4825
PNG
(1-[2-amino-6-(2,3-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-11(10-5-4-6-12(19)13(10)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 160n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4828
PNG
(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Br |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;3.58,1.94,;3.58,.4,;4.91,2.71,;4.91,4.25,;3.58,5.02,;2.24,4.25,;.91,5.02,)|
Show InChI InChI=1S/C18H18BrClN6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 180n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3437
PNG
(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Br)cccc1Br |(5.49,-4.29,;4.16,-3.52,;2.83,-4.29,;4.16,-5.06,;4.16,-1.98,;2.83,-1.21,;1.49,-1.98,;2.83,.33,;1.49,1.1,;.16,.33,;-1.17,1.1,;-2.51,.33,;-3.84,1.1,;-5.18,.33,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)|
Show InChI InChI=1S/C18H18Br2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4828
PNG
(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Br |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;3.58,1.94,;3.58,.4,;4.91,2.71,;4.91,4.25,;3.58,5.02,;2.24,4.25,;.91,5.02,)|
Show InChI InChI=1S/C18H18BrClN6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl |(4.56,-3.94,;3.23,-3.17,;1.89,-3.94,;3.23,-4.71,;3.23,-1.63,;1.89,-.86,;.56,-1.63,;1.89,.68,;.56,1.45,;-.77,.68,;-2.11,1.45,;-3.44,.68,;-4.78,1.45,;-6.11,.68,;-4.78,2.99,;-3.44,3.76,;-2.11,2.99,;-.77,3.76,;.56,2.99,;1.89,3.76,;1.89,5.3,;.56,6.07,;3.23,6.07,;4.56,5.3,;4.56,3.76,;3.23,2.99,;3.23,1.45,)|
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 220n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4837
PNG
(1-[2-amino-6-(2,4,6-trimethylphenyl)pyrido[2,3-d]p...)
Show SMILES Cc1cc(C)c(c(C)c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(6.24,5.02,;4.91,4.25,;3.58,5.02,;2.24,4.25,;.91,5.02,;2.24,2.71,;3.58,1.94,;3.51,.4,;4.82,2.53,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C21H26N6O/c1-11-7-12(2)16(13(3)8-11)15-9-14-10-23-19(22)25-17(14)24-18(15)26-20(28)27-21(4,5)6/h7-10H,1-6H3,(H4,22,23,24,25,26,27,28)
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n/an/a 270n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3437
PNG
(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Br)cccc1Br |(5.49,-4.29,;4.16,-3.52,;2.83,-4.29,;4.16,-5.06,;4.16,-1.98,;2.83,-1.21,;1.49,-1.98,;2.83,.33,;1.49,1.1,;.16,.33,;-1.17,1.1,;-2.51,.33,;-3.84,1.1,;-5.18,.33,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)|
Show InChI InChI=1S/C18H18Br2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 290n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3433
PNG
(1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(3.23,1.45,;3.23,2.99,;4.56,3.76,;4.56,5.3,;3.23,6.07,;1.89,5.3,;.56,6.07,;1.89,3.76,;.56,2.99,;-.77,3.76,;-2.11,2.99,;-3.44,3.76,;-4.78,2.99,;-4.78,1.45,;-6.11,.68,;-3.44,.68,;-2.11,1.45,;-.77,.68,;.56,1.45,;1.89,.68,;1.89,-.86,;.56,-1.63,;3.23,-1.63,;4.56,-.86,;5.89,-1.63,;4.56,.68,;5.89,-.09,)|
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-12(2)15(11)14-9-13-10-22-18(21)24-16(13)23-17(14)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 340n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4835
PNG
(1-[2-amino-6-(2,3-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-14(12(11)2)15-9-13-10-22-18(21)24-16(13)23-17(15)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 340n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4837
PNG
(1-[2-amino-6-(2,4,6-trimethylphenyl)pyrido[2,3-d]p...)
Show SMILES Cc1cc(C)c(c(C)c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(6.24,5.02,;4.91,4.25,;3.58,5.02,;2.24,4.25,;.91,5.02,;2.24,2.71,;3.58,1.94,;3.51,.4,;4.82,2.53,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C21H26N6O/c1-11-7-12(2)16(13(3)8-11)15-9-14-10-23-19(22)25-17(14)24-18(15)26-20(28)27-21(4,5)6/h7-10H,1-6H3,(H4,22,23,24,25,26,27,28)
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n/an/a 360n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4844
PNG
(1-[2-amino-6-(3-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1cccc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-14(11-6-5-7-13(8-11)27-4)9-12-10-21-17(20)23-15(12)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 360n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3433
PNG
(1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(3.23,1.45,;3.23,2.99,;4.56,3.76,;4.56,5.3,;3.23,6.07,;1.89,5.3,;.56,6.07,;1.89,3.76,;.56,2.99,;-.77,3.76,;-2.11,2.99,;-3.44,3.76,;-4.78,2.99,;-4.78,1.45,;-6.11,.68,;-3.44,.68,;-2.11,1.45,;-.77,.68,;.56,1.45,;1.89,.68,;1.89,-.86,;.56,-1.63,;3.23,-1.63,;4.56,-.86,;5.89,-1.63,;4.56,.68,;5.89,-.09,)|
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-12(2)15(11)14-9-13-10-22-18(21)24-16(13)23-17(14)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 400n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4832
PNG
(1-[2-amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES Cc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O/c1-11-7-5-6-8-13(11)14-9-12-10-21-17(20)23-15(12)22-16(14)24-18(26)25-19(2,3)4/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 410n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4828
PNG
(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Br |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;3.58,1.94,;3.58,.4,;4.91,2.71,;4.91,4.25,;3.58,5.02,;2.24,4.25,;.91,5.02,)|
Show InChI InChI=1S/C18H18BrClN6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 620n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4848
PNG
(1-[2-amino-6-(3-ethoxyphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES CCOc1cccc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O2/c1-5-28-14-8-6-7-12(9-14)15-10-13-11-22-18(21)24-16(13)23-17(15)25-19(27)26-20(2,3)4/h6-11H,5H2,1-4H3,(H4,21,22,23,24,25,26,27)
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n/an/a 670n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3441
PNG
(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Show SMILES Cc1cc(C)c(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(4.16,7.26,;4.16,5.72,;5.49,4.95,;5.49,3.41,;6.83,2.64,;4.16,2.64,;4.16,1.1,;2.83,3.41,;2.83,4.95,;1.49,5.72,;1.49,2.64,;.16,3.41,;-1.17,2.64,;-2.51,3.41,;-3.84,2.64,;-3.84,1.1,;-5.18,.33,;-2.51,.33,;-1.17,1.1,;.16,.33,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.67,-3.92,;5.49,-4.29,;4.16,-5.06,)|
Show InChI InChI=1S/C22H28N6O/c1-11-8-12(2)14(4)17(13(11)3)16-9-15-10-24-20(23)26-18(15)25-19(16)27-21(29)28-22(5,6)7/h8-10H,1-7H3,(H4,23,24,25,26,27,28,29)
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n/an/a 710n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4829
PNG
(1-[2-amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(F)cccc1F |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;2.24,4.25,;.91,5.02,;3.58,5.02,;4.91,4.25,;4.91,2.71,;3.58,1.94,;3.58,.4,)|
Show InChI InChI=1S/C18H18F2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 800n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4840
PNG
(1-(2-amino-6-{3-[2-(diethylamino)ethoxy]-2,6-dimet...)
Show SMILES CCN(CC)CCOc1ccc(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(7.58,11.95,;6.24,11.18,;6.24,9.64,;7.58,8.87,;8.91,9.64,;4.91,8.87,;4.91,7.33,;3.58,6.56,;3.58,5.02,;4.91,4.25,;4.82,2.53,;3.58,1.94,;3.51,.4,;2.24,2.71,;2.24,4.25,;.91,5.02,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C26H37N7O2/c1-8-33(9-2)12-13-35-20-11-10-16(3)21(17(20)4)19-14-18-15-28-24(27)30-22(18)29-23(19)31-25(34)32-26(5,6)7/h10-11,14-15H,8-9,12-13H2,1-7H3,(H4,27,28,29,30,31,32,34)
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n/an/a 890n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4832
PNG
(1-[2-amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES Cc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O/c1-11-7-5-6-8-13(11)14-9-12-10-21-17(20)23-15(12)22-16(14)24-18(26)25-19(2,3)4/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 1.05E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4830
PNG
(1-[2-amino-6-(3,5-difluorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N6O/c1-18(2,3)26-17(27)25-15-13(9-4-11(19)7-12(20)5-9)6-10-8-22-16(21)24-14(10)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4836
PNG
(1-[2-amino-6-(3,5-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cc(C)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-6-12(2)8-13(7-11)15-9-14-10-22-18(21)24-16(14)23-17(15)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.13E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl |(4.56,-3.94,;3.23,-3.17,;1.89,-3.94,;3.23,-4.71,;3.23,-1.63,;1.89,-.86,;.56,-1.63,;1.89,.68,;.56,1.45,;-.77,.68,;-2.11,1.45,;-3.44,.68,;-4.78,1.45,;-6.11,.68,;-4.78,2.99,;-3.44,3.76,;-2.11,2.99,;-.77,3.76,;.56,2.99,;1.89,3.76,;1.89,5.3,;.56,6.07,;3.23,6.07,;4.56,5.3,;4.56,3.76,;3.23,2.99,;3.23,1.45,)|
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.25E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4830
PNG
(1-[2-amino-6-(3,5-difluorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N6O/c1-18(2,3)26-17(27)25-15-13(9-4-11(19)7-12(20)5-9)6-10-8-22-16(21)24-14(10)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4832
PNG
(1-[2-amino-6-(2-methylphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES Cc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O/c1-11-7-5-6-8-13(11)14-9-12-10-21-17(20)23-15(12)22-16(14)24-18(26)25-19(2,3)4/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4826
PNG
(1-[2-amino-6-(2,3,6-trichlorophenyl)pyrido[2,3-d]p...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)ccc(Cl)c1Cl |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;3.58,1.94,;3.58,.4,;4.91,2.71,;4.91,4.25,;3.58,5.02,;3.58,6.56,;2.24,4.25,;.91,5.02,)|
Show InChI InChI=1S/C18H17Cl3N6O/c1-18(2,3)27-17(28)26-15-9(12-10(19)4-5-11(20)13(12)21)6-8-7-23-16(22)25-14(8)24-15/h4-7H,1-3H3,(H4,22,23,24,25,26,27,28)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3437
PNG
(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Br)cccc1Br |(5.49,-4.29,;4.16,-3.52,;2.83,-4.29,;4.16,-5.06,;4.16,-1.98,;2.83,-1.21,;1.49,-1.98,;2.83,.33,;1.49,1.1,;.16,.33,;-1.17,1.1,;-2.51,.33,;-3.84,1.1,;-5.18,.33,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)|
Show InChI InChI=1S/C18H18Br2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.42E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4837
PNG
(1-[2-amino-6-(2,4,6-trimethylphenyl)pyrido[2,3-d]p...)
Show SMILES Cc1cc(C)c(c(C)c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(6.24,5.02,;4.91,4.25,;3.58,5.02,;2.24,4.25,;.91,5.02,;2.24,2.71,;3.58,1.94,;3.51,.4,;4.82,2.53,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C21H26N6O/c1-11-7-12(2)16(13(3)8-11)15-9-14-10-23-19(22)25-17(14)24-18(15)26-20(28)27-21(4,5)6/h7-10H,1-6H3,(H4,22,23,24,25,26,27,28)
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n/an/a 1.47E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4839
PNG
(1-[2-amino-6-(2,3,4,5,6-pentamethylphenyl)pyrido[2...)
Show SMILES Cc1c(C)c(C)c(c(C)c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(6.26,4.98,;4.91,4.25,;3.58,5.02,;3.58,6.56,;2.24,4.25,;.91,5.02,;2.24,2.71,;3.58,1.94,;3.51,.4,;4.82,2.53,;6.1,1.67,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C23H30N6O/c1-11-12(2)14(4)18(15(5)13(11)3)17-9-16-10-25-21(24)27-19(16)26-20(17)28-22(30)29-23(6,7)8/h9-10H,1-8H3,(H4,24,25,26,27,28,29,30)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4840
PNG
(1-(2-amino-6-{3-[2-(diethylamino)ethoxy]-2,6-dimet...)
Show SMILES CCN(CC)CCOc1ccc(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(7.58,11.95,;6.24,11.18,;6.24,9.64,;7.58,8.87,;8.91,9.64,;4.91,8.87,;4.91,7.33,;3.58,6.56,;3.58,5.02,;4.91,4.25,;4.82,2.53,;3.58,1.94,;3.51,.4,;2.24,2.71,;2.24,4.25,;.91,5.02,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C26H37N7O2/c1-8-33(9-2)12-13-35-20-11-10-16(3)21(17(20)4)19-14-18-15-28-24(27)30-22(18)29-23(19)31-25(34)32-26(5,6)7/h10-11,14-15H,8-9,12-13H2,1-7H3,(H4,27,28,29,30,31,32,34)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4849
PNG
(1-[2-amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyri...)
Show SMILES CCOc1cc(OCC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O3/c1-6-30-15-8-13(9-16(11-15)31-7-2)17-10-14-12-24-20(23)26-18(14)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4829
PNG
(1-[2-amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(F)cccc1F |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;2.24,4.25,;.91,5.02,;3.58,5.02,;4.91,4.25,;4.91,2.71,;3.58,1.94,;3.58,.4,)|
Show InChI InChI=1S/C18H18F2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.67E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4833
PNG
(1-[2-amino-6-(4-methylphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES Cc1ccc(cc1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O/c1-11-5-7-12(8-6-11)14-9-13-10-21-17(20)23-15(13)22-16(14)24-18(26)25-19(2,3)4/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4825
PNG
(1-[2-amino-6-(2,3-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-11(10-5-4-6-12(19)13(10)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 2.26E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4845
PNG
(1-[2-amino-6-(4-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1ccc(cc1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-14(11-5-7-13(27-4)8-6-11)9-12-10-21-17(20)23-15(12)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 2.89E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4826
PNG
(1-[2-amino-6-(2,3,6-trichlorophenyl)pyrido[2,3-d]p...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)ccc(Cl)c1Cl |(6.86,-1.2,;5.37,-.8,;4.97,.69,;6.46,.29,;4.28,-1.89,;2.8,-1.49,;1.71,-2.58,;2.4,-0,;.91,.4,;-.42,-.37,;-1.76,.4,;-3.09,-.37,;-4.43,.4,;-5.76,-.37,;-4.43,1.94,;-3.09,2.71,;-1.76,1.94,;-.42,2.71,;.91,1.94,;2.24,2.71,;3.58,1.94,;3.58,.4,;4.91,2.71,;4.91,4.25,;3.58,5.02,;3.58,6.56,;2.24,4.25,;.91,5.02,)|
Show InChI InChI=1S/C18H17Cl3N6O/c1-18(2,3)27-17(28)26-15-9(12-10(19)4-5-11(20)13(12)21)6-8-7-23-16(22)25-14(8)24-15/h4-7H,1-3H3,(H4,22,23,24,25,26,27,28)
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n/an/a 2.96E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4845
PNG
(1-[2-amino-6-(4-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1ccc(cc1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-14(11-5-7-13(27-4)8-6-11)9-12-10-21-17(20)23-15(12)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4835
PNG
(1-[2-amino-6-(2,3-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-14(12(11)2)15-9-13-10-22-18(21)24-16(13)23-17(15)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 4.17E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4825
PNG
(1-[2-amino-6-(2,3-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-11(10-5-4-6-12(19)13(10)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 4.41E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4841
PNG
(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Show SMILES CCc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-5-12-8-6-7-9-14(12)15-10-13-11-22-18(21)24-16(13)23-17(15)25-19(27)26-20(2,3)4/h6-11H,5H2,1-4H3,(H4,21,22,23,24,25,26,27)
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n/an/a 4.48E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4843
PNG
(1-[2-amino-6-(2-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-13(12-7-5-6-8-14(12)27-4)9-11-10-21-17(20)23-15(11)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 4.48E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4835
PNG
(1-[2-amino-6-(2,3-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-14(12(11)2)15-9-13-10-22-18(21)24-16(13)23-17(15)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 6.05E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4833
PNG
(1-[2-amino-6-(4-methylphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES Cc1ccc(cc1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O/c1-11-5-7-12(8-6-11)14-9-13-10-21-17(20)23-15(13)22-16(14)24-18(26)25-19(2,3)4/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 6.31E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4842
PNG
(1-[2-amino-6-(3,5-diethylphenyl)pyrido[2,3-d]pyrim...)
Show SMILES CCc1cc(CC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O/c1-6-13-8-14(7-2)10-15(9-13)17-11-16-12-24-20(23)26-18(16)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29)
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n/an/a 7.76E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4823
PNG
(1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4830
PNG
(1-[2-amino-6-(3,5-difluorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N6O/c1-18(2,3)26-17(27)25-15-13(9-4-11(19)7-12(20)5-9)6-10-8-22-16(21)24-14(10)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 8.97E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4841
PNG
(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Show SMILES CCc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-5-12-8-6-7-9-14(12)15-10-13-11-22-18(21)24-16(13)23-17(15)25-19(27)26-20(2,3)4/h6-11H,5H2,1-4H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.04E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4843
PNG
(1-[2-amino-6-(2-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-13(12-7-5-6-8-14(12)27-4)9-11-10-21-17(20)23-15(11)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 1.04E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4841
PNG
(1-[2-amino-6-(2-ethylphenyl)pyrido[2,3-d]pyrimidin...)
Show SMILES CCc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-5-12-8-6-7-9-14(12)15-10-13-11-22-18(21)24-16(13)23-17(15)25-19(27)26-20(2,3)4/h6-11H,5H2,1-4H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4843
PNG
(1-[2-amino-6-(2-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-13(12-7-5-6-8-14(12)27-4)9-11-10-21-17(20)23-15(11)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4840
PNG
(1-(2-amino-6-{3-[2-(diethylamino)ethoxy]-2,6-dimet...)
Show SMILES CCN(CC)CCOc1ccc(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(7.58,11.95,;6.24,11.18,;6.24,9.64,;7.58,8.87,;8.91,9.64,;4.91,8.87,;4.91,7.33,;3.58,6.56,;3.58,5.02,;4.91,4.25,;4.82,2.53,;3.58,1.94,;3.51,.4,;2.24,2.71,;2.24,4.25,;.91,5.02,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C26H37N7O2/c1-8-33(9-2)12-13-35-20-11-10-16(3)21(17(20)4)19-14-18-15-28-24(27)30-22(18)29-23(19)31-25(34)32-26(5,6)7/h10-11,14-15H,8-9,12-13H2,1-7H3,(H4,27,28,29,30,31,32,34)
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n/an/a 1.18E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4823
PNG
(1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)
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n/an/a 1.32E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4850
PNG
(1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...)
Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C
Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4833
PNG
(1-[2-amino-6-(4-methylphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES Cc1ccc(cc1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O/c1-11-5-7-12(8-6-11)14-9-13-10-21-17(20)23-15(13)22-16(14)24-18(26)25-19(2,3)4/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 1.75E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4823
PNG
(1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c1-18(2,3)24-17(25)23-15-13(11-7-5-4-6-8-11)9-12-10-20-16(19)22-14(12)21-15/h4-10H,1-3H3,(H4,19,20,21,22,23,24,25)
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n/an/a 1.93E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4846
PNG
(1-[2-amino-6-(3,4-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1ccc(cc1OC)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-13(8-12-10-22-18(21)24-16(12)23-17)11-6-7-14(28-4)15(9-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 2.03E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4844
PNG
(1-[2-amino-6-(3-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1cccc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-14(11-6-5-7-13(8-11)27-4)9-12-10-21-17(20)23-15(12)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 2.29E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4848
PNG
(1-[2-amino-6-(3-ethoxyphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES CCOc1cccc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O2/c1-5-28-14-8-6-7-12(9-14)15-10-13-11-22-18(21)24-16(13)23-17(15)25-19(27)26-20(2,3)4/h6-11H,5H2,1-4H3,(H4,21,22,23,24,25,26,27)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4844
PNG
(1-[2-amino-6-(3-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1cccc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-14(11-6-5-7-13(8-11)27-4)9-12-10-21-17(20)23-15(12)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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n/an/a 3.64E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4831
PNG
(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H18F6N6O/c1-18(2,3)32-17(33)31-15-13(6-10-8-28-16(27)30-14(10)29-15)9-4-11(19(21,22)23)7-12(5-9)20(24,25)26/h4-8H,1-3H3,(H4,27,28,29,30,31,32,33)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3441
PNG
(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Show SMILES Cc1cc(C)c(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(4.16,7.26,;4.16,5.72,;5.49,4.95,;5.49,3.41,;6.83,2.64,;4.16,2.64,;4.16,1.1,;2.83,3.41,;2.83,4.95,;1.49,5.72,;1.49,2.64,;.16,3.41,;-1.17,2.64,;-2.51,3.41,;-3.84,2.64,;-3.84,1.1,;-5.18,.33,;-2.51,.33,;-1.17,1.1,;.16,.33,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.67,-3.92,;5.49,-4.29,;4.16,-5.06,)|
Show InChI InChI=1S/C22H28N6O/c1-11-8-12(2)14(4)17(13(11)3)16-9-15-10-24-20(23)26-18(15)25-19(16)27-21(29)28-22(5,6)7/h8-10H,1-7H3,(H4,23,24,25,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4842
PNG
(1-[2-amino-6-(3,5-diethylphenyl)pyrido[2,3-d]pyrim...)
Show SMILES CCc1cc(CC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O/c1-6-13-8-14(7-2)10-15(9-13)17-11-16-12-24-20(23)26-18(16)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM4831
PNG
(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H18F6N6O/c1-18(2,3)32-17(33)31-15-13(6-10-8-28-16(27)30-14(10)29-15)9-4-11(19(21,22)23)7-12(5-9)20(24,25)26/h4-8H,1-3H3,(H4,27,28,29,30,31,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3443
PNG
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4845
PNG
(1-[2-amino-6-(4-methoxyphenyl)pyrido[2,3-d]pyrimid...)
Show SMILES COc1ccc(cc1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-18(26)24-16-14(11-5-7-13(27-4)8-6-11)9-12-10-21-17(20)23-15(12)22-16/h5-10H,1-4H3,(H4,20,21,22,23,24,25,26)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3441
PNG
(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Show SMILES Cc1cc(C)c(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(4.16,7.26,;4.16,5.72,;5.49,4.95,;5.49,3.41,;6.83,2.64,;4.16,2.64,;4.16,1.1,;2.83,3.41,;2.83,4.95,;1.49,5.72,;1.49,2.64,;.16,3.41,;-1.17,2.64,;-2.51,3.41,;-3.84,2.64,;-3.84,1.1,;-5.18,.33,;-2.51,.33,;-1.17,1.1,;.16,.33,;1.49,1.1,;2.83,.33,;2.83,-1.21,;1.49,-1.98,;4.16,-1.98,;4.16,-3.52,;2.67,-3.92,;5.49,-4.29,;4.16,-5.06,)|
Show InChI InChI=1S/C22H28N6O/c1-11-8-12(2)14(4)17(13(11)3)16-9-15-10-24-20(23)26-18(15)25-19(16)27-21(29)28-22(5,6)7/h8-10H,1-7H3,(H4,23,24,25,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4842
PNG
(1-[2-amino-6-(3,5-diethylphenyl)pyrido[2,3-d]pyrim...)
Show SMILES CCc1cc(CC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O/c1-6-13-8-14(7-2)10-15(9-13)17-11-16-12-24-20(23)26-18(16)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4846
PNG
(1-[2-amino-6-(3,4-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1ccc(cc1OC)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-13(8-12-10-22-18(21)24-16(12)23-17)11-6-7-14(28-4)15(9-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3443
PNG
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4839
PNG
(1-[2-amino-6-(2,3,4,5,6-pentamethylphenyl)pyrido[2...)
Show SMILES Cc1c(C)c(C)c(c(C)c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(6.26,4.98,;4.91,4.25,;3.58,5.02,;3.58,6.56,;2.24,4.25,;.91,5.02,;2.24,2.71,;3.58,1.94,;3.51,.4,;4.82,2.53,;6.1,1.67,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C23H30N6O/c1-11-12(2)14(4)18(15(5)13(11)3)17-9-16-10-25-21(24)27-19(16)26-20(17)28-22(30)29-23(6,7)8/h9-10H,1-8H3,(H4,24,25,26,27,28,29,30)
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n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4850
PNG
(1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...)
Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C
Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4831
PNG
(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H18F6N6O/c1-18(2,3)32-17(33)31-15-13(6-10-8-28-16(27)30-14(10)29-15)9-4-11(19(21,22)23)7-12(5-9)20(24,25)26/h4-8H,1-3H3,(H4,27,28,29,30,31,32,33)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4848
PNG
(1-[2-amino-6-(3-ethoxyphenyl)pyrido[2,3-d]pyrimidi...)
Show SMILES CCOc1cccc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O2/c1-5-28-14-8-6-7-12(9-14)15-10-13-11-22-18(21)24-16(13)23-17(15)25-19(27)26-20(2,3)4/h6-11H,5H2,1-4H3,(H4,21,22,23,24,25,26,27)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4849
PNG
(1-[2-amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyri...)
Show SMILES CCOc1cc(OCC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O3/c1-6-30-15-8-13(9-16(11-15)31-7-2)17-10-14-12-24-20(23)26-18(14)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29)
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Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4846
PNG
(1-[2-amino-6-(3,4-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1ccc(cc1OC)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-13(8-12-10-22-18(21)24-16(12)23-17)11-6-7-14(28-4)15(9-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4849
PNG
(1-[2-amino-6-(3,5-diethoxyphenyl)pyrido[2,3-d]pyri...)
Show SMILES CCOc1cc(OCC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O3/c1-6-30-15-8-13(9-16(11-15)31-7-2)17-10-14-12-24-20(23)26-18(14)25-19(17)27-21(29)28-22(3,4)5/h8-12H,6-7H2,1-5H3,(H4,23,24,25,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4850
PNG
(1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...)
Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C
Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4839
PNG
(1-[2-amino-6-(2,3,4,5,6-pentamethylphenyl)pyrido[2...)
Show SMILES Cc1c(C)c(C)c(c(C)c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C |(6.26,4.98,;4.91,4.25,;3.58,5.02,;3.58,6.56,;2.24,4.25,;.91,5.02,;2.24,2.71,;3.58,1.94,;3.51,.4,;4.82,2.53,;6.1,1.67,;.91,1.94,;-.42,2.71,;-1.76,1.94,;-3.09,2.71,;-4.43,1.94,;-4.43,.4,;-5.76,-.37,;-3.09,-.37,;-1.76,.4,;-.42,-.37,;.91,.4,;2.4,-0,;2.8,-1.49,;1.71,-2.58,;4.28,-1.89,;5.37,-.8,;6.86,-1.2,;4.97,.69,;6.46,.29,)|
Show InChI InChI=1S/C23H30N6O/c1-11-12(2)14(4)18(15(5)13(11)3)17-9-16-10-25-21(24)27-19(16)26-20(17)28-22(30)29-23(6,7)8/h9-10H,1-8H3,(H4,24,25,26,27,28,29,30)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4836
PNG
(1-[2-amino-6-(3,5-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cc(C)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-6-12(2)8-13(7-11)15-9-14-10-22-18(21)24-16(14)23-17(15)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4836
PNG
(1-[2-amino-6-(3,5-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cc(C)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-6-12(2)8-13(7-11)15-9-14-10-22-18(21)24-16(14)23-17(15)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a 5.29E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...


Bioorg Med Chem Lett 7: 2415-20 (1997)


Article DOI: 10.1074/jbc.M606873200
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%