Affinity Data by PubMed id=23718281

PubMed code 23718281

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 receptor (unknown origin)				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	296	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2 receptor (unknown origin)				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401091 (CHEMBL2204436 \| CHEMBL2385894) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu3 receptor assessed as Ca2+ flux by FLIPR assay				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50401091 (CHEMBL2204436 \| CHEMBL2385894) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu2 receptor assessed as Ca2+ flux by FLIPR assay				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50434976 (CHEMBL2385886) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 15 mins prior to NADPH addition measured after 8 mins by L...				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50434976 (CHEMBL2385886) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins prior to NADPH addition measured after 8 mins by L...				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50434976 (CHEMBL2385886) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins prior to NADPH addition measured after 8 min...				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%