BindingDB logo
myBDB logout

PubMed code 23755884

Compile data set for download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50432398
PNG
(CHEMBL2348996)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1
Show InChI InChI=1S/C22H21N7O3/c1-13-10-17(28(2)26-13)22(31)23-15-4-3-5-16(11-15)32-20-9-8-19-24-18(12-29(19)27-20)25-21(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 5.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437508
PNG
(CHEMBL2409779)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1
Show InChI InChI=1S/C23H22N6O3/c1-14-10-19(28(2)27-14)23(31)24-16-4-3-5-17(11-16)32-18-8-9-21-25-20(13-29(21)12-18)26-22(30)15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,24,31)(H,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437507
PNG
(CHEMBL2409781)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1
Show InChI InChI=1S/C22H20N6O3S/c1-12-10-17(28(2)27-12)20(30)23-14-4-3-5-15(11-14)31-18-9-8-16-21(25-18)32-22(24-16)26-19(29)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,23,30)(H,24,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.30n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437509
PNG
(CHEMBL2409775)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1
Show InChI InChI=1S/C22H21N7O3/c1-13-10-18(28(2)26-13)21(31)23-15-4-3-5-16(11-15)32-17-8-9-19-24-22(27-29(19)12-17)25-20(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50437506
PNG
(CHEMBL2409790)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1
Show InChI InChI=1S/C23H21N5O3S/c1-13-10-19(28(2)27-13)22(30)24-15-4-3-5-16(11-15)31-17-8-9-18-20(12-17)32-23(25-18)26-21(29)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,24,30)(H,25,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50437509
PNG
(CHEMBL2409775)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1
Show InChI InChI=1S/C22H21N7O3/c1-13-10-18(28(2)26-13)21(31)23-15-4-3-5-16(11-15)32-17-8-9-19-24-22(27-29(19)12-17)25-20(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50437508
PNG
(CHEMBL2409779)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1
Show InChI InChI=1S/C23H22N6O3/c1-14-10-19(28(2)27-14)23(31)24-16-4-3-5-17(11-16)32-18-8-9-21-25-20(13-29(21)12-18)26-22(30)15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,24,31)(H,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50437509
PNG
(CHEMBL2409775)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1
Show InChI InChI=1S/C22H21N7O3/c1-13-10-18(28(2)26-13)21(31)23-15-4-3-5-16(11-15)32-17-8-9-19-24-22(27-29(19)12-17)25-20(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50432398
PNG
(CHEMBL2348996)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1
Show InChI InChI=1S/C22H21N7O3/c1-13-10-17(28(2)26-13)22(31)23-15-4-3-5-16(11-15)32-20-9-8-19-24-18(12-29(19)27-20)25-21(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50437506
PNG
(CHEMBL2409790)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1
Show InChI InChI=1S/C23H21N5O3S/c1-13-10-19(28(2)27-13)22(30)24-15-4-3-5-16(11-15)31-17-8-9-18-20(12-17)32-23(25-18)26-21(29)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,24,30)(H,25,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 680n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50437507
PNG
(CHEMBL2409781)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1
Show InChI InChI=1S/C22H20N6O3S/c1-12-10-17(28(2)27-12)20(30)23-14-4-3-5-15(11-14)31-18-9-8-16-21(25-18)32-22(24-16)26-19(29)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,23,30)(H,24,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50437507
PNG
(CHEMBL2409781)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1
Show InChI InChI=1S/C22H20N6O3S/c1-12-10-17(28(2)27-12)20(30)23-14-4-3-5-15(11-14)31-18-9-8-16-21(25-18)32-22(24-16)26-19(29)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,23,30)(H,24,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50432398
PNG
(CHEMBL2348996)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1
Show InChI InChI=1S/C22H21N7O3/c1-13-10-17(28(2)26-13)22(31)23-15-4-3-5-16(11-15)32-20-9-8-19-24-18(12-29(19)27-20)25-21(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50437506
PNG
(CHEMBL2409790)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1
Show InChI InChI=1S/C23H21N5O3S/c1-13-10-19(28(2)27-13)22(30)24-15-4-3-5-16(11-15)31-17-8-9-18-20(12-17)32-23(25-18)26-21(29)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,24,30)(H,25,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50437508
PNG
(CHEMBL2409779)
Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1
Show InChI InChI=1S/C23H22N6O3/c1-14-10-19(28(2)27-14)23(31)24-16-4-3-5-17(11-16)32-18-8-9-21-25-20(13-29(21)12-18)26-22(30)15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,24,31)(H,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of IR (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of N-terminal FLAG-tagged recombinant FAK (unknown origin) expressed in baculovirus expression system using biotinylated poly-GluTyr as su...


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50437505
PNG
(CHEMBL2409778)
Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1
Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of IGF1-R (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay


Bioorg Med Chem 21: 4714-29 (2013)


Article DOI: 10.1016/j.bmc.2013.04.042
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%