Found 23 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50432398
(CHEMBL2348996)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 Show InChI InChI=1S/C22H21N7O3/c1-13-10-17(28(2)26-13)22(31)23-15-4-3-5-16(11-15)32-20-9-8-19-24-18(12-29(19)27-20)25-21(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50437508
(CHEMBL2409779)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1 Show InChI InChI=1S/C23H22N6O3/c1-14-10-19(28(2)27-14)23(31)24-16-4-3-5-17(11-16)32-18-8-9-21-25-20(13-29(21)12-18)26-22(30)15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,24,31)(H,26,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50437507
(CHEMBL2409781)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1 Show InChI InChI=1S/C22H20N6O3S/c1-12-10-17(28(2)27-12)20(30)23-14-4-3-5-15(11-14)31-18-9-8-16-21(25-18)32-22(24-16)26-19(29)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,23,30)(H,24,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRalpha (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50437509
(CHEMBL2409775)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1 Show InChI InChI=1S/C22H21N7O3/c1-13-10-18(28(2)26-13)21(31)23-15-4-3-5-16(11-15)32-17-8-9-19-24-22(27-29(19)12-17)25-20(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50437506
(CHEMBL2409790)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1 Show InChI InChI=1S/C23H21N5O3S/c1-13-10-19(28(2)27-13)22(30)24-15-4-3-5-16(11-15)31-17-8-9-18-20(12-17)32-23(25-18)26-21(29)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,24,30)(H,25,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437509
(CHEMBL2409775)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1 Show InChI InChI=1S/C22H21N7O3/c1-13-10-18(28(2)26-13)21(31)23-15-4-3-5-16(11-15)32-17-8-9-19-24-22(27-29(19)12-17)25-20(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437508
(CHEMBL2409779)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1 Show InChI InChI=1S/C23H22N6O3/c1-14-10-19(28(2)27-14)23(31)24-16-4-3-5-17(11-16)32-18-8-9-21-25-20(13-29(21)12-18)26-22(30)15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,24,31)(H,26,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50437509
(CHEMBL2409775)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1 Show InChI InChI=1S/C22H21N7O3/c1-13-10-18(28(2)26-13)21(31)23-15-4-3-5-16(11-15)32-17-8-9-19-24-22(27-29(19)12-17)25-20(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50432398
(CHEMBL2348996)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 Show InChI InChI=1S/C22H21N7O3/c1-13-10-17(28(2)26-13)22(31)23-15-4-3-5-16(11-15)32-20-9-8-19-24-18(12-29(19)27-20)25-21(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437506
(CHEMBL2409790)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1 Show InChI InChI=1S/C23H21N5O3S/c1-13-10-19(28(2)27-13)22(30)24-15-4-3-5-16(11-15)31-17-8-9-18-20(12-17)32-23(25-18)26-21(29)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,24,30)(H,25,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50437507
(CHEMBL2409781)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1 Show InChI InChI=1S/C22H20N6O3S/c1-12-10-17(28(2)27-12)20(30)23-14-4-3-5-15(11-14)31-18-9-8-16-21(25-18)32-22(24-16)26-19(29)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,23,30)(H,24,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50437508
(CHEMBL2409779)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1 Show InChI InChI=1S/C23H22N6O3/c1-14-10-19(28(2)27-14)23(31)24-16-4-3-5-17(11-16)32-18-8-9-21-25-20(13-29(21)12-18)26-22(30)15-6-7-15/h3-5,8-13,15H,6-7H2,1-2H3,(H,24,31)(H,26,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50432398
(CHEMBL2348996)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 Show InChI InChI=1S/C22H21N7O3/c1-13-10-17(28(2)26-13)22(31)23-15-4-3-5-16(11-15)32-20-9-8-19-24-18(12-29(19)27-20)25-21(30)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,23,31)(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437507
(CHEMBL2409781)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1 Show InChI InChI=1S/C22H20N6O3S/c1-12-10-17(28(2)27-12)20(30)23-14-4-3-5-15(11-14)31-18-9-8-16-21(25-18)32-22(24-16)26-19(29)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,23,30)(H,24,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50437506
(CHEMBL2409790)Show SMILES Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1 Show InChI InChI=1S/C23H21N5O3S/c1-13-10-19(28(2)27-13)22(30)24-15-4-3-5-16(11-15)31-17-8-9-18-20(12-17)32-23(25-18)26-21(29)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,24,30)(H,25,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of IR (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal FLAG-tagged recombinant FAK (unknown origin) expressed in baculovirus expression system using biotinylated poly-GluTyr as su... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-R (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042
BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this
Ligand-Target Pair | |
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