Found 15 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438444
(CHEMBL2414370)Show SMILES COc1ccc(c(OC)c1)-n1c(n[nH]c1=S)-c1csc(NC(=S)Nc2ccccc2)n1 |(37.8,-11.38,;39.13,-12.15,;40.47,-11.38,;41.8,-12.15,;43.14,-11.38,;43.13,-9.83,;41.8,-9.07,;41.79,-7.53,;40.46,-6.76,;40.47,-9.84,;44.46,-9.06,;45.92,-9.55,;46.84,-8.31,;45.94,-7.06,;44.47,-7.53,;43.23,-6.61,;46.37,-11.02,;45.45,-12.25,;46.34,-13.51,;47.81,-13.05,;49.14,-13.82,;50.48,-13.05,;50.48,-11.52,;51.81,-13.83,;53.14,-13.06,;54.47,-13.84,;55.81,-13.08,;55.81,-11.54,;54.47,-10.76,;53.14,-11.53,;47.82,-11.51,)| Show InChI InChI=1S/C20H18N6O2S3/c1-27-13-8-9-15(16(10-13)28-2)26-17(24-25-20(26)30)14-11-31-19(22-14)23-18(29)21-12-6-4-3-5-7-12/h3-11H,1-2H3,(H,25,30)(H2,21,22,23,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM18050
(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438443
(CHEMBL2414364)Show SMILES COc1ccc(cc1)-n1c(n[nH]c1=S)-c1csc(n1)N(C(C)=O)C(C)=O Show InChI InChI=1S/C16H15N5O3S2/c1-9(22)20(10(2)23)16-17-13(8-26-16)14-18-19-15(25)21(14)11-4-6-12(24-3)7-5-11/h4-8H,1-3H3,(H,19,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438442
(CHEMBL2414365)Show SMILES COc1ccc(c(OC)c1)-n1c(n[nH]c1=S)-c1csc(n1)N(C(C)=O)C(C)=O |(3.25,-7.69,;4.59,-8.46,;5.92,-7.69,;7.26,-8.46,;8.59,-7.69,;8.59,-6.14,;7.25,-5.37,;7.25,-3.83,;5.91,-3.07,;5.92,-6.14,;9.92,-5.37,;11.38,-5.86,;12.3,-4.62,;11.4,-3.37,;9.93,-3.83,;8.69,-2.92,;11.83,-7.33,;10.91,-8.56,;11.8,-9.82,;13.27,-9.36,;13.28,-7.81,;14.51,-10.27,;14.33,-11.8,;15.57,-12.72,;12.92,-12.42,;15.92,-9.66,;17.16,-10.57,;16.09,-8.13,)| Show InChI InChI=1S/C17H17N5O4S2/c1-9(23)21(10(2)24)17-18-12(8-28-17)15-19-20-16(27)22(15)13-6-5-11(25-3)7-14(13)26-4/h5-8H,1-4H3,(H,20,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438440
(CHEMBL2414371)Show SMILES Cc1ccc(cc1)-n1c(n[nH]c1=S)-c1csc(NC(=S)Nc2ccccc2)n1 Show InChI InChI=1S/C19H16N6S3/c1-12-7-9-14(10-8-12)25-16(23-24-19(25)27)15-11-28-18(21-15)22-17(26)20-13-5-3-2-4-6-13/h2-11H,1H3,(H,24,27)(H2,20,21,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438441
(CHEMBL2414362)Show SMILES CC(=O)N(C(C)=O)c1nc(cs1)-c1n[nH]c(=S)n1-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H12ClN5O2S2/c1-8(22)20(9(2)23)15-17-12(7-25-15)13-18-19-14(24)21(13)11-5-3-10(16)4-6-11/h3-7H,1-2H3,(H,19,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438439
(CHEMBL2414366)Show SMILES CC(=O)N(C(C)=O)c1nc(cs1)-c1n[nH]c(=S)n1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C21H17N5O3S2/c1-13(27)25(14(2)28)21-22-18(12-31-21)19-23-24-20(30)26(19)15-8-10-17(11-9-15)29-16-6-4-3-5-7-16/h3-12H,1-2H3,(H,24,30) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438438
(CHEMBL2414374)Show InChI InChI=1S/C11H8ClN5S2/c12-6-1-3-7(4-2-6)17-9(15-16-11(17)18)8-5-19-10(13)14-8/h1-5H,(H2,13,14)(H,16,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438437
(CHEMBL2414376)Show InChI InChI=1S/C12H11N5OS2/c1-18-8-4-2-7(3-5-8)17-10(15-16-12(17)19)9-6-20-11(13)14-9/h2-6H,1H3,(H2,13,14)(H,16,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438435
(CHEMBL2414377)Show InChI InChI=1S/C12H11N5S2/c1-7-2-4-8(5-3-7)17-10(15-16-12(17)18)9-6-19-11(13)14-9/h2-6H,1H3,(H2,13,14)(H,16,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438436
(CHEMBL2414375)Show SMILES COc1ccccc1-n1c(n[nH]c1=S)-c1csc(N)n1 |(26.2,-4.75,;27.54,-5.52,;27.54,-7.06,;26.21,-7.83,;26.21,-9.37,;27.55,-10.14,;28.88,-9.37,;28.88,-7.82,;30.21,-7.05,;31.67,-7.55,;32.58,-6.31,;31.69,-5.05,;30.22,-5.52,;28.98,-4.6,;32.12,-9.01,;31.19,-10.25,;32.09,-11.5,;33.56,-11.04,;34.79,-11.96,;33.57,-9.5,)| Show InChI InChI=1S/C12H11N5OS2/c1-18-9-5-3-2-4-8(9)17-10(15-16-12(17)19)7-6-20-11(13)14-7/h2-6H,1H3,(H2,13,14)(H,16,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438434
(CHEMBL2414369)Show SMILES COc1ccc(cc1)-n1c(n[nH]c1=S)-c1csc(NC(=S)Nc2ccccc2)n1 Show InChI InChI=1S/C19H16N6OS3/c1-26-14-9-7-13(8-10-14)25-16(23-24-19(25)28)15-11-29-18(21-15)22-17(27)20-12-5-3-2-4-6-12/h2-11H,1H3,(H,24,28)(H2,20,21,22,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438432
(CHEMBL2414372)Show SMILES S=C(Nc1nc(cs1)-c1n[nH]c(=S)n1-c1ccc(Oc2ccccc2)cc1)Nc1ccccc1 Show InChI InChI=1S/C24H18N6OS3/c32-22(25-16-7-3-1-4-8-16)27-23-26-20(15-34-23)21-28-29-24(33)30(21)17-11-13-19(14-12-17)31-18-9-5-2-6-10-18/h1-15H,(H,29,33)(H2,25,26,27,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438433
(CHEMBL2414361)Show SMILES CC(=O)N(C(C)=O)c1nc(cs1)-c1n[nH]c(=S)n1-c1ccccc1 Show InChI InChI=1S/C15H13N5O2S2/c1-9(21)19(10(2)22)15-16-12(8-24-15)13-17-18-14(23)20(13)11-6-4-3-5-7-11/h3-8H,1-2H3,(H,18,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50438431
(CHEMBL2414367)Show SMILES Clc1ccc(cc1)-n1c(n[nH]c1=S)-c1csc(NC(=S)Nc2ccccc2)n1 Show InChI InChI=1S/C18H13ClN6S3/c19-11-6-8-13(9-7-11)25-15(23-24-18(25)27)14-10-28-17(21-14)22-16(26)20-12-4-2-1-3-5-12/h1-10H,(H,24,27)(H2,20,21,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of bovine liver DHFR measured every 1 min for 10 mins |
Eur J Med Chem 66: 135-45 (2013)
Article DOI: 10.1016/j.ejmech.2013.05.039 BindingDB Entry DOI: 10.7270/Q21C1Z9Q |
More data for this Ligand-Target Pair | |