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PubMed code 23916253

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439350
PNG
(CHEMBL2420385)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)Nc1cc(ccc1N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C35H35N5O4/c36-28-18-16-25(19-31(28)39-34(42)29(37)17-15-23-9-3-1-4-10-23)33(41)40-32(35(43)44-22-24-11-5-2-6-12-24)20-26-21-38-30-14-8-7-13-27(26)30/h1-14,16,18-19,21,29,32,38H,15,17,20,22,36-37H2,(H,39,42)(H,40,41)/t29-,32-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))		BDBM50439354
PNG
(CHEMBL2420381)
Show SMILES COC(=O)[C@H](CCCCN)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C24H33N5O4/c1-33-24(32)20(9-5-6-14-25)28-22(30)17-11-13-18(26)21(15-17)29-23(31)19(27)12-10-16-7-3-2-4-8-16/h2-4,7-8,11,13,15,19-20H,5-6,9-10,12,14,25-27H2,1H3,(H,28,30)(H,29,31)/t19-,20-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP1 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Leucine-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))		BDBM50439353
PNG
(CHEMBL2420382)
Show SMILES NCCCC[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(O)=O |r|
Show InChI InChI=1S/C23H31N5O4/c24-13-5-4-8-19(23(31)32)27-21(29)16-10-12-17(25)20(14-16)28-22(30)18(26)11-9-15-6-2-1-3-7-15/h1-3,6-7,10,12,14,18-19H,4-5,8-9,11,13,24-26H2,(H,27,29)(H,28,30)(H,31,32)/t18-,19-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP1 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Leucine-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439351
PNG
(CHEMBL2420384)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C27H30N4O5/c1-36-27(35)24(15-18-7-11-20(32)12-8-18)31-25(33)19-10-14-21(28)23(16-19)30-26(34)22(29)13-9-17-5-3-2-4-6-17/h2-8,10-12,14,16,22,24,32H,9,13,15,28-29H2,1H3,(H,30,34)(H,31,33)/t22-,24-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439357
PNG
(CHEMBL2420378)
Show SMILES CC(C)[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C29H34N4O4/c1-19(2)26(29(36)37-18-21-11-7-4-8-12-21)33-27(34)22-14-16-23(30)25(17-22)32-28(35)24(31)15-13-20-9-5-3-6-10-20/h3-12,14,16-17,19,24,26H,13,15,18,30-31H2,1-2H3,(H,32,35)(H,33,34)/t24-,26-/m0/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439353
PNG
(CHEMBL2420382)
Show SMILES NCCCC[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(O)=O |r|
Show InChI InChI=1S/C23H31N5O4/c24-13-5-4-8-19(23(31)32)27-21(29)16-10-12-17(25)20(14-16)28-22(30)18(26)11-9-15-6-2-1-3-7-15/h1-3,6-7,10,12,14,18-19H,4-5,8-9,11,13,24-26H2,(H,27,29)(H,28,30)(H,31,32)/t18-,19-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))		BDBM50439351
PNG
(CHEMBL2420384)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C27H30N4O5/c1-36-27(35)24(15-18-7-11-20(32)12-8-18)31-25(33)19-10-14-21(28)23(16-19)30-26(34)22(29)13-9-17-5-3-2-4-6-17/h2-8,10-12,14,16,22,24,32H,9,13,15,28-29H2,1H3,(H,30,34)(H,31,33)/t22-,24-/m0/s1
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n/an/a 7.70E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP1 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Leucine-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439353
PNG
(CHEMBL2420382)
Show SMILES NCCCC[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(O)=O |r|
Show InChI InChI=1S/C23H31N5O4/c24-13-5-4-8-19(23(31)32)27-21(29)16-10-12-17(25)20(14-16)28-22(30)18(26)11-9-15-6-2-1-3-7-15/h1-3,6-7,10,12,14,18-19H,4-5,8-9,11,13,24-26H2,(H,27,29)(H,28,30)(H,31,32)/t18-,19-/m0/s1
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n/an/a 8.90E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439352
PNG
(CHEMBL2420383)
Show SMILES [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-c1ccc(-[#7])c(-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-c2ccccc2)c1 |r|
Show InChI InChI=1S/C24H33N7O4/c1-35-23(34)19(8-5-13-29-24(27)28)30-21(32)16-10-12-17(25)20(14-16)31-22(33)18(26)11-9-15-6-3-2-4-7-15/h2-4,6-7,10,12,14,18-19H,5,8-9,11,13,25-26H2,1H3,(H,30,32)(H,31,33)(H4,27,28,29)/t18-,19-/m0/s1
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n/an/a 9.60E+3n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439354
PNG
(CHEMBL2420381)
Show SMILES COC(=O)[C@H](CCCCN)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C24H33N5O4/c1-33-24(32)20(9-5-6-14-25)28-22(30)17-11-13-18(26)21(15-17)29-23(31)19(27)12-10-16-7-3-2-4-8-16/h2-4,7-8,11,13,15,19-20H,5-6,9-10,12,14,25-27H2,1H3,(H,28,30)(H,29,31)/t19-,20-/m0/s1
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n/an/a 1.03E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439357
PNG
(CHEMBL2420378)
Show SMILES CC(C)[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C29H34N4O4/c1-19(2)26(29(36)37-18-21-11-7-4-8-12-21)33-27(34)22-14-16-23(30)25(17-22)32-28(35)24(31)15-13-20-9-5-3-6-10-20/h3-12,14,16-17,19,24,26H,13,15,18,30-31H2,1-2H3,(H,32,35)(H,33,34)/t24-,26-/m0/s1
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n/an/a 1.15E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439349
PNG
(CHEMBL2420386)
Show SMILES COC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C18H21N3O3/c1-24-18(23)13-8-10-14(19)16(11-13)21-17(22)15(20)9-7-12-5-3-2-4-6-12/h2-6,8,10-11,15H,7,9,19-20H2,1H3,(H,21,22)/t15-/m0/s1
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n/an/a 1.63E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439350
PNG
(CHEMBL2420385)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)Nc1cc(ccc1N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C35H35N5O4/c36-28-18-16-25(19-31(28)39-34(42)29(37)17-15-23-9-3-1-4-10-23)33(41)40-32(35(43)44-22-24-11-5-2-6-12-24)20-26-21-38-30-14-8-7-13-27(26)30/h1-14,16,18-19,21,29,32,38H,15,17,20,22,36-37H2,(H,39,42)(H,40,41)/t29-,32-/m0/s1
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n/an/a 2.39E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439354
PNG
(CHEMBL2420381)
Show SMILES COC(=O)[C@H](CCCCN)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C24H33N5O4/c1-33-24(32)20(9-5-6-14-25)28-22(30)17-11-13-18(26)21(15-17)29-23(31)19(27)12-10-16-7-3-2-4-8-16/h2-4,7-8,11,13,15,19-20H,5-6,9-10,12,14,25-27H2,1H3,(H,28,30)(H,29,31)/t19-,20-/m0/s1
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n/an/a 2.49E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439358
PNG
(CHEMBL2420377)
Show SMILES COC(=O)[C@H](C)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C21H26N4O4/c1-13(21(28)29-2)24-19(26)15-9-11-16(22)18(12-15)25-20(27)17(23)10-8-14-6-4-3-5-7-14/h3-7,9,11-13,17H,8,10,22-23H2,1-2H3,(H,24,26)(H,25,27)/t13-,17-/m0/s1
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n/an/a 3.83E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439355
PNG
(CHEMBL2420380)
Show SMILES COC(=O)[C@@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)[C@@H](C)O |r|
Show InChI InChI=1S/C22H28N4O5/c1-13(27)19(22(30)31-2)26-20(28)15-9-11-16(23)18(12-15)25-21(29)17(24)10-8-14-6-4-3-5-7-14/h3-7,9,11-13,17,19,27H,8,10,23-24H2,1-2H3,(H,25,29)(H,26,28)/t13-,17+,19+/m1/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 1


(Homo sapiens (Human))		BDBM50439357
PNG
(CHEMBL2420378)
Show SMILES CC(C)[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C29H34N4O4/c1-19(2)26(29(36)37-18-21-11-7-4-8-12-21)33-27(34)22-14-16-23(30)25(17-22)32-28(35)24(31)15-13-20-9-5-3-6-10-20/h3-12,14,16-17,19,24,26H,13,15,18,30-31H2,1-2H3,(H,32,35)(H,33,34)/t24-,26-/m0/s1
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n/an/a 9.55E+4n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP1 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Leucine-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439351
PNG
(CHEMBL2420384)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C27H30N4O5/c1-36-27(35)24(15-18-7-11-20(32)12-8-18)31-25(33)19-10-14-21(28)23(16-19)30-26(34)22(29)13-9-17-5-3-2-4-6-17/h2-8,10-12,14,16,22,24,32H,9,13,15,28-29H2,1H3,(H,30,34)(H,31,33)/t22-,24-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439348
PNG
(CHEMBL2420387)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)Nc1cc(ccc1N)C(O)=O |r|
Show InChI InChI=1S/C17H19N3O3/c18-13-9-7-12(17(22)23)10-15(13)20-16(21)14(19)8-6-11-4-2-1-3-5-11/h1-5,7,9-10,14H,6,8,18-19H2,(H,20,21)(H,22,23)/t14-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439349
PNG
(CHEMBL2420386)
Show SMILES COC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1 |r|
Show InChI InChI=1S/C18H21N3O3/c1-24-18(23)13-8-10-14(19)16(11-13)21-17(22)15(20)9-7-12-5-3-2-4-6-12/h2-6,8,10-11,15H,7,9,19-20H2,1H3,(H,21,22)/t15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM50439356
PNG
(CHEMBL2420379)
Show SMILES CC(C)[C@H](NC(=O)c1ccc(N)c(NC(=O)[C@@H](N)CCc2ccccc2)c1)C(O)=O |r|
Show InChI InChI=1S/C22H28N4O4/c1-13(2)19(22(29)30)26-20(27)15-9-11-16(23)18(12-15)25-21(28)17(24)10-8-14-6-4-3-5-7-14/h3-7,9,11-13,17,19H,8,10,23-24H2,1-2H3,(H,25,28)(H,26,27)(H,29,30)/t17-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IRAP expressed in HeLa cells assessed as L-Leucine-7-amido-4-methyl coumarin hydrolysis to 7-amido-4-methyl coumarin ...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
Endoplasmic reticulum aminopeptidase 2


(Homo sapiens (Human))		BDBM50439348
PNG
(CHEMBL2420387)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)Nc1cc(ccc1N)C(O)=O |r|
Show InChI InChI=1S/C17H19N3O3/c18-13-9-7-12(17(22)23)10-15(13)20-16(21)14(19)8-6-11-4-2-1-3-5-11/h1-5,7,9-10,14H,6,8,18-19H2,(H,20,21)(H,22,23)/t14-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of California San Diego

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus-infected Hi5 insect cells assessed as L-Arginyl-7-amido-4-methyl coumarin h...

Bioorg Med Chem Lett 23: 4832-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.024
BindingDB Entry DOI: 10.7270/Q2J38V00
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%