Affinity Data by PubMed id=23960073

PubMed code 23960073

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase PAK 1 [249-545,K299R] (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 2 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 3 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	19.3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 1 [249-545,K299R] (Homo sapiens (Human))	BDBM213235 (FRAX414) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 [249-545,K299R] (Homo sapiens (Human))	BDBM6276 (8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	483	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM213235 (FRAX414) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	559	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM6276 (8-Cyclopentyl-2-[4-(4-methylpiperazin-1-yl)phenyla...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair

* indicates data uncertainty>20%