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PubMed code 24120542

Compile data set for download or QSAR
Found 90 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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n/an/a 0.690n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443650
PNG
(CHEMBL3093074)
Show SMILES C1CC1[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H17N5O/c1-2-5-12(6-3-1)16(13-8-9-13)22-19-24-23-18(25-19)15-11-21-17-14(15)7-4-10-20-17/h1-7,10-11,13,16H,8-9H2,(H,20,21)(H,22,24)/t16-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443651
PNG
(CHEMBL3093073)
Show SMILES CC(C)[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H19N5O/c1-12(2)16(13-7-4-3-5-8-13)22-19-24-23-18(25-19)15-11-21-17-14(15)9-6-10-20-17/h3-12,16H,1-2H3,(H,20,21)(H,22,24)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443645
PNG
(CHEMBL3093079)
Show SMILES Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443652
PNG
(CHEMBL3093072)
Show SMILES CC[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H17N5O/c1-2-15(12-7-4-3-5-8-12)21-18-23-22-17(24-18)14-11-20-16-13(14)9-6-10-19-16/h3-11,15H,2H2,1H3,(H,19,20)(H,21,23)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443653
PNG
(CHEMBL3093071)
Show SMILES CC(C)(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-18(2,12-7-4-3-5-8-12)21-17-23-22-16(24-17)14-11-20-15-13(14)9-6-10-19-15/h3-11H,1-2H3,(H,19,20)(H,21,23)
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443642
PNG
(CHEMBL3093056)
Show SMILES Fc1cc2cc(ccc2cn1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C18H13FN4O/c19-16-9-15-8-13(6-7-14(15)11-20-16)17-22-23-18(24-17)21-10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,21,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443660
PNG
(CHEMBL3093064)
Show SMILES Fc1cccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C16H12FN5O/c17-11-4-1-3-10(7-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)5-2-6-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443665
PNG
(CHEMBL3093059)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H14N6O/c17-14-12-8-11(6-7-13(12)19-20-14)15-21-22-16(23-15)18-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,18,22)(H3,17,19,20)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443643
PNG
(CHEMBL3093055)
Show SMILES C(Nc1nnc(o1)-c1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-4-13(5-3-1)11-20-18-22-21-17(23-18)15-6-7-16-12-19-9-8-14(16)10-15/h1-10,12H,11H2,(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443666
PNG
(CHEMBL3093058)
Show SMILES C(Nc1nnc(o1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-4-11(5-3-1)9-17-16-21-20-15(22-16)12-6-7-14-13(8-12)10-18-19-14/h1-8,10H,9H2,(H,17,21)(H,18,19)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443662
PNG
(CHEMBL3093062)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-5-11(6-3-1)9-19-16-21-20-15(22-16)13-10-18-14-12(13)7-4-8-17-14/h1-8,10H,9H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443659
PNG
(CHEMBL3093065)
Show SMILES Fc1ccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)cc1
Show InChI InChI=1S/C16H12FN5O/c17-11-5-3-10(4-6-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)2-1-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin T1 (unknown origin) using 4eBP1 ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443654
PNG
(CHEMBL3093070)
Show SMILES C[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443655
PNG
(CHEMBL3093069)
Show SMILES C[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443661
PNG
(CHEMBL3093063)
Show SMILES Fc1ccccc1CNc1nnc(o1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H12FN5O/c17-13-6-2-1-4-10(13)8-20-16-22-21-15(23-16)12-9-19-14-11(12)5-3-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443660
PNG
(CHEMBL3093064)
Show SMILES Fc1cccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C16H12FN5O/c17-11-4-1-3-10(7-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)5-2-6-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443650
PNG
(CHEMBL3093074)
Show SMILES C1CC1[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H17N5O/c1-2-5-12(6-3-1)16(13-8-9-13)22-19-24-23-18(25-19)15-11-21-17-14(15)7-4-10-20-17/h1-7,10-11,13,16H,8-9H2,(H,20,21)(H,22,24)/t16-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443659
PNG
(CHEMBL3093065)
Show SMILES Fc1ccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)cc1
Show InChI InChI=1S/C16H12FN5O/c17-11-5-3-10(4-6-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)2-1-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443655
PNG
(CHEMBL3093069)
Show SMILES C[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443656
PNG
(CHEMBL3093068)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccncc1
Show InChI InChI=1S/C15H12N6O/c1-2-11-12(9-18-13(11)17-5-1)14-20-21-15(22-14)19-8-10-3-6-16-7-4-10/h1-7,9H,8H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443653
PNG
(CHEMBL3093071)
Show SMILES CC(C)(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-18(2,12-7-4-3-5-8-12)21-17-23-22-16(24-17)14-11-20-15-13(14)9-6-10-19-15/h3-11H,1-2H3,(H,19,20)(H,21,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin T1 (unknown origin) using 4eBP1 ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443651
PNG
(CHEMBL3093073)
Show SMILES CC(C)[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H19N5O/c1-12(2)16(13-7-4-3-5-8-13)22-19-24-23-18(25-19)15-11-21-17-14(15)9-6-10-20-17/h3-12,16H,1-2H3,(H,20,21)(H,22,24)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443652
PNG
(CHEMBL3093072)
Show SMILES CC[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H17N5O/c1-2-15(12-7-4-3-5-8-12)21-18-23-22-17(24-18)14-11-20-16-13(14)9-6-10-19-16/h3-11,15H,2H2,1H3,(H,19,20)(H,21,23)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443662
PNG
(CHEMBL3093062)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-5-11(6-3-1)9-19-16-21-20-15(22-16)13-10-18-14-12(13)7-4-8-17-14/h1-8,10H,9H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443666
PNG
(CHEMBL3093058)
Show SMILES C(Nc1nnc(o1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-4-11(5-3-1)9-17-16-21-20-15(22-16)12-6-7-14-13(8-12)10-18-19-14/h1-8,10H,9H2,(H,17,21)(H,18,19)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443658
PNG
(CHEMBL3093066)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccn1
Show InChI InChI=1S/C15H12N6O/c1-2-6-16-10(4-1)8-19-15-21-20-14(22-15)12-9-18-13-11(12)5-3-7-17-13/h1-7,9H,8H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443657
PNG
(CHEMBL3093067)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1cccnc1
Show InChI InChI=1S/C15H12N6O/c1-3-10(7-16-5-1)8-19-15-21-20-14(22-15)12-9-18-13-11(12)4-2-6-17-13/h1-7,9H,8H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443665
PNG
(CHEMBL3093059)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H14N6O/c17-14-12-8-11(6-7-13(12)19-20-14)15-21-22-16(23-15)18-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,18,22)(H3,17,19,20)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443645
PNG
(CHEMBL3093079)
Show SMILES Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443654
PNG
(CHEMBL3093070)
Show SMILES C[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443643
PNG
(CHEMBL3093055)
Show SMILES C(Nc1nnc(o1)-c1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-4-13(5-3-1)11-20-18-22-21-17(23-18)15-6-7-16-12-19-9-8-14(16)10-15/h1-10,12H,11H2,(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443656
PNG
(CHEMBL3093068)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccncc1
Show InChI InChI=1S/C15H12N6O/c1-2-11-12(9-18-13(11)17-5-1)14-20-21-15(22-14)19-8-10-3-6-16-7-4-10/h1-7,9H,8H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443654
PNG
(CHEMBL3093070)
Show SMILES C[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin T1 (unknown origin) using 4eBP1 ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443661
PNG
(CHEMBL3093063)
Show SMILES Fc1ccccc1CNc1nnc(o1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H12FN5O/c17-13-6-2-1-4-10(13)8-20-16-22-21-15(23-16)12-9-19-14-11(12)5-3-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443660
PNG
(CHEMBL3093064)
Show SMILES Fc1cccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C16H12FN5O/c17-11-4-1-3-10(7-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)5-2-6-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443664
PNG
(CHEMBL3093060)
Show SMILES O=c1[nH]c2ccc(cc2o1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H12N4O3/c21-16-18-12-7-6-11(8-13(12)22-16)14-19-20-15(23-14)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,17,20)(H,18,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443657
PNG
(CHEMBL3093067)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1cccnc1
Show InChI InChI=1S/C15H12N6O/c1-3-10(7-16-5-1)8-19-15-21-20-14(22-15)12-9-18-13-11(12)4-2-6-17-13/h1-7,9H,8H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443659
PNG
(CHEMBL3093065)
Show SMILES Fc1ccc(CNc2nnc(o2)-c2c[nH]c3ncccc23)cc1
Show InChI InChI=1S/C16H12FN5O/c17-11-5-3-10(4-6-11)8-20-16-22-21-15(23-16)13-9-19-14-12(13)2-1-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443643
PNG
(CHEMBL3093055)
Show SMILES C(Nc1nnc(o1)-c1ccc2cnccc2c1)c1ccccc1
Show InChI InChI=1S/C18H14N4O/c1-2-4-13(5-3-1)11-20-18-22-21-17(23-18)15-6-7-16-12-19-9-8-14(16)10-15/h1-10,12H,11H2,(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443666
PNG
(CHEMBL3093058)
Show SMILES C(Nc1nnc(o1)-c1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-4-11(5-3-1)9-17-16-21-20-15(22-16)12-6-7-14-13(8-12)10-18-19-14/h1-8,10H,9H2,(H,17,21)(H,18,19)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443663
PNG
(CHEMBL3093061)
Show SMILES O=C1Cc2cc(ccc2N1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C17H14N4O2/c22-15-9-13-8-12(6-7-14(13)19-15)16-20-21-17(23-16)18-10-11-4-2-1-3-5-11/h1-8H,9-10H2,(H,18,21)(H,19,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443662
PNG
(CHEMBL3093062)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C16H13N5O/c1-2-5-11(6-3-1)9-19-16-21-20-15(22-16)13-10-18-14-12(13)7-4-8-17-14/h1-8,10H,9H2,(H,17,18)(H,19,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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n/an/a 880n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin T1 (unknown origin) using 4eBP1 ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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n/an/a 940n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin T1 (unknown origin) using 4eBP1 ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443651
PNG
(CHEMBL3093073)
Show SMILES CC(C)[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H19N5O/c1-12(2)16(13-7-4-3-5-8-13)22-19-24-23-18(25-19)15-11-21-17-14(15)9-6-10-20-17/h3-12,16H,1-2H3,(H,20,21)(H,22,24)/t16-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443665
PNG
(CHEMBL3093059)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H14N6O/c17-14-12-8-11(6-7-13(12)19-20-14)15-21-22-16(23-15)18-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,18,22)(H3,17,19,20)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443650
PNG
(CHEMBL3093074)
Show SMILES C1CC1[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C19H17N5O/c1-2-5-12(6-3-1)16(13-8-9-13)22-19-24-23-18(25-19)15-11-21-17-14(15)7-4-10-20-17/h1-7,10-11,13,16H,8-9H2,(H,20,21)(H,22,24)/t16-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50443649
PNG
(CHEMBL3093075)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C19H16FN5O/c20-15-6-2-1-4-13(15)16(11-7-8-11)23-19-25-24-18(26-19)14-10-22-17-12(14)5-3-9-21-17/h1-6,9-11,16H,7-8H2,(H,21,22)(H,23,25)/t16-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443661
PNG
(CHEMBL3093063)
Show SMILES Fc1ccccc1CNc1nnc(o1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H12FN5O/c17-13-6-2-1-4-10(13)8-20-16-22-21-15(23-16)12-9-19-14-11(12)5-3-7-18-14/h1-7,9H,8H2,(H,18,19)(H,20,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443652
PNG
(CHEMBL3093072)
Show SMILES CC[C@@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H17N5O/c1-2-15(12-7-4-3-5-8-12)21-18-23-22-17(24-18)14-11-20-16-13(14)9-6-10-19-16/h3-11,15H,2H2,1H3,(H,19,20)(H,21,23)/t15-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50443667
PNG
(CHEMBL3093057)
Show SMILES C(Nc1nnc(o1)-c1nc2ccncc2s1)c1ccccc1
Show InChI InChI=1S/C15H11N5OS/c1-2-4-10(5-3-1)8-17-15-20-19-13(21-15)14-18-11-6-7-16-9-12(11)22-14/h1-7,9H,8H2,(H,17,20)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50443645
PNG
(CHEMBL3093079)
Show SMILES Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin T1 (unknown origin) using 4eBP1 ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443658
PNG
(CHEMBL3093066)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccn1
Show InChI InChI=1S/C15H12N6O/c1-2-6-16-10(4-1)8-19-15-21-20-14(22-15)12-9-18-13-11(12)5-3-7-17-13/h1-7,9H,8H2,(H,17,18)(H,19,21)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443655
PNG
(CHEMBL3093069)
Show SMILES C[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C17H15N5O/c1-11(12-6-3-2-4-7-12)20-17-22-21-16(23-17)14-10-19-15-13(14)8-5-9-18-15/h2-11H,1H3,(H,18,19)(H,20,22)/t11-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443642
PNG
(CHEMBL3093056)
Show SMILES Fc1cc2cc(ccc2cn1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C18H13FN4O/c19-16-9-15-8-13(6-7-14(15)11-20-16)17-22-23-18(24-17)21-10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,21,23)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443645
PNG
(CHEMBL3093079)
Show SMILES Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443653
PNG
(CHEMBL3093071)
Show SMILES CC(C)(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-18(2,12-7-4-3-5-8-12)21-17-23-22-16(24-17)14-11-20-15-13(14)9-6-10-19-15/h3-11H,1-2H3,(H,19,20)(H,21,23)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50443644
PNG
(CHEMBL3093080)
Show SMILES Fc1cnc2[nH]cc(-c3nnc(N[C@H](C4CC4)c4cccnc4F)o3)c2c1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-10-6-12-13(8-23-16(12)22-7-10)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-5-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443642
PNG
(CHEMBL3093056)
Show SMILES Fc1cc2cc(ccc2cn1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C18H13FN4O/c19-16-9-15-8-13(6-7-14(15)11-20-16)17-22-23-18(24-17)21-10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,21,23)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443657
PNG
(CHEMBL3093067)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1cccnc1
Show InChI InChI=1S/C15H12N6O/c1-3-10(7-16-5-1)8-19-15-21-20-14(22-15)12-9-18-13-11(12)4-2-6-17-13/h1-7,9H,8H2,(H,17,18)(H,19,21)
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n/an/a 7.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50443648
PNG
(CHEMBL3093076)
Show SMILES Fc1ncccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-15-12(4-2-7-20-15)14(10-5-6-10)23-18-25-24-17(26-18)13-9-22-16-11(13)3-1-8-21-16/h1-4,7-10,14H,5-6H2,(H,21,22)(H,23,25)/t14-/m1/s1
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n/an/a 7.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443656
PNG
(CHEMBL3093068)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccncc1
Show InChI InChI=1S/C15H12N6O/c1-2-11-12(9-18-13(11)17-5-1)14-20-21-15(22-14)19-8-10-3-6-16-7-4-10/h1-7,9H,8H2,(H,17,18)(H,19,21)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443658
PNG
(CHEMBL3093066)
Show SMILES C(Nc1nnc(o1)-c1c[nH]c2ncccc12)c1ccccn1
Show InChI InChI=1S/C15H12N6O/c1-2-6-16-10(4-1)8-19-15-21-20-14(22-15)12-9-18-13-11(12)5-3-7-17-13/h1-7,9H,8H2,(H,17,18)(H,19,21)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443667
PNG
(CHEMBL3093057)
Show SMILES C(Nc1nnc(o1)-c1nc2ccncc2s1)c1ccccc1
Show InChI InChI=1S/C15H11N5OS/c1-2-4-10(5-3-1)8-17-15-20-19-13(21-15)14-18-11-6-7-16-9-12(11)22-14/h1-7,9H,8H2,(H,17,20)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443663
PNG
(CHEMBL3093061)
Show SMILES O=C1Cc2cc(ccc2N1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C17H14N4O2/c22-15-9-13-8-12(6-7-14(13)19-15)16-20-21-17(23-16)18-10-11-4-2-1-3-5-11/h1-8H,9-10H2,(H,18,21)(H,19,22)
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n/an/a 3.30E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50443664
PNG
(CHEMBL3093060)
Show SMILES O=c1[nH]c2ccc(cc2o1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H12N4O3/c21-16-18-12-7-6-11(8-13(12)22-16)14-19-20-15(23-14)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,17,20)(H,18,21)
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n/an/a 4.70E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/cyclin E (unknown origin) using ULight peptide as substrate by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50443646
PNG
(CHEMBL3093078)
Show SMILES Fc1ccccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncncc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-4-2-1-3-11(14)15(10-5-6-10)23-18-25-24-17(26-18)13-8-21-16-12(13)7-20-9-22-16/h1-4,7-10,15H,5-6H2,(H,23,25)(H,20,21,22)/t15-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443664
PNG
(CHEMBL3093060)
Show SMILES O=c1[nH]c2ccc(cc2o1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C16H12N4O3/c21-16-18-12-7-6-11(8-13(12)22-16)14-19-20-15(23-14)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,17,20)(H,18,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50443647
PNG
(CHEMBL3093077)
Show SMILES Fc1cnccc1[C@H](Nc1nnc(o1)-c1c[nH]c2ncccc12)C1CC1 |r|
Show InChI InChI=1S/C18H15FN6O/c19-14-9-20-7-5-12(14)15(10-3-4-10)23-18-25-24-17(26-18)13-8-22-16-11(13)2-1-6-21-16/h1-2,5-10,15H,3-4H2,(H,21,22)(H,23,25)/t15-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50443645
PNG
(CHEMBL3093079)
Show SMILES Fc1ccc2c(c[nH]c2n1)-c1nnc(N[C@H](C2CC2)c2cccnc2F)o1 |r|
Show InChI InChI=1S/C18H14F2N6O/c19-13-6-5-10-12(8-22-16(10)23-13)17-25-26-18(27-17)24-14(9-3-4-9)11-2-1-7-21-15(11)20/h1-2,5-9,14H,3-4H2,(H,22,23)(H,24,26)/t14-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B (unknown origin) by HTRF assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443667
PNG
(CHEMBL3093057)
Show SMILES C(Nc1nnc(o1)-c1nc2ccncc2s1)c1ccccc1
Show InChI InChI=1S/C15H11N5OS/c1-2-4-10(5-3-1)8-17-15-20-19-13(21-15)14-18-11-6-7-16-9-12(11)22-14/h1-7,9H,8H2,(H,17,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50443663
PNG
(CHEMBL3093061)
Show SMILES O=C1Cc2cc(ccc2N1)-c1nnc(NCc2ccccc2)o1
Show InChI InChI=1S/C17H14N4O2/c22-15-9-13-8-12(6-7-14(13)19-15)16-20-21-17(23-16)18-10-11-4-2-1-3-5-11/h1-8H,9-10H2,(H,18,21)(H,19,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7-mediated MCM2 phosphorylation at Ser53 in human HCT116 cells after 14 hrs by immunostaining assay


Bioorg Med Chem Lett 23: 6396-400 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.055
BindingDB Entry DOI: 10.7270/Q2P84DC0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%