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PubMed code 24219778

Compile data set for download or QSAR
Found 139 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444240
PNG
(CHEMBL3093635)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](N)CC2)n1 |r,wU:29.30,wD:32.34,(.04,-21.39,;1.37,-20.63,;2.71,-21.4,;4.04,-20.63,;5.37,-21.4,;6.71,-20.63,;8.04,-21.4,;9.38,-20.63,;9.37,-19.08,;10.7,-18.3,;10.7,-16.76,;12.04,-19.07,;13.37,-18.29,;14.71,-19.07,;16.03,-18.29,;16.03,-16.75,;14.68,-15.99,;13.36,-16.76,;17.36,-15.97,;16.58,-14.63,;18.13,-14.62,;18.7,-16.74,;18.69,-18.27,;20.02,-19.03,;21.36,-18.26,;21.35,-16.72,;20.01,-15.95,;8.04,-18.32,;8.03,-16.78,;6.7,-16.01,;5.36,-16.79,;4.03,-16.01,;4.03,-14.47,;2.69,-13.7,;5.36,-13.71,;6.69,-14.47,;6.71,-19.09,)|
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-12-27-25-28-17-22(23(31-25)29-19-6-4-18(26)5-7-19)24(33)30-20-8-10-21(11-9-20)37(34,35)32-13-15-36-16-14-32/h8-11,17-19H,2-7,12-16,26H2,1H3,(H,30,33)(H2,27,28,29,31)/t18-,19-
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n/an/a 2.10n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444253
PNG
(CHEMBL3093648)
Show SMILES CCCCNc1ncc(C(=O)NC2CCN(CC2)c2ncccn2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(19.76,-36.09,;21.1,-35.32,;22.43,-36.09,;23.76,-35.32,;25.1,-36.09,;26.43,-35.32,;27.76,-36.09,;29.1,-35.32,;29.1,-33.77,;30.43,-33,;30.42,-31.46,;31.76,-33.76,;33.09,-32.99,;34.43,-33.76,;35.76,-32.99,;35.76,-31.45,;34.42,-30.68,;33.08,-31.45,;37.09,-30.68,;38.42,-31.45,;39.75,-30.68,;39.75,-29.14,;38.41,-28.37,;37.08,-29.14,;27.76,-33.01,;27.76,-31.47,;26.42,-30.7,;25.09,-31.48,;23.75,-30.71,;23.75,-29.16,;22.42,-28.39,;25.08,-28.4,;26.41,-29.16,;26.43,-33.78,)|
Show InChI InChI=1S/C24H36N8O2/c1-2-3-11-25-23-28-16-20(21(31-23)29-17-5-7-19(33)8-6-17)22(34)30-18-9-14-32(15-10-18)24-26-12-4-13-27-24/h4,12-13,16-19,33H,2-3,5-11,14-15H2,1H3,(H,30,34)(H2,25,28,29,31)/t17-,19-
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n/an/a 4.10n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444241
PNG
(CHEMBL3093756 | US9649309, Compound UNC2881A)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(48.43,-9.69,;49.77,-8.92,;51.1,-9.69,;52.43,-8.92,;53.77,-9.69,;55.1,-8.93,;56.43,-9.7,;57.77,-8.92,;57.77,-7.37,;59.1,-6.6,;59.09,-5.06,;60.43,-7.36,;61.76,-6.59,;63.1,-7.35,;63.1,-8.89,;64.44,-9.66,;65.77,-8.88,;65.76,-7.33,;64.42,-6.58,;67.11,-9.64,;68.5,-9.01,;69.54,-10.15,;68.78,-11.49,;67.27,-11.18,;56.43,-6.61,;56.43,-5.07,;55.09,-4.3,;53.76,-5.08,;52.42,-4.31,;52.42,-2.77,;51.09,-2,;53.75,-2,;55.08,-2.77,;55.1,-7.38,)|
Show InChI InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-
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n/an/a 4.30n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444242
PNG
(CHEMBL3093755)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)S(N)(=O)=O)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.25,wD:28.29,(24.27,-9.22,;25.6,-8.45,;26.93,-9.22,;28.27,-8.45,;29.6,-9.22,;30.94,-8.45,;32.27,-9.22,;33.61,-8.45,;33.6,-6.9,;34.93,-6.12,;34.93,-4.58,;36.27,-6.89,;37.6,-6.11,;38.94,-6.88,;38.94,-8.42,;40.27,-9.18,;41.6,-8.41,;41.59,-6.86,;40.26,-6.1,;42.94,-9.17,;44.27,-8.39,;43.7,-10.5,;42.17,-10.5,;32.27,-6.14,;32.26,-4.6,;30.93,-3.83,;29.59,-4.61,;28.25,-3.84,;28.25,-2.29,;26.92,-1.52,;29.59,-1.53,;30.92,-2.29,;30.94,-6.91,)|
Show InChI InChI=1S/C22H32N6O4S/c1-2-3-12-24-22-26-14-19(20(28-22)27-16-6-8-17(29)9-7-16)21(30)25-13-15-4-10-18(11-5-15)33(23,31)32/h4-5,10-11,14,16-17,29H,2-3,6-9,12-13H2,1H3,(H,25,30)(H2,23,31,32)(H2,24,26,27,28)/t16-,17-
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n/an/a 5.20n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444244
PNG
(CHEMBL3093753)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(46.77,-58.29,;48.1,-57.52,;49.43,-58.29,;50.77,-57.52,;52.1,-58.3,;53.43,-57.53,;54.77,-58.3,;56.11,-57.53,;56.1,-55.98,;57.43,-55.2,;57.43,-53.66,;58.77,-55.97,;60.1,-55.19,;61.43,-55.96,;62.76,-55.19,;62.76,-53.65,;61.41,-52.88,;60.09,-53.66,;64.09,-52.87,;64.85,-51.53,;63.31,-51.54,;65.42,-53.63,;65.42,-55.17,;66.75,-55.93,;68.08,-55.16,;68.08,-53.62,;66.74,-52.85,;54.76,-55.21,;54.76,-53.67,;53.42,-52.91,;52.09,-53.69,;50.75,-52.91,;50.75,-51.37,;49.42,-50.6,;52.09,-50.6,;53.42,-51.37,;53.44,-55.98,)|
Show InChI InChI=1S/C25H36N6O5S/c1-2-3-12-26-25-27-17-22(23(30-25)28-18-4-8-20(32)9-5-18)24(33)29-19-6-10-21(11-7-19)37(34,35)31-13-15-36-16-14-31/h6-7,10-11,17-18,20,32H,2-5,8-9,12-16H2,1H3,(H,29,33)(H2,26,27,28,30)/t18-,20-
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n/an/a 6.30n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444245
PNG
(CHEMBL3093752)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(CN3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(21.61,-58.16,;22.95,-57.39,;24.28,-58.16,;25.61,-57.39,;26.95,-58.16,;28.28,-57.39,;29.62,-58.16,;30.95,-57.39,;30.95,-55.84,;32.28,-55.07,;32.27,-53.53,;33.61,-55.83,;34.95,-55.06,;36.28,-55.83,;37.61,-55.06,;37.6,-53.51,;38.93,-52.74,;40.27,-53.5,;40.27,-55.03,;41.6,-55.8,;42.93,-55.03,;42.93,-53.49,;41.59,-52.71,;36.26,-52.75,;34.93,-53.53,;29.61,-55.08,;29.61,-53.54,;28.27,-52.77,;26.94,-53.55,;25.6,-52.78,;25.6,-51.24,;24.27,-50.47,;26.94,-50.47,;28.26,-51.23,;28.28,-55.85,)|
Show InChI InChI=1S/C26H38N6O3/c1-2-3-12-27-26-28-17-23(24(31-26)29-20-8-10-22(33)11-9-20)25(34)30-21-6-4-19(5-7-21)18-32-13-15-35-16-14-32/h4-7,17,20,22,33H,2-3,8-16,18H2,1H3,(H,30,34)(H2,27,28,29,31)/t20-,22-
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n/an/a 6.70n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444271
PNG
(CHEMBL3093627)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCCC2CC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(51.32,-15.73,;52.65,-16.5,;52.65,-18.04,;53.99,-18.82,;55.31,-18.05,;55.31,-16.5,;53.98,-15.73,;56.65,-18.81,;56.65,-20.35,;55.32,-21.12,;55.32,-22.67,;53.99,-23.44,;52.65,-22.66,;51.32,-23.43,;49.99,-22.66,;49.22,-21.33,;48.45,-22.66,;56.66,-23.44,;57.99,-22.67,;57.99,-21.12,;59.32,-20.34,;59.31,-18.8,;60.65,-21.11,;61.99,-20.33,;63.32,-21.1,;64.65,-20.33,;64.64,-18.79,;63.3,-18.02,;61.97,-18.8,;65.97,-18,;65.2,-16.67,;66.74,-16.66,;67.31,-18.77,;67.31,-20.31,;68.64,-21.07,;69.97,-20.3,;69.97,-18.76,;68.63,-17.99,)|
Show InChI InChI=1S/C26H36N6O5S/c33-21-7-3-19(4-8-21)29-24-23(17-28-26(31-24)27-12-11-18-1-2-18)25(34)30-20-5-9-22(10-6-20)38(35,36)32-13-15-37-16-14-32/h5-6,9-10,17-19,21,33H,1-4,7-8,11-16H2,(H,30,34)(H2,27,28,29,31)/t19-,21-
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n/an/a 7.30n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444251
PNG
(CHEMBL3093746 | US9649309, Compound UNC2602A)
Show SMILES CCCCNc1ncc(C(=O)NC2CCCCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(54.57,-35.57,;55.9,-34.8,;57.23,-35.58,;58.57,-34.81,;59.9,-35.58,;61.23,-34.81,;62.57,-35.58,;63.91,-34.81,;63.9,-33.26,;65.23,-32.48,;65.23,-30.94,;66.57,-33.25,;67.9,-32.47,;69.23,-33.24,;70.56,-32.47,;70.56,-30.93,;69.23,-30.16,;67.89,-30.94,;62.57,-32.49,;62.56,-30.95,;61.22,-30.19,;59.89,-30.97,;58.55,-30.19,;58.55,-28.65,;57.22,-27.88,;59.89,-27.88,;61.22,-28.65,;61.24,-33.26,)|
Show InChI InChI=1S/C21H35N5O2/c1-2-3-13-22-21-23-14-18(20(28)25-15-7-5-4-6-8-15)19(26-21)24-16-9-11-17(27)12-10-16/h14-17,27H,2-13H2,1H3,(H,25,28)(H2,22,23,24,26)/t16-,17-
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n/an/a 8n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444254
PNG
(CHEMBL3093763)
Show SMILES CCCCNc1ncc(C(=O)NC2CCN(CC2)C(C)C)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:23.23,wD:26.27,(.87,-34.95,;2.2,-34.18,;3.54,-34.95,;4.87,-34.19,;6.21,-34.96,;7.54,-34.19,;8.87,-34.96,;10.21,-34.19,;10.21,-32.64,;11.54,-31.86,;11.53,-30.32,;12.87,-32.63,;14.2,-31.85,;15.54,-32.62,;16.86,-31.85,;16.87,-30.31,;15.53,-29.54,;14.19,-30.31,;18.2,-29.54,;19.53,-30.31,;18.2,-28,;8.87,-31.87,;8.87,-30.33,;7.53,-29.57,;6.2,-30.35,;4.86,-29.57,;4.86,-28.03,;3.52,-27.26,;6.19,-27.26,;7.52,-28.03,;7.54,-32.64,)|
Show InChI InChI=1S/C23H40N6O2/c1-4-5-12-24-23-25-15-20(21(28-23)26-17-6-8-19(30)9-7-17)22(31)27-18-10-13-29(14-11-18)16(2)3/h15-19,30H,4-14H2,1-3H3,(H,27,31)(H2,24,25,26,28)/t17-,19-
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n/an/a 8.40n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444256
PNG
(CHEMBL3093761)
Show SMILES CCCCNc1ncc(C(=O)NC2CCNCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(37.14,-23.53,;38.48,-22.76,;39.81,-23.53,;41.15,-22.76,;42.48,-23.53,;43.81,-22.76,;45.15,-23.53,;46.48,-22.76,;46.48,-21.21,;47.81,-20.43,;47.8,-18.9,;49.15,-21.2,;50.48,-20.42,;51.81,-21.2,;53.14,-20.43,;53.14,-18.89,;51.8,-18.12,;50.47,-18.89,;45.14,-20.45,;45.14,-18.91,;43.8,-18.14,;42.47,-18.92,;41.13,-18.15,;41.13,-16.6,;39.8,-15.83,;42.47,-15.84,;43.8,-16.6,;43.82,-21.22,)|
Show InChI InChI=1S/C20H34N6O2/c1-2-3-10-22-20-23-13-17(19(28)25-15-8-11-21-12-9-15)18(26-20)24-14-4-6-16(27)7-5-14/h13-16,21,27H,2-12H2,1H3,(H,25,28)(H2,22,23,24,26)/t14-,16-
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n/an/a 9n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444273
PNG
(CHEMBL3093625)
Show SMILES CCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(2.34,-21.85,;3.67,-22.62,;5,-21.85,;6.34,-22.62,;7.67,-21.85,;9.01,-22.62,;10.34,-21.85,;10.34,-20.3,;11.67,-19.52,;11.66,-17.98,;13,-20.29,;14.34,-19.51,;15.67,-20.29,;17,-19.51,;16.99,-17.97,;15.65,-17.21,;14.32,-17.98,;18.32,-17.19,;17.55,-15.85,;19.09,-15.85,;19.66,-17.96,;19.66,-19.49,;20.99,-20.25,;22.32,-19.48,;22.32,-17.94,;20.98,-17.17,;9,-19.54,;9,-18,;7.66,-17.23,;6.34,-18,;5,-17.23,;5,-15.69,;3.67,-14.91,;6.33,-14.92,;7.66,-15.68,;7.67,-20.31,)|
Show InChI InChI=1S/C24H34N6O5S/c1-2-11-25-24-26-16-21(22(29-24)27-17-3-7-19(31)8-4-17)23(32)28-18-5-9-20(10-6-18)36(33,34)30-12-14-35-15-13-30/h5-6,9-10,16-17,19,31H,2-4,7-8,11-15H2,1H3,(H,28,32)(H2,25,26,27,29)/t17-,19-
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n/an/a 11n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444252
PNG
(CHEMBL3093649)
Show SMILES CCCCNc1ncc(C(=O)NC2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(39.42,-35.6,;40.75,-34.83,;42.08,-35.6,;43.42,-34.83,;44.75,-35.6,;46.08,-34.83,;47.42,-35.6,;48.76,-34.83,;48.75,-33.28,;50.08,-32.51,;50.08,-30.97,;51.42,-33.27,;52.75,-32.5,;54.08,-33.27,;55.41,-32.5,;55.41,-30.96,;54.07,-30.19,;52.74,-30.96,;47.41,-32.52,;47.41,-30.98,;46.07,-30.21,;44.74,-30.99,;43.4,-30.22,;43.4,-28.67,;42.07,-27.9,;44.74,-27.91,;46.07,-28.67,;46.09,-33.29,)|
Show InChI InChI=1S/C20H33N5O3/c1-2-3-10-21-20-22-13-17(19(27)24-15-8-11-28-12-9-15)18(25-20)23-14-4-6-16(26)7-5-14/h13-16,26H,2-12H2,1H3,(H,24,27)(H2,21,22,23,25)/t14-,16-
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n/an/a 13n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444246
PNG
(CHEMBL3093751)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(-.47,-58.49,;.87,-57.72,;2.21,-58.49,;3.54,-57.72,;4.87,-58.49,;6.21,-57.72,;7.54,-58.49,;8.88,-57.72,;8.87,-56.17,;10.21,-55.4,;10.2,-53.86,;11.54,-56.16,;12.87,-55.39,;14.21,-56.16,;15.54,-55.38,;15.53,-53.84,;14.18,-53.08,;12.86,-53.86,;16.86,-53.07,;18.19,-53.83,;19.52,-53.06,;19.52,-51.52,;18.18,-50.75,;16.84,-51.53,;7.54,-55.41,;7.53,-53.87,;6.2,-53.1,;4.86,-53.88,;3.53,-53.11,;3.53,-51.57,;2.19,-50.8,;4.86,-50.8,;6.19,-51.56,;6.21,-56.18,)|
Show InChI InChI=1S/C25H36N6O3/c1-2-3-12-26-25-27-17-22(23(30-25)28-18-6-10-21(32)11-7-18)24(33)29-19-4-8-20(9-5-19)31-13-15-34-16-14-31/h4-5,8-9,17-18,21,32H,2-3,6-7,10-16H2,1H3,(H,29,33)(H2,26,27,28,30)/t18-,21-
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n/an/a 14n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444243
PNG
(CHEMBL3093754)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(1.93,-9.16,;3.26,-8.39,;4.6,-9.16,;5.93,-8.39,;7.26,-9.17,;8.6,-8.4,;9.93,-9.17,;11.27,-8.4,;11.26,-6.85,;12.59,-6.07,;12.59,-4.53,;13.93,-6.84,;15.26,-6.06,;16.6,-6.83,;16.6,-8.36,;17.93,-9.13,;19.27,-8.35,;20.6,-9.12,;19.26,-6.8,;17.92,-6.05,;9.93,-6.08,;9.92,-4.54,;8.59,-3.78,;7.25,-4.56,;5.92,-3.78,;5.92,-2.24,;4.58,-1.47,;7.25,-1.47,;8.58,-2.24,;8.6,-6.85,)|
Show InChI InChI=1S/C22H30FN5O2/c1-2-3-12-24-22-26-14-19(20(28-22)27-17-8-10-18(29)11-9-17)21(30)25-13-15-4-6-16(23)7-5-15/h4-7,14,17-18,29H,2-3,8-13H2,1H3,(H,25,30)(H2,24,26,27,28)/t17-,18-
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n/an/a 14n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444249
PNG
(CHEMBL3093748 | US9649309, Compound UNC2776A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(OC)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(20.21,-47.13,;21.55,-46.36,;22.88,-47.13,;24.21,-46.36,;25.55,-47.13,;26.88,-46.37,;28.22,-47.14,;29.55,-46.36,;29.55,-44.81,;30.88,-44.04,;30.87,-42.5,;32.22,-44.8,;33.55,-44.03,;34.88,-44.8,;36.21,-44.03,;36.2,-42.49,;37.53,-41.71,;38.87,-42.47,;34.86,-41.72,;33.53,-42.5,;28.21,-44.05,;28.21,-42.51,;26.87,-41.74,;25.54,-42.52,;24.2,-41.75,;24.2,-40.21,;22.87,-39.44,;25.54,-39.44,;26.86,-40.21,;26.88,-44.82,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-13-23-22-24-14-19(20(27-22)25-15-5-9-17(28)10-6-15)21(29)26-16-7-11-18(30-2)12-8-16/h7-8,11-12,14-15,17,28H,3-6,9-10,13H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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n/an/a 15n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444241
PNG
(CHEMBL3093756 | US9649309, Compound UNC2881A)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(48.43,-9.69,;49.77,-8.92,;51.1,-9.69,;52.43,-8.92,;53.77,-9.69,;55.1,-8.93,;56.43,-9.7,;57.77,-8.92,;57.77,-7.37,;59.1,-6.6,;59.09,-5.06,;60.43,-7.36,;61.76,-6.59,;63.1,-7.35,;63.1,-8.89,;64.44,-9.66,;65.77,-8.88,;65.76,-7.33,;64.42,-6.58,;67.11,-9.64,;68.5,-9.01,;69.54,-10.15,;68.78,-11.49,;67.27,-11.18,;56.43,-6.61,;56.43,-5.07,;55.09,-4.3,;53.76,-5.08,;52.42,-4.31,;52.42,-2.77,;51.09,-2,;53.75,-2,;55.08,-2.77,;55.1,-7.38,)|
Show InChI InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-
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n/an/a 22n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase phosphorylation in human 697 B-ALL cells after 1 hr by Western blot analysis

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444260
PNG
(CHEMBL3093757)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:21.21,wD:24.25,(35.28,-9.93,;36.61,-9.16,;37.95,-9.93,;39.28,-9.16,;40.61,-9.93,;41.95,-9.17,;43.28,-9.94,;44.62,-9.17,;44.61,-7.61,;45.94,-6.84,;45.94,-5.3,;47.28,-7.6,;48.61,-6.83,;49.94,-7.6,;51.27,-6.83,;51.27,-5.29,;52.6,-4.51,;49.92,-4.52,;48.6,-5.3,;43.28,-6.85,;43.27,-5.31,;41.94,-4.55,;40.6,-5.33,;39.27,-4.55,;39.26,-3.01,;37.93,-2.24,;40.6,-2.24,;41.93,-3.01,;41.95,-7.62,)|
Show InChI InChI=1S/C21H28FN5O2/c1-2-3-12-23-21-24-13-18(20(29)26-16-6-4-14(22)5-7-16)19(27-21)25-15-8-10-17(28)11-9-15/h4-7,13,15,17,28H,2-3,8-12H2,1H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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n/an/a 23n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444268
PNG
(CHEMBL3093630)
Show SMILES CC(C)Nc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(51.96,-34.69,;53.29,-33.92,;53.29,-32.38,;54.62,-34.69,;55.96,-33.92,;57.29,-34.69,;58.63,-33.92,;58.62,-32.37,;59.95,-31.59,;59.95,-30.05,;61.29,-32.36,;62.62,-31.58,;63.95,-32.35,;65.28,-31.58,;65.28,-30.04,;63.93,-29.28,;62.61,-30.05,;66.61,-29.26,;65.83,-27.92,;67.38,-27.91,;67.95,-30.03,;67.94,-31.56,;69.27,-32.32,;70.61,-31.55,;70.6,-30.01,;69.26,-29.24,;57.29,-31.6,;57.28,-30.07,;55.95,-29.3,;54.62,-30.07,;53.29,-29.3,;53.28,-27.75,;51.95,-26.98,;54.62,-26.99,;55.95,-27.75,;55.96,-32.38,)|
Show InChI InChI=1S/C24H34N6O5S/c1-16(2)26-24-25-15-21(22(29-24)27-17-3-7-19(31)8-4-17)23(32)28-18-5-9-20(10-6-18)36(33,34)30-11-13-35-14-12-30/h5-6,9-10,15-17,19,31H,3-4,7-8,11-14H2,1-2H3,(H,28,32)(H2,25,26,27,29)/t17-,19-
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n/an/a 24n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444272
PNG
(CHEMBL3093626)
Show SMILES CCCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:30.31,wD:33.35,(23.85,-22.37,;25.18,-23.14,;26.52,-22.37,;27.85,-23.14,;29.18,-22.37,;30.52,-23.14,;31.85,-22.37,;33.19,-23.14,;34.52,-22.37,;34.52,-20.82,;35.85,-20.05,;35.84,-18.51,;37.18,-20.81,;38.52,-20.04,;39.85,-20.81,;41.18,-20.03,;41.17,-18.49,;39.83,-17.73,;38.5,-18.51,;42.5,-17.71,;41.73,-16.37,;43.27,-16.37,;43.84,-18.48,;43.84,-20.01,;45.17,-20.78,;46.5,-20.01,;46.5,-18.46,;45.16,-17.69,;33.18,-20.06,;33.18,-18.52,;31.84,-17.75,;30.52,-18.52,;29.18,-17.75,;29.18,-16.21,;27.84,-15.44,;30.51,-15.44,;31.84,-16.2,;31.85,-20.83,)|
Show InChI InChI=1S/C26H38N6O5S/c1-2-3-4-13-27-26-28-18-23(24(31-26)29-19-5-9-21(33)10-6-19)25(34)30-20-7-11-22(12-8-20)38(35,36)32-14-16-37-17-15-32/h7-8,11-12,18-19,21,33H,2-6,9-10,13-17H2,1H3,(H,30,34)(H2,27,28,29,31)/t19-,21-
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n/an/a 27n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444248
PNG
(CHEMBL3093749)
Show SMILES CCCCNc1ncc(C(=O)Nc2cccc(OC)c2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(37.13,-46.79,;38.46,-46.02,;39.8,-46.79,;41.13,-46.02,;42.46,-46.79,;43.8,-46.02,;45.13,-46.79,;46.47,-46.02,;46.46,-44.47,;47.79,-43.7,;47.79,-42.16,;49.13,-44.46,;50.46,-43.69,;50.45,-42.16,;51.77,-41.38,;53.12,-42.14,;53.12,-43.68,;54.46,-44.45,;55.79,-43.68,;51.79,-44.46,;45.13,-43.71,;45.12,-42.17,;43.79,-41.4,;42.45,-42.18,;41.12,-41.41,;41.12,-39.87,;39.78,-39.1,;42.45,-39.1,;43.78,-39.86,;43.8,-44.48,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-12-23-22-24-14-19(20(27-22)25-15-8-10-17(28)11-9-15)21(29)26-16-6-5-7-18(13-16)30-2/h5-7,13-15,17,28H,3-4,8-12H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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n/an/a 29n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444274
PNG
(CHEMBL3093647)
Show SMILES CCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(50.31,-10.83,;51.65,-10.06,;52.98,-10.83,;54.31,-10.06,;55.65,-10.83,;56.98,-10.06,;56.98,-8.51,;58.31,-7.73,;58.3,-6.19,;59.65,-8.5,;60.98,-7.72,;62.31,-8.5,;63.64,-7.72,;63.64,-6.18,;62.29,-5.42,;60.97,-6.19,;64.96,-5.4,;64.19,-4.06,;65.73,-4.06,;66.3,-6.17,;66.3,-7.7,;67.63,-8.46,;68.96,-7.69,;68.96,-6.15,;67.62,-5.38,;55.64,-7.75,;55.64,-6.21,;54.3,-5.44,;52.98,-6.21,;51.64,-5.44,;51.64,-3.89,;50.31,-3.12,;52.98,-3.13,;54.3,-3.89,;54.31,-8.52,)|
Show InChI InChI=1S/C23H32N6O5S/c1-2-24-23-25-15-20(21(28-23)26-16-3-7-18(30)8-4-16)22(31)27-17-5-9-19(10-6-17)35(32,33)29-11-13-34-14-12-29/h5-6,9-10,15-16,18,30H,2-4,7-8,11-14H2,1H3,(H,27,31)(H2,24,25,26,28)/t16-,18-
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n/an/a 37n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444284
PNG
(CHEMBL3093637 | US9649309, Compound UNC2084A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NCC2CCNCC2)n1
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-7,18-19,26H,2-3,8-17H2,1H3,(H,30,33)(H2,27,28,29,31)
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n/an/a 37n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444247
PNG
(CHEMBL3093750 | US9649309, Compound UNC2775A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccccc2OC)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(54.22,-47.24,;55.55,-46.47,;56.88,-47.24,;58.22,-46.47,;59.55,-47.24,;60.88,-46.47,;62.22,-47.25,;63.56,-46.47,;63.55,-44.92,;64.88,-44.15,;64.88,-42.61,;66.22,-44.91,;67.55,-44.14,;67.54,-42.61,;68.86,-41.83,;70.21,-42.59,;70.21,-44.14,;68.88,-44.91,;68.88,-46.45,;70.22,-47.22,;62.22,-44.16,;62.21,-42.62,;60.87,-41.85,;59.54,-42.63,;58.2,-41.86,;58.2,-40.32,;56.87,-39.55,;59.54,-39.55,;60.87,-40.32,;60.89,-44.93,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-13-23-22-24-14-17(20(27-22)25-15-9-11-16(28)12-10-15)21(29)26-18-7-5-6-8-19(18)30-2/h5-8,14-16,28H,3-4,9-13H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,16-
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n/an/a 39n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444262
PNG
(CHEMBL3093764)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(.7,-12.07,;2.03,-11.3,;3.37,-12.07,;4.7,-11.3,;6.03,-12.07,;7.37,-11.31,;8.7,-12.08,;10.04,-11.3,;10.03,-9.75,;11.37,-8.98,;11.36,-7.44,;12.7,-9.74,;14.03,-8.97,;15.37,-9.74,;16.7,-8.97,;16.69,-7.43,;18.02,-6.65,;15.35,-6.66,;14.02,-7.44,;8.7,-8.99,;8.69,-7.45,;7.36,-6.68,;7.35,-5.14,;6.02,-4.38,;6.02,-2.83,;7.36,-2.06,;7.36,-.52,;8.69,-2.83,;8.69,-4.37,;7.37,-9.76,)|
Show InChI InChI=1S/C22H31FN6O/c1-2-3-12-25-22-27-14-19(21(30)28-18-10-6-16(23)7-11-18)20(29-22)26-13-15-4-8-17(24)9-5-15/h6-7,10-11,14-15,17H,2-5,8-9,12-13,24H2,1H3,(H,28,30)(H2,25,26,27,29)/t15-,17-
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n/an/a 40n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444267
PNG
(CHEMBL3093631)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NC2CCCCC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(3.66,-38.22,;4.99,-38.99,;4.99,-40.53,;6.33,-41.3,;7.65,-40.53,;7.65,-38.99,;6.32,-38.22,;8.99,-41.3,;8.99,-42.84,;7.66,-43.61,;7.66,-45.15,;6.33,-45.92,;4.99,-45.15,;4.99,-43.61,;3.67,-42.84,;2.33,-43.6,;2.33,-45.14,;3.66,-45.92,;8.99,-45.92,;10.33,-45.15,;10.33,-43.6,;11.66,-42.83,;11.65,-41.29,;12.99,-43.59,;14.32,-42.82,;15.66,-43.59,;16.99,-42.81,;16.98,-41.27,;15.63,-40.51,;14.31,-41.29,;18.31,-40.49,;17.53,-39.15,;19.08,-39.15,;19.65,-41.26,;19.64,-42.79,;20.97,-43.56,;22.31,-42.79,;22.3,-41.24,;20.96,-40.47,)|
Show InChI InChI=1S/C27H38N6O5S/c34-22-10-6-20(7-11-22)29-25-24(18-28-27(32-25)31-19-4-2-1-3-5-19)26(35)30-21-8-12-23(13-9-21)39(36,37)33-14-16-38-17-15-33/h8-9,12-13,18-20,22,34H,1-7,10-11,14-17H2,(H,30,35)(H2,28,29,31,32)/t20-,22-
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n/an/a 47n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444269
PNG
(CHEMBL3093629)
Show SMILES OCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(24.63,-35.11,;25.96,-34.34,;27.3,-35.11,;28.63,-34.34,;29.96,-35.12,;31.3,-34.35,;32.63,-35.12,;33.97,-34.35,;33.96,-32.8,;35.29,-32.02,;35.29,-30.48,;36.63,-32.79,;37.96,-32.01,;39.29,-32.78,;40.62,-32.01,;40.62,-30.47,;39.27,-29.7,;37.95,-30.48,;41.95,-29.68,;41.17,-28.35,;42.72,-28.34,;43.28,-30.45,;43.28,-31.99,;44.61,-32.75,;45.94,-31.98,;45.94,-30.44,;44.6,-29.67,;32.63,-32.03,;32.62,-30.49,;31.29,-29.73,;29.96,-30.5,;28.62,-29.72,;28.62,-28.18,;27.29,-27.41,;29.96,-27.41,;31.29,-28.18,;31.3,-32.8,)|
Show InChI InChI=1S/C24H34N6O6S/c31-13-1-10-25-24-26-16-21(22(29-24)27-17-2-6-19(32)7-3-17)23(33)28-18-4-8-20(9-5-18)37(34,35)30-11-14-36-15-12-30/h4-5,8-9,16-17,19,31-32H,1-3,6-7,10-15H2,(H,28,33)(H2,25,26,27,29)/t17-,19-
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n/an/a 59n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444282
PNG
(CHEMBL3093639 | US9649309, Compound UNC2086A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCNCC2)n1
Show InChI InChI=1S/C24H35N7O4S/c1-2-3-10-26-24-27-17-21(22(30-24)28-19-8-11-25-12-9-19)23(32)29-18-4-6-20(7-5-18)36(33,34)31-13-15-35-16-14-31/h4-7,17,19,25H,2-3,8-16H2,1H3,(H,29,32)(H2,26,27,28,30)
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n/an/a 62n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444258
PNG
(CHEMBL3093759)
Show SMILES CCCCNC(=O)c1cnc(NCCCC)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:19.19,wD:22.23,(18.97,-21.28,;17.63,-20.52,;16.3,-21.29,;14.97,-20.53,;13.64,-21.3,;12.3,-20.54,;12.29,-19,;10.97,-21.31,;10.97,-22.86,;9.64,-23.63,;8.3,-22.86,;6.97,-23.63,;5.63,-22.86,;4.3,-23.63,;2.97,-22.86,;1.63,-23.63,;8.3,-21.32,;9.63,-20.55,;9.63,-19.01,;8.29,-18.24,;6.96,-19.02,;5.62,-18.25,;5.62,-16.71,;4.29,-15.93,;6.96,-15.94,;8.28,-16.7,)|
Show InChI InChI=1S/C19H33N5O2/c1-3-5-11-20-18(26)16-13-22-19(21-12-6-4-2)24-17(16)23-14-7-9-15(25)10-8-14/h13-15,25H,3-12H2,1-2H3,(H,20,26)(H2,21,22,23,24)/t14-,15-
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n/an/a 67n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444270
PNG
(CHEMBL3093628)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCCCC(F)(F)F)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(4.09,-26.59,;5.43,-27.36,;5.43,-28.9,;6.76,-29.68,;8.09,-28.9,;8.09,-27.36,;6.76,-26.59,;9.43,-29.67,;9.43,-31.21,;8.1,-31.98,;8.1,-33.53,;6.76,-34.29,;5.43,-33.52,;4.1,-34.29,;2.76,-33.52,;1.43,-34.29,;.1,-33.52,;1.43,-35.83,;.09,-35.05,;9.43,-34.3,;10.77,-33.52,;10.77,-31.97,;12.1,-31.2,;12.09,-29.66,;13.43,-31.96,;14.76,-31.19,;16.1,-31.96,;17.43,-31.19,;17.42,-29.64,;16.08,-28.88,;14.75,-29.66,;18.75,-28.86,;17.97,-27.52,;19.52,-27.52,;20.09,-29.63,;20.08,-31.17,;21.41,-31.93,;22.75,-31.16,;22.74,-29.62,;21.41,-28.84,)|
Show InChI InChI=1S/C25H33F3N6O5S/c26-25(27,28)10-1-11-29-24-30-16-21(22(33-24)31-17-2-6-19(35)7-3-17)23(36)32-18-4-8-20(9-5-18)40(37,38)34-12-14-39-15-13-34/h4-5,8-9,16-17,19,35H,1-3,6-7,10-15H2,(H,32,36)(H2,29,30,31,33)/t17-,19-
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n/an/a 86n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444280
PNG
(CHEMBL3093641 | US9649309, Compound UNC2091A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CCNC2)n1 |r|
Show InChI InChI=1S/C23H33N7O4S/c1-2-3-9-25-23-26-16-20(21(29-23)27-18-8-10-24-15-18)22(31)28-17-4-6-19(7-5-17)35(32,33)30-11-13-34-14-12-30/h4-7,16,18,24H,2-3,8-15H2,1H3,(H,28,31)(H2,25,26,27,29)/t18-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444265
PNG
(CHEMBL3093633)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCc2ccc(F)cc2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(51.68,-38.67,;53.01,-39.44,;53.01,-40.98,;54.35,-41.76,;55.67,-40.99,;55.67,-39.44,;54.35,-38.68,;57.01,-41.75,;57.01,-43.29,;55.69,-44.06,;55.68,-45.61,;54.35,-46.38,;53.02,-45.61,;51.68,-46.37,;50.36,-45.59,;49.03,-46.36,;49.02,-47.9,;47.68,-48.66,;50.35,-48.67,;51.69,-47.91,;57.02,-46.38,;58.35,-45.61,;58.35,-44.06,;59.68,-43.28,;59.67,-41.74,;61.02,-44.05,;62.35,-43.27,;63.68,-44.04,;65.01,-43.27,;65,-41.73,;63.66,-40.96,;62.33,-41.74,;66.33,-40.95,;65.56,-39.61,;67.1,-39.6,;67.67,-41.71,;67.67,-43.25,;69,-44.01,;70.33,-43.24,;70.33,-41.7,;68.99,-40.93,)|
Show InChI InChI=1S/C28H33FN6O5S/c29-20-3-1-19(2-4-20)17-30-28-31-18-25(26(34-28)32-21-5-9-23(36)10-6-21)27(37)33-22-7-11-24(12-8-22)41(38,39)35-13-15-40-16-14-35/h1-4,7-8,11-12,18,21,23,36H,5-6,9-10,13-17H2,(H,33,37)(H2,30,31,32,34)/t21-,23-
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n/an/a 120n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444283
PNG
(CHEMBL3093638 | US9649309, Compound UNC2090A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC[C@@H]2CCCNC2)n1 |r|
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-11-27-25-29-18-22(23(31-25)28-17-19-5-4-10-26-16-19)24(33)30-20-6-8-21(9-7-20)37(34,35)32-12-14-36-15-13-32/h6-9,18-19,26H,2-5,10-17H2,1H3,(H,30,33)(H2,27,28,29,31)/t19-/m1/s1
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444275
PNG
(CHEMBL3093646)
Show SMILES CNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(28.37,-10.25,;29.71,-11.02,;31.04,-10.25,;32.37,-11.02,;33.71,-10.25,;33.7,-8.7,;35.04,-7.93,;35.03,-6.39,;36.37,-8.69,;37.7,-7.92,;39.03,-8.69,;40.36,-7.91,;40.36,-6.37,;39.01,-5.61,;37.69,-6.39,;41.69,-5.59,;40.91,-4.25,;42.46,-4.25,;43.02,-6.36,;43.02,-7.89,;44.35,-8.66,;45.68,-7.89,;45.68,-6.34,;44.34,-5.57,;32.37,-7.94,;32.37,-6.4,;31.03,-5.63,;29.7,-6.4,;28.37,-5.63,;28.37,-4.09,;27.03,-3.32,;29.7,-3.32,;31.03,-4.09,;31.04,-8.71,)|
Show InChI InChI=1S/C22H30N6O5S/c1-23-22-24-14-19(20(27-22)25-15-2-6-17(29)7-3-15)21(30)26-16-4-8-18(9-5-16)34(31,32)28-10-12-33-13-11-28/h4-5,8-9,14-15,17,29H,2-3,6-7,10-13H2,1H3,(H,26,30)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444278
PNG
(CHEMBL3093643 | US9649309, Compound UNC2061A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCOCC2)n1
Show InChI InChI=1S/C24H34N6O5S/c1-2-3-10-25-24-26-17-21(22(29-24)27-19-8-13-34-14-9-19)23(31)28-18-4-6-20(7-5-18)36(32,33)30-11-15-35-16-12-30/h4-7,17,19H,2-3,8-16H2,1H3,(H,28,31)(H2,25,26,27,29)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444266
PNG
(CHEMBL3093632)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NC2CCOCC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(27.5,-38.82,;28.84,-39.59,;28.84,-41.13,;30.17,-41.9,;31.5,-41.13,;31.5,-39.58,;30.17,-38.82,;32.84,-41.9,;32.84,-43.44,;31.51,-44.21,;31.51,-45.75,;30.18,-46.52,;28.84,-45.75,;28.85,-44.21,;27.53,-43.44,;26.19,-44.2,;26.18,-45.74,;27.52,-46.52,;32.84,-46.52,;34.18,-45.75,;34.18,-44.2,;35.51,-43.43,;35.5,-41.89,;36.84,-44.19,;38.17,-43.42,;39.51,-44.19,;40.84,-43.41,;40.83,-41.87,;39.49,-41.11,;38.16,-41.89,;42.16,-41.09,;41.38,-39.75,;42.93,-39.75,;43.5,-41.86,;43.5,-43.39,;44.83,-44.16,;46.16,-43.38,;46.16,-41.84,;44.82,-41.07,)|
Show InChI InChI=1S/C26H36N6O6S/c33-21-5-1-18(2-6-21)28-24-23(17-27-26(31-24)30-20-9-13-37-14-10-20)25(34)29-19-3-7-22(8-4-19)39(35,36)32-11-15-38-16-12-32/h3-4,7-8,17-18,20-21,33H,1-2,5-6,9-16H2,(H,29,34)(H2,27,28,30,31)/t18-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444254
PNG
(CHEMBL3093763)
Show SMILES CCCCNc1ncc(C(=O)NC2CCN(CC2)C(C)C)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:23.23,wD:26.27,(.87,-34.95,;2.2,-34.18,;3.54,-34.95,;4.87,-34.19,;6.21,-34.96,;7.54,-34.19,;8.87,-34.96,;10.21,-34.19,;10.21,-32.64,;11.54,-31.86,;11.53,-30.32,;12.87,-32.63,;14.2,-31.85,;15.54,-32.62,;16.86,-31.85,;16.87,-30.31,;15.53,-29.54,;14.19,-30.31,;18.2,-29.54,;19.53,-30.31,;18.2,-28,;8.87,-31.87,;8.87,-30.33,;7.53,-29.57,;6.2,-30.35,;4.86,-29.57,;4.86,-28.03,;3.52,-27.26,;6.19,-27.26,;7.52,-28.03,;7.54,-32.64,)|
Show InChI InChI=1S/C23H40N6O2/c1-4-5-12-24-23-25-15-20(21(28-23)26-17-6-8-19(30)9-7-17)22(31)27-18-10-13-29(14-11-18)16(2)3/h15-19,30H,4-14H2,1-3H3,(H,27,31)(H2,24,25,26,28)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444250
PNG
(CHEMBL3093747 | US9649309, Compound UNC2803A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)C(F)(F)F)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:24.24,wD:27.28,(1.92,-47.36,;3.25,-46.59,;4.59,-47.36,;5.92,-46.59,;7.26,-47.36,;8.59,-46.59,;9.92,-47.36,;11.26,-46.59,;11.26,-45.04,;12.59,-44.27,;12.58,-42.73,;13.92,-45.03,;15.25,-44.26,;16.59,-45.03,;17.92,-44.26,;17.91,-42.71,;16.57,-41.95,;15.24,-42.73,;19.24,-41.94,;20.58,-42.7,;19.23,-40.4,;20.57,-41.15,;9.92,-44.28,;9.92,-42.74,;8.58,-41.97,;7.25,-42.75,;5.91,-41.98,;5.91,-40.44,;4.57,-39.67,;7.24,-39.67,;8.57,-40.43,;8.59,-45.05,)|
Show InChI InChI=1S/C22H28F3N5O2/c1-2-3-12-26-21-27-13-18(19(30-21)28-15-8-10-17(31)11-9-15)20(32)29-16-6-4-14(5-7-16)22(23,24)25/h4-7,13,15,17,31H,2-3,8-12H2,1H3,(H,29,32)(H2,26,27,28,30)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444245
PNG
(CHEMBL3093752)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(CN3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(21.61,-58.16,;22.95,-57.39,;24.28,-58.16,;25.61,-57.39,;26.95,-58.16,;28.28,-57.39,;29.62,-58.16,;30.95,-57.39,;30.95,-55.84,;32.28,-55.07,;32.27,-53.53,;33.61,-55.83,;34.95,-55.06,;36.28,-55.83,;37.61,-55.06,;37.6,-53.51,;38.93,-52.74,;40.27,-53.5,;40.27,-55.03,;41.6,-55.8,;42.93,-55.03,;42.93,-53.49,;41.59,-52.71,;36.26,-52.75,;34.93,-53.53,;29.61,-55.08,;29.61,-53.54,;28.27,-52.77,;26.94,-53.55,;25.6,-52.78,;25.6,-51.24,;24.27,-50.47,;26.94,-50.47,;28.26,-51.23,;28.28,-55.85,)|
Show InChI InChI=1S/C26H38N6O3/c1-2-3-12-27-26-28-17-23(24(31-26)29-20-8-10-22(33)11-9-20)25(34)30-21-6-4-19(5-7-21)18-32-13-15-35-16-14-32/h4-7,17,20,22,33H,2-3,8-16,18H2,1H3,(H,30,34)(H2,27,28,29,31)/t20-,22-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444241
PNG
(CHEMBL3093756 | US9649309, Compound UNC2881A)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(48.43,-9.69,;49.77,-8.92,;51.1,-9.69,;52.43,-8.92,;53.77,-9.69,;55.1,-8.93,;56.43,-9.7,;57.77,-8.92,;57.77,-7.37,;59.1,-6.6,;59.09,-5.06,;60.43,-7.36,;61.76,-6.59,;63.1,-7.35,;63.1,-8.89,;64.44,-9.66,;65.77,-8.88,;65.76,-7.33,;64.42,-6.58,;67.11,-9.64,;68.5,-9.01,;69.54,-10.15,;68.78,-11.49,;67.27,-11.18,;56.43,-6.61,;56.43,-5.07,;55.09,-4.3,;53.76,-5.08,;52.42,-4.31,;52.42,-2.77,;51.09,-2,;53.75,-2,;55.08,-2.77,;55.1,-7.38,)|
Show InChI InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444242
PNG
(CHEMBL3093755)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)S(N)(=O)=O)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.25,wD:28.29,(24.27,-9.22,;25.6,-8.45,;26.93,-9.22,;28.27,-8.45,;29.6,-9.22,;30.94,-8.45,;32.27,-9.22,;33.61,-8.45,;33.6,-6.9,;34.93,-6.12,;34.93,-4.58,;36.27,-6.89,;37.6,-6.11,;38.94,-6.88,;38.94,-8.42,;40.27,-9.18,;41.6,-8.41,;41.59,-6.86,;40.26,-6.1,;42.94,-9.17,;44.27,-8.39,;43.7,-10.5,;42.17,-10.5,;32.27,-6.14,;32.26,-4.6,;30.93,-3.83,;29.59,-4.61,;28.25,-3.84,;28.25,-2.29,;26.92,-1.52,;29.59,-1.53,;30.92,-2.29,;30.94,-6.91,)|
Show InChI InChI=1S/C22H32N6O4S/c1-2-3-12-24-22-26-14-19(20(28-22)27-16-6-8-17(29)9-7-16)21(30)25-13-15-4-10-18(11-5-15)33(23,31)32/h4-5,10-11,14,16-17,29H,2-3,6-9,12-13H2,1H3,(H,25,30)(H2,23,31,32)(H2,24,26,27,28)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444242
PNG
(CHEMBL3093755)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)S(N)(=O)=O)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.25,wD:28.29,(24.27,-9.22,;25.6,-8.45,;26.93,-9.22,;28.27,-8.45,;29.6,-9.22,;30.94,-8.45,;32.27,-9.22,;33.61,-8.45,;33.6,-6.9,;34.93,-6.12,;34.93,-4.58,;36.27,-6.89,;37.6,-6.11,;38.94,-6.88,;38.94,-8.42,;40.27,-9.18,;41.6,-8.41,;41.59,-6.86,;40.26,-6.1,;42.94,-9.17,;44.27,-8.39,;43.7,-10.5,;42.17,-10.5,;32.27,-6.14,;32.26,-4.6,;30.93,-3.83,;29.59,-4.61,;28.25,-3.84,;28.25,-2.29,;26.92,-1.52,;29.59,-1.53,;30.92,-2.29,;30.94,-6.91,)|
Show InChI InChI=1S/C22H32N6O4S/c1-2-3-12-24-22-26-14-19(20(28-22)27-16-6-8-17(29)9-7-16)21(30)25-13-15-4-10-18(11-5-15)33(23,31)32/h4-5,10-11,14,16-17,29H,2-3,6-9,12-13H2,1H3,(H,25,30)(H2,23,31,32)(H2,24,26,27,28)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444271
PNG
(CHEMBL3093627)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCCC2CC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(51.32,-15.73,;52.65,-16.5,;52.65,-18.04,;53.99,-18.82,;55.31,-18.05,;55.31,-16.5,;53.98,-15.73,;56.65,-18.81,;56.65,-20.35,;55.32,-21.12,;55.32,-22.67,;53.99,-23.44,;52.65,-22.66,;51.32,-23.43,;49.99,-22.66,;49.22,-21.33,;48.45,-22.66,;56.66,-23.44,;57.99,-22.67,;57.99,-21.12,;59.32,-20.34,;59.31,-18.8,;60.65,-21.11,;61.99,-20.33,;63.32,-21.1,;64.65,-20.33,;64.64,-18.79,;63.3,-18.02,;61.97,-18.8,;65.97,-18,;65.2,-16.67,;66.74,-16.66,;67.31,-18.77,;67.31,-20.31,;68.64,-21.07,;69.97,-20.3,;69.97,-18.76,;68.63,-17.99,)|
Show InChI InChI=1S/C26H36N6O5S/c33-21-7-3-19(4-8-21)29-24-23(17-28-26(31-24)27-12-11-18-1-2-18)25(34)30-20-5-9-22(10-6-20)38(35,36)32-13-15-37-16-14-32/h5-6,9-10,17-19,21,33H,1-4,7-8,11-16H2,(H,30,34)(H2,27,28,29,31)/t19-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444241
PNG
(CHEMBL3093756 | US9649309, Compound UNC2881A)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(48.43,-9.69,;49.77,-8.92,;51.1,-9.69,;52.43,-8.92,;53.77,-9.69,;55.1,-8.93,;56.43,-9.7,;57.77,-8.92,;57.77,-7.37,;59.1,-6.6,;59.09,-5.06,;60.43,-7.36,;61.76,-6.59,;63.1,-7.35,;63.1,-8.89,;64.44,-9.66,;65.77,-8.88,;65.76,-7.33,;64.42,-6.58,;67.11,-9.64,;68.5,-9.01,;69.54,-10.15,;68.78,-11.49,;67.27,-11.18,;56.43,-6.61,;56.43,-5.07,;55.09,-4.3,;53.76,-5.08,;52.42,-4.31,;52.42,-2.77,;51.09,-2,;53.75,-2,;55.08,-2.77,;55.1,-7.38,)|
Show InChI InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444245
PNG
(CHEMBL3093752)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(CN3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(21.61,-58.16,;22.95,-57.39,;24.28,-58.16,;25.61,-57.39,;26.95,-58.16,;28.28,-57.39,;29.62,-58.16,;30.95,-57.39,;30.95,-55.84,;32.28,-55.07,;32.27,-53.53,;33.61,-55.83,;34.95,-55.06,;36.28,-55.83,;37.61,-55.06,;37.6,-53.51,;38.93,-52.74,;40.27,-53.5,;40.27,-55.03,;41.6,-55.8,;42.93,-55.03,;42.93,-53.49,;41.59,-52.71,;36.26,-52.75,;34.93,-53.53,;29.61,-55.08,;29.61,-53.54,;28.27,-52.77,;26.94,-53.55,;25.6,-52.78,;25.6,-51.24,;24.27,-50.47,;26.94,-50.47,;28.26,-51.23,;28.28,-55.85,)|
Show InChI InChI=1S/C26H38N6O3/c1-2-3-12-27-26-28-17-23(24(31-26)29-20-8-10-22(33)11-9-20)25(34)30-21-6-4-19(5-7-21)18-32-13-15-35-16-14-32/h4-7,17,20,22,33H,2-3,8-16,18H2,1H3,(H,30,34)(H2,27,28,29,31)/t20-,22-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444251
PNG
(CHEMBL3093746 | US9649309, Compound UNC2602A)
Show SMILES CCCCNc1ncc(C(=O)NC2CCCCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(54.57,-35.57,;55.9,-34.8,;57.23,-35.58,;58.57,-34.81,;59.9,-35.58,;61.23,-34.81,;62.57,-35.58,;63.91,-34.81,;63.9,-33.26,;65.23,-32.48,;65.23,-30.94,;66.57,-33.25,;67.9,-32.47,;69.23,-33.24,;70.56,-32.47,;70.56,-30.93,;69.23,-30.16,;67.89,-30.94,;62.57,-32.49,;62.56,-30.95,;61.22,-30.19,;59.89,-30.97,;58.55,-30.19,;58.55,-28.65,;57.22,-27.88,;59.89,-27.88,;61.22,-28.65,;61.24,-33.26,)|
Show InChI InChI=1S/C21H35N5O2/c1-2-3-13-22-21-23-14-18(20(28)25-15-7-5-4-6-8-15)19(26-21)24-16-9-11-17(27)12-10-16/h14-17,27H,2-13H2,1H3,(H,25,28)(H2,22,23,24,26)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444251
PNG
(CHEMBL3093746 | US9649309, Compound UNC2602A)
Show SMILES CCCCNc1ncc(C(=O)NC2CCCCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(54.57,-35.57,;55.9,-34.8,;57.23,-35.58,;58.57,-34.81,;59.9,-35.58,;61.23,-34.81,;62.57,-35.58,;63.91,-34.81,;63.9,-33.26,;65.23,-32.48,;65.23,-30.94,;66.57,-33.25,;67.9,-32.47,;69.23,-33.24,;70.56,-32.47,;70.56,-30.93,;69.23,-30.16,;67.89,-30.94,;62.57,-32.49,;62.56,-30.95,;61.22,-30.19,;59.89,-30.97,;58.55,-30.19,;58.55,-28.65,;57.22,-27.88,;59.89,-27.88,;61.22,-28.65,;61.24,-33.26,)|
Show InChI InChI=1S/C21H35N5O2/c1-2-3-13-22-21-23-14-18(20(28)25-15-7-5-4-6-8-15)19(26-21)24-16-9-11-17(27)12-10-16/h14-17,27H,2-13H2,1H3,(H,25,28)(H2,22,23,24,26)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444240
PNG
(CHEMBL3093635)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](N)CC2)n1 |r,wU:29.30,wD:32.34,(.04,-21.39,;1.37,-20.63,;2.71,-21.4,;4.04,-20.63,;5.37,-21.4,;6.71,-20.63,;8.04,-21.4,;9.38,-20.63,;9.37,-19.08,;10.7,-18.3,;10.7,-16.76,;12.04,-19.07,;13.37,-18.29,;14.71,-19.07,;16.03,-18.29,;16.03,-16.75,;14.68,-15.99,;13.36,-16.76,;17.36,-15.97,;16.58,-14.63,;18.13,-14.62,;18.7,-16.74,;18.69,-18.27,;20.02,-19.03,;21.36,-18.26,;21.35,-16.72,;20.01,-15.95,;8.04,-18.32,;8.03,-16.78,;6.7,-16.01,;5.36,-16.79,;4.03,-16.01,;4.03,-14.47,;2.69,-13.7,;5.36,-13.71,;6.69,-14.47,;6.71,-19.09,)|
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-12-27-25-28-17-22(23(31-25)29-19-6-4-18(26)5-7-19)24(33)30-20-8-10-21(11-9-20)37(34,35)32-13-15-36-16-14-32/h8-11,17-19H,2-7,12-16,26H2,1H3,(H,30,33)(H2,27,28,29,31)/t18-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444240
PNG
(CHEMBL3093635)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](N)CC2)n1 |r,wU:29.30,wD:32.34,(.04,-21.39,;1.37,-20.63,;2.71,-21.4,;4.04,-20.63,;5.37,-21.4,;6.71,-20.63,;8.04,-21.4,;9.38,-20.63,;9.37,-19.08,;10.7,-18.3,;10.7,-16.76,;12.04,-19.07,;13.37,-18.29,;14.71,-19.07,;16.03,-18.29,;16.03,-16.75,;14.68,-15.99,;13.36,-16.76,;17.36,-15.97,;16.58,-14.63,;18.13,-14.62,;18.7,-16.74,;18.69,-18.27,;20.02,-19.03,;21.36,-18.26,;21.35,-16.72,;20.01,-15.95,;8.04,-18.32,;8.03,-16.78,;6.7,-16.01,;5.36,-16.79,;4.03,-16.01,;4.03,-14.47,;2.69,-13.7,;5.36,-13.71,;6.69,-14.47,;6.71,-19.09,)|
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-12-27-25-28-17-22(23(31-25)29-19-6-4-18(26)5-7-19)24(33)30-20-8-10-21(11-9-20)37(34,35)32-13-15-36-16-14-32/h8-11,17-19H,2-7,12-16,26H2,1H3,(H,30,33)(H2,27,28,29,31)/t18-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444254
PNG
(CHEMBL3093763)
Show SMILES CCCCNc1ncc(C(=O)NC2CCN(CC2)C(C)C)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:23.23,wD:26.27,(.87,-34.95,;2.2,-34.18,;3.54,-34.95,;4.87,-34.19,;6.21,-34.96,;7.54,-34.19,;8.87,-34.96,;10.21,-34.19,;10.21,-32.64,;11.54,-31.86,;11.53,-30.32,;12.87,-32.63,;14.2,-31.85,;15.54,-32.62,;16.86,-31.85,;16.87,-30.31,;15.53,-29.54,;14.19,-30.31,;18.2,-29.54,;19.53,-30.31,;18.2,-28,;8.87,-31.87,;8.87,-30.33,;7.53,-29.57,;6.2,-30.35,;4.86,-29.57,;4.86,-28.03,;3.52,-27.26,;6.19,-27.26,;7.52,-28.03,;7.54,-32.64,)|
Show InChI InChI=1S/C23H40N6O2/c1-4-5-12-24-23-25-15-20(21(28-23)26-17-6-8-19(30)9-7-17)22(31)27-18-10-13-29(14-11-18)16(2)3/h15-19,30H,4-14H2,1-3H3,(H,27,31)(H2,24,25,26,28)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444246
PNG
(CHEMBL3093751)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(-.47,-58.49,;.87,-57.72,;2.21,-58.49,;3.54,-57.72,;4.87,-58.49,;6.21,-57.72,;7.54,-58.49,;8.88,-57.72,;8.87,-56.17,;10.21,-55.4,;10.2,-53.86,;11.54,-56.16,;12.87,-55.39,;14.21,-56.16,;15.54,-55.38,;15.53,-53.84,;14.18,-53.08,;12.86,-53.86,;16.86,-53.07,;18.19,-53.83,;19.52,-53.06,;19.52,-51.52,;18.18,-50.75,;16.84,-51.53,;7.54,-55.41,;7.53,-53.87,;6.2,-53.1,;4.86,-53.88,;3.53,-53.11,;3.53,-51.57,;2.19,-50.8,;4.86,-50.8,;6.19,-51.56,;6.21,-56.18,)|
Show InChI InChI=1S/C25H36N6O3/c1-2-3-12-26-25-27-17-22(23(30-25)28-18-6-10-21(32)11-7-18)24(33)29-19-4-8-20(9-5-19)31-13-15-34-16-14-31/h4-5,8-9,17-18,21,32H,2-3,6-7,10-16H2,1H3,(H,29,33)(H2,26,27,28,30)/t18-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444253
PNG
(CHEMBL3093648)
Show SMILES CCCCNc1ncc(C(=O)NC2CCN(CC2)c2ncccn2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(19.76,-36.09,;21.1,-35.32,;22.43,-36.09,;23.76,-35.32,;25.1,-36.09,;26.43,-35.32,;27.76,-36.09,;29.1,-35.32,;29.1,-33.77,;30.43,-33,;30.42,-31.46,;31.76,-33.76,;33.09,-32.99,;34.43,-33.76,;35.76,-32.99,;35.76,-31.45,;34.42,-30.68,;33.08,-31.45,;37.09,-30.68,;38.42,-31.45,;39.75,-30.68,;39.75,-29.14,;38.41,-28.37,;37.08,-29.14,;27.76,-33.01,;27.76,-31.47,;26.42,-30.7,;25.09,-31.48,;23.75,-30.71,;23.75,-29.16,;22.42,-28.39,;25.08,-28.4,;26.41,-29.16,;26.43,-33.78,)|
Show InChI InChI=1S/C24H36N8O2/c1-2-3-11-25-23-28-16-20(21(31-23)29-17-5-7-19(33)8-6-17)22(34)30-18-9-14-32(15-10-18)24-26-12-4-13-27-24/h4,12-13,16-19,33H,2-3,5-11,14-15H2,1H3,(H,30,34)(H2,25,28,29,31)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444256
PNG
(CHEMBL3093761)
Show SMILES CCCCNc1ncc(C(=O)NC2CCNCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(37.14,-23.53,;38.48,-22.76,;39.81,-23.53,;41.15,-22.76,;42.48,-23.53,;43.81,-22.76,;45.15,-23.53,;46.48,-22.76,;46.48,-21.21,;47.81,-20.43,;47.8,-18.9,;49.15,-21.2,;50.48,-20.42,;51.81,-21.2,;53.14,-20.43,;53.14,-18.89,;51.8,-18.12,;50.47,-18.89,;45.14,-20.45,;45.14,-18.91,;43.8,-18.14,;42.47,-18.92,;41.13,-18.15,;41.13,-16.6,;39.8,-15.83,;42.47,-15.84,;43.8,-16.6,;43.82,-21.22,)|
Show InChI InChI=1S/C20H34N6O2/c1-2-3-10-22-20-23-13-17(19(28)25-15-8-11-21-12-9-15)18(26-20)24-14-4-6-16(27)7-5-14/h13-16,21,27H,2-12H2,1H3,(H,25,28)(H2,22,23,24,26)/t14-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444244
PNG
(CHEMBL3093753)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(46.77,-58.29,;48.1,-57.52,;49.43,-58.29,;50.77,-57.52,;52.1,-58.3,;53.43,-57.53,;54.77,-58.3,;56.11,-57.53,;56.1,-55.98,;57.43,-55.2,;57.43,-53.66,;58.77,-55.97,;60.1,-55.19,;61.43,-55.96,;62.76,-55.19,;62.76,-53.65,;61.41,-52.88,;60.09,-53.66,;64.09,-52.87,;64.85,-51.53,;63.31,-51.54,;65.42,-53.63,;65.42,-55.17,;66.75,-55.93,;68.08,-55.16,;68.08,-53.62,;66.74,-52.85,;54.76,-55.21,;54.76,-53.67,;53.42,-52.91,;52.09,-53.69,;50.75,-52.91,;50.75,-51.37,;49.42,-50.6,;52.09,-50.6,;53.42,-51.37,;53.44,-55.98,)|
Show InChI InChI=1S/C25H36N6O5S/c1-2-3-12-26-25-27-17-22(23(30-25)28-18-4-8-20(32)9-5-18)24(33)29-19-6-10-21(11-7-19)37(34,35)31-13-15-36-16-14-31/h6-7,10-11,17-18,20,32H,2-5,8-9,12-16H2,1H3,(H,29,33)(H2,26,27,28,30)/t18-,20-
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n/an/a 530n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444256
PNG
(CHEMBL3093761)
Show SMILES CCCCNc1ncc(C(=O)NC2CCNCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(37.14,-23.53,;38.48,-22.76,;39.81,-23.53,;41.15,-22.76,;42.48,-23.53,;43.81,-22.76,;45.15,-23.53,;46.48,-22.76,;46.48,-21.21,;47.81,-20.43,;47.8,-18.9,;49.15,-21.2,;50.48,-20.42,;51.81,-21.2,;53.14,-20.43,;53.14,-18.89,;51.8,-18.12,;50.47,-18.89,;45.14,-20.45,;45.14,-18.91,;43.8,-18.14,;42.47,-18.92,;41.13,-18.15,;41.13,-16.6,;39.8,-15.83,;42.47,-15.84,;43.8,-16.6,;43.82,-21.22,)|
Show InChI InChI=1S/C20H34N6O2/c1-2-3-10-22-20-23-13-17(19(28)25-15-8-11-21-12-9-15)18(26-20)24-14-4-6-16(27)7-5-14/h13-16,21,27H,2-12H2,1H3,(H,25,28)(H2,22,23,24,26)/t14-,16-
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n/an/a 530n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444252
PNG
(CHEMBL3093649)
Show SMILES CCCCNc1ncc(C(=O)NC2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(39.42,-35.6,;40.75,-34.83,;42.08,-35.6,;43.42,-34.83,;44.75,-35.6,;46.08,-34.83,;47.42,-35.6,;48.76,-34.83,;48.75,-33.28,;50.08,-32.51,;50.08,-30.97,;51.42,-33.27,;52.75,-32.5,;54.08,-33.27,;55.41,-32.5,;55.41,-30.96,;54.07,-30.19,;52.74,-30.96,;47.41,-32.52,;47.41,-30.98,;46.07,-30.21,;44.74,-30.99,;43.4,-30.22,;43.4,-28.67,;42.07,-27.9,;44.74,-27.91,;46.07,-28.67,;46.09,-33.29,)|
Show InChI InChI=1S/C20H33N5O3/c1-2-3-10-21-20-22-13-17(19(27)24-15-8-11-28-12-9-15)18(25-20)23-14-4-6-16(26)7-5-14/h13-16,26H,2-12H2,1H3,(H,24,27)(H2,21,22,23,25)/t14-,16-
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n/an/a 540n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444253
PNG
(CHEMBL3093648)
Show SMILES CCCCNc1ncc(C(=O)NC2CCN(CC2)c2ncccn2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(19.76,-36.09,;21.1,-35.32,;22.43,-36.09,;23.76,-35.32,;25.1,-36.09,;26.43,-35.32,;27.76,-36.09,;29.1,-35.32,;29.1,-33.77,;30.43,-33,;30.42,-31.46,;31.76,-33.76,;33.09,-32.99,;34.43,-33.76,;35.76,-32.99,;35.76,-31.45,;34.42,-30.68,;33.08,-31.45,;37.09,-30.68,;38.42,-31.45,;39.75,-30.68,;39.75,-29.14,;38.41,-28.37,;37.08,-29.14,;27.76,-33.01,;27.76,-31.47,;26.42,-30.7,;25.09,-31.48,;23.75,-30.71,;23.75,-29.16,;22.42,-28.39,;25.08,-28.4,;26.41,-29.16,;26.43,-33.78,)|
Show InChI InChI=1S/C24H36N8O2/c1-2-3-11-25-23-28-16-20(21(31-23)29-17-5-7-19(33)8-6-17)22(34)30-18-9-14-32(15-10-18)24-26-12-4-13-27-24/h4,12-13,16-19,33H,2-3,5-11,14-15H2,1H3,(H,30,34)(H2,25,28,29,31)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444243
PNG
(CHEMBL3093754)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(1.93,-9.16,;3.26,-8.39,;4.6,-9.16,;5.93,-8.39,;7.26,-9.17,;8.6,-8.4,;9.93,-9.17,;11.27,-8.4,;11.26,-6.85,;12.59,-6.07,;12.59,-4.53,;13.93,-6.84,;15.26,-6.06,;16.6,-6.83,;16.6,-8.36,;17.93,-9.13,;19.27,-8.35,;20.6,-9.12,;19.26,-6.8,;17.92,-6.05,;9.93,-6.08,;9.92,-4.54,;8.59,-3.78,;7.25,-4.56,;5.92,-3.78,;5.92,-2.24,;4.58,-1.47,;7.25,-1.47,;8.58,-2.24,;8.6,-6.85,)|
Show InChI InChI=1S/C22H30FN5O2/c1-2-3-12-24-22-26-14-19(20(28-22)27-17-8-10-18(29)11-9-17)21(30)25-13-15-4-6-16(23)7-5-15/h4-7,14,17-18,29H,2-3,8-13H2,1H3,(H,25,30)(H2,24,26,27,28)/t17-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444246
PNG
(CHEMBL3093751)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(-.47,-58.49,;.87,-57.72,;2.21,-58.49,;3.54,-57.72,;4.87,-58.49,;6.21,-57.72,;7.54,-58.49,;8.88,-57.72,;8.87,-56.17,;10.21,-55.4,;10.2,-53.86,;11.54,-56.16,;12.87,-55.39,;14.21,-56.16,;15.54,-55.38,;15.53,-53.84,;14.18,-53.08,;12.86,-53.86,;16.86,-53.07,;18.19,-53.83,;19.52,-53.06,;19.52,-51.52,;18.18,-50.75,;16.84,-51.53,;7.54,-55.41,;7.53,-53.87,;6.2,-53.1,;4.86,-53.88,;3.53,-53.11,;3.53,-51.57,;2.19,-50.8,;4.86,-50.8,;6.19,-51.56,;6.21,-56.18,)|
Show InChI InChI=1S/C25H36N6O3/c1-2-3-12-26-25-27-17-22(23(30-25)28-18-6-10-21(32)11-7-18)24(33)29-19-4-8-20(9-5-19)31-13-15-34-16-14-31/h4-5,8-9,17-18,21,32H,2-3,6-7,10-16H2,1H3,(H,29,33)(H2,26,27,28,30)/t18-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444252
PNG
(CHEMBL3093649)
Show SMILES CCCCNc1ncc(C(=O)NC2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(39.42,-35.6,;40.75,-34.83,;42.08,-35.6,;43.42,-34.83,;44.75,-35.6,;46.08,-34.83,;47.42,-35.6,;48.76,-34.83,;48.75,-33.28,;50.08,-32.51,;50.08,-30.97,;51.42,-33.27,;52.75,-32.5,;54.08,-33.27,;55.41,-32.5,;55.41,-30.96,;54.07,-30.19,;52.74,-30.96,;47.41,-32.52,;47.41,-30.98,;46.07,-30.21,;44.74,-30.99,;43.4,-30.22,;43.4,-28.67,;42.07,-27.9,;44.74,-27.91,;46.07,-28.67,;46.09,-33.29,)|
Show InChI InChI=1S/C20H33N5O3/c1-2-3-10-21-20-22-13-17(19(27)24-15-8-11-28-12-9-15)18(25-20)23-14-4-6-16(26)7-5-14/h13-16,26H,2-12H2,1H3,(H,24,27)(H2,21,22,23,25)/t14-,16-
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n/an/a 580n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444285
PNG
(CHEMBL3093636 | US9649309, Compound UNC2082A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCCCC2)n1
Show InChI InChI=1S/C25H36N6O4S/c1-2-3-13-26-25-27-18-22(23(30-25)28-19-7-5-4-6-8-19)24(32)29-20-9-11-21(12-10-20)36(33,34)31-14-16-35-17-15-31/h9-12,18-19H,2-8,13-17H2,1H3,(H,29,32)(H2,26,27,28,30)
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n/an/a 590n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444273
PNG
(CHEMBL3093625)
Show SMILES CCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(2.34,-21.85,;3.67,-22.62,;5,-21.85,;6.34,-22.62,;7.67,-21.85,;9.01,-22.62,;10.34,-21.85,;10.34,-20.3,;11.67,-19.52,;11.66,-17.98,;13,-20.29,;14.34,-19.51,;15.67,-20.29,;17,-19.51,;16.99,-17.97,;15.65,-17.21,;14.32,-17.98,;18.32,-17.19,;17.55,-15.85,;19.09,-15.85,;19.66,-17.96,;19.66,-19.49,;20.99,-20.25,;22.32,-19.48,;22.32,-17.94,;20.98,-17.17,;9,-19.54,;9,-18,;7.66,-17.23,;6.34,-18,;5,-17.23,;5,-15.69,;3.67,-14.91,;6.33,-14.92,;7.66,-15.68,;7.67,-20.31,)|
Show InChI InChI=1S/C24H34N6O5S/c1-2-11-25-24-26-16-21(22(29-24)27-17-3-7-19(31)8-4-17)23(32)28-18-5-9-20(10-6-18)36(33,34)30-12-14-35-15-13-30/h5-6,9-10,16-17,19,31H,2-4,7-8,11-15H2,1H3,(H,28,32)(H2,25,26,27,29)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444279
PNG
(CHEMBL3093642)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H31N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-9,11-12,18H,2-3,10,13-17H2,1H3,(H,30,33)(H2,27,28,29,31)
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n/an/a 620n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444284
PNG
(CHEMBL3093637 | US9649309, Compound UNC2084A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NCC2CCNCC2)n1
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-7,18-19,26H,2-3,8-17H2,1H3,(H,30,33)(H2,27,28,29,31)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444249
PNG
(CHEMBL3093748 | US9649309, Compound UNC2776A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(OC)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(20.21,-47.13,;21.55,-46.36,;22.88,-47.13,;24.21,-46.36,;25.55,-47.13,;26.88,-46.37,;28.22,-47.14,;29.55,-46.36,;29.55,-44.81,;30.88,-44.04,;30.87,-42.5,;32.22,-44.8,;33.55,-44.03,;34.88,-44.8,;36.21,-44.03,;36.2,-42.49,;37.53,-41.71,;38.87,-42.47,;34.86,-41.72,;33.53,-42.5,;28.21,-44.05,;28.21,-42.51,;26.87,-41.74,;25.54,-42.52,;24.2,-41.75,;24.2,-40.21,;22.87,-39.44,;25.54,-39.44,;26.86,-40.21,;26.88,-44.82,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-13-23-22-24-14-19(20(27-22)25-15-5-9-17(28)10-6-15)21(29)26-16-7-11-18(30-2)12-8-16/h7-8,11-12,14-15,17,28H,3-6,9-10,13H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444244
PNG
(CHEMBL3093753)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(46.77,-58.29,;48.1,-57.52,;49.43,-58.29,;50.77,-57.52,;52.1,-58.3,;53.43,-57.53,;54.77,-58.3,;56.11,-57.53,;56.1,-55.98,;57.43,-55.2,;57.43,-53.66,;58.77,-55.97,;60.1,-55.19,;61.43,-55.96,;62.76,-55.19,;62.76,-53.65,;61.41,-52.88,;60.09,-53.66,;64.09,-52.87,;64.85,-51.53,;63.31,-51.54,;65.42,-53.63,;65.42,-55.17,;66.75,-55.93,;68.08,-55.16,;68.08,-53.62,;66.74,-52.85,;54.76,-55.21,;54.76,-53.67,;53.42,-52.91,;52.09,-53.69,;50.75,-52.91,;50.75,-51.37,;49.42,-50.6,;52.09,-50.6,;53.42,-51.37,;53.44,-55.98,)|
Show InChI InChI=1S/C25H36N6O5S/c1-2-3-12-26-25-27-17-22(23(30-25)28-18-4-8-20(32)9-5-18)24(33)29-19-6-10-21(11-7-19)37(34,35)31-13-15-36-16-14-31/h6-7,10-11,17-18,20,32H,2-5,8-9,12-16H2,1H3,(H,29,33)(H2,26,27,28,30)/t18-,20-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444274
PNG
(CHEMBL3093647)
Show SMILES CCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(50.31,-10.83,;51.65,-10.06,;52.98,-10.83,;54.31,-10.06,;55.65,-10.83,;56.98,-10.06,;56.98,-8.51,;58.31,-7.73,;58.3,-6.19,;59.65,-8.5,;60.98,-7.72,;62.31,-8.5,;63.64,-7.72,;63.64,-6.18,;62.29,-5.42,;60.97,-6.19,;64.96,-5.4,;64.19,-4.06,;65.73,-4.06,;66.3,-6.17,;66.3,-7.7,;67.63,-8.46,;68.96,-7.69,;68.96,-6.15,;67.62,-5.38,;55.64,-7.75,;55.64,-6.21,;54.3,-5.44,;52.98,-6.21,;51.64,-5.44,;51.64,-3.89,;50.31,-3.12,;52.98,-3.13,;54.3,-3.89,;54.31,-8.52,)|
Show InChI InChI=1S/C23H32N6O5S/c1-2-24-23-25-15-20(21(28-23)26-16-3-7-18(30)8-4-16)22(31)27-17-5-9-19(10-6-17)35(32,33)29-11-13-34-14-12-29/h5-6,9-10,15-16,18,30H,2-4,7-8,11-14H2,1H3,(H,27,31)(H2,24,25,26,28)/t16-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444243
PNG
(CHEMBL3093754)
Show SMILES CCCCNc1ncc(C(=O)NCc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(1.93,-9.16,;3.26,-8.39,;4.6,-9.16,;5.93,-8.39,;7.26,-9.17,;8.6,-8.4,;9.93,-9.17,;11.27,-8.4,;11.26,-6.85,;12.59,-6.07,;12.59,-4.53,;13.93,-6.84,;15.26,-6.06,;16.6,-6.83,;16.6,-8.36,;17.93,-9.13,;19.27,-8.35,;20.6,-9.12,;19.26,-6.8,;17.92,-6.05,;9.93,-6.08,;9.92,-4.54,;8.59,-3.78,;7.25,-4.56,;5.92,-3.78,;5.92,-2.24,;4.58,-1.47,;7.25,-1.47,;8.58,-2.24,;8.6,-6.85,)|
Show InChI InChI=1S/C22H30FN5O2/c1-2-3-12-24-22-26-14-19(20(28-22)27-17-8-10-18(29)11-9-17)21(30)25-13-15-4-6-16(23)7-5-15/h4-7,14,17-18,29H,2-3,8-13H2,1H3,(H,25,30)(H2,24,26,27,28)/t17-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444248
PNG
(CHEMBL3093749)
Show SMILES CCCCNc1ncc(C(=O)Nc2cccc(OC)c2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(37.13,-46.79,;38.46,-46.02,;39.8,-46.79,;41.13,-46.02,;42.46,-46.79,;43.8,-46.02,;45.13,-46.79,;46.47,-46.02,;46.46,-44.47,;47.79,-43.7,;47.79,-42.16,;49.13,-44.46,;50.46,-43.69,;50.45,-42.16,;51.77,-41.38,;53.12,-42.14,;53.12,-43.68,;54.46,-44.45,;55.79,-43.68,;51.79,-44.46,;45.13,-43.71,;45.12,-42.17,;43.79,-41.4,;42.45,-42.18,;41.12,-41.41,;41.12,-39.87,;39.78,-39.1,;42.45,-39.1,;43.78,-39.86,;43.8,-44.48,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-12-23-22-24-14-19(20(27-22)25-15-8-10-17(28)11-9-15)21(29)26-16-6-5-7-18(13-16)30-2/h5-7,13-15,17,28H,3-4,8-12H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444249
PNG
(CHEMBL3093748 | US9649309, Compound UNC2776A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(OC)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(20.21,-47.13,;21.55,-46.36,;22.88,-47.13,;24.21,-46.36,;25.55,-47.13,;26.88,-46.37,;28.22,-47.14,;29.55,-46.36,;29.55,-44.81,;30.88,-44.04,;30.87,-42.5,;32.22,-44.8,;33.55,-44.03,;34.88,-44.8,;36.21,-44.03,;36.2,-42.49,;37.53,-41.71,;38.87,-42.47,;34.86,-41.72,;33.53,-42.5,;28.21,-44.05,;28.21,-42.51,;26.87,-41.74,;25.54,-42.52,;24.2,-41.75,;24.2,-40.21,;22.87,-39.44,;25.54,-39.44,;26.86,-40.21,;26.88,-44.82,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-13-23-22-24-14-19(20(27-22)25-15-5-9-17(28)10-6-15)21(29)26-16-7-11-18(30-2)12-8-16/h7-8,11-12,14-15,17,28H,3-6,9-10,13H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444262
PNG
(CHEMBL3093764)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(.7,-12.07,;2.03,-11.3,;3.37,-12.07,;4.7,-11.3,;6.03,-12.07,;7.37,-11.31,;8.7,-12.08,;10.04,-11.3,;10.03,-9.75,;11.37,-8.98,;11.36,-7.44,;12.7,-9.74,;14.03,-8.97,;15.37,-9.74,;16.7,-8.97,;16.69,-7.43,;18.02,-6.65,;15.35,-6.66,;14.02,-7.44,;8.7,-8.99,;8.69,-7.45,;7.36,-6.68,;7.35,-5.14,;6.02,-4.38,;6.02,-2.83,;7.36,-2.06,;7.36,-.52,;8.69,-2.83,;8.69,-4.37,;7.37,-9.76,)|
Show InChI InChI=1S/C22H31FN6O/c1-2-3-12-25-22-27-14-19(21(30)28-18-10-6-16(23)7-11-18)20(29-22)26-13-15-4-8-17(24)9-5-15/h6-7,10-11,14-15,17H,2-5,8-9,12-13,24H2,1H3,(H,28,30)(H2,25,26,27,29)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444271
PNG
(CHEMBL3093627)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCCC2CC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(51.32,-15.73,;52.65,-16.5,;52.65,-18.04,;53.99,-18.82,;55.31,-18.05,;55.31,-16.5,;53.98,-15.73,;56.65,-18.81,;56.65,-20.35,;55.32,-21.12,;55.32,-22.67,;53.99,-23.44,;52.65,-22.66,;51.32,-23.43,;49.99,-22.66,;49.22,-21.33,;48.45,-22.66,;56.66,-23.44,;57.99,-22.67,;57.99,-21.12,;59.32,-20.34,;59.31,-18.8,;60.65,-21.11,;61.99,-20.33,;63.32,-21.1,;64.65,-20.33,;64.64,-18.79,;63.3,-18.02,;61.97,-18.8,;65.97,-18,;65.2,-16.67,;66.74,-16.66,;67.31,-18.77,;67.31,-20.31,;68.64,-21.07,;69.97,-20.3,;69.97,-18.76,;68.63,-17.99,)|
Show InChI InChI=1S/C26H36N6O5S/c33-21-7-3-19(4-8-21)29-24-23(17-28-26(31-24)27-12-11-18-1-2-18)25(34)30-20-5-9-22(10-6-20)38(35,36)32-13-15-37-16-14-32/h5-6,9-10,17-19,21,33H,1-4,7-8,11-16H2,(H,30,34)(H2,27,28,29,31)/t19-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444281
PNG
(CHEMBL3093640 | US9649309, Compound UNC2089A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@@H]2CCNC2)n1 |r|
Show InChI InChI=1S/C23H33N7O4S/c1-2-3-9-25-23-26-16-20(21(29-23)27-18-8-10-24-15-18)22(31)28-17-4-6-19(7-5-17)35(32,33)30-11-13-34-14-12-30/h4-7,16,18,24H,2-3,8-15H2,1H3,(H,28,31)(H2,25,26,27,29)/t18-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444272
PNG
(CHEMBL3093626)
Show SMILES CCCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:30.31,wD:33.35,(23.85,-22.37,;25.18,-23.14,;26.52,-22.37,;27.85,-23.14,;29.18,-22.37,;30.52,-23.14,;31.85,-22.37,;33.19,-23.14,;34.52,-22.37,;34.52,-20.82,;35.85,-20.05,;35.84,-18.51,;37.18,-20.81,;38.52,-20.04,;39.85,-20.81,;41.18,-20.03,;41.17,-18.49,;39.83,-17.73,;38.5,-18.51,;42.5,-17.71,;41.73,-16.37,;43.27,-16.37,;43.84,-18.48,;43.84,-20.01,;45.17,-20.78,;46.5,-20.01,;46.5,-18.46,;45.16,-17.69,;33.18,-20.06,;33.18,-18.52,;31.84,-17.75,;30.52,-18.52,;29.18,-17.75,;29.18,-16.21,;27.84,-15.44,;30.51,-15.44,;31.84,-16.2,;31.85,-20.83,)|
Show InChI InChI=1S/C26H38N6O5S/c1-2-3-4-13-27-26-28-18-23(24(31-26)29-19-5-9-21(33)10-6-19)25(34)30-20-7-11-22(12-8-20)38(35,36)32-14-16-37-17-15-32/h7-8,11-12,18-19,21,33H,2-6,9-10,13-17H2,1H3,(H,30,34)(H2,27,28,29,31)/t19-,21-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444275
PNG
(CHEMBL3093646)
Show SMILES CNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(28.37,-10.25,;29.71,-11.02,;31.04,-10.25,;32.37,-11.02,;33.71,-10.25,;33.7,-8.7,;35.04,-7.93,;35.03,-6.39,;36.37,-8.69,;37.7,-7.92,;39.03,-8.69,;40.36,-7.91,;40.36,-6.37,;39.01,-5.61,;37.69,-6.39,;41.69,-5.59,;40.91,-4.25,;42.46,-4.25,;43.02,-6.36,;43.02,-7.89,;44.35,-8.66,;45.68,-7.89,;45.68,-6.34,;44.34,-5.57,;32.37,-7.94,;32.37,-6.4,;31.03,-5.63,;29.7,-6.4,;28.37,-5.63,;28.37,-4.09,;27.03,-3.32,;29.7,-3.32,;31.03,-4.09,;31.04,-8.71,)|
Show InChI InChI=1S/C22H30N6O5S/c1-23-22-24-14-19(20(27-22)25-15-2-6-17(29)7-3-15)21(30)26-16-4-8-18(9-5-16)34(31,32)28-10-12-33-13-11-28/h4-5,8-9,14-15,17,29H,2-3,6-7,10-13H2,1H3,(H,26,30)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444273
PNG
(CHEMBL3093625)
Show SMILES CCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(2.34,-21.85,;3.67,-22.62,;5,-21.85,;6.34,-22.62,;7.67,-21.85,;9.01,-22.62,;10.34,-21.85,;10.34,-20.3,;11.67,-19.52,;11.66,-17.98,;13,-20.29,;14.34,-19.51,;15.67,-20.29,;17,-19.51,;16.99,-17.97,;15.65,-17.21,;14.32,-17.98,;18.32,-17.19,;17.55,-15.85,;19.09,-15.85,;19.66,-17.96,;19.66,-19.49,;20.99,-20.25,;22.32,-19.48,;22.32,-17.94,;20.98,-17.17,;9,-19.54,;9,-18,;7.66,-17.23,;6.34,-18,;5,-17.23,;5,-15.69,;3.67,-14.91,;6.33,-14.92,;7.66,-15.68,;7.67,-20.31,)|
Show InChI InChI=1S/C24H34N6O5S/c1-2-11-25-24-26-16-21(22(29-24)27-17-3-7-19(31)8-4-17)23(32)28-18-5-9-20(10-6-18)36(33,34)30-12-14-35-15-13-30/h5-6,9-10,16-17,19,31H,2-4,7-8,11-15H2,1H3,(H,28,32)(H2,25,26,27,29)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444247
PNG
(CHEMBL3093750 | US9649309, Compound UNC2775A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccccc2OC)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(54.22,-47.24,;55.55,-46.47,;56.88,-47.24,;58.22,-46.47,;59.55,-47.24,;60.88,-46.47,;62.22,-47.25,;63.56,-46.47,;63.55,-44.92,;64.88,-44.15,;64.88,-42.61,;66.22,-44.91,;67.55,-44.14,;67.54,-42.61,;68.86,-41.83,;70.21,-42.59,;70.21,-44.14,;68.88,-44.91,;68.88,-46.45,;70.22,-47.22,;62.22,-44.16,;62.21,-42.62,;60.87,-41.85,;59.54,-42.63,;58.2,-41.86,;58.2,-40.32,;56.87,-39.55,;59.54,-39.55,;60.87,-40.32,;60.89,-44.93,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-13-23-22-24-14-17(20(27-22)25-15-9-11-16(28)12-10-15)21(29)26-18-7-5-6-8-19(18)30-2/h5-8,14-16,28H,3-4,9-13H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444283
PNG
(CHEMBL3093638 | US9649309, Compound UNC2090A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC[C@@H]2CCCNC2)n1 |r|
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-11-27-25-29-18-22(23(31-25)28-17-19-5-4-10-26-16-19)24(33)30-20-6-8-21(9-7-20)37(34,35)32-12-14-36-15-13-32/h6-9,18-19,26H,2-5,10-17H2,1H3,(H,30,33)(H2,27,28,29,31)/t19-/m1/s1
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444268
PNG
(CHEMBL3093630)
Show SMILES CC(C)Nc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(51.96,-34.69,;53.29,-33.92,;53.29,-32.38,;54.62,-34.69,;55.96,-33.92,;57.29,-34.69,;58.63,-33.92,;58.62,-32.37,;59.95,-31.59,;59.95,-30.05,;61.29,-32.36,;62.62,-31.58,;63.95,-32.35,;65.28,-31.58,;65.28,-30.04,;63.93,-29.28,;62.61,-30.05,;66.61,-29.26,;65.83,-27.92,;67.38,-27.91,;67.95,-30.03,;67.94,-31.56,;69.27,-32.32,;70.61,-31.55,;70.6,-30.01,;69.26,-29.24,;57.29,-31.6,;57.28,-30.07,;55.95,-29.3,;54.62,-30.07,;53.29,-29.3,;53.28,-27.75,;51.95,-26.98,;54.62,-26.99,;55.95,-27.75,;55.96,-32.38,)|
Show InChI InChI=1S/C24H34N6O5S/c1-16(2)26-24-25-15-21(22(29-24)27-17-3-7-19(31)8-4-17)23(32)28-18-5-9-20(10-6-18)36(33,34)30-11-13-35-14-12-30/h5-6,9-10,15-17,19,31H,3-4,7-8,11-14H2,1-2H3,(H,28,32)(H2,25,26,27,29)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444248
PNG
(CHEMBL3093749)
Show SMILES CCCCNc1ncc(C(=O)Nc2cccc(OC)c2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(37.13,-46.79,;38.46,-46.02,;39.8,-46.79,;41.13,-46.02,;42.46,-46.79,;43.8,-46.02,;45.13,-46.79,;46.47,-46.02,;46.46,-44.47,;47.79,-43.7,;47.79,-42.16,;49.13,-44.46,;50.46,-43.69,;50.45,-42.16,;51.77,-41.38,;53.12,-42.14,;53.12,-43.68,;54.46,-44.45,;55.79,-43.68,;51.79,-44.46,;45.13,-43.71,;45.12,-42.17,;43.79,-41.4,;42.45,-42.18,;41.12,-41.41,;41.12,-39.87,;39.78,-39.1,;42.45,-39.1,;43.78,-39.86,;43.8,-44.48,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-12-23-22-24-14-19(20(27-22)25-15-8-10-17(28)11-9-15)21(29)26-16-6-5-7-18(13-16)30-2/h5-7,13-15,17,28H,3-4,8-12H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444260
PNG
(CHEMBL3093757)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:21.21,wD:24.25,(35.28,-9.93,;36.61,-9.16,;37.95,-9.93,;39.28,-9.16,;40.61,-9.93,;41.95,-9.17,;43.28,-9.94,;44.62,-9.17,;44.61,-7.61,;45.94,-6.84,;45.94,-5.3,;47.28,-7.6,;48.61,-6.83,;49.94,-7.6,;51.27,-6.83,;51.27,-5.29,;52.6,-4.51,;49.92,-4.52,;48.6,-5.3,;43.28,-6.85,;43.27,-5.31,;41.94,-4.55,;40.6,-5.33,;39.27,-4.55,;39.26,-3.01,;37.93,-2.24,;40.6,-2.24,;41.93,-3.01,;41.95,-7.62,)|
Show InChI InChI=1S/C21H28FN5O2/c1-2-3-12-23-21-24-13-18(20(29)26-16-6-4-14(22)5-7-16)19(27-21)25-15-8-10-17(28)11-9-15/h4-7,13,15,17,28H,2-3,8-12H2,1H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444268
PNG
(CHEMBL3093630)
Show SMILES CC(C)Nc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(51.96,-34.69,;53.29,-33.92,;53.29,-32.38,;54.62,-34.69,;55.96,-33.92,;57.29,-34.69,;58.63,-33.92,;58.62,-32.37,;59.95,-31.59,;59.95,-30.05,;61.29,-32.36,;62.62,-31.58,;63.95,-32.35,;65.28,-31.58,;65.28,-30.04,;63.93,-29.28,;62.61,-30.05,;66.61,-29.26,;65.83,-27.92,;67.38,-27.91,;67.95,-30.03,;67.94,-31.56,;69.27,-32.32,;70.61,-31.55,;70.6,-30.01,;69.26,-29.24,;57.29,-31.6,;57.28,-30.07,;55.95,-29.3,;54.62,-30.07,;53.29,-29.3,;53.28,-27.75,;51.95,-26.98,;54.62,-26.99,;55.95,-27.75,;55.96,-32.38,)|
Show InChI InChI=1S/C24H34N6O5S/c1-16(2)26-24-25-15-21(22(29-24)27-17-3-7-19(31)8-4-17)23(32)28-18-5-9-20(10-6-18)36(33,34)30-11-13-35-14-12-30/h5-6,9-10,15-17,19,31H,3-4,7-8,11-14H2,1-2H3,(H,28,32)(H2,25,26,27,29)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444280
PNG
(CHEMBL3093641 | US9649309, Compound UNC2091A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CCNC2)n1 |r|
Show InChI InChI=1S/C23H33N7O4S/c1-2-3-9-25-23-26-16-20(21(29-23)27-18-8-10-24-15-18)22(31)28-17-4-6-19(7-5-17)35(32,33)30-11-13-34-14-12-30/h4-7,16,18,24H,2-3,8-15H2,1H3,(H,28,31)(H2,25,26,27,29)/t18-/m0/s1
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444282
PNG
(CHEMBL3093639 | US9649309, Compound UNC2086A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCNCC2)n1
Show InChI InChI=1S/C24H35N7O4S/c1-2-3-10-26-24-27-17-21(22(30-24)28-19-8-11-25-12-9-19)23(32)29-18-4-6-20(7-5-18)36(33,34)31-13-15-35-16-14-31/h4-7,17,19,25H,2-3,8-16H2,1H3,(H,29,32)(H2,26,27,28,30)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444262
PNG
(CHEMBL3093764)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(.7,-12.07,;2.03,-11.3,;3.37,-12.07,;4.7,-11.3,;6.03,-12.07,;7.37,-11.31,;8.7,-12.08,;10.04,-11.3,;10.03,-9.75,;11.37,-8.98,;11.36,-7.44,;12.7,-9.74,;14.03,-8.97,;15.37,-9.74,;16.7,-8.97,;16.69,-7.43,;18.02,-6.65,;15.35,-6.66,;14.02,-7.44,;8.7,-8.99,;8.69,-7.45,;7.36,-6.68,;7.35,-5.14,;6.02,-4.38,;6.02,-2.83,;7.36,-2.06,;7.36,-.52,;8.69,-2.83,;8.69,-4.37,;7.37,-9.76,)|
Show InChI InChI=1S/C22H31FN6O/c1-2-3-12-25-22-27-14-19(21(30)28-18-10-6-16(23)7-11-18)20(29-22)26-13-15-4-8-17(24)9-5-15/h6-7,10-11,14-15,17H,2-5,8-9,12-13,24H2,1H3,(H,28,30)(H2,25,26,27,29)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444260
PNG
(CHEMBL3093757)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:21.21,wD:24.25,(35.28,-9.93,;36.61,-9.16,;37.95,-9.93,;39.28,-9.16,;40.61,-9.93,;41.95,-9.17,;43.28,-9.94,;44.62,-9.17,;44.61,-7.61,;45.94,-6.84,;45.94,-5.3,;47.28,-7.6,;48.61,-6.83,;49.94,-7.6,;51.27,-6.83,;51.27,-5.29,;52.6,-4.51,;49.92,-4.52,;48.6,-5.3,;43.28,-6.85,;43.27,-5.31,;41.94,-4.55,;40.6,-5.33,;39.27,-4.55,;39.26,-3.01,;37.93,-2.24,;40.6,-2.24,;41.93,-3.01,;41.95,-7.62,)|
Show InChI InChI=1S/C21H28FN5O2/c1-2-3-12-23-21-24-13-18(20(29)26-16-6-4-14(22)5-7-16)19(27-21)25-15-8-10-17(28)11-9-15/h4-7,13,15,17,28H,2-3,8-12H2,1H3,(H,26,29)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444266
PNG
(CHEMBL3093632)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NC2CCOCC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(27.5,-38.82,;28.84,-39.59,;28.84,-41.13,;30.17,-41.9,;31.5,-41.13,;31.5,-39.58,;30.17,-38.82,;32.84,-41.9,;32.84,-43.44,;31.51,-44.21,;31.51,-45.75,;30.18,-46.52,;28.84,-45.75,;28.85,-44.21,;27.53,-43.44,;26.19,-44.2,;26.18,-45.74,;27.52,-46.52,;32.84,-46.52,;34.18,-45.75,;34.18,-44.2,;35.51,-43.43,;35.5,-41.89,;36.84,-44.19,;38.17,-43.42,;39.51,-44.19,;40.84,-43.41,;40.83,-41.87,;39.49,-41.11,;38.16,-41.89,;42.16,-41.09,;41.38,-39.75,;42.93,-39.75,;43.5,-41.86,;43.5,-43.39,;44.83,-44.16,;46.16,-43.38,;46.16,-41.84,;44.82,-41.07,)|
Show InChI InChI=1S/C26H36N6O6S/c33-21-5-1-18(2-6-21)28-24-23(17-27-26(31-24)30-20-9-13-37-14-10-20)25(34)29-19-3-7-22(8-4-19)39(35,36)32-11-15-38-16-12-32/h3-4,7-8,17-18,20-21,33H,1-2,5-6,9-16H2,(H,29,34)(H2,27,28,30,31)/t18-,21-
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n/an/a 2.30E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444276
PNG
(CHEMBL3093645)
Show SMILES Nc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.26,wD:28.30,(5.87,-10.2,;7.2,-9.43,;8.54,-10.21,;9.87,-9.43,;9.87,-7.88,;11.2,-7.11,;11.19,-5.57,;12.53,-7.87,;13.86,-7.1,;15.2,-7.87,;16.53,-7.1,;16.52,-5.56,;15.18,-4.79,;13.85,-5.57,;17.85,-4.77,;17.07,-3.44,;18.62,-3.43,;19.19,-5.54,;19.18,-7.08,;20.51,-7.84,;21.85,-7.07,;21.84,-5.53,;20.5,-4.76,;8.53,-7.12,;8.53,-5.58,;7.19,-4.82,;5.87,-5.59,;4.53,-4.81,;4.53,-3.27,;3.2,-2.5,;5.87,-2.5,;7.19,-3.27,;7.2,-7.89,)|
Show InChI InChI=1S/C21H28N6O5S/c22-21-23-13-18(19(26-21)24-14-1-5-16(28)6-2-14)20(29)25-15-3-7-17(8-4-15)33(30,31)27-9-11-32-12-10-27/h3-4,7-8,13-14,16,28H,1-2,5-6,9-12H2,(H,25,29)(H3,22,23,24,26)/t14-,16-
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n/an/a 2.40E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444255
PNG
(CHEMBL3093762)
Show SMILES CCCCNc1ncc(C(=O)N2CCC(N)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(54.73,-23.53,;56.06,-22.76,;57.39,-23.53,;58.73,-22.76,;60.06,-23.53,;61.4,-22.76,;62.73,-23.53,;64.07,-22.76,;64.06,-21.21,;65.39,-20.43,;65.39,-18.89,;66.73,-21.2,;66.73,-22.73,;68.06,-23.5,;69.39,-22.73,;70.73,-23.5,;69.39,-21.19,;68.05,-20.42,;62.73,-20.45,;62.72,-18.91,;61.39,-18.14,;60.05,-18.92,;58.72,-18.15,;58.71,-16.6,;57.38,-15.83,;60.05,-15.84,;61.38,-16.6,;61.4,-21.22,)|
Show InChI InChI=1S/C20H34N6O2/c1-2-3-10-22-20-23-13-17(19(28)26-11-8-14(21)9-12-26)18(25-20)24-15-4-6-16(27)7-5-15/h13-16,27H,2-12,21H2,1H3,(H2,22,23,24,25)/t15-,16-
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n/an/a 2.50E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444258
PNG
(CHEMBL3093759)
Show SMILES CCCCNC(=O)c1cnc(NCCCC)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:19.19,wD:22.23,(18.97,-21.28,;17.63,-20.52,;16.3,-21.29,;14.97,-20.53,;13.64,-21.3,;12.3,-20.54,;12.29,-19,;10.97,-21.31,;10.97,-22.86,;9.64,-23.63,;8.3,-22.86,;6.97,-23.63,;5.63,-22.86,;4.3,-23.63,;2.97,-22.86,;1.63,-23.63,;8.3,-21.32,;9.63,-20.55,;9.63,-19.01,;8.29,-18.24,;6.96,-19.02,;5.62,-18.25,;5.62,-16.71,;4.29,-15.93,;6.96,-15.94,;8.28,-16.7,)|
Show InChI InChI=1S/C19H33N5O2/c1-3-5-11-20-18(26)16-13-22-19(21-12-6-4-2)24-17(16)23-14-7-9-15(25)10-8-14/h13-15,25H,3-12H2,1-2H3,(H,20,26)(H2,21,22,23,24)/t14-,15-
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n/an/a 3.00E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444247
PNG
(CHEMBL3093750 | US9649309, Compound UNC2775A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccccc2OC)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:22.22,wD:25.26,(54.22,-47.24,;55.55,-46.47,;56.88,-47.24,;58.22,-46.47,;59.55,-47.24,;60.88,-46.47,;62.22,-47.25,;63.56,-46.47,;63.55,-44.92,;64.88,-44.15,;64.88,-42.61,;66.22,-44.91,;67.55,-44.14,;67.54,-42.61,;68.86,-41.83,;70.21,-42.59,;70.21,-44.14,;68.88,-44.91,;68.88,-46.45,;70.22,-47.22,;62.22,-44.16,;62.21,-42.62,;60.87,-41.85,;59.54,-42.63,;58.2,-41.86,;58.2,-40.32,;56.87,-39.55,;59.54,-39.55,;60.87,-40.32,;60.89,-44.93,)|
Show InChI InChI=1S/C22H31N5O3/c1-3-4-13-23-22-24-14-17(20(27-22)25-15-9-11-16(28)12-10-15)21(29)26-18-7-5-6-8-19(18)30-2/h5-8,14-16,28H,3-4,9-13H2,1-2H3,(H,26,29)(H2,23,24,25,27)/t15-,16-
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n/an/a 3.80E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444279
PNG
(CHEMBL3093642)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H31N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-9,11-12,18H,2-3,10,13-17H2,1H3,(H,30,33)(H2,27,28,29,31)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444269
PNG
(CHEMBL3093629)
Show SMILES OCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(24.63,-35.11,;25.96,-34.34,;27.3,-35.11,;28.63,-34.34,;29.96,-35.12,;31.3,-34.35,;32.63,-35.12,;33.97,-34.35,;33.96,-32.8,;35.29,-32.02,;35.29,-30.48,;36.63,-32.79,;37.96,-32.01,;39.29,-32.78,;40.62,-32.01,;40.62,-30.47,;39.27,-29.7,;37.95,-30.48,;41.95,-29.68,;41.17,-28.35,;42.72,-28.34,;43.28,-30.45,;43.28,-31.99,;44.61,-32.75,;45.94,-31.98,;45.94,-30.44,;44.6,-29.67,;32.63,-32.03,;32.62,-30.49,;31.29,-29.73,;29.96,-30.5,;28.62,-29.72,;28.62,-28.18,;27.29,-27.41,;29.96,-27.41,;31.29,-28.18,;31.3,-32.8,)|
Show InChI InChI=1S/C24H34N6O6S/c31-13-1-10-25-24-26-16-21(22(29-24)27-17-2-6-19(32)7-3-17)23(33)28-18-4-8-20(9-5-18)37(34,35)30-11-14-36-15-12-30/h4-5,8-9,16-17,19,31-32H,1-3,6-7,10-15H2,(H,28,33)(H2,25,26,27,29)/t17-,19-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444267
PNG
(CHEMBL3093631)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NC2CCCCC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(3.66,-38.22,;4.99,-38.99,;4.99,-40.53,;6.33,-41.3,;7.65,-40.53,;7.65,-38.99,;6.32,-38.22,;8.99,-41.3,;8.99,-42.84,;7.66,-43.61,;7.66,-45.15,;6.33,-45.92,;4.99,-45.15,;4.99,-43.61,;3.67,-42.84,;2.33,-43.6,;2.33,-45.14,;3.66,-45.92,;8.99,-45.92,;10.33,-45.15,;10.33,-43.6,;11.66,-42.83,;11.65,-41.29,;12.99,-43.59,;14.32,-42.82,;15.66,-43.59,;16.99,-42.81,;16.98,-41.27,;15.63,-40.51,;14.31,-41.29,;18.31,-40.49,;17.53,-39.15,;19.08,-39.15,;19.65,-41.26,;19.64,-42.79,;20.97,-43.56,;22.31,-42.79,;22.3,-41.24,;20.96,-40.47,)|
Show InChI InChI=1S/C27H38N6O5S/c34-22-10-6-20(7-11-22)29-25-24(18-28-27(32-25)31-19-4-2-1-3-5-19)26(35)30-21-8-12-23(13-9-21)39(36,37)33-14-16-38-17-15-33/h8-9,12-13,18-20,22,34H,1-7,10-11,14-17H2,(H,30,35)(H2,28,29,31,32)/t20-,22-
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n/an/a 4.30E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444284
PNG
(CHEMBL3093637 | US9649309, Compound UNC2084A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NCC2CCNCC2)n1
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-7,18-19,26H,2-3,8-17H2,1H3,(H,30,33)(H2,27,28,29,31)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444270
PNG
(CHEMBL3093628)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCCCC(F)(F)F)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(4.09,-26.59,;5.43,-27.36,;5.43,-28.9,;6.76,-29.68,;8.09,-28.9,;8.09,-27.36,;6.76,-26.59,;9.43,-29.67,;9.43,-31.21,;8.1,-31.98,;8.1,-33.53,;6.76,-34.29,;5.43,-33.52,;4.1,-34.29,;2.76,-33.52,;1.43,-34.29,;.1,-33.52,;1.43,-35.83,;.09,-35.05,;9.43,-34.3,;10.77,-33.52,;10.77,-31.97,;12.1,-31.2,;12.09,-29.66,;13.43,-31.96,;14.76,-31.19,;16.1,-31.96,;17.43,-31.19,;17.42,-29.64,;16.08,-28.88,;14.75,-29.66,;18.75,-28.86,;17.97,-27.52,;19.52,-27.52,;20.09,-29.63,;20.08,-31.17,;21.41,-31.93,;22.75,-31.16,;22.74,-29.62,;21.41,-28.84,)|
Show InChI InChI=1S/C25H33F3N6O5S/c26-25(27,28)10-1-11-29-24-30-16-21(22(33-24)31-17-2-6-19(35)7-3-17)23(36)32-18-4-8-20(9-5-18)40(37,38)34-12-14-39-15-13-34/h4-5,8-9,16-17,19,35H,1-3,6-7,10-15H2,(H,32,36)(H2,29,30,31,33)/t17-,19-
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n/an/a 5.10E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444270
PNG
(CHEMBL3093628)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCCCC(F)(F)F)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(4.09,-26.59,;5.43,-27.36,;5.43,-28.9,;6.76,-29.68,;8.09,-28.9,;8.09,-27.36,;6.76,-26.59,;9.43,-29.67,;9.43,-31.21,;8.1,-31.98,;8.1,-33.53,;6.76,-34.29,;5.43,-33.52,;4.1,-34.29,;2.76,-33.52,;1.43,-34.29,;.1,-33.52,;1.43,-35.83,;.09,-35.05,;9.43,-34.3,;10.77,-33.52,;10.77,-31.97,;12.1,-31.2,;12.09,-29.66,;13.43,-31.96,;14.76,-31.19,;16.1,-31.96,;17.43,-31.19,;17.42,-29.64,;16.08,-28.88,;14.75,-29.66,;18.75,-28.86,;17.97,-27.52,;19.52,-27.52,;20.09,-29.63,;20.08,-31.17,;21.41,-31.93,;22.75,-31.16,;22.74,-29.62,;21.41,-28.84,)|
Show InChI InChI=1S/C25H33F3N6O5S/c26-25(27,28)10-1-11-29-24-30-16-21(22(33-24)31-17-2-6-19(35)7-3-17)23(36)32-18-4-8-20(9-5-18)40(37,38)34-12-14-39-15-13-34/h4-5,8-9,16-17,19,35H,1-3,6-7,10-15H2,(H,32,36)(H2,29,30,31,33)/t17-,19-
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n/an/a 5.70E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444257
PNG
(CHEMBL3093760)
Show SMILES CCCCNc1ncc(C(=O)N(C)CCCC)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:19.18,wD:22.22,(20.52,-24.04,;21.85,-23.27,;23.18,-24.04,;24.52,-23.27,;25.85,-24.04,;27.19,-23.28,;28.52,-24.05,;29.86,-23.27,;29.85,-21.72,;31.18,-20.95,;31.18,-19.41,;32.52,-21.71,;32.53,-23.25,;33.85,-20.94,;35.19,-21.7,;36.52,-20.93,;37.85,-21.69,;28.52,-20.96,;28.51,-19.42,;27.18,-18.65,;25.84,-19.43,;24.51,-18.66,;24.5,-17.12,;23.17,-16.35,;25.84,-16.35,;27.17,-17.12,;27.19,-21.73,)|
Show InChI InChI=1S/C20H35N5O2/c1-4-6-12-21-20-22-14-17(19(27)25(3)13-7-5-2)18(24-20)23-15-8-10-16(26)11-9-15/h14-16,26H,4-13H2,1-3H3,(H2,21,22,23,24)/t15-,16-
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n/an/a 5.90E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444258
PNG
(CHEMBL3093759)
Show SMILES CCCCNC(=O)c1cnc(NCCCC)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:19.19,wD:22.23,(18.97,-21.28,;17.63,-20.52,;16.3,-21.29,;14.97,-20.53,;13.64,-21.3,;12.3,-20.54,;12.29,-19,;10.97,-21.31,;10.97,-22.86,;9.64,-23.63,;8.3,-22.86,;6.97,-23.63,;5.63,-22.86,;4.3,-23.63,;2.97,-22.86,;1.63,-23.63,;8.3,-21.32,;9.63,-20.55,;9.63,-19.01,;8.29,-18.24,;6.96,-19.02,;5.62,-18.25,;5.62,-16.71,;4.29,-15.93,;6.96,-15.94,;8.28,-16.7,)|
Show InChI InChI=1S/C19H33N5O2/c1-3-5-11-20-18(26)16-13-22-19(21-12-6-4-2)24-17(16)23-14-7-9-15(25)10-8-14/h13-15,25H,3-12H2,1-2H3,(H,20,26)(H2,21,22,23,24)/t14-,15-
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n/an/a 6.70E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444269
PNG
(CHEMBL3093629)
Show SMILES OCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(24.63,-35.11,;25.96,-34.34,;27.3,-35.11,;28.63,-34.34,;29.96,-35.12,;31.3,-34.35,;32.63,-35.12,;33.97,-34.35,;33.96,-32.8,;35.29,-32.02,;35.29,-30.48,;36.63,-32.79,;37.96,-32.01,;39.29,-32.78,;40.62,-32.01,;40.62,-30.47,;39.27,-29.7,;37.95,-30.48,;41.95,-29.68,;41.17,-28.35,;42.72,-28.34,;43.28,-30.45,;43.28,-31.99,;44.61,-32.75,;45.94,-31.98,;45.94,-30.44,;44.6,-29.67,;32.63,-32.03,;32.62,-30.49,;31.29,-29.73,;29.96,-30.5,;28.62,-29.72,;28.62,-28.18,;27.29,-27.41,;29.96,-27.41,;31.29,-28.18,;31.3,-32.8,)|
Show InChI InChI=1S/C24H34N6O6S/c31-13-1-10-25-24-26-16-21(22(29-24)27-17-2-6-19(32)7-3-17)23(33)28-18-4-8-20(9-5-18)37(34,35)30-11-14-36-15-12-30/h4-5,8-9,16-17,19,31-32H,1-3,6-7,10-15H2,(H,28,33)(H2,25,26,27,29)/t17-,19-
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n/an/a 6.70E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444266
PNG
(CHEMBL3093632)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NC2CCOCC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(27.5,-38.82,;28.84,-39.59,;28.84,-41.13,;30.17,-41.9,;31.5,-41.13,;31.5,-39.58,;30.17,-38.82,;32.84,-41.9,;32.84,-43.44,;31.51,-44.21,;31.51,-45.75,;30.18,-46.52,;28.84,-45.75,;28.85,-44.21,;27.53,-43.44,;26.19,-44.2,;26.18,-45.74,;27.52,-46.52,;32.84,-46.52,;34.18,-45.75,;34.18,-44.2,;35.51,-43.43,;35.5,-41.89,;36.84,-44.19,;38.17,-43.42,;39.51,-44.19,;40.84,-43.41,;40.83,-41.87,;39.49,-41.11,;38.16,-41.89,;42.16,-41.09,;41.38,-39.75,;42.93,-39.75,;43.5,-41.86,;43.5,-43.39,;44.83,-44.16,;46.16,-43.38,;46.16,-41.84,;44.82,-41.07,)|
Show InChI InChI=1S/C26H36N6O6S/c33-21-5-1-18(2-6-21)28-24-23(17-27-26(31-24)30-20-9-13-37-14-10-20)25(34)29-19-3-7-22(8-4-19)39(35,36)32-11-15-38-16-12-32/h3-4,7-8,17-18,20-21,33H,1-2,5-6,9-16H2,(H,29,34)(H2,27,28,30,31)/t18-,21-
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n/an/a 7.40E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444267
PNG
(CHEMBL3093631)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NC2CCCCC2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(3.66,-38.22,;4.99,-38.99,;4.99,-40.53,;6.33,-41.3,;7.65,-40.53,;7.65,-38.99,;6.32,-38.22,;8.99,-41.3,;8.99,-42.84,;7.66,-43.61,;7.66,-45.15,;6.33,-45.92,;4.99,-45.15,;4.99,-43.61,;3.67,-42.84,;2.33,-43.6,;2.33,-45.14,;3.66,-45.92,;8.99,-45.92,;10.33,-45.15,;10.33,-43.6,;11.66,-42.83,;11.65,-41.29,;12.99,-43.59,;14.32,-42.82,;15.66,-43.59,;16.99,-42.81,;16.98,-41.27,;15.63,-40.51,;14.31,-41.29,;18.31,-40.49,;17.53,-39.15,;19.08,-39.15,;19.65,-41.26,;19.64,-42.79,;20.97,-43.56,;22.31,-42.79,;22.3,-41.24,;20.96,-40.47,)|
Show InChI InChI=1S/C27H38N6O5S/c34-22-10-6-20(7-11-22)29-25-24(18-28-27(32-25)31-19-4-2-1-3-5-19)26(35)30-21-8-12-23(13-9-21)39(36,37)33-14-16-38-17-15-33/h8-9,12-13,18-20,22,34H,1-7,10-11,14-17H2,(H,30,35)(H2,28,29,31,32)/t20-,22-
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n/an/a 9.00E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444277
PNG
(CHEMBL3093644 | US9649309, Compound UNC2081A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C23H32N6O5S/c1-2-3-8-24-23-25-17-20(21(27-23)28-9-13-33-14-10-28)22(30)26-18-4-6-19(7-5-18)35(31,32)29-11-15-34-16-12-29/h4-7,17H,2-3,8-16H2,1H3,(H,26,30)(H,24,25,27)
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n/an/a 9.90E+3n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444282
PNG
(CHEMBL3093639 | US9649309, Compound UNC2086A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCNCC2)n1
Show InChI InChI=1S/C24H35N7O4S/c1-2-3-10-26-24-27-17-21(22(30-24)28-19-8-11-25-12-9-19)23(32)29-18-4-6-20(7-5-18)36(33,34)31-13-15-35-16-14-31/h4-7,17,19,25H,2-3,8-16H2,1H3,(H,29,32)(H2,26,27,28,30)
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n/an/a 1.07E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444280
PNG
(CHEMBL3093641 | US9649309, Compound UNC2091A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CCNC2)n1 |r|
Show InChI InChI=1S/C23H33N7O4S/c1-2-3-9-25-23-26-16-20(21(29-23)27-18-8-10-24-15-18)22(31)28-17-4-6-19(7-5-17)35(32,33)30-11-13-34-14-12-30/h4-7,16,18,24H,2-3,8-15H2,1H3,(H,28,31)(H2,25,26,27,29)/t18-/m0/s1
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n/an/a 1.26E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444261
PNG
(CHEMBL3093765)
Show SMILES CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(18,-11.88,;19.34,-11.11,;20.67,-11.89,;22.01,-11.12,;23.34,-11.89,;24.67,-11.12,;26.01,-11.89,;27.35,-11.12,;27.34,-9.57,;28.67,-8.79,;30.01,-9.56,;30.01,-11.1,;31.34,-8.78,;32.67,-9.55,;34,-8.78,;34,-7.24,;35.33,-6.46,;32.65,-6.47,;31.33,-7.25,;26,-8.8,;26,-7.26,;24.66,-6.5,;24.66,-4.96,;23.33,-4.2,;23.33,-2.65,;24.67,-1.88,;24.67,-.34,;26,-2.65,;26,-4.19,;24.68,-9.57,)|
Show InChI InChI=1S/C22H31FN6O/c1-2-3-12-25-22-27-14-19(28-21(30)16-6-8-17(23)9-7-16)20(29-22)26-13-15-4-10-18(24)11-5-15/h6-9,14-15,18H,2-5,10-13,24H2,1H3,(H,28,30)(H2,25,26,27,29)/t15-,18-
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n/an/a 1.26E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444283
PNG
(CHEMBL3093638 | US9649309, Compound UNC2090A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC[C@@H]2CCCNC2)n1 |r|
Show InChI InChI=1S/C25H37N7O4S/c1-2-3-11-27-25-29-18-22(23(31-25)28-17-19-5-4-10-26-16-19)24(33)30-20-6-8-21(9-7-20)37(34,35)32-12-14-36-15-13-32/h6-9,18-19,26H,2-5,10-17H2,1H3,(H,30,33)(H2,27,28,29,31)/t19-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444274
PNG
(CHEMBL3093647)
Show SMILES CCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(50.31,-10.83,;51.65,-10.06,;52.98,-10.83,;54.31,-10.06,;55.65,-10.83,;56.98,-10.06,;56.98,-8.51,;58.31,-7.73,;58.3,-6.19,;59.65,-8.5,;60.98,-7.72,;62.31,-8.5,;63.64,-7.72,;63.64,-6.18,;62.29,-5.42,;60.97,-6.19,;64.96,-5.4,;64.19,-4.06,;65.73,-4.06,;66.3,-6.17,;66.3,-7.7,;67.63,-8.46,;68.96,-7.69,;68.96,-6.15,;67.62,-5.38,;55.64,-7.75,;55.64,-6.21,;54.3,-5.44,;52.98,-6.21,;51.64,-5.44,;51.64,-3.89,;50.31,-3.12,;52.98,-3.13,;54.3,-3.89,;54.31,-8.52,)|
Show InChI InChI=1S/C23H32N6O5S/c1-2-24-23-25-15-20(21(28-23)26-16-3-7-18(30)8-4-16)22(31)27-17-5-9-19(10-6-17)35(32,33)29-11-13-34-14-12-29/h5-6,9-10,15-16,18,30H,2-4,7-8,11-14H2,1H3,(H,27,31)(H2,24,25,26,28)/t16-,18-
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n/an/a 1.62E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444250
PNG
(CHEMBL3093747 | US9649309, Compound UNC2803A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)C(F)(F)F)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:24.24,wD:27.28,(1.92,-47.36,;3.25,-46.59,;4.59,-47.36,;5.92,-46.59,;7.26,-47.36,;8.59,-46.59,;9.92,-47.36,;11.26,-46.59,;11.26,-45.04,;12.59,-44.27,;12.58,-42.73,;13.92,-45.03,;15.25,-44.26,;16.59,-45.03,;17.92,-44.26,;17.91,-42.71,;16.57,-41.95,;15.24,-42.73,;19.24,-41.94,;20.58,-42.7,;19.23,-40.4,;20.57,-41.15,;9.92,-44.28,;9.92,-42.74,;8.58,-41.97,;7.25,-42.75,;5.91,-41.98,;5.91,-40.44,;4.57,-39.67,;7.24,-39.67,;8.57,-40.43,;8.59,-45.05,)|
Show InChI InChI=1S/C22H28F3N5O2/c1-2-3-12-26-21-27-13-18(19(30-21)28-15-8-10-17(31)11-9-15)20(32)29-16-6-4-14(5-7-16)22(23,24)25/h4-7,13,15,17,31H,2-3,8-12H2,1H3,(H,29,32)(H2,26,27,28,30)/t15-,17-
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n/an/a 1.66E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444276
PNG
(CHEMBL3093645)
Show SMILES Nc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.26,wD:28.30,(5.87,-10.2,;7.2,-9.43,;8.54,-10.21,;9.87,-9.43,;9.87,-7.88,;11.2,-7.11,;11.19,-5.57,;12.53,-7.87,;13.86,-7.1,;15.2,-7.87,;16.53,-7.1,;16.52,-5.56,;15.18,-4.79,;13.85,-5.57,;17.85,-4.77,;17.07,-3.44,;18.62,-3.43,;19.19,-5.54,;19.18,-7.08,;20.51,-7.84,;21.85,-7.07,;21.84,-5.53,;20.5,-4.76,;8.53,-7.12,;8.53,-5.58,;7.19,-4.82,;5.87,-5.59,;4.53,-4.81,;4.53,-3.27,;3.2,-2.5,;5.87,-2.5,;7.19,-3.27,;7.2,-7.89,)|
Show InChI InChI=1S/C21H28N6O5S/c22-21-23-13-18(19(26-21)24-14-1-5-16(28)6-2-14)20(29)25-15-3-7-17(8-4-15)33(30,31)27-9-11-32-12-10-27/h3-4,7-8,13-14,16,28H,1-2,5-6,9-12H2,(H,25,29)(H3,22,23,24,26)/t14-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444250
PNG
(CHEMBL3093747 | US9649309, Compound UNC2803A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)C(F)(F)F)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:24.24,wD:27.28,(1.92,-47.36,;3.25,-46.59,;4.59,-47.36,;5.92,-46.59,;7.26,-47.36,;8.59,-46.59,;9.92,-47.36,;11.26,-46.59,;11.26,-45.04,;12.59,-44.27,;12.58,-42.73,;13.92,-45.03,;15.25,-44.26,;16.59,-45.03,;17.92,-44.26,;17.91,-42.71,;16.57,-41.95,;15.24,-42.73,;19.24,-41.94,;20.58,-42.7,;19.23,-40.4,;20.57,-41.15,;9.92,-44.28,;9.92,-42.74,;8.58,-41.97,;7.25,-42.75,;5.91,-41.98,;5.91,-40.44,;4.57,-39.67,;7.24,-39.67,;8.57,-40.43,;8.59,-45.05,)|
Show InChI InChI=1S/C22H28F3N5O2/c1-2-3-12-26-21-27-13-18(19(30-21)28-15-8-10-17(31)11-9-15)20(32)29-16-6-4-14(5-7-16)22(23,24)25/h4-7,13,15,17,31H,2-3,8-12H2,1H3,(H,29,32)(H2,26,27,28,30)/t15-,17-
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n/an/a 1.79E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444281
PNG
(CHEMBL3093640 | US9649309, Compound UNC2089A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@@H]2CCNC2)n1 |r|
Show InChI InChI=1S/C23H33N7O4S/c1-2-3-9-25-23-26-16-20(21(29-23)27-18-8-10-24-15-18)22(31)28-17-4-6-19(7-5-17)35(32,33)30-11-13-34-14-12-30/h4-7,16,18,24H,2-3,8-15H2,1H3,(H,28,31)(H2,25,26,27,29)/t18-/m1/s1
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n/an/a 1.95E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444279
PNG
(CHEMBL3093642)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H31N7O4S/c1-2-3-10-27-25-29-18-22(23(31-25)28-17-19-8-11-26-12-9-19)24(33)30-20-4-6-21(7-5-20)37(34,35)32-13-15-36-16-14-32/h4-9,11-12,18H,2-3,10,13-17H2,1H3,(H,30,33)(H2,27,28,29,31)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444272
PNG
(CHEMBL3093626)
Show SMILES CCCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:30.31,wD:33.35,(23.85,-22.37,;25.18,-23.14,;26.52,-22.37,;27.85,-23.14,;29.18,-22.37,;30.52,-23.14,;31.85,-22.37,;33.19,-23.14,;34.52,-22.37,;34.52,-20.82,;35.85,-20.05,;35.84,-18.51,;37.18,-20.81,;38.52,-20.04,;39.85,-20.81,;41.18,-20.03,;41.17,-18.49,;39.83,-17.73,;38.5,-18.51,;42.5,-17.71,;41.73,-16.37,;43.27,-16.37,;43.84,-18.48,;43.84,-20.01,;45.17,-20.78,;46.5,-20.01,;46.5,-18.46,;45.16,-17.69,;33.18,-20.06,;33.18,-18.52,;31.84,-17.75,;30.52,-18.52,;29.18,-17.75,;29.18,-16.21,;27.84,-15.44,;30.51,-15.44,;31.84,-16.2,;31.85,-20.83,)|
Show InChI InChI=1S/C26H38N6O5S/c1-2-3-4-13-27-26-28-18-23(24(31-26)29-19-5-9-21(33)10-6-19)25(34)30-20-7-11-22(12-8-20)38(35,36)32-14-16-37-17-15-32/h7-8,11-12,18-19,21,33H,2-6,9-10,13-17H2,1H3,(H,30,34)(H2,27,28,29,31)/t19-,21-
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n/an/a 2.19E+4n/an/an/an/an/an/a



Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444259
PNG
(CHEMBL3093758)
Show SMILES CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:21.21,wD:24.25,(54.17,-10.17,;55.5,-9.4,;56.83,-10.17,;58.17,-9.41,;59.5,-10.18,;60.83,-9.41,;62.17,-10.18,;63.51,-9.41,;63.5,-7.86,;64.83,-7.08,;66.17,-7.85,;66.17,-9.39,;67.5,-7.07,;68.83,-7.84,;70.16,-7.07,;70.16,-5.53,;71.49,-4.75,;68.81,-4.76,;67.49,-5.54,;62.17,-7.09,;62.16,-5.55,;60.82,-4.79,;59.5,-5.57,;58.16,-4.79,;58.16,-3.25,;56.83,-2.48,;59.5,-2.48,;60.82,-3.25,;60.84,-7.86,)|
Show InChI InChI=1S/C21H28FN5O2/c1-2-3-12-23-21-24-13-18(26-20(29)14-4-6-15(22)7-5-14)19(27-21)25-16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12H2,1H3,(H,26,29)(H2,23,24,25,27)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444277
PNG
(CHEMBL3093644 | US9649309, Compound UNC2081A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C23H32N6O5S/c1-2-3-8-24-23-25-17-20(21(27-23)28-9-13-33-14-10-28)22(30)26-18-4-6-19(7-5-18)35(31,32)29-11-15-34-16-12-29/h4-7,17H,2-3,8-16H2,1H3,(H,26,30)(H,24,25,27)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444264
PNG
(CHEMBL3093634)
Show SMILES CN(C)c1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(5.16,-56.77,;6.49,-57.54,;6.49,-59.08,;7.82,-56.77,;9.16,-57.54,;10.5,-56.77,;10.49,-55.22,;11.82,-54.45,;11.81,-52.91,;13.16,-55.21,;14.49,-54.44,;15.82,-55.21,;17.15,-54.43,;17.14,-52.89,;15.8,-52.13,;14.48,-52.91,;18.47,-52.11,;17.7,-50.77,;19.24,-50.77,;19.81,-52.88,;19.81,-54.41,;21.14,-55.17,;22.47,-54.4,;22.47,-52.86,;21.13,-52.09,;9.16,-54.46,;9.15,-52.92,;7.82,-52.15,;6.49,-52.92,;5.15,-52.15,;5.15,-50.61,;3.82,-49.84,;6.49,-49.84,;7.82,-50.61,;7.83,-55.23,)|
Show InChI InChI=1S/C23H32N6O5S/c1-28(2)23-24-15-20(21(27-23)25-16-3-7-18(30)8-4-16)22(31)26-17-5-9-19(10-6-17)35(32,33)29-11-13-34-14-12-29/h5-6,9-10,15-16,18,30H,3-4,7-8,11-14H2,1-2H3,(H,26,31)(H,24,25,27)/t16-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444257
PNG
(CHEMBL3093760)
Show SMILES CCCCNc1ncc(C(=O)N(C)CCCC)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:19.18,wD:22.22,(20.52,-24.04,;21.85,-23.27,;23.18,-24.04,;24.52,-23.27,;25.85,-24.04,;27.19,-23.28,;28.52,-24.05,;29.86,-23.27,;29.85,-21.72,;31.18,-20.95,;31.18,-19.41,;32.52,-21.71,;32.53,-23.25,;33.85,-20.94,;35.19,-21.7,;36.52,-20.93,;37.85,-21.69,;28.52,-20.96,;28.51,-19.42,;27.18,-18.65,;25.84,-19.43,;24.51,-18.66,;24.5,-17.12,;23.17,-16.35,;25.84,-16.35,;27.17,-17.12,;27.19,-21.73,)|
Show InChI InChI=1S/C20H35N5O2/c1-4-6-12-21-20-22-14-17(19(27)25(3)13-7-5-2)18(24-20)23-15-8-10-16(26)11-9-15/h14-16,26H,4-13H2,1-3H3,(H2,21,22,23,24)/t15-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444263
PNG
(CHEMBL3093624)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1)N1CCOCC1 |r,wU:4.7,wD:1.0,(27.91,-50.35,;29.24,-51.12,;29.24,-52.66,;30.58,-53.43,;31.91,-52.66,;31.91,-51.12,;30.58,-50.35,;33.24,-53.43,;33.25,-54.97,;31.92,-55.74,;31.92,-57.28,;33.25,-58.05,;34.59,-57.28,;34.58,-55.73,;35.91,-54.96,;35.91,-53.42,;37.25,-55.72,;38.58,-54.95,;39.91,-55.72,;41.24,-54.94,;41.24,-53.4,;39.89,-52.64,;38.57,-53.42,;42.56,-52.62,;41.79,-51.28,;43.33,-51.28,;43.9,-53.39,;43.9,-54.92,;45.23,-55.68,;46.56,-54.91,;46.56,-53.37,;45.22,-52.6,;30.58,-58.05,;29.26,-57.27,;27.93,-58.03,;27.92,-59.57,;29.25,-60.35,;30.59,-59.58,)|
Show InChI InChI=1S/C25H34N6O6S/c32-20-5-1-18(2-6-20)27-23-22(17-26-25(29-23)30-9-13-36-14-10-30)24(33)28-19-3-7-21(8-4-19)38(34,35)31-11-15-37-16-12-31/h3-4,7-8,17-18,20,32H,1-2,5-6,9-16H2,(H,28,33)(H,26,27,29)/t18-,20-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444263
PNG
(CHEMBL3093624)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1)N1CCOCC1 |r,wU:4.7,wD:1.0,(27.91,-50.35,;29.24,-51.12,;29.24,-52.66,;30.58,-53.43,;31.91,-52.66,;31.91,-51.12,;30.58,-50.35,;33.24,-53.43,;33.25,-54.97,;31.92,-55.74,;31.92,-57.28,;33.25,-58.05,;34.59,-57.28,;34.58,-55.73,;35.91,-54.96,;35.91,-53.42,;37.25,-55.72,;38.58,-54.95,;39.91,-55.72,;41.24,-54.94,;41.24,-53.4,;39.89,-52.64,;38.57,-53.42,;42.56,-52.62,;41.79,-51.28,;43.33,-51.28,;43.9,-53.39,;43.9,-54.92,;45.23,-55.68,;46.56,-54.91,;46.56,-53.37,;45.22,-52.6,;30.58,-58.05,;29.26,-57.27,;27.93,-58.03,;27.92,-59.57,;29.25,-60.35,;30.59,-59.58,)|
Show InChI InChI=1S/C25H34N6O6S/c32-20-5-1-18(2-6-20)27-23-22(17-26-25(29-23)30-9-13-36-14-10-30)24(33)28-19-3-7-21(8-4-19)38(34,35)31-11-15-37-16-12-31/h3-4,7-8,17-18,20,32H,1-2,5-6,9-16H2,(H,28,33)(H,26,27,29)/t18-,20-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444281
PNG
(CHEMBL3093640 | US9649309, Compound UNC2089A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@@H]2CCNC2)n1 |r|
Show InChI InChI=1S/C23H33N7O4S/c1-2-3-9-25-23-26-16-20(21(29-23)27-18-8-10-24-15-18)22(31)28-17-4-6-19(7-5-17)35(32,33)30-11-13-34-14-12-30/h4-7,16,18,24H,2-3,8-15H2,1H3,(H,28,31)(H2,25,26,27,29)/t18-/m1/s1
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444265
PNG
(CHEMBL3093633)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCc2ccc(F)cc2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(51.68,-38.67,;53.01,-39.44,;53.01,-40.98,;54.35,-41.76,;55.67,-40.99,;55.67,-39.44,;54.35,-38.68,;57.01,-41.75,;57.01,-43.29,;55.69,-44.06,;55.68,-45.61,;54.35,-46.38,;53.02,-45.61,;51.68,-46.37,;50.36,-45.59,;49.03,-46.36,;49.02,-47.9,;47.68,-48.66,;50.35,-48.67,;51.69,-47.91,;57.02,-46.38,;58.35,-45.61,;58.35,-44.06,;59.68,-43.28,;59.67,-41.74,;61.02,-44.05,;62.35,-43.27,;63.68,-44.04,;65.01,-43.27,;65,-41.73,;63.66,-40.96,;62.33,-41.74,;66.33,-40.95,;65.56,-39.61,;67.1,-39.6,;67.67,-41.71,;67.67,-43.25,;69,-44.01,;70.33,-43.24,;70.33,-41.7,;68.99,-40.93,)|
Show InChI InChI=1S/C28H33FN6O5S/c29-20-3-1-19(2-4-20)17-30-28-31-18-25(26(34-28)32-21-5-9-23(36)10-6-21)27(37)33-22-7-11-24(12-8-22)41(38,39)35-13-15-40-16-14-35/h1-4,7-8,11-12,18,21,23,36H,5-6,9-10,13-17H2,(H,33,37)(H2,30,31,32,34)/t21-,23-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444261
PNG
(CHEMBL3093765)
Show SMILES CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(18,-11.88,;19.34,-11.11,;20.67,-11.89,;22.01,-11.12,;23.34,-11.89,;24.67,-11.12,;26.01,-11.89,;27.35,-11.12,;27.34,-9.57,;28.67,-8.79,;30.01,-9.56,;30.01,-11.1,;31.34,-8.78,;32.67,-9.55,;34,-8.78,;34,-7.24,;35.33,-6.46,;32.65,-6.47,;31.33,-7.25,;26,-8.8,;26,-7.26,;24.66,-6.5,;24.66,-4.96,;23.33,-4.2,;23.33,-2.65,;24.67,-1.88,;24.67,-.34,;26,-2.65,;26,-4.19,;24.68,-9.57,)|
Show InChI InChI=1S/C22H31FN6O/c1-2-3-12-25-22-27-14-19(28-21(30)16-6-8-17(23)9-7-16)20(29-22)26-13-15-4-10-18(24)11-5-15/h6-9,14-15,18H,2-5,10-13,24H2,1H3,(H,28,30)(H2,25,26,27,29)/t15-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM50444259
PNG
(CHEMBL3093758)
Show SMILES CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:21.21,wD:24.25,(54.17,-10.17,;55.5,-9.4,;56.83,-10.17,;58.17,-9.41,;59.5,-10.18,;60.83,-9.41,;62.17,-10.18,;63.51,-9.41,;63.5,-7.86,;64.83,-7.08,;66.17,-7.85,;66.17,-9.39,;67.5,-7.07,;68.83,-7.84,;70.16,-7.07,;70.16,-5.53,;71.49,-4.75,;68.81,-4.76,;67.49,-5.54,;62.17,-7.09,;62.16,-5.55,;60.82,-4.79,;59.5,-5.57,;58.16,-4.79,;58.16,-3.25,;56.83,-2.48,;59.5,-2.48,;60.82,-3.25,;60.84,-7.86,)|
Show InChI InChI=1S/C21H28FN5O2/c1-2-3-12-23-21-24-13-18(26-20(29)14-4-6-15(22)7-5-14)19(27-21)25-16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12H2,1H3,(H,26,29)(H2,23,24,25,27)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444278
PNG
(CHEMBL3093643 | US9649309, Compound UNC2061A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCOCC2)n1
Show InChI InChI=1S/C24H34N6O5S/c1-2-3-10-25-24-26-17-21(22(29-24)27-19-8-13-34-14-9-19)23(31)28-18-4-6-20(7-5-18)36(32,33)30-11-15-35-16-12-30/h4-7,17,19H,2-3,8-16H2,1H3,(H,28,31)(H2,25,26,27,29)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444261
PNG
(CHEMBL3093765)
Show SMILES CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(18,-11.88,;19.34,-11.11,;20.67,-11.89,;22.01,-11.12,;23.34,-11.89,;24.67,-11.12,;26.01,-11.89,;27.35,-11.12,;27.34,-9.57,;28.67,-8.79,;30.01,-9.56,;30.01,-11.1,;31.34,-8.78,;32.67,-9.55,;34,-8.78,;34,-7.24,;35.33,-6.46,;32.65,-6.47,;31.33,-7.25,;26,-8.8,;26,-7.26,;24.66,-6.5,;24.66,-4.96,;23.33,-4.2,;23.33,-2.65,;24.67,-1.88,;24.67,-.34,;26,-2.65,;26,-4.19,;24.68,-9.57,)|
Show InChI InChI=1S/C22H31FN6O/c1-2-3-12-25-22-27-14-19(28-21(30)16-6-8-17(23)9-7-16)20(29-22)26-13-15-4-10-18(24)11-5-15/h6-9,14-15,18H,2-5,10-13,24H2,1H3,(H,28,30)(H2,25,26,27,29)/t15-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444264
PNG
(CHEMBL3093634)
Show SMILES CN(C)c1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(5.16,-56.77,;6.49,-57.54,;6.49,-59.08,;7.82,-56.77,;9.16,-57.54,;10.5,-56.77,;10.49,-55.22,;11.82,-54.45,;11.81,-52.91,;13.16,-55.21,;14.49,-54.44,;15.82,-55.21,;17.15,-54.43,;17.14,-52.89,;15.8,-52.13,;14.48,-52.91,;18.47,-52.11,;17.7,-50.77,;19.24,-50.77,;19.81,-52.88,;19.81,-54.41,;21.14,-55.17,;22.47,-54.4,;22.47,-52.86,;21.13,-52.09,;9.16,-54.46,;9.15,-52.92,;7.82,-52.15,;6.49,-52.92,;5.15,-52.15,;5.15,-50.61,;3.82,-49.84,;6.49,-49.84,;7.82,-50.61,;7.83,-55.23,)|
Show InChI InChI=1S/C23H32N6O5S/c1-28(2)23-24-15-20(21(27-23)25-16-3-7-18(30)8-4-16)22(31)26-17-5-9-19(10-6-17)35(32,33)29-11-13-34-14-12-29/h5-6,9-10,15-16,18,30H,3-4,7-8,11-14H2,1-2H3,(H,26,31)(H,24,25,27)/t16-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444265
PNG
(CHEMBL3093633)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(NCc2ccc(F)cc2)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(51.68,-38.67,;53.01,-39.44,;53.01,-40.98,;54.35,-41.76,;55.67,-40.99,;55.67,-39.44,;54.35,-38.68,;57.01,-41.75,;57.01,-43.29,;55.69,-44.06,;55.68,-45.61,;54.35,-46.38,;53.02,-45.61,;51.68,-46.37,;50.36,-45.59,;49.03,-46.36,;49.02,-47.9,;47.68,-48.66,;50.35,-48.67,;51.69,-47.91,;57.02,-46.38,;58.35,-45.61,;58.35,-44.06,;59.68,-43.28,;59.67,-41.74,;61.02,-44.05,;62.35,-43.27,;63.68,-44.04,;65.01,-43.27,;65,-41.73,;63.66,-40.96,;62.33,-41.74,;66.33,-40.95,;65.56,-39.61,;67.1,-39.6,;67.67,-41.71,;67.67,-43.25,;69,-44.01,;70.33,-43.24,;70.33,-41.7,;68.99,-40.93,)|
Show InChI InChI=1S/C28H33FN6O5S/c29-20-3-1-19(2-4-20)17-30-28-31-18-25(26(34-28)32-21-5-9-23(36)10-6-21)27(37)33-22-7-11-24(12-8-22)41(38,39)35-13-15-40-16-14-35/h1-4,7-8,11-12,18,21,23,36H,5-6,9-10,13-17H2,(H,33,37)(H2,30,31,32,34)/t21-,23-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444285
PNG
(CHEMBL3093636 | US9649309, Compound UNC2082A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCCCC2)n1
Show InChI InChI=1S/C25H36N6O4S/c1-2-3-13-26-25-27-18-22(23(30-25)28-19-7-5-4-6-8-19)24(32)29-20-9-11-21(12-10-20)36(33,34)31-14-16-35-17-15-31/h9-12,18-19H,2-8,13-17H2,1H3,(H,29,32)(H2,26,27,28,30)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444275
PNG
(CHEMBL3093646)
Show SMILES CNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(28.37,-10.25,;29.71,-11.02,;31.04,-10.25,;32.37,-11.02,;33.71,-10.25,;33.7,-8.7,;35.04,-7.93,;35.03,-6.39,;36.37,-8.69,;37.7,-7.92,;39.03,-8.69,;40.36,-7.91,;40.36,-6.37,;39.01,-5.61,;37.69,-6.39,;41.69,-5.59,;40.91,-4.25,;42.46,-4.25,;43.02,-6.36,;43.02,-7.89,;44.35,-8.66,;45.68,-7.89,;45.68,-6.34,;44.34,-5.57,;32.37,-7.94,;32.37,-6.4,;31.03,-5.63,;29.7,-6.4,;28.37,-5.63,;28.37,-4.09,;27.03,-3.32,;29.7,-3.32,;31.03,-4.09,;31.04,-8.71,)|
Show InChI InChI=1S/C22H30N6O5S/c1-23-22-24-14-19(20(27-22)25-15-2-6-17(29)7-3-15)21(30)26-16-4-8-18(9-5-16)34(31,32)28-10-12-33-13-11-28/h4-5,8-9,14-15,17,29H,2-3,6-7,10-13H2,1H3,(H,26,30)(H2,23,24,25,27)/t15-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444277
PNG
(CHEMBL3093644 | US9649309, Compound UNC2081A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(n1)N1CCOCC1
Show InChI InChI=1S/C23H32N6O5S/c1-2-3-8-24-23-25-17-20(21(27-23)28-9-13-33-14-10-28)22(30)26-18-4-6-19(7-5-18)35(31,32)29-11-15-34-16-12-29/h4-7,17H,2-3,8-16H2,1H3,(H,26,30)(H,24,25,27)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444276
PNG
(CHEMBL3093645)
Show SMILES Nc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:25.26,wD:28.30,(5.87,-10.2,;7.2,-9.43,;8.54,-10.21,;9.87,-9.43,;9.87,-7.88,;11.2,-7.11,;11.19,-5.57,;12.53,-7.87,;13.86,-7.1,;15.2,-7.87,;16.53,-7.1,;16.52,-5.56,;15.18,-4.79,;13.85,-5.57,;17.85,-4.77,;17.07,-3.44,;18.62,-3.43,;19.19,-5.54,;19.18,-7.08,;20.51,-7.84,;21.85,-7.07,;21.84,-5.53,;20.5,-4.76,;8.53,-7.12,;8.53,-5.58,;7.19,-4.82,;5.87,-5.59,;4.53,-4.81,;4.53,-3.27,;3.2,-2.5,;5.87,-2.5,;7.19,-3.27,;7.2,-7.89,)|
Show InChI InChI=1S/C21H28N6O5S/c22-21-23-13-18(19(26-21)24-14-1-5-16(28)6-2-14)20(29)25-15-3-7-17(8-4-15)33(30,31)27-9-11-32-12-10-27/h3-4,7-8,13-14,16,28H,1-2,5-6,9-12H2,(H,25,29)(H3,22,23,24,26)/t14-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444255
PNG
(CHEMBL3093762)
Show SMILES CCCCNc1ncc(C(=O)N2CCC(N)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(54.73,-23.53,;56.06,-22.76,;57.39,-23.53,;58.73,-22.76,;60.06,-23.53,;61.4,-22.76,;62.73,-23.53,;64.07,-22.76,;64.06,-21.21,;65.39,-20.43,;65.39,-18.89,;66.73,-21.2,;66.73,-22.73,;68.06,-23.5,;69.39,-22.73,;70.73,-23.5,;69.39,-21.19,;68.05,-20.42,;62.73,-20.45,;62.72,-18.91,;61.39,-18.14,;60.05,-18.92,;58.72,-18.15,;58.71,-16.6,;57.38,-15.83,;60.05,-15.84,;61.38,-16.6,;61.4,-21.22,)|
Show InChI InChI=1S/C20H34N6O2/c1-2-3-10-22-20-23-13-17(19(28)26-11-8-14(21)9-12-26)18(25-20)24-15-4-6-16(27)7-5-15/h13-16,27H,2-12,21H2,1H3,(H2,22,23,24,25)/t15-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444285
PNG
(CHEMBL3093636 | US9649309, Compound UNC2082A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCCCC2)n1
Show InChI InChI=1S/C25H36N6O4S/c1-2-3-13-26-25-27-18-22(23(30-25)28-19-7-5-4-6-8-19)24(32)29-20-9-11-21(12-10-20)36(33,34)31-14-16-35-17-15-31/h9-12,18-19H,2-8,13-17H2,1H3,(H,29,32)(H2,26,27,28,30)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444263
PNG
(CHEMBL3093624)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1nc(ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1)N1CCOCC1 |r,wU:4.7,wD:1.0,(27.91,-50.35,;29.24,-51.12,;29.24,-52.66,;30.58,-53.43,;31.91,-52.66,;31.91,-51.12,;30.58,-50.35,;33.24,-53.43,;33.25,-54.97,;31.92,-55.74,;31.92,-57.28,;33.25,-58.05,;34.59,-57.28,;34.58,-55.73,;35.91,-54.96,;35.91,-53.42,;37.25,-55.72,;38.58,-54.95,;39.91,-55.72,;41.24,-54.94,;41.24,-53.4,;39.89,-52.64,;38.57,-53.42,;42.56,-52.62,;41.79,-51.28,;43.33,-51.28,;43.9,-53.39,;43.9,-54.92,;45.23,-55.68,;46.56,-54.91,;46.56,-53.37,;45.22,-52.6,;30.58,-58.05,;29.26,-57.27,;27.93,-58.03,;27.92,-59.57,;29.25,-60.35,;30.59,-59.58,)|
Show InChI InChI=1S/C25H34N6O6S/c32-20-5-1-18(2-6-20)27-23-22(17-26-25(29-23)30-9-13-36-14-10-30)24(33)28-19-3-7-21(8-4-19)38(34,35)31-11-15-37-16-12-31/h3-4,7-8,17-18,20,32H,1-2,5-6,9-16H2,(H,28,33)(H,26,27,29)/t18-,20-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444257
PNG
(CHEMBL3093760)
Show SMILES CCCCNc1ncc(C(=O)N(C)CCCC)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:19.18,wD:22.22,(20.52,-24.04,;21.85,-23.27,;23.18,-24.04,;24.52,-23.27,;25.85,-24.04,;27.19,-23.28,;28.52,-24.05,;29.86,-23.27,;29.85,-21.72,;31.18,-20.95,;31.18,-19.41,;32.52,-21.71,;32.53,-23.25,;33.85,-20.94,;35.19,-21.7,;36.52,-20.93,;37.85,-21.69,;28.52,-20.96,;28.51,-19.42,;27.18,-18.65,;25.84,-19.43,;24.51,-18.66,;24.5,-17.12,;23.17,-16.35,;25.84,-16.35,;27.17,-17.12,;27.19,-21.73,)|
Show InChI InChI=1S/C20H35N5O2/c1-4-6-12-21-20-22-14-17(19(27)25(3)13-7-5-2)18(24-20)23-15-8-10-16(26)11-9-15/h14-16,26H,4-13H2,1-3H3,(H2,21,22,23,24)/t15-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444255
PNG
(CHEMBL3093762)
Show SMILES CCCCNc1ncc(C(=O)N2CCC(N)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(54.73,-23.53,;56.06,-22.76,;57.39,-23.53,;58.73,-22.76,;60.06,-23.53,;61.4,-22.76,;62.73,-23.53,;64.07,-22.76,;64.06,-21.21,;65.39,-20.43,;65.39,-18.89,;66.73,-21.2,;66.73,-22.73,;68.06,-23.5,;69.39,-22.73,;70.73,-23.5,;69.39,-21.19,;68.05,-20.42,;62.73,-20.45,;62.72,-18.91,;61.39,-18.14,;60.05,-18.92,;58.72,-18.15,;58.71,-16.6,;57.38,-15.83,;60.05,-15.84,;61.38,-16.6,;61.4,-21.22,)|
Show InChI InChI=1S/C20H34N6O2/c1-2-3-10-22-20-23-13-17(19(28)26-11-8-14(21)9-12-26)18(25-20)24-15-4-6-16(27)7-5-15/h13-16,27H,2-12,21H2,1H3,(H2,22,23,24,25)/t15-,16-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444278
PNG
(CHEMBL3093643 | US9649309, Compound UNC2061A)
Show SMILES CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(NC2CCOCC2)n1
Show InChI InChI=1S/C24H34N6O5S/c1-2-3-10-25-24-26-17-21(22(29-24)27-19-8-13-34-14-9-19)23(31)28-18-4-6-20(7-5-18)36(32,33)30-11-15-35-16-12-30/h4-7,17,19H,2-3,8-16H2,1H3,(H,28,31)(H2,25,26,27,29)
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM50444259
PNG
(CHEMBL3093758)
Show SMILES CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:21.21,wD:24.25,(54.17,-10.17,;55.5,-9.4,;56.83,-10.17,;58.17,-9.41,;59.5,-10.18,;60.83,-9.41,;62.17,-10.18,;63.51,-9.41,;63.5,-7.86,;64.83,-7.08,;66.17,-7.85,;66.17,-9.39,;67.5,-7.07,;68.83,-7.84,;70.16,-7.07,;70.16,-5.53,;71.49,-4.75,;68.81,-4.76,;67.49,-5.54,;62.17,-7.09,;62.16,-5.55,;60.82,-4.79,;59.5,-5.57,;58.16,-4.79,;58.16,-3.25,;56.83,-2.48,;59.5,-2.48,;60.82,-3.25,;60.84,-7.86,)|
Show InChI InChI=1S/C21H28FN5O2/c1-2-3-12-23-21-24-13-18(26-20(29)14-4-6-15(22)7-5-14)19(27-21)25-16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12H2,1H3,(H,26,29)(H2,23,24,25,27)/t16-,17-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))		BDBM50444264
PNG
(CHEMBL3093634)
Show SMILES CN(C)c1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(5.16,-56.77,;6.49,-57.54,;6.49,-59.08,;7.82,-56.77,;9.16,-57.54,;10.5,-56.77,;10.49,-55.22,;11.82,-54.45,;11.81,-52.91,;13.16,-55.21,;14.49,-54.44,;15.82,-55.21,;17.15,-54.43,;17.14,-52.89,;15.8,-52.13,;14.48,-52.91,;18.47,-52.11,;17.7,-50.77,;19.24,-50.77,;19.81,-52.88,;19.81,-54.41,;21.14,-55.17,;22.47,-54.4,;22.47,-52.86,;21.13,-52.09,;9.16,-54.46,;9.15,-52.92,;7.82,-52.15,;6.49,-52.92,;5.15,-52.15,;5.15,-50.61,;3.82,-49.84,;6.49,-49.84,;7.82,-50.61,;7.83,-55.23,)|
Show InChI InChI=1S/C23H32N6O5S/c1-28(2)23-24-15-20(21(27-23)25-16-3-7-18(30)8-4-16)22(31)26-17-5-9-19(10-6-17)35(32,33)29-11-13-34-14-12-29/h5-6,9-10,15-16,18,30H,3-4,7-8,11-14H2,1-2H3,(H,26,31)(H,24,25,27)/t16-,18-
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Eshelman School of Pharmacy�Department of Pharmacology�Lineberger Compreh

Curated by ChEMBL


Assay Description
Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...

J Med Chem 56: 9693-700 (2014)


Article DOI: 10.1021/jm4013888
BindingDB Entry DOI: 10.7270/Q21G0NQ1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%