Affinity Data by PubMed id=24256330

PubMed code 24256330

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50425555 (CHEMBL2313653) Show SMILES Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC2 (unknown origin)				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50011368 (CHEMBL3260989) Show SMILES [I-].COCCC[n+]1c(C)csc1Nc1c(C)cc(C)cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC2 (unknown origin)				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50326557 ((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activity				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50011357 (CHEMBL3260988) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50011360 (CHEMBL3260990) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50011358 (CHEMBL1372282) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Rap guanine nucleotide exchange factor 4 (Homo sapiens (Human))	BDBM50384264 (CHEMBL316966) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of EPAC2 (unknown origin)				J Med Chem 57: 3651-65 (2014) Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%