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PubMed code 24262886

Compile data set for download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50402251
PNG
(CHEMBL2204791)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)C(C)(C)C
Show InChI InChI=1S/C13H17N3O2S/c1-7-10(19-12(15-7)16-8(2)17)9-6-14-11(18-9)13(3,4)5/h6H,1-5H3,(H,15,16,17)
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n/an/a 3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444445
PNG
(CHEMBL3092373)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(C)(C)CO)no1
Show InChI InChI=1S/C13H18N4O3S/c1-7-10(21-12(14-7)15-8(2)19)11-16-9(17-20-11)5-13(3,4)6-18/h18H,5-6H2,1-4H3,(H,14,15,19)
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n/an/a 7.20n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444447
PNG
(CHEMBL3092365)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C(C)(C)C
Show InChI InChI=1S/C12H16N4O2S/c1-6-8(19-11(13-6)14-7(2)17)9-15-10(16-18-9)12(3,4)5/h1-5H3,(H,13,14,17)
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n/an/a 14n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444444
PNG
(CHEMBL3092375)
Show SMILES CC(O)C(C)(C)Cc1noc(n1)-c1sc(NC(C)=O)nc1C
Show InChI InChI=1S/C14H20N4O3S/c1-7-11(22-13(15-7)16-9(3)20)12-17-10(18-21-12)6-14(4,5)8(2)19/h8,19H,6H2,1-5H3,(H,15,16,20)
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n/an/a 17n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444446
PNG
(CHEMBL3092367)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(F)(F)F)no1
Show InChI InChI=1S/C10H9F3N4O2S/c1-4-7(20-9(14-4)15-5(2)18)8-16-6(17-19-8)3-10(11,12)13/h3H2,1-2H3,(H,14,15,18)
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n/an/a 28n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444443
PNG
(CHEMBL3092376)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)N1CCCC(O)C1
Show InChI InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)
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n/an/a 29n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444453
PNG
(CHEMBL3092369)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C(C)(C)CO
Show InChI InChI=1S/C12H16N4O3S/c1-6-8(20-11(13-6)14-7(2)18)9-15-10(16-19-9)12(3,4)5-17/h17H,5H2,1-4H3,(H,13,14,18)
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n/an/a 52n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444440
PNG
(CHEMBL3092362)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C1CCOC1
Show InChI InChI=1S/C12H14N4O3S/c1-6-9(20-12(13-6)14-7(2)17)11-15-10(16-19-11)8-3-4-18-5-8/h8H,3-5H2,1-2H3,(H,13,14,17)
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n/an/a 57n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444450
PNG
(CHEMBL3092372)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C(C)(C)CCO
Show InChI InChI=1S/C13H18N4O3S/c1-7-9(21-12(14-7)15-8(2)19)10-16-11(17-20-10)13(3,4)5-6-18/h18H,5-6H2,1-4H3,(H,14,15,19)
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n/an/a 62n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444452
PNG
(CHEMBL3092370)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(C)(C)O)no1
Show InChI InChI=1S/C12H16N4O3S/c1-6-9(20-11(13-6)14-7(2)17)10-15-8(16-19-10)5-12(3,4)18/h18H,5H2,1-4H3,(H,13,14,17)
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n/an/a 68n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444448
PNG
(CHEMBL3092361)
Show SMILES COCC(C)(C)Cc1noc(n1)-c1sc(NC(C)=O)nc1C
Show InChI InChI=1S/C14H20N4O3S/c1-8-11(22-13(15-8)16-9(2)19)12-17-10(18-21-12)6-14(3,4)7-20-5/h6-7H2,1-5H3,(H,15,16,19)
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n/an/a 68n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444441
PNG
(CHEMBL3092366)
Show SMILES Cc1nc(N)sc1-c1nc(no1)C(C)(C)C
Show InChI InChI=1S/C10H14N4OS/c1-5-6(16-9(11)12-5)7-13-8(14-15-7)10(2,3)4/h1-4H3,(H2,11,12)
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n/an/a 68n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444442
PNG
(CHEMBL3092364)
Show SMILES Cc1nc(N)sc1-c1cnc(o1)C(C)(C)C
Show InChI InChI=1S/C11H15N3OS/c1-6-8(16-10(12)14-6)7-5-13-9(15-7)11(2,3)4/h5H,1-4H3,(H2,12,14)
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n/an/a 81n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444439
PNG
(CHEMBL3092363)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)N1CCOCC1
Show InChI InChI=1S/C12H15N5O3S/c1-7-9(21-12(13-7)14-8(2)18)10-15-11(16-20-10)17-3-5-19-6-4-17/h3-6H2,1-2H3,(H,13,14,18)
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n/an/a 100n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444451
PNG
(CHEMBL3092371)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CCCO)no1
Show InChI InChI=1S/C11H14N4O3S/c1-6-9(19-11(12-6)13-7(2)17)10-14-8(15-18-10)4-3-5-16/h16H,3-5H2,1-2H3,(H,12,13,17)
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n/an/a 121n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Mus musculus (Mouse))
BDBM50444444
PNG
(CHEMBL3092375)
Show SMILES CC(O)C(C)(C)Cc1noc(n1)-c1sc(NC(C)=O)nc1C
Show InChI InChI=1S/C14H20N4O3S/c1-7-11(22-13(15-7)16-9(3)20)12-17-10(18-21-12)6-14(4,5)8(2)19/h8,19H,6H2,1-5H3,(H,15,16,20)
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n/an/a 155n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444454
PNG
(CHEMBL3092368)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CCO)no1
Show InChI InChI=1S/C10H12N4O3S/c1-5-8(18-10(11-5)12-6(2)16)9-13-7(3-4-15)14-17-9/h15H,3-4H2,1-2H3,(H,11,12,16)
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n/an/a 158n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Mus musculus (Mouse))
BDBM50444445
PNG
(CHEMBL3092373)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(C)(C)CO)no1
Show InChI InChI=1S/C13H18N4O3S/c1-7-10(21-12(14-7)15-8(2)19)11-16-9(17-20-11)5-13(3,4)6-18/h18H,5-6H2,1-4H3,(H,14,15,19)
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n/an/a 191n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50444449
PNG
(CHEMBL3092374)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CCC(C)(C)O)no1
Show InChI InChI=1S/C13H18N4O3S/c1-7-10(21-12(14-7)15-8(2)18)11-16-9(17-20-11)5-6-13(3,4)19/h19H,5-6H2,1-4H3,(H,14,15,18)
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n/an/a 203n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATP


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Mus musculus (Mouse))
BDBM50444447
PNG
(CHEMBL3092365)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C(C)(C)C
Show InChI InChI=1S/C12H16N4O2S/c1-6-8(19-11(13-6)14-7(2)17)9-15-10(16-18-9)12(3,4)5/h1-5H3,(H,13,14,17)
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n/an/a 231n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Mus musculus (Mouse))
BDBM50444446
PNG
(CHEMBL3092367)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(F)(F)F)no1
Show InChI InChI=1S/C10H9F3N4O2S/c1-4-7(20-9(14-4)15-5(2)18)8-16-6(17-19-8)3-10(11,12)13/h3H2,1-2H3,(H,14,15,18)
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n/an/a 278n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Mus musculus (Mouse))
BDBM50444443
PNG
(CHEMBL3092376)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)N1CCCC(O)C1
Show InChI InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)
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n/an/a 294n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Mus musculus (Mouse))
BDBM50444440
PNG
(CHEMBL3092362)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C1CCOC1
Show InChI InChI=1S/C12H14N4O3S/c1-6-9(20-12(13-6)14-7(2)17)11-15-10(16-19-11)8-3-4-18-5-8/h8H,3-5H2,1-2H3,(H,13,14,17)
PDB

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n/an/a 558n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Bioorg Med Chem 21: 7578-83 (2013)


Article DOI: 10.1016/j.bmc.2013.10.042
BindingDB Entry DOI: 10.7270/Q27082W9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%