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PubMed code 24292338

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444781
PNG
(CHEMBL3099118)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-22(25(18-7-3-2-4-8-18)27-28(17)16-24(29)30)15-19-9-5-6-10-23(19)33(31,32)21-13-11-20(26)12-14-21/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 in human RBC assessed as inhibition of PGD2-induced eosinophil shape change

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50434451
PNG
(CHEMBL2385124)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c2cc(F)ccc2n1CC(O)=O
Show InChI InChI=1S/C24H20FNO4S/c1-16-20(21-14-18(25)11-12-22(21)26(16)15-24(27)28)13-17-7-5-6-10-23(17)31(29,30)19-8-3-2-4-9-19/h2-12,14H,13,15H2,1H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444781
PNG
(CHEMBL3099118)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-22(25(18-7-3-2-4-8-18)27-28(17)16-24(29)30)15-19-9-5-6-10-23(19)33(31,32)21-13-11-20(26)12-14-21/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444782
PNG
(CHEMBL3099133)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H22N2O4S/c1-18-22(25(19-10-4-2-5-11-19)26-27(18)17-24(28)29)16-20-12-8-9-15-23(20)32(30,31)21-13-6-3-7-14-21/h2-15H,16-17H2,1H3,(H,28,29)
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n/an/a 40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444782
PNG
(CHEMBL3099133)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H22N2O4S/c1-18-22(25(19-10-4-2-5-11-19)26-27(18)17-24(28)29)16-20-12-8-9-15-23(20)32(30,31)21-13-6-3-7-14-21/h2-15H,16-17H2,1H3,(H,28,29)
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n/an/a 50n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 in human RBC assessed as inhibition of PGD2-induced eosinophil shape change

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444781
PNG
(CHEMBL3099118)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-22(25(18-7-3-2-4-8-18)27-28(17)16-24(29)30)15-19-9-5-6-10-23(19)33(31,32)21-13-11-20(26)12-14-21/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 50n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444780
PNG
(CHEMBL3099129)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H21F3N2O4S/c1-17-22(15-18-8-5-6-13-23(18)36(34,35)21-11-3-2-4-12-21)25(30-31(17)16-24(32)33)19-9-7-10-20(14-19)26(27,28)29/h2-14H,15-16H2,1H3,(H,32,33)
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n/an/a 50n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444806
PNG
(CHEMBL3099106)
Show SMILES COc1ccc(c(Cc2c(C)n(CC(O)=O)nc2-c2ccccc2)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H24N2O5S/c1-18-23(26(19-9-5-3-6-10-19)27-28(18)17-25(29)30)16-20-15-21(33-2)13-14-24(20)34(31,32)22-11-7-4-8-12-22/h3-15H,16-17H2,1-2H3,(H,29,30)
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n/an/a 60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444781
PNG
(CHEMBL3099118)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(F)cc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-22(25(18-7-3-2-4-8-18)27-28(17)16-24(29)30)15-19-9-5-6-10-23(19)33(31,32)21-13-11-20(26)12-14-21/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444804
PNG
(CHEMBL3099108)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2c(C)cccc2C)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H26N2O4S/c1-18-10-9-11-19(2)27(18)34(32,33)24-15-8-7-14-22(24)16-23-20(3)29(17-25(30)31)28-26(23)21-12-5-4-6-13-21/h4-15H,16-17H2,1-3H3,(H,30,31)
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n/an/a 70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444811
PNG
(CHEMBL3099132)
Show SMILES COc1ccc(Cc2c(C)n(CC(O)=O)nc2-c2ccccc2)c(c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H24N2O5S/c1-18-23(26(19-9-5-3-6-10-19)27-28(18)17-25(29)30)15-20-13-14-21(33-2)16-24(20)34(31,32)22-11-7-4-8-12-22/h3-14,16H,15,17H2,1-2H3,(H,29,30)
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n/an/a 70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444786
PNG
(CHEMBL3099097)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1cncnc1
Show InChI InChI=1S/C23H20N4O4S/c1-16-20(23(18-12-24-15-25-13-18)26-27(16)14-22(28)29)11-17-7-5-6-10-21(17)32(30,31)19-8-3-2-4-9-19/h2-10,12-13,15H,11,14H2,1H3,(H,28,29)
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n/an/a 87n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444794
PNG
(CHEMBL3099119)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(Cl)cc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21ClN2O4S/c1-17-22(25(18-7-3-2-4-8-18)27-28(17)16-24(29)30)15-19-9-5-6-10-23(19)33(31,32)21-13-11-20(26)12-14-21/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 110n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444813
PNG
(CHEMBL3099130)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2F)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-20(25(18-9-3-2-4-10-18)27-28(17)16-24(29)30)15-19-11-5-7-13-22(19)33(31,32)23-14-8-6-12-21(23)26/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 110n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444789
PNG
(CHEMBL3099124)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)Cc2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24N2O4S/c1-19-23(26(21-12-6-3-7-13-21)27-28(19)17-25(29)30)16-22-14-8-9-15-24(22)33(31,32)18-20-10-4-2-5-11-20/h2-15H,16-18H2,1H3,(H,29,30)
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n/an/a 110n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444807
PNG
(CHEMBL3099105)
Show SMILES Cc1c(Cc2cc(F)ccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-22(25(18-8-4-2-5-9-18)27-28(17)16-24(29)30)15-19-14-20(26)12-13-23(19)33(31,32)21-10-6-3-7-11-21/h2-14H,15-16H2,1H3,(H,29,30)
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n/an/a 160n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444793
PNG
(CHEMBL3099120)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C26H24N2O5S/c1-18-23(26(19-8-4-3-5-9-19)27-28(18)17-25(29)30)16-20-10-6-7-11-24(20)34(31,32)22-14-12-21(33-2)13-15-22/h3-15H,16-17H2,1-2H3,(H,29,30)
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n/an/a 200n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444803
PNG
(CHEMBL3099109)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2cccc(F)c2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21FN2O4S/c1-17-22(25(18-8-3-2-4-9-18)27-28(17)16-24(29)30)14-19-10-5-6-13-23(19)33(31,32)21-12-7-11-20(26)15-21/h2-13,15H,14,16H2,1H3,(H,29,30)
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n/an/a 200n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444805
PNG
(CHEMBL3099107)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2C)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24N2O4S/c1-18-10-6-8-14-23(18)33(31,32)24-15-9-7-13-21(24)16-22-19(2)28(17-25(29)30)27-26(22)20-11-4-3-5-12-20/h3-15H,16-17H2,1-2H3,(H,29,30)
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n/an/a 220n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444802
PNG
(CHEMBL3099110)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2cccc(Cl)c2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H21ClN2O4S/c1-17-22(25(18-8-3-2-4-9-18)27-28(17)16-24(29)30)14-19-10-5-6-13-23(19)33(31,32)21-12-7-11-20(26)15-21/h2-13,15H,14,16H2,1H3,(H,29,30)
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n/an/a 230n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444782
PNG
(CHEMBL3099133)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H22N2O4S/c1-18-22(25(19-10-4-2-5-11-19)26-27(18)17-24(28)29)16-20-12-8-9-15-23(20)32(30,31)21-13-6-3-7-14-21/h2-15H,16-17H2,1H3,(H,28,29)
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n/an/a 240n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444788
PNG
(CHEMBL3098141)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2cccc3cccnc23)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C28H23N3O4S/c1-19-23(27(20-9-3-2-4-10-20)30-31(19)18-26(32)33)17-22-11-5-6-14-24(22)36(34,35)25-15-7-12-21-13-8-16-29-28(21)25/h2-16H,17-18H2,1H3,(H,32,33)
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n/an/a 270n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444785
PNG
(CHEMBL3099098)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccncc1
Show InChI InChI=1S/C24H21N3O4S/c1-17-21(24(18-11-13-25-14-12-18)26-27(17)16-23(28)29)15-19-7-5-6-10-22(19)32(30,31)20-8-3-2-4-9-20/h2-14H,15-16H2,1H3,(H,28,29)
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n/an/a 300n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444795
PNG
(CHEMBL3099117)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(C)c(C)c2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H26N2O4S/c1-18-13-14-23(15-19(18)2)34(32,33)25-12-8-7-11-22(25)16-24-20(3)29(17-26(30)31)28-27(24)21-9-5-4-6-10-21/h4-15H,16-17H2,1-3H3,(H,30,31)
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n/an/a 380n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444810
PNG
(CHEMBL3099102)
Show SMILES Cc1c(Cc2ccc(cc2S(=O)(=O)c2ccccc2)C(O)=O)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H22N2O6S/c1-17-22(25(18-8-4-2-5-9-18)27-28(17)16-24(29)30)14-19-12-13-20(26(31)32)15-23(19)35(33,34)21-10-6-3-7-11-21/h2-13,15H,14,16H2,1H3,(H,29,30)(H,31,32)
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n/an/a 400n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444783
PNG
(CHEMBL3099101)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)C(=O)N1CCOCC1
Show InChI InChI=1S/C24H25N3O6S/c1-17-20(23(25-27(17)16-22(28)29)24(30)26-11-13-33-14-12-26)15-18-7-5-6-10-21(18)34(31,32)19-8-3-2-4-9-19/h2-10H,11-16H2,1H3,(H,28,29)
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n/an/a 440n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444812
PNG
(CHEMBL3099131)
Show SMILES Cc1c(Cc2ccc(cc2S(=O)(=O)c2ccccc2)C(F)(F)F)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H21F3N2O4S/c1-17-22(25(18-8-4-2-5-9-18)30-31(17)16-24(32)33)14-19-12-13-20(26(27,28)29)15-23(19)36(34,35)21-10-6-3-7-11-21/h2-13,15H,14,16H2,1H3,(H,32,33)
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n/an/a 450n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444791
PNG
(CHEMBL3099122)
Show SMILES CN(C)c1ccc(cc1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C27H27N3O4S/c1-19-24(27(20-9-5-4-6-10-20)28-30(19)18-26(31)32)17-21-11-7-8-12-25(21)35(33,34)23-15-13-22(14-16-23)29(2)3/h4-16H,17-18H2,1-3H3,(H,31,32)
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n/an/a 450n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444792
PNG
(CHEMBL3099121)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H21F3N2O5S/c1-17-22(25(18-7-3-2-4-8-18)30-31(17)16-24(32)33)15-19-9-5-6-10-23(19)37(34,35)21-13-11-20(12-14-21)36-26(27,28)29/h2-14H,15-16H2,1H3,(H,32,33)
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n/an/a 470n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444782
PNG
(CHEMBL3099133)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C25H22N2O4S/c1-18-22(25(19-10-4-2-5-11-19)26-27(18)17-24(28)29)16-20-12-8-9-15-23(20)32(30,31)21-13-6-3-7-14-21/h2-15H,16-17H2,1H3,(H,28,29)
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n/an/a 520n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444799
PNG
(CHEMBL3099113)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C26H24N2O5S/c1-18-23(26(19-9-4-3-5-10-19)27-28(18)17-25(29)30)15-20-11-6-7-14-24(20)34(31,32)22-13-8-12-21(16-22)33-2/h3-14,16H,15,17H2,1-2H3,(H,29,30)
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n/an/a 520n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444796
PNG
(CHEMBL3099116)
Show SMILES Cc1c(Cc2ccccc2S(=O)c2ccc(C)c(C)c2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H26N2O3S/c1-18-13-14-23(15-19(18)2)33(32)25-12-8-7-11-22(25)16-24-20(3)29(17-26(30)31)28-27(24)21-9-5-4-6-10-21/h4-15H,16-17H2,1-3H3,(H,30,31)
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n/an/a 720n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444801
PNG
(CHEMBL3099111)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2cccc(c2)C(F)(F)F)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H21F3N2O4S/c1-17-22(25(18-8-3-2-4-9-18)30-31(17)16-24(32)33)14-19-10-5-6-13-23(19)36(34,35)21-12-7-11-20(15-21)26(27,28)29/h2-13,15H,14,16H2,1H3,(H,32,33)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444787
PNG
(CHEMBL3099126)
Show SMILES Cc1nn(CC(O)=O)c(C)c1Cc1ccccc1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O4S/c1-14-18(15(2)22(21-14)13-20(23)24)12-16-8-6-7-11-19(16)27(25,26)17-9-4-3-5-10-17/h3-11H,12-13H2,1-2H3,(H,23,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444808
PNG
(CHEMBL3099104)
Show SMILES Cc1c(Cc2ccncc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H21N3O4S/c1-17-21(24(18-8-4-2-5-9-18)26-27(17)16-23(28)29)14-19-12-13-25-15-22(19)32(30,31)20-10-6-3-7-11-20/h2-13,15H,14,16H2,1H3,(H,28,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444797
PNG
(CHEMBL3099115)
Show SMILES Cc1c(Cc2ccccc2Sc2ccc(C)c(C)c2)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C27H26N2O2S/c1-18-13-14-23(15-19(18)2)32-25-12-8-7-11-22(25)16-24-20(3)29(17-26(30)31)28-27(24)21-9-5-4-6-10-21/h4-15H,16-17H2,1-3H3,(H,30,31)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444809
PNG
(CHEMBL3099103)
Show SMILES COC(=O)c1ccc(Cc2c(C)n(CC(O)=O)nc2-c2ccccc2)c(c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H24N2O6S/c1-18-23(26(19-9-5-3-6-10-19)28-29(18)17-25(30)31)15-20-13-14-21(27(32)35-2)16-24(20)36(33,34)22-11-7-4-8-12-22/h3-14,16H,15,17H2,1-2H3,(H,30,31)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444790
PNG
(CHEMBL3099123)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccc(cc2)S(C)(=O)=O)c(nn1CC(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H24N2O6S2/c1-18-23(26(19-8-4-3-5-9-19)27-28(18)17-25(29)30)16-20-10-6-7-11-24(20)36(33,34)22-14-12-21(13-15-22)35(2,31)32/h3-15H,16-17H2,1-2H3,(H,29,30)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444784
PNG
(CHEMBL3099099)
Show SMILES Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(nn1CC(O)=O)-c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C25H20Cl2N2O4S/c1-16-20(25(28-29(16)15-24(30)31)21-14-18(26)11-12-22(21)27)13-17-7-5-6-10-23(17)34(32,33)19-8-3-2-4-9-19/h2-12,14H,13,15H2,1H3,(H,30,31)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444800
PNG
(CHEMBL3099112)
Show SMILES COc1cccc(Sc2ccccc2Cc2c(C)n(CC(O)=O)nc2-c2ccccc2)c1
Show InChI InChI=1S/C26H24N2O3S/c1-18-23(26(19-9-4-3-5-10-19)27-28(18)17-25(29)30)15-20-11-6-7-14-24(20)32-22-13-8-12-21(16-22)31-2/h3-14,16H,15,17H2,1-2H3,(H,29,30)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50444798
PNG
(CHEMBL3099114)
Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)c1ccccc1Cc1c(C)n(CC(O)=O)nc1-c1ccccc1
Show InChI InChI=1S/C28H27N3O5S/c1-19-24(27(20-10-5-4-6-11-20)29-31(19)18-26(32)33)17-21-12-7-8-15-25(21)37(35,36)23-14-9-13-22(16-23)28(34)30(2)3/h4-16H,17-18H2,1-3H3,(H,32,33)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 (unknown origin) expressed in CHO.K1 cells assessed as inhibition of PGD2-induced [35S]-GTPgammaS binding after 2 hrs by...

Eur J Med Chem 71: 168-84 (2014)


Article DOI: 10.1016/j.ejmech.2013.10.072
BindingDB Entry DOI: 10.7270/Q2GB25HZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%