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PubMed code 24479418

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 970n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ALK (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 1.94E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1R (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 2.19E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ALK (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 3.03E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant FAK (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 3.12E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MET (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a 3.31E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1R (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a 3.38E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ALK (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 3.89E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant aurora kinase B (unknown origin) using tetra(LRRWSLG) as substrate assessed as incorporation of [gamma-33P]-ATP into substr...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 4.56E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant FAK (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase NEK6


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 7.72E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK6 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a 7.78E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant FAK (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 1.18E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1R (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 1.31E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 1.47E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK2 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a 1.47E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 2.03E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PIM1 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 2.17E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PLK1 (unknown origin) using casein as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric ...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
NUAK family SNF1-like kinase 1


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 2.94E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ARK5 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 2.99E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK2 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 4.03E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MET (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 (unknown origin) using GSK3 (14 to 27) as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by rad...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 6.10E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant aurora kinase B (unknown origin) using tetra(LRRWSLG) as substrate assessed as incorporation of [gamma-33P]-ATP into substr...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 6.26E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PIM1 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 7.32E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 (unknown origin) using GSK3 (14 to 27) as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by rad...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase NEK6


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 9.08E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK6 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase NEK6


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK6 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MET (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PLK1 (unknown origin) using casein as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric ...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK2 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PIM1 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 (unknown origin) using GSK3 (14 to 27) as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by rad...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Protein kinase N1


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PRK1 (unknown origin) using casein as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric ...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
NUAK family SNF1-like kinase 1


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ARK5 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PLK1 (unknown origin) using casein as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric ...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50446565
PNG
(CHEMBL3109402)
Show SMILES COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,c:25|
Show InChI InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1
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Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant aurora kinase B (unknown origin) using tetra(LRRWSLG) as substrate assessed as incorporation of [gamma-33P]-ATP into substr...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
NUAK family SNF1-like kinase 1


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ARK5 (unknown origin) assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric assay


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Protein kinase N1


(Homo sapiens (Human))
BDBM50446564
PNG
(CHEMBL3109404)
Show SMILES COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 |r,c:24|
Show InChI InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PRK1 (unknown origin) using casein as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric ...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
Protein kinase N1


(Homo sapiens (Human))
BDBM50446566
PNG
(CHEMBL3109401)
Show SMILES CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O |r,w:5.5,c:26|
Show InChI InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PRK1 (unknown origin) using casein as substrate assessed as incorporation of [gamma-33P]-ATP into substrate by radiometric ...


J Nat Prod 77: 218-26 (2014)


Article DOI: 10.1021/np400633m
BindingDB Entry DOI: 10.7270/Q24F1S7C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%