Found 43 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446585
(CHEMBL3116440)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16| Show InChI InChI=1S/C35H34FN5O6/c1-22-6-9-24(10-7-22)41-34(43)26(33(42)39-35(41)44)21-38-23-8-11-30(27(36)18-23)47-29-12-13-37-28-20-32(31(45-2)19-25(28)29)46-17-5-16-40-14-3-4-15-40/h6-13,18-21,43H,3-5,14-17H2,1-2H3,(H,39,42,44) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446615
(CHEMBL3116243)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16| Show InChI InChI=1S/C37H38FN5O6/c1-23-5-8-26(9-6-23)43-36(45)28(35(44)41-37(43)46)22-40-25-7-10-32(29(38)19-25)49-31-11-14-39-30-21-34(33(47-3)20-27(30)31)48-18-4-15-42-16-12-24(2)13-17-42/h5-11,14,19-22,24,45H,4,12-13,15-18H2,1-3H3,(H,41,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
(FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446600
(CHEMBL3116222)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16| Show InChI InChI=1S/C35H34FN5O7/c1-22-4-7-24(8-5-22)41-34(43)26(33(42)39-35(41)44)21-38-23-6-9-30(27(36)18-23)48-29-10-11-37-28-20-32(31(45-2)19-25(28)29)47-15-3-12-40-13-16-46-17-14-40/h4-11,18-21,43H,3,12-17H2,1-2H3,(H,39,42,44) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446607
(CHEMBL3116441)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4c(C)cccc4C)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16,(56.48,-11.29,;57.81,-10.52,;59.15,-11.29,;60.48,-10.52,;61.81,-11.29,;63.14,-10.51,;63.13,-8.97,;64.46,-8.2,;65.79,-8.97,;67.12,-8.19,;67.11,-6.65,;65.76,-5.89,;64.44,-6.67,;63.1,-5.91,;68.44,-5.87,;69.78,-6.63,;71.1,-5.85,;72.45,-6.62,;72.45,-8.16,;73.77,-5.85,;75.11,-6.61,;76.43,-5.84,;76.42,-4.3,;77.77,-6.6,;77.78,-8.15,;76.44,-8.92,;75.11,-8.15,;73.78,-8.93,;73.77,-4.31,;75.1,-3.53,;72.43,-3.54,;71.09,-4.32,;69.76,-3.55,;64.47,-11.27,;64.48,-12.82,;63.15,-13.6,;61.81,-12.83,;60.48,-13.61,;59.14,-12.84,;57.81,-13.61,;56.48,-12.84,;55.14,-13.6,;53.81,-12.83,;52.48,-13.6,;51.07,-12.99,;50.04,-14.13,;50.81,-15.46,;52.32,-15.14,)| Show InChI InChI=1S/C36H36FN5O6/c1-22-8-6-9-23(2)33(22)42-35(44)26(34(43)40-36(42)45)21-39-24-10-11-30(27(37)18-24)48-29-12-13-38-28-20-32(31(46-3)19-25(28)29)47-17-7-16-41-14-4-5-15-41/h6,8-13,18-21,44H,4-5,7,14-17H2,1-3H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446604
(CHEMBL3116218)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)c(Cl)c4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16| Show InChI InChI=1S/C34H30ClF2N5O6/c1-46-30-17-22-27(18-31(30)47-14-4-13-41-11-2-3-12-41)38-10-9-28(22)48-29-8-5-20(15-26(29)37)39-19-23-32(43)40-34(45)42(33(23)44)21-6-7-25(36)24(35)16-21/h5-10,15-19,44H,2-4,11-14H2,1H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446623
(CHEMBL3116444)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16| Show InChI InChI=1S/C36H36FN5O6/c1-23-7-10-25(11-8-23)42-35(44)27(34(43)40-36(42)45)22-39-24-9-12-31(28(37)19-24)48-30-13-14-38-29-21-33(32(46-2)20-26(29)30)47-18-6-17-41-15-4-3-5-16-41/h7-14,19-22,44H,3-6,15-18H2,1-2H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446592
(CHEMBL3116230)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16| Show InChI InChI=1S/C36H37FN6O6/c1-23-5-8-25(9-6-23)43-35(45)27(34(44)40-36(43)46)22-39-24-7-10-31(28(37)19-24)49-30-11-12-38-29-21-33(32(47-3)20-26(29)30)48-18-4-13-42-16-14-41(2)15-17-42/h5-12,19-22,45H,4,13-18H2,1-3H3,(H,40,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446606
(CHEMBL3116442)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16| Show InChI InChI=1S/C34H31F2N5O6/c1-45-30-18-24-27(19-31(30)46-16-4-15-40-13-2-3-14-40)37-12-11-28(24)47-29-10-7-22(17-26(29)36)38-20-25-32(42)39-34(44)41(33(25)43)23-8-5-21(35)6-9-23/h5-12,17-20,43H,2-4,13-16H2,1H3,(H,39,42,44) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446614
(CHEMBL3116244)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4c(C)cccc4C)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16,(58.92,-12.23,;60.25,-11.46,;61.59,-12.23,;62.92,-11.46,;64.25,-12.22,;65.58,-11.45,;65.57,-9.91,;66.9,-9.13,;68.23,-9.9,;69.56,-9.12,;69.55,-7.58,;68.2,-6.82,;66.88,-7.6,;65.54,-6.84,;70.88,-6.8,;72.22,-7.56,;73.55,-6.78,;74.89,-7.55,;74.89,-9.09,;76.21,-6.78,;77.55,-7.54,;78.87,-6.77,;78.86,-5.23,;80.21,-7.53,;80.22,-9.08,;78.88,-9.85,;77.55,-9.09,;76.22,-9.86,;76.21,-5.24,;77.54,-4.47,;74.87,-4.48,;73.54,-5.25,;72.2,-4.49,;66.91,-12.21,;66.92,-13.76,;65.59,-14.53,;64.25,-13.76,;62.92,-14.54,;61.59,-13.77,;60.25,-14.54,;58.92,-13.77,;57.58,-14.54,;56.25,-13.77,;54.92,-14.54,;53.59,-13.76,;52.26,-14.52,;52.26,-16.06,;50.92,-16.82,;53.59,-16.84,;54.93,-16.07,)| Show InChI InChI=1S/C38H40FN5O6/c1-23-12-16-43(17-13-23)15-6-18-49-34-21-30-27(20-33(34)48-4)31(11-14-40-30)50-32-10-9-26(19-29(32)39)41-22-28-36(45)42-38(47)44(37(28)46)35-24(2)7-5-8-25(35)3/h5,7-11,14,19-23,46H,6,12-13,15-18H2,1-4H3,(H,42,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446599
(CHEMBL3116223)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4c(C)cccc4C)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16,(61.58,-9.6,;62.91,-8.83,;64.25,-9.6,;65.58,-8.83,;66.91,-9.59,;68.24,-8.82,;68.23,-7.28,;69.56,-6.5,;70.89,-7.27,;72.22,-6.49,;72.21,-4.95,;70.86,-4.19,;69.54,-4.97,;68.2,-4.21,;73.54,-4.17,;74.88,-4.93,;76.21,-4.16,;77.55,-4.92,;77.55,-6.46,;78.87,-4.15,;80.21,-4.92,;81.53,-4.14,;81.52,-2.6,;82.87,-4.9,;82.88,-6.45,;81.54,-7.22,;80.21,-6.46,;78.88,-7.23,;78.87,-2.61,;80.2,-1.84,;77.53,-1.85,;76.2,-2.62,;74.86,-1.86,;69.57,-9.58,;69.58,-11.13,;68.25,-11.9,;66.91,-11.13,;65.58,-11.91,;64.25,-11.14,;62.91,-11.91,;61.58,-11.14,;60.24,-11.91,;58.91,-11.14,;57.58,-11.91,;56.25,-11.13,;54.92,-11.89,;54.92,-13.43,;56.25,-14.21,;57.59,-13.44,)| Show InChI InChI=1S/C36H36FN5O7/c1-22-6-4-7-23(2)33(22)42-35(44)26(34(43)40-36(42)45)21-39-24-8-9-30(27(37)18-24)49-29-10-11-38-28-20-32(31(46-3)19-25(28)29)48-15-5-12-41-13-16-47-17-14-41/h4,6-11,18-21,44H,5,12-17H2,1-3H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446613
(CHEMBL3116434)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16| Show InChI InChI=1S/C36H35F2N5O6/c1-22-11-15-42(16-12-22)14-3-17-48-33-20-29-26(19-32(33)47-2)30(10-13-39-29)49-31-9-6-24(18-28(31)38)40-21-27-34(44)41-36(46)43(35(27)45)25-7-4-23(37)5-8-25/h4-10,13,18-22,45H,3,11-12,14-17H2,1-2H3,(H,41,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446619
(CHEMBL3116239)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)c(Cl)c4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16| Show InChI InChI=1S/C35H32ClF2N5O6/c1-47-31-18-23-28(19-32(31)48-15-5-14-42-12-3-2-4-13-42)39-11-10-29(23)49-30-9-6-21(16-27(30)38)40-20-24-33(44)41-35(46)43(34(24)45)22-7-8-26(37)25(36)17-22/h6-11,16-20,45H,2-5,12-15H2,1H3,(H,41,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446588
(CHEMBL3116234)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)c(Cl)c4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16| Show InChI InChI=1S/C35H33ClF2N6O6/c1-42-11-13-43(14-12-42)10-3-15-49-32-19-28-23(18-31(32)48-2)29(8-9-39-28)50-30-7-4-21(16-27(30)38)40-20-24-33(45)41-35(47)44(34(24)46)22-5-6-26(37)25(36)17-22/h4-9,16-20,46H,3,10-15H2,1-2H3,(H,41,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446590
(CHEMBL3116232)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16| Show InChI InChI=1S/C35H34F2N6O6/c1-41-13-15-42(16-14-41)12-3-17-48-32-20-28-25(19-31(32)47-2)29(10-11-38-28)49-30-9-6-23(18-27(30)37)39-21-26-33(44)40-35(46)43(34(26)45)24-7-4-22(36)5-8-24/h4-11,18-21,45H,3,12-17H2,1-2H3,(H,40,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446593
(CHEMBL3116229)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16| Show InChI InChI=1S/C35H35FN6O6/c1-40-14-16-41(17-15-40)13-6-18-47-32-21-28-25(20-31(32)46-2)29(11-12-37-28)48-30-10-9-23(19-27(30)36)38-22-26-33(43)39-35(45)42(34(26)44)24-7-4-3-5-8-24/h3-5,7-12,19-22,44H,6,13-18H2,1-2H3,(H,39,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446591
(CHEMBL3116231)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4c(C)cccc4C)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16,(59.77,-9.66,;61.11,-8.89,;62.44,-9.66,;63.77,-8.89,;65.1,-9.65,;66.43,-8.88,;66.42,-7.34,;67.75,-6.56,;69.08,-7.33,;70.41,-6.56,;70.4,-5.01,;69.05,-4.25,;67.73,-5.03,;66.39,-4.28,;71.73,-4.24,;73.07,-5,;74.4,-4.22,;75.74,-4.99,;75.75,-6.53,;77.07,-4.21,;78.4,-4.98,;79.72,-4.21,;79.72,-2.67,;81.06,-4.96,;81.07,-6.51,;79.74,-7.29,;78.4,-6.52,;77.07,-7.29,;77.06,-2.67,;78.39,-1.9,;75.72,-1.91,;74.39,-2.68,;73.05,-1.92,;67.77,-9.64,;67.78,-11.19,;66.44,-11.96,;65.11,-11.2,;63.77,-11.98,;62.44,-11.2,;61.1,-11.97,;59.77,-11.2,;58.44,-11.97,;57.1,-11.2,;55.77,-11.97,;54.45,-11.19,;53.12,-11.95,;53.11,-13.49,;51.77,-14.26,;54.44,-14.27,;55.78,-13.5,)| Show InChI InChI=1S/C37H39FN6O6/c1-23-7-5-8-24(2)34(23)44-36(46)27(35(45)41-37(44)47)22-40-25-9-10-31(28(38)19-25)50-30-11-12-39-29-21-33(32(48-4)20-26(29)30)49-18-6-13-43-16-14-42(3)15-17-43/h5,7-12,19-22,46H,6,13-18H2,1-4H3,(H,41,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446608
(CHEMBL3116439)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16| Show InChI InChI=1S/C34H32FN5O6/c1-44-30-19-24-27(20-31(30)45-17-7-16-39-14-5-6-15-39)36-13-12-28(24)46-29-11-10-22(18-26(29)35)37-21-25-32(41)38-34(43)40(33(25)42)23-8-3-2-4-9-23/h2-4,8-13,18-21,42H,5-7,14-17H2,1H3,(H,38,41,43) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446598
(CHEMBL3116224)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16| Show InChI InChI=1S/C34H31F2N5O7/c1-45-30-18-24-27(19-31(30)47-14-2-11-40-12-15-46-16-13-40)37-10-9-28(24)48-29-8-5-22(17-26(29)36)38-20-25-32(42)39-34(44)41(33(25)43)23-6-3-21(35)4-7-23/h3-10,17-20,43H,2,11-16H2,1H3,(H,39,42,44) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446621
(CHEMBL3116237)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16| Show InChI InChI=1S/C35H33F2N5O6/c1-46-31-19-25-28(20-32(31)47-17-5-16-41-14-3-2-4-15-41)38-13-12-29(25)48-30-11-8-23(18-27(30)37)39-21-26-33(43)40-35(45)42(34(26)44)24-9-6-22(36)7-10-24/h6-13,18-21,44H,2-5,14-17H2,1H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446622
(CHEMBL3116445)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4c(C)cccc4C)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16,(58.52,-11.17,;59.85,-10.4,;61.19,-11.17,;62.51,-10.4,;63.85,-11.16,;65.18,-10.39,;65.17,-8.85,;66.5,-8.07,;67.83,-8.84,;69.15,-8.07,;69.15,-6.52,;67.8,-5.76,;66.48,-6.54,;65.13,-5.79,;70.48,-5.74,;71.81,-6.51,;73.14,-5.73,;74.49,-6.5,;74.49,-8.04,;75.81,-5.72,;77.15,-6.49,;78.47,-5.71,;78.46,-4.17,;79.81,-6.47,;79.81,-8.02,;78.48,-8.79,;77.15,-8.03,;75.81,-8.8,;75.81,-4.18,;77.14,-3.41,;74.47,-3.42,;73.13,-4.19,;71.8,-3.43,;66.51,-11.15,;66.52,-12.7,;65.19,-13.47,;63.85,-12.71,;62.52,-13.48,;61.18,-12.71,;59.85,-13.48,;58.52,-12.71,;57.18,-13.48,;55.85,-12.71,;54.51,-13.48,;53.19,-12.7,;51.86,-13.46,;51.85,-15,;53.18,-15.78,;54.53,-15.01,)| Show InChI InChI=1S/C37H38FN5O6/c1-23-9-7-10-24(2)34(23)43-36(45)27(35(44)41-37(43)46)22-40-25-11-12-31(28(38)19-25)49-30-13-14-39-29-21-33(32(47-3)20-26(29)30)48-18-8-17-42-15-5-4-6-16-42/h7,9-14,19-22,45H,4-6,8,15-18H2,1-3H3,(H,41,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446616
(CHEMBL3116242)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16| Show InChI InChI=1S/C36H36FN5O6/c1-23-12-16-41(17-13-23)15-6-18-47-33-21-29-26(20-32(33)46-2)30(11-14-38-29)48-31-10-9-24(19-28(31)37)39-22-27-34(43)40-36(45)42(35(27)44)25-7-4-3-5-8-25/h3-5,7-11,14,19-23,44H,6,12-13,15-18H2,1-2H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446624
(CHEMBL3116446)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16| Show InChI InChI=1S/C35H34FN5O6/c1-45-31-20-25-28(21-32(31)46-18-8-17-40-15-6-3-7-16-40)37-14-13-29(25)47-30-12-11-23(19-27(30)36)38-22-26-33(42)39-35(44)41(34(26)43)24-9-4-2-5-10-24/h2,4-5,9-14,19-22,43H,3,6-8,15-18H2,1H3,(H,39,42,44) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446601
(CHEMBL3116221)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16| Show InChI InChI=1S/C34H32FN5O7/c1-44-30-19-24-27(20-31(30)46-15-5-12-39-13-16-45-17-14-39)36-11-10-28(24)47-29-9-8-22(18-26(29)35)37-21-25-32(41)38-34(43)40(33(25)42)23-6-3-2-4-7-23/h2-4,6-11,18-21,42H,5,12-17H2,1H3,(H,38,41,43) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446611
(CHEMBL3116436)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)c(Cl)c4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16| Show InChI InChI=1S/C36H34ClF2N5O6/c1-21-9-13-43(14-10-21)12-3-15-49-33-19-29-24(18-32(33)48-2)30(8-11-40-29)50-31-7-4-22(16-28(31)39)41-20-25-34(45)42-36(47)44(35(25)46)23-5-6-27(38)26(37)17-23/h4-8,11,16-21,46H,3,9-10,12-15H2,1-2H3,(H,42,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446596
(CHEMBL3116226)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)c(Cl)c4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16| Show InChI InChI=1S/C34H30ClF2N5O7/c1-46-30-17-22-27(18-31(30)48-12-2-9-41-10-13-47-14-11-41)38-8-7-28(22)49-29-6-3-20(15-26(29)37)39-19-23-32(43)40-34(45)42(33(23)44)21-4-5-25(36)24(35)16-21/h3-8,15-19,44H,2,9-14H2,1H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446603
(CHEMBL3116219)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16,(11.54,-46.54,;12.87,-45.77,;14.21,-46.54,;15.54,-45.77,;16.87,-46.53,;18.2,-45.76,;18.19,-44.22,;19.52,-43.44,;20.85,-44.21,;22.18,-43.44,;22.17,-41.9,;20.82,-41.13,;19.5,-41.91,;18.16,-41.16,;23.5,-41.12,;24.84,-41.88,;26.16,-41.1,;27.51,-41.87,;27.51,-43.41,;28.83,-41.1,;30.17,-41.86,;30.17,-43.4,;31.5,-44.17,;32.84,-43.39,;32.83,-41.84,;31.49,-41.09,;31.48,-39.55,;32.81,-38.77,;30.7,-38.2,;31.87,-38.05,;28.83,-39.56,;30.16,-38.78,;27.49,-38.79,;26.15,-39.57,;24.82,-38.8,;19.53,-46.52,;19.54,-48.07,;18.21,-48.84,;16.87,-48.08,;15.54,-48.86,;14.2,-48.09,;12.87,-48.85,;11.54,-48.08,;10.2,-48.85,;8.87,-48.08,;7.54,-48.85,;6.13,-48.23,;5.09,-49.37,;5.86,-50.71,;7.37,-50.39,)| Show InChI InChI=1S/C35H31F4N5O6/c1-48-30-18-22-26(19-31(30)49-16-6-15-43-13-4-5-14-43)40-12-11-28(22)50-29-10-9-21(17-25(29)36)41-20-23-32(45)42-34(47)44(33(23)46)27-8-3-2-7-24(27)35(37,38)39/h2-3,7-12,17-20,46H,4-6,13-16H2,1H3,(H,42,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446587
(CHEMBL3116235)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16,(17.75,-47.24,;19.09,-46.47,;20.42,-47.24,;21.75,-46.47,;23.09,-47.24,;24.41,-46.46,;24.4,-44.92,;25.73,-44.15,;27.06,-44.91,;28.39,-44.14,;28.38,-42.6,;27.04,-41.83,;25.71,-42.61,;24.37,-41.86,;29.71,-41.82,;31.05,-42.58,;32.38,-41.8,;33.72,-42.57,;33.73,-44.11,;35.05,-41.8,;36.38,-42.56,;36.38,-44.1,;37.72,-44.87,;39.05,-44.09,;39.04,-42.55,;37.71,-41.79,;37.7,-40.25,;39.03,-39.47,;36.91,-38.9,;38.09,-38.75,;35.04,-40.26,;36.38,-39.48,;33.71,-39.49,;32.37,-40.27,;31.03,-39.5,;25.75,-47.22,;25.76,-48.77,;24.42,-49.55,;23.09,-48.78,;21.75,-49.56,;20.42,-48.79,;19.09,-49.56,;17.75,-48.78,;16.42,-49.55,;15.08,-48.78,;13.75,-49.55,;12.42,-48.78,;11.09,-49.54,;11.08,-51.08,;9.75,-51.85,;12.42,-51.86,;13.76,-51.09,)| Show InChI InChI=1S/C36H34F4N6O6/c1-44-13-15-45(16-14-44)12-5-17-51-32-20-27-23(19-31(32)50-2)29(10-11-41-27)52-30-9-8-22(18-26(30)37)42-21-24-33(47)43-35(49)46(34(24)48)28-7-4-3-6-25(28)36(38,39)40/h3-4,6-11,18-21,48H,5,12-17H2,1-2H3,(H,43,47,49) | PDB
MMDB
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UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446589
(CHEMBL3116233)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCN(C)CC1 |w:15.16,(38.63,-27.6,;39.96,-26.83,;41.3,-27.6,;42.63,-26.83,;43.96,-27.6,;45.29,-26.82,;45.28,-25.28,;46.61,-24.51,;47.94,-25.28,;49.27,-24.5,;49.26,-22.96,;47.91,-22.2,;46.59,-22.98,;45.25,-22.22,;50.59,-22.18,;51.93,-22.94,;53.26,-22.16,;54.6,-22.93,;54.61,-24.47,;55.92,-22.16,;57.26,-22.92,;57.26,-24.46,;58.59,-25.23,;59.93,-24.46,;61.26,-25.22,;59.92,-22.91,;58.58,-22.15,;58.57,-20.61,;55.92,-20.62,;57.25,-19.84,;54.58,-19.85,;53.25,-20.63,;51.91,-19.86,;46.62,-27.58,;46.63,-29.13,;45.3,-29.91,;43.96,-29.14,;42.63,-29.92,;41.3,-29.15,;39.96,-29.92,;38.63,-29.15,;37.29,-29.92,;35.96,-29.14,;34.63,-29.91,;33.3,-29.13,;31.97,-29.9,;31.96,-31.44,;30.63,-32.2,;33.3,-32.21,;34.64,-31.45,)| Show InChI InChI=1S/C35H33F3N6O6/c1-42-11-13-43(14-12-42)10-3-15-49-32-19-27-23(18-31(32)48-2)29(8-9-39-27)50-30-7-5-22(17-26(30)38)40-20-24-33(45)41-35(47)44(34(24)46)28-6-4-21(36)16-25(28)37/h4-9,16-20,46H,3,10-15H2,1-2H3,(H,41,45,47) | PDB
MMDB
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UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446620
(CHEMBL3116238)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16,(33.29,-27.25,;34.62,-26.48,;35.95,-27.24,;37.28,-26.47,;38.62,-27.24,;39.94,-26.46,;39.94,-24.92,;41.26,-24.15,;42.59,-24.92,;43.92,-24.14,;43.92,-22.6,;42.57,-21.84,;41.24,-22.62,;39.9,-21.86,;45.24,-21.82,;46.58,-22.58,;47.91,-21.8,;49.25,-22.57,;49.26,-24.11,;50.58,-21.8,;51.91,-22.56,;51.91,-24.1,;53.25,-24.87,;54.58,-24.1,;55.92,-24.86,;54.57,-22.55,;53.24,-21.79,;53.23,-20.25,;50.58,-20.26,;51.91,-19.49,;49.24,-19.49,;47.9,-20.27,;46.56,-19.51,;41.28,-27.23,;41.29,-28.77,;39.95,-29.55,;38.62,-28.78,;37.29,-29.56,;35.95,-28.79,;34.62,-29.56,;33.28,-28.79,;31.95,-29.56,;30.62,-28.78,;29.28,-29.55,;27.96,-28.78,;26.63,-29.54,;26.62,-31.08,;27.95,-31.85,;29.29,-31.09,)| Show InChI InChI=1S/C35H32F3N5O6/c1-47-31-18-23-27(19-32(31)48-15-5-14-42-12-3-2-4-13-42)39-11-10-29(23)49-30-9-7-22(17-26(30)38)40-20-24-33(44)41-35(46)43(34(24)45)28-8-6-21(36)16-25(28)37/h6-11,16-20,45H,2-5,12-15H2,1H3,(H,41,44,46) | PDB
MMDB
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446605
(CHEMBL3116443)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16,(11.51,-36.53,;12.84,-35.76,;14.17,-36.53,;15.5,-35.76,;16.84,-36.53,;18.16,-35.75,;18.15,-34.21,;19.48,-33.43,;20.82,-34.2,;22.14,-33.43,;22.14,-31.89,;20.79,-31.12,;19.46,-31.9,;18.12,-31.15,;23.46,-31.1,;24.8,-31.87,;26.13,-31.09,;27.47,-31.86,;27.48,-33.4,;28.8,-31.08,;30.14,-31.85,;30.14,-33.39,;31.47,-34.15,;32.8,-33.38,;34.14,-34.14,;32.79,-31.84,;31.46,-31.07,;31.45,-29.53,;28.79,-29.54,;30.13,-28.77,;27.46,-28.78,;26.12,-29.55,;24.78,-28.79,;19.5,-36.51,;19.51,-38.06,;18.17,-38.83,;16.84,-38.07,;15.5,-38.84,;14.17,-38.08,;12.84,-38.84,;11.51,-38.07,;10.17,-38.84,;8.83,-38.07,;7.49,-38.84,;7.03,-40.31,;5.49,-40.33,;4.99,-38.88,;6.23,-37.95,)| Show InChI InChI=1S/C34H30F3N5O6/c1-46-30-17-22-26(18-31(30)47-14-4-13-41-11-2-3-12-41)38-10-9-28(22)48-29-8-6-21(16-25(29)37)39-19-23-32(43)40-34(45)42(33(23)44)27-7-5-20(35)15-24(27)36/h5-10,15-19,44H,2-4,11-14H2,1H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446597
(CHEMBL3116225)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16,(36.35,-25.68,;37.69,-24.91,;39.02,-25.68,;40.35,-24.9,;41.68,-25.67,;43.01,-24.9,;43,-23.36,;44.33,-22.58,;45.66,-23.35,;46.99,-22.57,;46.98,-21.03,;45.63,-20.27,;44.31,-21.05,;42.97,-20.29,;48.31,-20.25,;49.65,-21.01,;50.98,-20.23,;52.32,-21,;52.33,-22.54,;53.65,-20.23,;54.98,-20.99,;54.98,-22.53,;56.32,-23.3,;57.65,-22.53,;58.99,-23.29,;57.64,-20.98,;56.3,-20.22,;56.3,-18.68,;53.64,-18.69,;54.97,-17.92,;52.3,-17.92,;50.97,-18.7,;49.63,-17.94,;44.35,-25.66,;44.36,-27.2,;43.02,-27.98,;41.69,-27.21,;40.35,-27.99,;39.02,-27.22,;37.68,-27.99,;36.35,-27.22,;35.02,-27.99,;33.68,-27.22,;32.35,-27.98,;31.03,-27.21,;29.7,-27.97,;29.69,-29.51,;31.02,-30.28,;32.36,-29.52,)| Show InChI InChI=1S/C34H30F3N5O7/c1-46-30-17-22-26(18-31(30)48-12-2-9-41-10-13-47-14-11-41)38-8-7-28(22)49-29-6-4-21(16-25(29)37)39-19-23-32(43)40-34(45)42(33(23)44)27-5-3-20(35)15-24(27)36/h3-8,15-19,44H,2,9-14H2,1H3,(H,40,43,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446612
(CHEMBL3116435)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(F)cc4F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16,(37.78,-30.17,;39.12,-29.4,;40.45,-30.17,;41.78,-29.4,;43.11,-30.16,;44.44,-29.39,;44.43,-27.85,;45.76,-27.07,;47.09,-27.84,;48.42,-27.07,;48.41,-25.53,;47.07,-24.76,;45.74,-25.54,;44.4,-24.79,;49.74,-24.75,;51.08,-25.51,;52.41,-24.73,;53.75,-25.5,;53.76,-27.04,;55.08,-24.73,;56.41,-25.49,;56.41,-27.03,;57.75,-27.8,;59.08,-27.02,;60.42,-27.79,;59.07,-25.47,;57.74,-24.72,;57.73,-23.18,;55.07,-23.18,;56.41,-22.41,;53.74,-22.42,;52.4,-23.19,;51.06,-22.43,;45.78,-30.15,;45.79,-31.7,;44.45,-32.47,;43.12,-31.71,;41.78,-32.49,;40.45,-31.71,;39.11,-32.48,;37.78,-31.71,;36.45,-32.48,;35.11,-31.71,;33.78,-32.48,;32.46,-31.7,;31.13,-32.46,;31.12,-34,;29.78,-34.77,;32.45,-34.78,;33.79,-34.01,)| Show InChI InChI=1S/C36H34F3N5O6/c1-21-9-13-43(14-10-21)12-3-15-49-33-19-28-24(18-32(33)48-2)30(8-11-40-28)50-31-7-5-23(17-27(31)39)41-20-25-34(45)42-36(47)44(35(25)46)29-6-4-22(37)16-26(29)38/h4-8,11,16-21,46H,3,9-10,12-15H2,1-2H3,(H,42,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446602
(CHEMBL3116220)Show SMILES COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCCC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(63.28,-46.33,;64.61,-45.56,;64.61,-44.02,;63.27,-43.25,;63.27,-41.71,;64.6,-40.94,;64.59,-39.4,;65.92,-38.62,;65.93,-41.7,;65.94,-43.25,;67.28,-44.01,;61.94,-40.95,;60.61,-41.72,;60.62,-43.26,;59.27,-40.95,;57.94,-41.73,;56.6,-40.97,;55.27,-41.75,;55.28,-43.29,;53.95,-44.07,;52.62,-43.3,;51.29,-44.08,;51.3,-45.62,;52.64,-46.38,;52.65,-47.92,;51.31,-48.7,;49.98,-47.93,;48.64,-48.71,;47.31,-47.94,;45.97,-48.71,;44.64,-47.94,;43.31,-48.71,;41.97,-47.94,;40.64,-48.7,;39.24,-48.09,;38.21,-49.23,;38.97,-50.57,;40.48,-50.25,;47.31,-46.4,;45.98,-45.63,;44.64,-46.4,;48.64,-45.62,;49.97,-46.39,;52.6,-41.77,;51.26,-41.01,;53.93,-40.99,;59.26,-39.42,;57.92,-38.66,;60.6,-38.64,;61.93,-39.41,;63.27,-38.64,)| Show InChI InChI=1S/C36H35ClFN5O8/c1-47-30-19-27(31(48-2)17-24(30)37)43-35(45)23(34(44)41-36(43)46)20-40-21-7-8-29(25(38)15-21)51-28-9-10-39-26-18-33(32(49-3)16-22(26)28)50-14-6-13-42-11-4-5-12-42/h7-10,15-20,45H,4-6,11-14H2,1-3H3,(H,41,44,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446610
(CHEMBL3116437)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCC(C)CC1 |w:15.16,(16.91,-49.81,;18.24,-49.04,;19.57,-49.81,;20.9,-49.04,;22.24,-49.8,;23.56,-49.03,;23.56,-47.49,;24.89,-46.71,;26.21,-47.48,;27.54,-46.7,;27.54,-45.16,;26.19,-44.4,;24.87,-45.18,;23.52,-44.42,;28.86,-44.38,;30.2,-45.14,;31.53,-44.37,;32.87,-45.13,;32.88,-46.67,;34.2,-44.36,;35.53,-45.13,;35.53,-46.67,;36.87,-47.43,;38.2,-46.66,;38.19,-45.11,;36.86,-44.35,;36.85,-42.81,;38.18,-42.04,;36.06,-41.47,;37.24,-41.31,;34.2,-42.82,;35.53,-42.05,;32.86,-42.06,;31.52,-42.83,;30.18,-42.07,;24.9,-49.79,;24.91,-51.34,;23.57,-52.11,;22.24,-51.34,;20.91,-52.12,;19.57,-51.35,;18.24,-52.12,;16.9,-51.35,;15.57,-52.12,;14.24,-51.35,;12.9,-52.12,;11.58,-51.35,;10.25,-52.11,;10.24,-53.65,;8.9,-54.41,;11.57,-54.42,;12.91,-53.66,)| Show InChI InChI=1S/C37H35F4N5O6/c1-22-11-15-45(16-12-22)14-5-17-51-33-20-28-24(19-32(33)50-2)30(10-13-42-28)52-31-9-8-23(18-27(31)38)43-21-25-34(47)44-36(49)46(35(25)48)29-7-4-3-6-26(29)37(39,40)41/h3-4,6-10,13,18-22,48H,5,11-12,14-17H2,1-2H3,(H,44,47,49) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446618
(CHEMBL3116240)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCCC1 |w:15.16,(9.96,-44.3,;11.29,-43.53,;12.63,-44.3,;13.96,-43.53,;15.29,-44.3,;16.62,-43.52,;16.61,-41.98,;17.94,-41.2,;19.27,-41.97,;20.6,-41.2,;20.59,-39.66,;19.24,-38.89,;17.92,-39.67,;16.58,-38.92,;21.92,-38.88,;23.26,-39.64,;24.59,-38.86,;25.93,-39.63,;25.93,-41.17,;27.25,-38.86,;28.59,-39.62,;28.59,-41.16,;29.92,-41.93,;31.26,-41.15,;31.25,-39.61,;29.91,-38.85,;29.9,-37.31,;31.23,-36.53,;29.12,-35.96,;30.29,-35.81,;27.25,-37.32,;28.58,-36.54,;25.91,-36.55,;24.58,-37.33,;23.24,-36.56,;17.95,-44.28,;17.96,-45.83,;16.63,-46.61,;15.29,-45.84,;13.96,-46.62,;12.63,-45.85,;11.29,-46.61,;9.96,-45.84,;8.62,-46.61,;7.29,-45.84,;5.96,-46.61,;4.63,-45.84,;3.31,-46.6,;3.3,-48.14,;4.62,-48.92,;5.97,-48.15,)| Show InChI InChI=1S/C36H33F4N5O6/c1-49-31-19-23-27(20-32(31)50-17-7-16-44-14-5-2-6-15-44)41-13-12-29(23)51-30-11-10-22(18-26(30)37)42-21-24-33(46)43-35(48)45(34(24)47)28-9-4-3-8-25(28)36(38,39)40/h3-4,8-13,18-21,47H,2,5-7,14-17H2,1H3,(H,43,46,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446609
(CHEMBL3116438)Show SMILES COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCC(C)CC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(70.71,-47,;72.04,-46.23,;72.04,-44.69,;70.71,-43.92,;70.7,-42.38,;72.03,-41.61,;72.02,-40.07,;73.35,-39.29,;73.36,-42.37,;73.37,-43.91,;74.71,-44.68,;69.37,-41.62,;68.04,-42.39,;68.05,-43.93,;66.7,-41.62,;65.37,-42.4,;64.03,-41.64,;62.71,-42.42,;62.71,-43.96,;61.38,-44.73,;60.06,-43.97,;58.73,-44.74,;58.73,-46.28,;60.07,-47.04,;60.08,-48.59,;58.74,-49.37,;57.41,-48.6,;56.08,-49.38,;54.74,-48.61,;53.41,-49.38,;52.07,-48.6,;50.74,-49.37,;49.41,-48.6,;48.07,-49.37,;46.75,-48.59,;45.42,-49.36,;45.41,-50.9,;44.07,-51.66,;46.74,-51.67,;48.09,-50.91,;54.74,-47.06,;53.41,-46.29,;52.08,-47.06,;56.07,-46.29,;57.41,-47.06,;60.04,-42.43,;58.69,-41.68,;61.36,-41.65,;66.69,-40.09,;65.36,-39.32,;68.03,-39.31,;69.37,-40.08,;70.7,-39.3,)| Show InChI InChI=1S/C38H39ClFN5O8/c1-22-9-13-44(14-10-22)12-5-15-52-35-19-28-24(17-34(35)51-4)30(8-11-41-28)53-31-7-6-23(16-27(31)40)42-21-25-36(46)43-38(48)45(37(25)47)29-20-32(49-2)26(39)18-33(29)50-3/h6-8,11,16-22,47H,5,9-10,12-15H2,1-4H3,(H,43,46,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446595
(CHEMBL3116227)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccccc4C(F)(F)F)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCOCC1 |w:15.16,(13.03,-42.73,;14.36,-41.96,;15.69,-42.73,;17.02,-41.96,;18.36,-42.72,;19.68,-41.95,;19.67,-40.41,;21,-39.63,;22.33,-40.4,;23.66,-39.63,;23.65,-38.09,;22.31,-37.32,;20.98,-38.1,;19.64,-37.35,;24.98,-37.31,;26.32,-38.07,;27.65,-37.29,;28.99,-38.06,;29,-39.6,;30.32,-37.28,;31.65,-38.05,;31.65,-39.59,;32.99,-40.36,;34.32,-39.58,;34.31,-38.03,;32.98,-37.28,;32.97,-35.74,;34.3,-34.96,;32.18,-34.39,;33.36,-34.24,;30.32,-35.74,;31.65,-34.97,;28.98,-34.98,;27.64,-35.75,;26.3,-34.99,;21.02,-42.71,;21.03,-44.26,;19.69,-45.03,;18.36,-44.27,;17.02,-45.05,;15.69,-44.27,;14.36,-45.04,;13.02,-44.27,;11.69,-45.04,;10.36,-44.27,;9.02,-45.04,;7.69,-44.27,;6.37,-45.03,;6.37,-46.57,;7.69,-47.35,;9.03,-46.58,)| Show InChI InChI=1S/C35H31F4N5O7/c1-48-30-18-22-26(19-31(30)50-14-4-11-43-12-15-49-16-13-43)40-10-9-28(22)51-29-8-7-21(17-25(29)36)41-20-23-32(45)42-34(47)44(33(23)46)27-6-3-2-5-24(27)35(37,38)39/h2-3,5-10,17-20,46H,4,11-16H2,1H3,(H,42,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446586
(CHEMBL3116236)Show SMILES COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCN(C)CC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(71.56,-44.43,;72.89,-43.66,;72.89,-42.12,;71.55,-41.36,;71.55,-39.81,;72.88,-39.04,;72.87,-37.5,;74.2,-36.72,;74.21,-39.8,;74.22,-41.35,;75.56,-42.11,;70.22,-39.05,;68.89,-39.82,;68.9,-41.36,;67.55,-39.05,;66.22,-39.83,;64.88,-39.07,;63.55,-39.85,;63.56,-41.39,;62.23,-42.17,;60.9,-41.4,;59.57,-42.18,;59.58,-43.72,;60.92,-44.48,;60.93,-46.02,;59.59,-46.8,;58.26,-46.03,;56.92,-46.81,;55.59,-46.04,;54.26,-46.81,;52.92,-46.04,;51.59,-46.81,;50.25,-46.04,;48.92,-46.8,;47.6,-46.03,;46.27,-46.79,;46.26,-48.33,;44.92,-49.09,;47.59,-49.1,;48.93,-48.34,;55.59,-44.5,;54.26,-43.73,;52.92,-44.5,;56.92,-43.72,;58.26,-44.49,;60.88,-39.87,;59.54,-39.11,;62.21,-39.09,;67.54,-37.52,;66.2,-36.76,;68.88,-36.74,;70.21,-37.51,;71.55,-36.74,)| Show InChI InChI=1S/C37H38ClFN6O8/c1-43-11-13-44(14-12-43)10-5-15-52-34-19-27-23(17-33(34)51-4)29(8-9-40-27)53-30-7-6-22(16-26(30)39)41-21-24-35(46)42-37(48)45(36(24)47)28-20-31(49-2)25(38)18-32(28)50-3/h6-9,16-21,47H,5,10-15H2,1-4H3,(H,42,46,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446617
(CHEMBL3116241)Show SMILES COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(62.8,-43.66,;64.13,-42.89,;64.13,-41.35,;62.8,-40.59,;62.79,-39.04,;64.12,-38.27,;64.11,-36.73,;65.44,-35.95,;65.45,-39.03,;65.46,-40.58,;66.8,-41.34,;61.46,-38.28,;60.13,-39.05,;60.14,-40.59,;58.79,-38.28,;57.46,-39.06,;56.12,-38.3,;54.8,-39.08,;54.8,-40.62,;53.47,-41.4,;52.15,-40.63,;50.82,-41.41,;50.82,-42.95,;52.16,-43.71,;52.17,-45.26,;50.83,-46.03,;49.5,-45.26,;48.17,-46.04,;46.83,-45.27,;45.5,-46.04,;44.16,-45.27,;42.83,-46.04,;41.5,-45.27,;40.16,-46.03,;38.84,-45.26,;37.51,-46.02,;37.5,-47.56,;38.83,-48.33,;40.18,-47.57,;46.83,-43.73,;45.5,-42.96,;44.17,-43.73,;48.16,-42.95,;49.5,-43.72,;52.13,-39.1,;50.78,-38.34,;53.45,-38.32,;58.78,-36.75,;57.44,-35.99,;60.12,-35.97,;61.46,-36.74,;62.79,-35.97,)| Show InChI InChI=1S/C37H37ClFN5O8/c1-48-31-20-28(32(49-2)18-25(31)38)44-36(46)24(35(45)42-37(44)47)21-41-22-8-9-30(26(39)16-22)52-29-10-11-40-27-19-34(33(50-3)17-23(27)29)51-15-7-14-43-12-5-4-6-13-43/h8-11,16-21,46H,4-7,12-15H2,1-3H3,(H,42,45,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50446594
(CHEMBL3116228)Show SMILES COc1cc(c(OC)cc1Cl)-n1c(O)c(C=Nc2ccc(Oc3ccnc4cc(OCCCN5CCOCC5)c(OC)cc34)c(F)c2)c(=O)[nH]c1=O |w:15.15,(65.87,-42.1,;67.2,-41.32,;67.2,-39.78,;65.86,-39.02,;65.86,-37.47,;67.19,-36.7,;67.18,-35.16,;68.51,-34.38,;68.52,-37.46,;68.53,-39.01,;69.87,-39.77,;64.53,-36.71,;63.2,-37.48,;63.21,-39.02,;61.86,-36.71,;60.53,-37.49,;59.19,-36.73,;57.86,-37.51,;57.87,-39.05,;56.54,-39.83,;55.21,-39.06,;53.88,-39.84,;53.89,-41.38,;55.23,-42.14,;55.24,-43.69,;53.9,-44.46,;52.57,-43.69,;51.23,-44.47,;49.9,-43.7,;48.56,-44.47,;47.23,-43.7,;45.9,-44.47,;44.56,-43.7,;43.23,-44.47,;41.91,-43.69,;40.58,-44.45,;40.57,-45.99,;41.9,-46.77,;43.24,-46,;49.9,-42.16,;48.57,-41.39,;47.23,-42.16,;51.23,-41.39,;52.56,-42.15,;55.19,-37.53,;53.85,-36.77,;56.52,-36.75,;61.85,-35.18,;60.51,-34.42,;63.19,-34.41,;64.52,-35.17,;65.86,-34.4,)| Show InChI InChI=1S/C36H35ClFN5O9/c1-47-30-19-27(31(48-2)17-24(30)37)43-35(45)23(34(44)41-36(43)46)20-40-21-5-6-29(25(38)15-21)52-28-7-8-39-26-18-33(32(49-3)16-22(26)28)51-12-4-9-42-10-13-50-14-11-42/h5-8,15-20,45H,4,9-14H2,1-3H3,(H,41,44,46) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50446585
(CHEMBL3116440)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16| Show InChI InChI=1S/C35H34FN5O6/c1-22-6-9-24(10-7-22)41-34(43)26(33(42)39-35(41)44)21-38-23-8-11-30(27(36)18-23)47-29-12-13-37-28-20-32(31(45-2)19-25(28)29)46-17-5-16-40-14-3-4-15-40/h6-13,18-21,43H,3-5,14-17H2,1-2H3,(H,39,42,44) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 496 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of Flt-3 (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50446585
(CHEMBL3116440)Show SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(O)n(-c4ccc(C)cc4)c(=O)[nH]c3=O)ccnc2cc1OCCCN1CCCC1 |w:15.16| Show InChI InChI=1S/C35H34FN5O6/c1-22-6-9-24(10-7-22)41-34(43)26(33(42)39-35(41)44)21-38-23-8-11-30(27(36)18-23)47-29-12-13-37-28-20-32(31(45-2)19-25(28)29)46-17-5-16-40-14-3-4-15-40/h6-13,18-21,43H,3-5,14-17H2,1-2H3,(H,39,42,44) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR (unknown origin) using poly (Glu, Tyr) 4:1 after 30 mins by HTRF assay |
Bioorg Med Chem 22: 1236-49 (2014)
Article DOI: 10.1016/j.bmc.2014.01.014
BindingDB Entry DOI: 10.7270/Q2GQ708F |
More data for this
Ligand-Target Pair | |
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