Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 [44-166,W81A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 835 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 106 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,L94A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 42.8 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,I246A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.71E+4 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 14.5 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,I246A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 415 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,Y97F] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 10.5 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D144A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,I246A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D144A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D145A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.38E+4 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,L94A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 85.3 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D144A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 44 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D145A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 16.8 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,Y139F] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,W81A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 13.7 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,N140A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 8.60 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,P82A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.12E+4 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,Y97F] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 475 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D144A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 56.6 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,L94A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.14 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,P82A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 174 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,M149A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 9.70 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,Y139F] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 61.3 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,M149A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 7.27E+4 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D145A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 15.8 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,I246A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 112 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,W81A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.22E+4 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,L94A] (Homo sapiens (Human)) | BDBM227644 (Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 3.98E+4 | n/a | n/a | n/a | 7.5 | 4 |
Bayer HealthCare | Assay Description The experiments were performed in 384-well black small volume microtiter plates(Greiner) in a buffer composed of 50mM Hepes, pH 7.5 (Applichem), 50 m... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,P82A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 229 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,Y139F] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 11.4 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,M149A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 268 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,P82A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.64 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,Y139F] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,D145A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | 7.5 | n/a |
Bayer HealthCare | Assay Description In a typical TSA, 0.4 μg of BRD4 BD1 protein were mixed with 5× Sypro Orange (Molecular Probe) and adjusted to a final volume of 5 μl with ... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [44-166,N140A] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 448 | n/a | n/a | n/a | 7.5 | 25 |
Bayer HealthCare | Assay Description For KD determinations, 10 nM JQ1-TAMRA probe was incubated in 384-well smallvolume black microtiter plates with serial (1:2) dilutions of each BRD4 v... | J Biol Chem 289: 9304-19 (2014) Article DOI: 10.1074/jbc.M113.523019 BindingDB Entry DOI: 10.7270/Q2VQ31JB | |||||||||||
More data for this Ligand-Target Pair |