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PubMed code 2456389

Compile data set for download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227493
PNG
(CHEMBL288111)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CSc3ccccn3)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C21H23N3S/c1-24-12-14(13-25-20-7-2-3-8-22-20)9-17-16-5-4-6-18-21(16)15(11-23-18)10-19(17)24/h2-9,14-15,19,23H,10-13H2,1H3/t14-,15-,19-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227485
PNG
(CHEMBL291097)
Show SMILES [H][C@]1(C)CN(C)[C@]2([H])Cc3c[nH]c4cccc(C2=C1)c34 |c:18|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,10,15,17H,7,9H2,1-2H3/t10-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227483
PNG
(CHEMBL36379)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CSc3ccccc3)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C22H24N2S/c1-24-13-15(14-25-17-6-3-2-4-7-17)10-19-18-8-5-9-20-22(18)16(12-23-20)11-21(19)24/h2-10,15-16,21,23H,11-14H2,1H3/t15-,16-,21-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50016479
PNG
((7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]qui...)
Show SMILES CN1C[C@H](CO)C=C2[C@H]1Cc1c[nH]c3cccc2c13 |c:6|
Show InChI InChI=1S/C16H18N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,7,10,15,17,19H,6,8-9H2,1H3/t10-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227484
PNG
(CHEMBL37867)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(C)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,10-11,15,17H,7-9H2,1-2H3/t10-,11-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227496
PNG
(CHEMBL39604)
Show SMILES [H][C@@]12Cc3c[nH]c4cccc(C1=CC(=C)CN2C)c34 |c:12|
Show InChI InChI=1S/C16H16N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,15,17H,1,7,9H2,2H3/t15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227497
PNG
(CHEMBL291044)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CSC)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C17H22N2S/c1-19-9-11(10-20-2)6-14-13-4-3-5-15-17(13)12(8-18-15)7-16(14)19/h3-6,11-12,16,18H,7-10H2,1-2H3/t11-,12-,16-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227486
PNG
(CHEMBL289517)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@]([H])(C)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,10-11,15,17H,7-9H2,1-2H3/t10-,11+,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227482
PNG
(CHEMBL285723)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CC#N)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C17H19N3/c1-20-10-11(5-6-18)7-14-13-3-2-4-15-17(13)12(9-19-15)8-16(14)20/h2-4,7,11-12,16,19H,5,8-10H2,1H3/t11-,12-,16-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227490
PNG
(CHEMBL288480)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CO)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H20N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,10-11,15,17,19H,6-9H2,1H3/t10-,11-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227520
PNG
(CHEMBL285284)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@]([H])(CN(C)[C@]1([H])C2)C(=O)OC |t:12|
Show InChI InChI=1S/C17H20N2O2/c1-19-9-11(17(20)21-2)6-13-12-4-3-5-14-16(12)10(8-18-14)7-15(13)19/h3-6,10-11,15,18H,7-9H2,1-2H3/t10-,11-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227489
PNG
(CHEMBL40047)
Show SMILES [H][C@@]1(C)CN(C)[C@]2([H])Cc3c[nH]c4cccc(C2=C1)c34 |c:18|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,10,15,17H,7,9H2,1-2H3/t10-,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227492
PNG
(CHEMBL36980)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=CC(=C)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,11,15,17H,1,7-9H2,2H3/t11-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227485
PNG
(CHEMBL291097)
Show SMILES [H][C@]1(C)CN(C)[C@]2([H])Cc3c[nH]c4cccc(C2=C1)c34 |c:18|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,10,15,17H,7,9H2,1-2H3/t10-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227493
PNG
(CHEMBL288111)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CSc3ccccn3)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C21H23N3S/c1-24-12-14(13-25-20-7-2-3-8-22-20)9-17-16-5-4-6-18-21(16)15(11-23-18)10-19(17)24/h2-9,14-15,19,23H,10-13H2,1H3/t14-,15-,19-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227495
PNG
(9,10-Dihydrolysergol | CHEMBL290217)
Show SMILES [H][C@]1(CO)CN(C)[C@]2([H])Cc3c[nH]c4cccc(c34)[C@@]2([H])C1
Show InChI InChI=1S/C16H20N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-4,7,10,13,15,17,19H,5-6,8-9H2,1H3/t10-,13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227487
PNG
(CHEMBL291218)
Show SMILES [H][C@@]12CNc3cccc(c13)[C@@]1([H])C=C(C)CN(C)[C@]1([H])C2 |t:14|
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,11,13,15,17H,7-9H2,1-2H3/t11-,13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor in rat frontal cortex homogenates using [3H]5-HT as a radioligand

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227489
PNG
(CHEMBL40047)
Show SMILES [H][C@@]1(C)CN(C)[C@]2([H])Cc3c[nH]c4cccc(C2=C1)c34 |c:18|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,10,15,17H,7,9H2,1-2H3/t10-,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227496
PNG
(CHEMBL39604)
Show SMILES [H][C@@]12Cc3c[nH]c4cccc(C1=CC(=C)CN2C)c34 |c:12|
Show InChI InChI=1S/C16H16N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,15,17H,1,7,9H2,2H3/t15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50016490
PNG
((6aR,10aR)-7,9-Dimethyl-4,6,6a,7,8,10a-hexahydro-i...)
Show SMILES CN1CC(C)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |c:4|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,13,15,17H,7,9H2,1-2H3/t13-,15-/m1/s1
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Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50016479
PNG
((7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]qui...)
Show SMILES CN1C[C@H](CO)C=C2[C@H]1Cc1c[nH]c3cccc2c13 |c:6|
Show InChI InChI=1S/C16H18N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,7,10,15,17,19H,6,8-9H2,1H3/t10-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227518
PNG
(CHEMBL38058)
Show SMILES [H][C@@]12CN(C)c3cccc(c13)C1=C[C@@]([H])(C)CN(C)[C@]1([H])C2 |t:13|
Show InChI InChI=1S/C17H22N2/c1-11-7-14-13-5-4-6-15-17(13)12(10-19(15)3)8-16(14)18(2)9-11/h4-7,11-12,16H,8-10H2,1-3H3/t11-,12-,16-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227483
PNG
(CHEMBL36379)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CSc3ccccc3)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C22H24N2S/c1-24-13-15(14-25-17-6-3-2-4-7-17)10-19-18-8-5-9-20-22(18)16(12-23-20)11-21(19)24/h2-10,15-16,21,23H,11-14H2,1H3/t15-,16-,21-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227488
PNG
(CHEMBL291030)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(C)CN(CCC)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C18H24N2/c1-3-7-20-11-12(2)8-15-14-5-4-6-16-18(14)13(10-19-16)9-17(15)20/h4-6,8,12-13,17,19H,3,7,9-11H2,1-2H3/t12-,13-,17-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50016490
PNG
((6aR,10aR)-7,9-Dimethyl-4,6,6a,7,8,10a-hexahydro-i...)
Show SMILES CN1CC(C)=C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |c:4|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,8,13,15,17H,7,9H2,1-2H3/t13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50016489
PNG
((6aR,9R,10aR)-7,9-Dimethyl-4,6,6a,7,8,9,10,10a-oct...)
Show SMILES C[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-5,8,10,13,15,17H,6-7,9H2,1-2H3/t10-,13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A/1B/1D/1F


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)		BDBM50227491
PNG
(CHEMBL39769)
Show SMILES [H][C@@]12CNc3cccc(c13)[C@@]1([H])C[C@@]([H])(C)CN(C)[C@]1([H])C2
Show InChI InChI=1S/C16H22N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-5,10-11,13,15,17H,6-9H2,1-2H3/t10-,11-,13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1 receptor in rat frontal cortex homogenates using [3H]5-HT as a radioligand

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50016489
PNG
((6aR,9R,10aR)-7,9-Dimethyl-4,6,6a,7,8,9,10,10a-oct...)
Show SMILES C[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-5,8,10,13,15,17H,6-7,9H2,1-2H3/t10-,13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227495
PNG
(9,10-Dihydrolysergol | CHEMBL290217)
Show SMILES [H][C@]1(CO)CN(C)[C@]2([H])Cc3c[nH]c4cccc(c34)[C@@]2([H])C1
Show InChI InChI=1S/C16H20N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-4,7,10,13,15,17,19H,5-6,8-9H2,1H3/t10-,13-,15-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227486
PNG
(CHEMBL289517)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@]([H])(C)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,10-11,15,17H,7-9H2,1-2H3/t10-,11+,15+/m0/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227488
PNG
(CHEMBL291030)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(C)CN(CCC)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C18H24N2/c1-3-7-20-11-12(2)8-15-14-5-4-6-16-18(14)13(10-19-16)9-17(15)20/h4-6,8,12-13,17,19H,3,7,9-11H2,1-2H3/t12-,13-,17-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227518
PNG
(CHEMBL38058)
Show SMILES [H][C@@]12CN(C)c3cccc(c13)C1=C[C@@]([H])(C)CN(C)[C@]1([H])C2 |t:13|
Show InChI InChI=1S/C17H22N2/c1-11-7-14-13-5-4-6-15-17(13)12(10-19(15)3)8-16(14)18(2)9-11/h4-7,11-12,16H,8-10H2,1-3H3/t11-,12-,16-/m1/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227497
PNG
(CHEMBL291044)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CSC)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C17H22N2S/c1-19-9-11(10-20-2)6-14-13-4-3-5-15-17(13)12(8-18-15)7-16(14)19/h3-6,11-12,16,18H,7-10H2,1-2H3/t11-,12-,16-/m1/s1
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n/an/a 1.33E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227520
PNG
(CHEMBL285284)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@]([H])(CN(C)[C@]1([H])C2)C(=O)OC |t:12|
Show InChI InChI=1S/C17H20N2O2/c1-19-9-11(17(20)21-2)6-13-12-4-3-5-14-16(12)10(8-18-14)7-15(13)19/h3-6,10-11,15,18H,7-9H2,1-2H3/t10-,11-,15-/m1/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227484
PNG
(CHEMBL37867)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(C)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,10-11,15,17H,7-9H2,1-2H3/t10-,11-,15-/m1/s1
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n/an/a 1.67E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227487
PNG
(CHEMBL291218)
Show SMILES [H][C@@]12CNc3cccc(c13)[C@@]1([H])C=C(C)CN(C)[C@]1([H])C2 |t:14|
Show InChI InChI=1S/C16H20N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,11,13,15,17H,7-9H2,1-2H3/t11-,13-,15-/m1/s1
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n/an/a 1.85E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227482
PNG
(CHEMBL285723)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CC#N)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C17H19N3/c1-20-10-11(5-6-18)7-14-13-3-2-4-15-17(13)12(9-19-15)8-16(14)20/h2-4,7,11-12,16,19H,5,8-10H2,1H3/t11-,12-,16-/m1/s1
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n/an/a 2.12E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227490
PNG
(CHEMBL288480)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=C[C@@]([H])(CO)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H20N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,10-11,15,17,19H,6-9H2,1H3/t10-,11-,15-/m1/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227492
PNG
(CHEMBL36980)
Show SMILES [H][C@@]12CNc3cccc(c13)C1=CC(=C)CN(C)[C@]1([H])C2 |t:12|
Show InChI InChI=1S/C16H18N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-6,11,15,17H,1,7-9H2,2H3/t11-,15-/m1/s1
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n/an/a 3.82E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50227491
PNG
(CHEMBL39769)
Show SMILES [H][C@@]12CNc3cccc(c13)[C@@]1([H])C[C@@]([H])(C)CN(C)[C@]1([H])C2
Show InChI InChI=1S/C16H22N2/c1-10-6-13-12-4-3-5-14-16(12)11(8-17-14)7-15(13)18(2)9-10/h3-5,10-11,13,15,17H,6-9H2,1-2H3/t10-,11-,13-,15-/m1/s1
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n/an/a 4.22E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from rat frontal cortex homogenates by [3H]-spiperone displacement.

J Med Chem 31: 1512-9 (1988)


BindingDB Entry DOI: 10.7270/Q2571F61
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%