Affinity Data by PubMed id=24580531

PubMed code 24580531

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008057 (BMS-722782 \| CHEBI:64153 \| TANESPIMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of human HSP90alpha expressed in yeast assessed as growth inhibition of host after 72 hrs				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM50008057 (BMS-722782 \| CHEBI:64153 \| TANESPIMYCIN) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of human HSP90beta expressed in yeast assessed as growth inhibition of host after 72 hrs				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM50008055 (CHEMBL3234416) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of human HSP90beta expressed in yeast assessed as growth inhibition of host after 72 hrs				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008055 (CHEMBL3234416) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.09E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of human HSP90alpha expressed in yeast assessed as growth inhibition of host after 72 hrs				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Binding affinity to N-terminal FLAG-tagged human recombinant HSP90beta expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assay				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	714	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Binding affinity to N-terminal FLAG-tagged human recombinant HSP90alpha expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assay				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%