Found 4 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50044260
(CHEMBL3310053)Show InChI InChI=1S/C14H13N5O3/c1-10-15-8-13(19(20)21)18(10)6-7-22-14-11-4-2-3-5-12(11)16-9-17-14/h2-5,8-9H,6-7H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Eur J Med Chem 76: 193-244 (2014)
Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50044259
(CHEMBL3310052)Show SMILES Oc1ncnc2c(ccc(Nc3ccc(NC(=O)Nc4ccc(cc4Cl)C(F)(F)F)cc3)c12)[N+]([O-])=O Show InChI InChI=1S/C22H14ClF3N6O4/c23-14-9-11(22(24,25)26)1-6-15(14)31-21(34)30-13-4-2-12(3-5-13)29-16-7-8-17(32(35)36)19-18(16)20(33)28-10-27-19/h1-10,29H,(H,27,28,33)(H2,30,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Eur J Med Chem 76: 193-244 (2014)
Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50044261
(CHEMBL3310054)Show SMILES Brc1ccc(Nc2ncnc3ccc(NC(=O)Cc4cccc(Br)c4)cc23)cc1 Show InChI InChI=1S/C22H16Br2N4O/c23-15-4-6-17(7-5-15)28-22-19-12-18(8-9-20(19)25-13-26-22)27-21(29)11-14-2-1-3-16(24)10-14/h1-10,12-13H,11H2,(H,27,29)(H,25,26,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description
Inhibition of c-Src (unknown origin) |
Eur J Med Chem 76: 193-244 (2014)
Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50331095
(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Quaid-i-Azam University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Eur J Med Chem 76: 193-244 (2014)
Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M |
More data for this
Ligand-Target Pair | |
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