Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527] (Homo sapiens (Human)) | BDBM50322535 (3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Harvard NeuroDiscovery Center | Assay Description The kinase assays for phosphorylation of LRRKtide (RLGRDKYKTLRQIRQ) or LRRKtideS (RLGRDKYKSLRQIRQ) were conducted in buffer containing 20 mM HEPES (p... | J Biol Chem 289: 13042-53 (2014) Article DOI: 10.1074/jbc.M113.537811 BindingDB Entry DOI: 10.7270/Q28S4NT5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527] (Homo sapiens (Human)) | BDBM228657 (GSK3-XIII) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Harvard NeuroDiscovery Center | Assay Description The kinase assays for phosphorylation of LRRKtide (RLGRDKYKTLRQIRQ) or LRRKtideS (RLGRDKYKSLRQIRQ) were conducted in buffer containing 20 mM HEPES (p... | J Biol Chem 289: 13042-53 (2014) Article DOI: 10.1074/jbc.M113.537811 BindingDB Entry DOI: 10.7270/Q28S4NT5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] (Homo sapiens (Human)) | BDBM50322535 (3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Harvard NeuroDiscovery Center | Assay Description The kinase assays for phosphorylation of LRRKtide (RLGRDKYKTLRQIRQ) or LRRKtideS (RLGRDKYKSLRQIRQ) were conducted in buffer containing 20 mM HEPES (p... | J Biol Chem 289: 13042-53 (2014) Article DOI: 10.1074/jbc.M113.537811 BindingDB Entry DOI: 10.7270/Q28S4NT5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] (Homo sapiens (Human)) | BDBM228657 (GSK3-XIII) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Harvard NeuroDiscovery Center | Assay Description The kinase assays for phosphorylation of LRRKtide (RLGRDKYKTLRQIRQ) or LRRKtideS (RLGRDKYKSLRQIRQ) were conducted in buffer containing 20 mM HEPES (p... | J Biol Chem 289: 13042-53 (2014) Article DOI: 10.1074/jbc.M113.537811 BindingDB Entry DOI: 10.7270/Q28S4NT5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Harvard NeuroDiscovery Center | Assay Description The kinase assays for phosphorylation of LRRKtide (RLGRDKYKTLRQIRQ) or LRRKtideS (RLGRDKYKSLRQIRQ) were conducted in buffer containing 20 mM HEPES (p... | J Biol Chem 289: 13042-53 (2014) Article DOI: 10.1074/jbc.M113.537811 BindingDB Entry DOI: 10.7270/Q28S4NT5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] (Homo sapiens (Human)) | BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Harvard NeuroDiscovery Center | Assay Description The kinase assays for phosphorylation of LRRKtide (RLGRDKYKTLRQIRQ) or LRRKtideS (RLGRDKYKSLRQIRQ) were conducted in buffer containing 20 mM HEPES (p... | J Biol Chem 289: 13042-53 (2014) Article DOI: 10.1074/jbc.M113.537811 BindingDB Entry DOI: 10.7270/Q28S4NT5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
