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PubMed code 24704197

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50252542
PNG
(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Show SMILES Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
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n/an/a 17n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012777
PNG
(CHEMBL3261096)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8S/c1-16-4-2-7-21(28-16)24-20(18-8-9-22-26-15-27-32(22)12-18)13-31(30-24)14-23(33)29-19-6-3-5-17(10-19)11-25/h2-10,12-13,15H,14H2,1H3,(H,29,33)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012803
PNG
(CHEMBL3261090)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20N8OS/c1-14-4-2-7-18(29-14)22-21(17-8-9-20-27-13-28-32(20)12-17)30-19(31-22)11-26-24(34)16-6-3-5-15(10-16)23(25)33/h2-10,12-13H,11H2,1H3,(H2,25,33)(H,26,34)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012815
PNG
(CHEMBL3261093)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8O/c1-16-4-2-7-21(28-16)24-20(18-8-9-22-26-15-27-32(22)12-18)13-31(30-24)14-23(33)29-19-6-3-5-17(10-19)11-25/h2-10,12-13,15H,14H2,1H3,(H,29,33)
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n/an/a 27n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012812
PNG
(CHEMBL3261088)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7S/c1-14-5-4-8-18(28-14)22-21(15-9-10-20-26-13-27-31(20)12-15)29-19(30-22)11-25-23(32)16-6-2-3-7-17(16)24/h2-10,12-13H,11H2,1H3,(H,25,32)(H,29,30)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012776
PNG
(CHEMBL3261095)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2F)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7S/c1-15-5-4-8-20(27-15)23-17(16-9-10-21-25-14-26-31(21)11-16)12-30(29-23)13-22(32)28-19-7-3-2-6-18(19)24/h2-12,14H,13H2,1H3,(H,28,32)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012807
PNG
(CHEMBL3261089)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8S/c1-15-4-2-7-19(29-15)23-22(18-8-9-21-27-14-28-32(21)13-18)30-20(31-23)12-26-24(33)17-6-3-5-16(10-17)11-25/h2-10,13-14H,12H2,1H3,(H,26,33)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012814
PNG
(CHEMBL3261094)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20N8O2/c1-15-4-2-7-20(28-15)23-19(17-8-9-21-26-14-27-32(21)11-17)12-31(30-23)13-22(33)29-18-6-3-5-16(10-18)24(25)34/h2-12,14H,13H2,1H3,(H2,25,34)(H,29,33)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012771
PNG
(CHEMBL3261084)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7O/c1-14-5-4-8-18(28-14)22-21(15-9-10-20-26-13-27-31(20)12-15)29-19(30-22)11-25-23(32)16-6-2-3-7-17(16)24/h2-10,12-13H,11H2,1H3,(H,25,32)(H,29,30)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012784
PNG
(CHEMBL3261087)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19N7S/c1-15-6-5-9-18(27-15)22-21(17-10-11-20-25-14-26-30(20)13-17)28-19(29-22)12-24-23(31)16-7-3-2-4-8-16/h2-11,13-14H,12H2,1H3,(H,24,31)(H,28,29)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50298220
PNG
(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Show SMILES Cc1cccc(n1)-c1nc([nH]c1-c1ccc2OCOc2c1)C(C)(C)C
Show InChI InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012774
PNG
(CHEMBL3261083)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19N7O/c1-15-6-5-9-18(27-15)22-21(17-10-11-20-25-14-26-30(20)13-17)28-19(29-22)12-24-23(31)16-7-3-2-4-8-16/h2-11,13-14H,12H2,1H3,(H,24,31)(H,28,29)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012684
PNG
(CHEMBL3261091)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19N7O/c1-16-6-5-9-20(26-16)23-19(17-10-11-21-24-15-25-30(21)12-17)13-29(28-23)14-22(31)27-18-7-3-2-4-8-18/h2-13,15H,14H2,1H3,(H,27,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012671
PNG
(CHEMBL3261092)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2F)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7O/c1-15-5-4-8-20(27-15)23-17(16-9-10-21-25-14-26-31(21)11-16)12-30(29-23)13-22(32)28-19-7-3-2-6-18(19)24/h2-12,14H,13H2,1H3,(H,28,32)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012769
PNG
(CHEMBL3261085)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8O/c1-15-4-2-7-19(29-15)23-22(18-8-9-21-27-14-28-32(21)13-18)30-20(31-23)12-26-24(33)17-6-3-5-16(10-17)11-25/h2-10,13-14H,12H2,1H3,(H,26,33)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012759
PNG
(CHEMBL3261086)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20N8O2/c1-14-4-2-7-18(29-14)22-21(17-8-9-20-27-13-28-32(20)12-17)30-19(31-22)11-26-24(34)16-6-3-5-15(10-16)23(25)33/h2-10,12-13H,11H2,1H3,(H2,25,33)(H,26,34)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based ass...

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50252542
PNG
(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Show SMILES Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50298220
PNG
(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Show SMILES Cc1cccc(n1)-c1nc([nH]c1-c1ccc2OCOc2c1)C(C)(C)C
Show InChI InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012812
PNG
(CHEMBL3261088)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7S/c1-14-5-4-8-18(28-14)22-21(15-9-10-20-26-13-27-31(20)12-15)29-19(30-22)11-25-23(32)16-6-2-3-7-17(16)24/h2-10,12-13H,11H2,1H3,(H,25,32)(H,29,30)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012807
PNG
(CHEMBL3261089)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8S/c1-15-4-2-7-19(29-15)23-22(18-8-9-21-27-14-28-32(21)13-18)30-20(31-23)12-26-24(33)17-6-3-5-16(10-17)11-25/h2-10,13-14H,12H2,1H3,(H,26,33)(H,30,31)
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n/an/a 1.49E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012803
PNG
(CHEMBL3261090)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20N8OS/c1-14-4-2-7-18(29-14)22-21(17-8-9-20-27-13-28-32(20)12-17)30-19(31-22)11-26-24(34)16-6-3-5-15(10-16)23(25)33/h2-10,12-13H,11H2,1H3,(H2,25,33)(H,26,34)(H,30,31)
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n/an/a 2.83E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012784
PNG
(CHEMBL3261087)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=S)c2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19N7S/c1-15-6-5-9-18(27-15)22-21(17-10-11-20-25-14-26-30(20)13-17)28-19(29-22)12-24-23(31)16-7-3-2-4-8-16/h2-11,13-14H,12H2,1H3,(H,24,31)(H,28,29)
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n/an/a 3.77E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012777
PNG
(CHEMBL3261096)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8S/c1-16-4-2-7-21(28-16)24-20(18-8-9-22-26-15-27-32(22)12-18)13-31(30-24)14-23(33)29-19-6-3-5-17(10-19)11-25/h2-10,12-13,15H,14H2,1H3,(H,29,33)
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n/an/a 5.11E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012776
PNG
(CHEMBL3261095)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2F)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7S/c1-15-5-4-8-20(27-15)23-17(16-9-10-21-25-14-26-31(21)11-16)12-30(29-23)13-22(32)28-19-7-3-2-6-18(19)24/h2-12,14H,13H2,1H3,(H,28,32)
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n/an/a 5.21E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012771
PNG
(CHEMBL3261084)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2ccccc2F)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7O/c1-14-5-4-8-18(28-14)22-21(15-9-10-20-26-13-27-31(20)12-15)29-19(30-22)11-25-23(32)16-6-2-3-7-17(16)24/h2-10,12-13H,11H2,1H3,(H,25,32)(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012684
PNG
(CHEMBL3261091)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19N7O/c1-16-6-5-9-20(26-16)23-19(17-10-11-21-24-15-25-30(21)12-17)13-29(28-23)14-22(31)27-18-7-3-2-4-8-18/h2-13,15H,14H2,1H3,(H,27,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012759
PNG
(CHEMBL3261086)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2cccc(c2)C(N)=O)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20N8O2/c1-14-4-2-7-18(29-14)22-21(17-8-9-20-27-13-28-32(20)12-17)30-19(31-22)11-26-24(34)16-6-3-5-15(10-16)23(25)33/h2-10,12-13H,11H2,1H3,(H2,25,33)(H,26,34)(H,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012769
PNG
(CHEMBL3261085)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8O/c1-15-4-2-7-19(29-15)23-22(18-8-9-21-27-14-28-32(21)13-18)30-20(31-23)12-26-24(33)17-6-3-5-16(10-17)11-25/h2-10,13-14H,12H2,1H3,(H,26,33)(H,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012671
PNG
(CHEMBL3261092)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2F)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H18FN7O/c1-15-5-4-8-20(27-15)23-17(16-9-10-21-25-14-26-31(21)11-16)12-30(29-23)13-22(32)28-19-7-3-2-6-18(19)24/h2-12,14H,13H2,1H3,(H,28,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012814
PNG
(CHEMBL3261094)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H20N8O2/c1-15-4-2-7-20(28-15)23-19(17-8-9-21-26-14-27-32(21)11-17)12-31(30-23)13-22(33)29-18-6-3-5-16(10-18)24(25)34/h2-12,14H,13H2,1H3,(H2,25,34)(H,29,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012774
PNG
(CHEMBL3261083)
Show SMILES Cc1cccc(n1)-c1[nH]c(CNC(=O)c2ccccc2)nc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C23H19N7O/c1-15-6-5-9-18(27-15)22-21(17-10-11-20-25-14-26-30(20)13-17)28-19(29-22)12-24-23(31)16-7-3-2-4-8-16/h2-11,13-14H,12H2,1H3,(H,24,31)(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50012815
PNG
(CHEMBL3261093)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2ncnn2c1
Show InChI InChI=1S/C24H18N8O/c1-16-4-2-7-21(28-16)24-20(18-8-9-22-26-15-27-32(22)12-18)13-31(30-24)14-23(33)29-19-6-3-5-17(10-19)11-25/h2-10,12-13,15H,14H2,1H3,(H,29,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay

Bioorg Med Chem 22: 2724-32 (2014)


Article DOI: 10.1016/j.bmc.2014.03.022
BindingDB Entry DOI: 10.7270/Q2CC1275
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%