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PubMed code 24735492

Compile data set for download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50017268
PNG
(CHEMBL3287723 | US10099993, Compound 96)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-22-14-17(24(28)29)8-10-21(22)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human histamine H4 receptor at 10 uM by radioligand displacement assay


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50017264
PNG
(CHEMBL3287718)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2c(OC)cccc2C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O7/c1-4-8-18(24)16-11-12-19(15(2)21(16)25)29-13-5-6-14-30-22-17(23(26)27)9-7-10-20(22)28-3/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGlu1 receptor expressed in HEK293 cells


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50017268
PNG
(CHEMBL3287723 | US10099993, Compound 96)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-22-14-17(24(28)29)8-10-21(22)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human histamine H2 receptor at 10 uM by radioligand displacement assay


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50017264
PNG
(CHEMBL3287718)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2c(OC)cccc2C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O7/c1-4-8-18(24)16-11-12-19(15(2)21(16)25)29-13-5-6-14-30-22-17(23(26)27)9-7-10-20(22)28-3/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGlu4 receptor expressed in HEK293 cells


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017251
PNG
(CHEMBL3287692)
Show SMILES Cc1cc(ccc1OCCCCOc1ccc(C(=O)CC2CCCC2)c(O)c1C)C(O)=O
Show InChI InChI=1S/C26H32O6/c1-17-15-20(26(29)30)9-11-23(17)31-13-5-6-14-32-24-12-10-21(25(28)18(24)2)22(27)16-19-7-3-4-8-19/h9-12,15,19,28H,3-8,13-14,16H2,1-2H3,(H,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017277
PNG
(CHEMBL3287680 | US10099993, Compound 29)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccccc1C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H30O6/c1-17-22(13-12-19(24(17)27)21(26)16-18-8-2-3-9-18)30-14-6-7-15-31-23-11-5-4-10-20(23)25(28)29/h4-5,10-13,18,27H,2-3,6-9,14-16H2,1H3,(H,28,29)
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n/an/an/an/a 335n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017263
PNG
(CHEMBL3287716 | US10099993, Compound 65)
Show SMILES CC(C)C(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H25FO6/c1-13(2)20(24)16-7-9-19(14(3)21(16)25)29-11-5-4-10-28-15-6-8-18(23)17(12-15)22(26)27/h6-9,12-13,25H,4-5,10-11H2,1-3H3,(H,26,27)
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n/an/an/an/a 171n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017212
PNG
(CHEMBL3287671 | US10099993, Compound 20)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-15(2)14-20(24)19-10-11-21(16(3)22(19)25)29-13-5-4-12-28-18-8-6-17(7-9-18)23(26)27/h6-11,15,25H,4-5,12-14H2,1-3H3,(H,26,27)
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n/an/an/an/a 2.72E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017246
PNG
(CHEMBL3287687 | US10099993, Compound 36)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H27FO6/c1-14(2)12-20(25)17-7-9-21(15(3)22(17)26)30-11-5-4-10-29-16-6-8-19(24)18(13-16)23(27)28/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 920n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017252
PNG
(CHEMBL3287693 | US10099993, Compound 42)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2F)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H27FO6/c1-14(2)12-19(25)17-7-9-20(15(3)22(17)26)29-10-4-5-11-30-21-8-6-16(23(27)28)13-18(21)24/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 1.42E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017261
PNG
(CHEMBL3287709 | US10099993, Compound 58)
Show SMILES CCC(=O)c1ccc(OCCCCOc2cc(ccc2OC)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H26O7/c1-4-17(23)16-8-10-18(14(2)21(16)24)28-11-5-6-12-29-20-13-15(22(25)26)7-9-19(20)27-3/h7-10,13,24H,4-6,11-12H2,1-3H3,(H,25,26)
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n/an/an/an/a 6.36E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017262
PNG
(CHEMBL3287714 | US10099993, Compound 63)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)C(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C23H28O7/c1-14(2)21(24)17-8-10-18(15(3)22(17)25)29-11-5-6-12-30-20-13-16(23(26)27)7-9-19(20)28-4/h7-10,13-14,25H,5-6,11-12H2,1-4H3,(H,26,27)
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n/an/an/an/a 588n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017264
PNG
(CHEMBL3287718)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2c(OC)cccc2C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O7/c1-4-8-18(24)16-11-12-19(15(2)21(16)25)29-13-5-6-14-30-22-17(23(26)27)9-7-10-20(22)28-3/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)
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n/an/an/an/a 1.83E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017266
PNG
(CHEMBL3287720 | US10099993, Compound 69)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2cccc(C(O)=O)c2C)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-4-8-19(24)18-11-12-21(16(3)22(18)25)29-14-6-5-13-28-20-10-7-9-17(15(20)2)23(26)27/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017249
PNG
(CHEMBL3287690 | US10099993, Compound 39)
Show SMILES Cc1ccc(cc1OCCCCOc1ccc(C(=O)CC2CCCC2)c(O)c1C)C(O)=O
Show InChI InChI=1S/C26H32O6/c1-17-9-10-20(26(29)30)16-24(17)32-14-6-5-13-31-23-12-11-21(25(28)18(23)2)22(27)15-19-7-3-4-8-19/h9-12,16,19,28H,3-8,13-15H2,1-2H3,(H,29,30)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017257
PNG
(CHEMBL3287699 | US10099993, Compound 48)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(C(O)=O)c(C)c2)c(C)c1O
Show InChI InChI=1S/C24H30O6/c1-15(2)13-21(25)20-9-10-22(17(4)23(20)26)30-12-6-5-11-29-18-7-8-19(24(27)28)16(3)14-18/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 173n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017279
PNG
(CHEMBL3287703 | US10099993, Compound 52)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(C)=O)c(O)c1C)C(O)=O
Show InChI InChI=1S/C21H24O7/c1-13-17(9-7-16(14(2)22)20(13)23)27-10-4-5-11-28-18-8-6-15(21(24)25)12-19(18)26-3/h6-9,12,23H,4-5,10-11H2,1-3H3,(H,24,25)
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n/an/an/an/a 161n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017288
PNG
(CHEMBL3287713 | US10099993, Compound 62)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)C(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C23H28O7/c1-14(2)21(24)17-8-10-18(15(3)22(17)25)29-11-5-6-12-30-19-9-7-16(23(26)27)13-20(19)28-4/h7-10,13-14,25H,5-6,11-12H2,1-4H3,(H,26,27)
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n/an/an/an/a 113n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017213
PNG
(CHEMBL3287672 | US10099993, Compound 21)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H30O6/c1-17-23(13-12-21(24(17)27)22(26)16-18-6-2-3-7-18)31-15-5-4-14-30-20-10-8-19(9-11-20)25(28)29/h8-13,18,27H,2-7,14-16H2,1H3,(H,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017243
PNG
(CHEMBL3287683 | US10099993, Compound 32)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(C(O)=O)c(Cl)c2)c(C)c1O
Show InChI InChI=1S/C23H27ClO6/c1-14(2)12-20(25)18-8-9-21(15(3)22(18)26)30-11-5-4-10-29-16-6-7-17(23(27)28)19(24)13-16/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 2.05E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017263
PNG
(CHEMBL3287716 | US10099993, Compound 65)
Show SMILES CC(C)C(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H25FO6/c1-13(2)20(24)16-7-9-19(14(3)21(16)25)29-11-5-4-10-28-15-6-8-18(23)17(12-15)22(26)27/h6-9,12-13,25H,4-5,10-11H2,1-3H3,(H,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50335255
PNG
(3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-...)
Show SMILES Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1C)C1CCCC1
Show InChI InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
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n/an/an/an/a 441n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assay


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017213
PNG
(CHEMBL3287672 | US10099993, Compound 21)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H30O6/c1-17-23(13-12-21(24(17)27)22(26)16-18-6-2-3-7-18)31-15-5-4-14-30-20-10-8-19(9-11-20)25(28)29/h8-13,18,27H,2-7,14-16H2,1H3,(H,28,29)
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n/an/an/an/a 824n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017228
PNG
(CHEMBL3287676 | US10099993, Compound 25)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1cccc(c1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H30O6/c1-17-23(12-11-21(24(17)27)22(26)15-18-7-2-3-8-18)31-14-5-4-13-30-20-10-6-9-19(16-20)25(28)29/h6,9-12,16,18,27H,2-5,7-8,13-15H2,1H3,(H,28,29)
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n/an/an/an/a 451n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017274
PNG
(CHEMBL3287677 | US10099993, Compound 26)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccccc2C(O)=O)c(C)c1C
Show InChI InChI=1S/C24H30O5/c1-16(2)15-21(25)19-11-12-22(18(4)17(19)3)28-13-7-8-14-29-23-10-6-5-9-20(23)24(26)27/h5-6,9-12,16H,7-8,13-15H2,1-4H3,(H,26,27)
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n/an/an/an/a 976n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017276
PNG
(CHEMBL3287679 | US10099993, Compound 28)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccccc2C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-15(2)14-19(24)17-10-11-20(16(3)22(17)25)28-12-6-7-13-29-21-9-5-4-8-18(21)23(26)27/h4-5,8-11,15,25H,6-7,12-14H2,1-3H3,(H,26,27)
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n/an/an/an/a 415n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017278
PNG
(CHEMBL3287681 | US10099993, Compound 30)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(C(O)=O)c(Cl)c2)c(C)c1C
Show InChI InChI=1S/C24H29ClO5/c1-15(2)13-22(26)19-9-10-23(17(4)16(19)3)30-12-6-5-11-29-18-7-8-20(24(27)28)21(25)14-18/h7-10,14-15H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017252
PNG
(CHEMBL3287693 | US10099993, Compound 42)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2F)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H27FO6/c1-14(2)12-19(25)17-7-9-20(15(3)22(17)26)29-10-4-5-11-30-21-8-6-16(23(27)28)13-18(21)24/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 102n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017253
PNG
(CHEMBL3287694 | US10099993, Compound 43)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1F)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29FO6/c1-16-22(11-9-19(24(16)28)21(27)14-17-6-2-3-7-17)31-12-4-5-13-32-23-10-8-18(25(29)30)15-20(23)26/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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n/an/an/an/a 639n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017260
PNG
(CHEMBL3287702 | US10099993, Compound 51)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC2CCCC2)c(O)c1C)C(O)=O
Show InChI InChI=1S/C26H32O7/c1-17-22(12-10-20(25(17)28)21(27)15-18-7-3-4-8-18)32-13-5-6-14-33-24-16-19(26(29)30)9-11-23(24)31-2/h9-12,16,18,28H,3-8,13-15H2,1-2H3,(H,29,30)
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n/an/an/an/a 425n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017287
PNG
(CHEMBL3287712 | US10099993, Compound 61)
Show SMILES CCC(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H26O6/c1-4-18(23)17-8-10-20(15(3)21(17)24)28-12-6-5-11-27-19-9-7-16(22(25)26)13-14(19)2/h7-10,13,24H,4-6,11-12H2,1-3H3,(H,25,26)
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n/an/an/an/a 82n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017264
PNG
(CHEMBL3287718)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2c(OC)cccc2C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O7/c1-4-8-18(24)16-11-12-19(15(2)21(16)25)29-13-5-6-14-30-22-17(23(26)27)9-7-10-20(22)28-3/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)
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n/an/an/an/a 34n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017211
PNG
(CHEMBL3287695 | US10099993, Compound 44)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-21-9-7-17(24(27)28)14-22(21)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 12n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assay


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017228
PNG
(CHEMBL3287676 | US10099993, Compound 25)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1cccc(c1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H30O6/c1-17-23(12-11-21(24(17)27)22(26)15-18-7-2-3-8-18)31-14-5-4-13-30-20-10-6-9-19(16-20)25(28)29/h6,9-12,16,18,27H,2-5,7-8,13-15H2,1H3,(H,28,29)
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n/an/an/an/a 3.40E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017230
PNG
(CHEMBL3287682 | US10099993, Compound 31)
Show SMILES Cc1c(C)c(ccc1OCCCCOc1ccc(C(O)=O)c(Cl)c1)C(=O)CC1CCCC1
Show InChI InChI=1S/C26H31ClO5/c1-17-18(2)25(12-11-21(17)24(28)15-19-7-3-4-8-19)32-14-6-5-13-31-20-9-10-22(26(29)30)23(27)16-20/h9-12,16,19H,3-8,13-15H2,1-2H3,(H,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017245
PNG
(CHEMBL3287684 | US10099993, Compound 33)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(C(O)=O)c(Cl)c1)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29ClO6/c1-16-23(11-10-20(24(16)28)22(27)14-17-6-2-3-7-17)32-13-5-4-12-31-18-8-9-19(25(29)30)21(26)15-18/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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n/an/an/an/a 2.25E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017250
PNG
(CHEMBL3287691)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C24H30O6/c1-15(2)13-20(25)19-8-10-22(17(4)23(19)26)30-12-6-5-11-29-21-9-7-18(24(27)28)14-16(21)3/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 1.85E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017254
PNG
(CHEMBL3287696)
Show SMILES Cc1c(O)c(ccc1OCCCCOCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C26H32O7/c1-18-24(13-12-22(25(18)28)23(27)16-19-6-2-3-7-19)32-15-5-4-14-31-17-33-21-10-8-20(9-11-21)26(29)30/h8-13,19,28H,2-7,14-17H2,1H3,(H,29,30)
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n/an/an/an/a 1.91E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017265
PNG
(CHEMBL3287719 | US10099993, Compound 68)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2cc(ccc2OC)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O7/c1-4-7-18(24)17-9-11-19(15(2)22(17)25)29-12-5-6-13-30-21-14-16(23(26)27)8-10-20(21)28-3/h8-11,14,25H,4-7,12-13H2,1-3H3,(H,26,27)
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n/an/an/an/a 496n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50017269
PNG
(CHEMBL3287724 | US10099993, Compound 73)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-21-10-8-17(24(28)29)14-22(21)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu6 receptor expressed in HEK293 cells


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017272
PNG
(CHEMBL193982 | US10099993, Compound 5)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(CCC(O)=O)c(O)c2)c(C)c1O
Show InChI InChI=1S/C25H32O7/c1-16(2)14-22(27)20-9-10-23(17(3)25(20)30)32-13-5-4-12-31-19-8-6-18(21(26)15-19)7-11-24(28)29/h6,8-10,15-16,26,30H,4-5,7,11-14H2,1-3H3,(H,28,29)
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n/an/an/an/a 2.45E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017273
PNG
(CHEMBL371464)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc3ccc(=O)oc3c2)c(C)c1O
Show InChI InChI=1S/C25H28O6/c1-16(2)14-21(26)20-9-10-22(17(3)25(20)28)30-13-5-4-12-29-19-8-6-18-7-11-24(27)31-23(18)15-19/h6-11,15-16,28H,4-5,12-14H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017275
PNG
(CHEMBL3287678 | US10099993, Compound 27)
Show SMILES Cc1c(C)c(ccc1OCCCCOc1ccccc1C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C26H32O5/c1-18-19(2)24(14-13-21(18)23(27)17-20-9-3-4-10-20)30-15-7-8-16-31-25-12-6-5-11-22(25)26(28)29/h5-6,11-14,20H,3-4,7-10,15-17H2,1-2H3,(H,28,29)
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n/an/an/an/a 2.58E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017254
PNG
(CHEMBL3287696)
Show SMILES Cc1c(O)c(ccc1OCCCCOCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C26H32O7/c1-18-24(13-12-22(25(18)28)23(27)16-19-6-2-3-7-19)32-15-5-4-14-31-17-33-21-10-8-20(9-11-21)26(29)30/h8-13,19,28H,2-7,14-17H2,1H3,(H,29,30)
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n/an/an/an/a 228n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017256
PNG
(CHEMBL3287698 | US10099993, Compound 47)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1Cl)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29ClO6/c1-16-22(11-9-19(24(16)28)21(27)14-17-6-2-3-7-17)31-12-4-5-13-32-23-10-8-18(25(29)30)15-20(23)26/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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n/an/an/an/a 237n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017285
PNG
(CHEMBL3287710 | US10099993, Compound 59)
Show SMILES CCC(=O)c1ccc(OCCCCOc2cccc(C(O)=O)c2C)c(C)c1O
Show InChI InChI=1S/C22H26O6/c1-4-18(23)17-10-11-20(15(3)21(17)24)28-13-6-5-12-27-19-9-7-8-16(14(19)2)22(25)26/h7-11,24H,4-6,12-13H2,1-3H3,(H,25,26)
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n/an/an/an/a 62n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017266
PNG
(CHEMBL3287720 | US10099993, Compound 69)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2cccc(C(O)=O)c2C)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-4-8-19(24)18-11-12-21(16(3)22(18)25)29-14-6-5-13-28-20-10-7-9-17(15(20)2)23(26)27/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)
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n/an/an/an/a 52n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017267
PNG
(CHEMBL3287721 | US10099993, Compound 70)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H25FO6/c1-3-6-19(24)16-8-10-20(14(2)21(16)25)29-12-5-4-11-28-15-7-9-18(23)17(13-15)22(26)27/h7-10,13,25H,3-6,11-12H2,1-2H3,(H,26,27)
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n/an/an/an/a 74n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017227
PNG
(CHEMBL3287675 | US10099993, Compound 24)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2cccc(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-15(2)13-20(24)19-9-10-21(16(3)22(19)25)29-12-5-4-11-28-18-8-6-7-17(14-18)23(26)27/h6-10,14-15,25H,4-5,11-13H2,1-3H3,(H,26,27)
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n/an/an/an/a 1.43E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017247
PNG
(CHEMBL3287688 | US10099993, Compound 37)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29FO6/c1-16-23(11-9-19(24(16)28)22(27)14-17-6-2-3-7-17)32-13-5-4-12-31-18-8-10-21(26)20(15-18)25(29)30/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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n/an/an/an/a 2.49E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017257
PNG
(CHEMBL3287699 | US10099993, Compound 48)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(C(O)=O)c(C)c2)c(C)c1O
Show InChI InChI=1S/C24H30O6/c1-15(2)13-21(25)20-9-10-22(17(4)23(20)26)30-12-6-5-11-29-18-7-8-19(24(27)28)16(3)14-18/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 3.91E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017260
PNG
(CHEMBL3287702 | US10099993, Compound 51)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC2CCCC2)c(O)c1C)C(O)=O
Show InChI InChI=1S/C26H32O7/c1-17-22(12-10-20(25(17)28)21(27)15-18-7-3-4-8-18)32-13-5-6-14-33-24-16-19(26(29)30)9-11-23(24)31-2/h9-12,16,18,28H,3-8,13-15H2,1-2H3,(H,29,30)
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n/an/an/an/a 1.02E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017212
PNG
(CHEMBL3287671 | US10099993, Compound 20)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-15(2)14-20(24)19-10-11-21(16(3)22(19)25)29-13-5-4-12-28-18-8-6-17(7-9-18)23(26)27/h6-11,15,25H,4-5,12-14H2,1-3H3,(H,26,27)
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n/an/an/an/a 122n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017230
PNG
(CHEMBL3287682 | US10099993, Compound 31)
Show SMILES Cc1c(C)c(ccc1OCCCCOc1ccc(C(O)=O)c(Cl)c1)C(=O)CC1CCCC1
Show InChI InChI=1S/C26H31ClO5/c1-17-18(2)25(12-11-21(17)24(28)15-19-7-3-4-8-19)32-14-6-5-13-31-20-9-10-22(26(29)30)23(27)16-20/h9-12,16,19H,3-8,13-15H2,1-2H3,(H,29,30)
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n/an/an/an/a 2.42E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017245
PNG
(CHEMBL3287684 | US10099993, Compound 33)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(C(O)=O)c(Cl)c1)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29ClO6/c1-16-23(11-10-20(24(16)28)22(27)14-17-6-2-3-7-17)32-13-5-4-12-31-18-8-9-19(25(29)30)21(26)15-18/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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n/an/an/an/a 510n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017246
PNG
(CHEMBL3287687 | US10099993, Compound 36)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H27FO6/c1-14(2)12-20(25)17-7-9-21(15(3)22(17)26)30-11-5-4-10-29-16-6-8-19(24)18(13-16)23(27)28/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 153n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017282
PNG
(CHEMBL3287706 | US10099993, Compound 55)
Show SMILES CC(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C20H21FO6/c1-12-18(8-6-15(13(2)22)19(12)23)27-10-4-3-9-26-14-5-7-17(21)16(11-14)20(24)25/h5-8,11,23H,3-4,9-10H2,1-2H3,(H,24,25)
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n/an/an/an/a 259n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017290
PNG
(CHEMBL3287717 | US10099993, Compound 66)
Show SMILES CC(C)C(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-14(2)21(24)18-8-10-20(16(4)22(18)25)29-12-6-5-11-28-19-9-7-17(23(26)27)13-15(19)3/h7-10,13-14,25H,5-6,11-12H2,1-4H3,(H,26,27)
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n/an/an/an/a 234n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017207
PNG
(CHEMBL3287722 | US10099993, Compound 71)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-4-7-19(24)18-9-11-21(16(3)22(18)25)29-13-6-5-12-28-20-10-8-17(23(26)27)14-15(20)2/h8-11,14,25H,4-7,12-13H2,1-3H3,(H,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017249
PNG
(CHEMBL3287690 | US10099993, Compound 39)
Show SMILES Cc1ccc(cc1OCCCCOc1ccc(C(=O)CC2CCCC2)c(O)c1C)C(O)=O
Show InChI InChI=1S/C26H32O6/c1-17-9-10-20(26(29)30)16-24(17)32-14-6-5-13-31-23-12-11-21(25(28)18(23)2)22(27)15-19-7-3-4-8-19/h9-12,16,19,28H,3-8,13-15H2,1-2H3,(H,29,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017211
PNG
(CHEMBL3287695 | US10099993, Compound 44)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-21-9-7-17(24(27)28)14-22(21)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017268
PNG
(CHEMBL3287723 | US10099993, Compound 96)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-22-14-17(24(28)29)8-10-21(22)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/an/an/a 151n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017269
PNG
(CHEMBL3287724 | US10099993, Compound 73)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-21-10-8-17(24(28)29)14-22(21)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/an/an/a 310n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017251
PNG
(CHEMBL3287692)
Show SMILES Cc1cc(ccc1OCCCCOc1ccc(C(=O)CC2CCCC2)c(O)c1C)C(O)=O
Show InChI InChI=1S/C26H32O6/c1-17-15-20(26(29)30)9-11-23(17)31-13-5-6-14-32-24-12-10-21(25(28)18(24)2)22(27)16-19-7-3-4-8-19/h9-12,15,19,28H,3-8,13-14,16H2,1-2H3,(H,29,30)
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n/an/an/an/a 608n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017211
PNG
(CHEMBL3287695 | US10099993, Compound 44)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-21-9-7-17(24(27)28)14-22(21)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 40n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017259
PNG
(CHEMBL3287701 | US10099993, Compound 50)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-22-14-17(24(27)28)7-9-21(22)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 155n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017261
PNG
(CHEMBL3287709 | US10099993, Compound 58)
Show SMILES CCC(=O)c1ccc(OCCCCOc2cc(ccc2OC)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H26O7/c1-4-17(23)16-8-10-18(14(2)21(16)24)28-11-5-6-12-29-20-13-15(22(25)26)7-9-19(20)27-3/h7-10,13,24H,4-6,11-12H2,1-3H3,(H,25,26)
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n/an/an/an/a 162n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017262
PNG
(CHEMBL3287714 | US10099993, Compound 63)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)C(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C23H28O7/c1-14(2)21(24)17-8-10-18(15(3)22(17)25)29-11-5-6-12-30-20-13-16(23(26)27)7-9-19(20)28-4/h7-10,13-14,25H,5-6,11-12H2,1-4H3,(H,26,27)
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n/an/an/an/a 116n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017265
PNG
(CHEMBL3287719 | US10099993, Compound 68)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2cc(ccc2OC)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O7/c1-4-7-18(24)17-9-11-19(15(2)22(17)25)29-12-5-6-13-30-21-14-16(23(26)27)8-10-20(21)28-3/h8-11,14,25H,4-7,12-13H2,1-3H3,(H,26,27)
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n/an/an/an/a 103n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017211
PNG
(CHEMBL3287695 | US10099993, Compound 44)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-21-9-7-17(24(27)28)14-22(21)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 1.77E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in TREx293 cells by calcium mobilization assay


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017253
PNG
(CHEMBL3287694 | US10099993, Compound 43)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1F)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29FO6/c1-16-22(11-9-19(24(16)28)21(27)14-17-6-2-3-7-17)31-12-4-5-13-32-23-10-8-18(25(29)30)15-20(23)26/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017256
PNG
(CHEMBL3287698 | US10099993, Compound 47)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1Cl)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29ClO6/c1-16-22(11-9-19(24(16)28)21(27)14-17-6-2-3-7-17)31-12-4-5-13-32-23-10-8-18(25(29)30)15-20(23)26/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017258
PNG
(CHEMBL3287700 | US10099993, Compound 49)
Show SMILES Cc1cc(OCCCCOc2ccc(C(=O)CC3CCCC3)c(O)c2C)ccc1C(O)=O
Show InChI InChI=1S/C26H32O6/c1-17-15-20(9-10-21(17)26(29)30)31-13-5-6-14-32-24-12-11-22(25(28)18(24)2)23(27)16-19-7-3-4-8-19/h9-12,15,19,28H,3-8,13-14,16H2,1-2H3,(H,29,30)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017267
PNG
(CHEMBL3287721 | US10099993, Compound 70)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H25FO6/c1-3-6-19(24)16-8-10-20(14(2)21(16)25)29-12-5-4-11-28-15-7-9-18(23)17(13-15)22(26)27/h7-10,13,25H,3-6,11-12H2,1-2H3,(H,26,27)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017248
PNG
(CHEMBL3287689 | US10099993, Compound 38)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2cc(ccc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C24H30O6/c1-15(2)13-20(25)19-9-10-21(17(4)23(19)26)29-11-5-6-12-30-22-14-18(24(27)28)8-7-16(22)3/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017250
PNG
(CHEMBL3287691)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C24H30O6/c1-15(2)13-20(25)19-8-10-22(17(4)23(19)26)30-12-6-5-11-29-21-9-7-18(24(27)28)14-16(21)3/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 192n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017280
PNG
(CHEMBL3287704 | US10099993, Compound 53)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(C)=O)c(O)c1C)C(O)=O
Show InChI InChI=1S/C21H24O7/c1-13-17(9-7-16(14(2)22)20(13)23)27-10-4-5-11-28-19-12-15(21(24)25)6-8-18(19)26-3/h6-9,12,23H,4-5,10-11H2,1-3H3,(H,24,25)
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n/an/an/an/a 1.09E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017281
PNG
(CHEMBL3287705 | US10099993, Compound 54)
Show SMILES CC(=O)c1ccc(OCCCCOc2cccc(C(O)=O)c2C)c(C)c1O
Show InChI InChI=1S/C21H24O6/c1-13-16(21(24)25)7-6-8-18(13)26-11-4-5-12-27-19-10-9-17(15(3)22)20(23)14(19)2/h6-10,23H,4-5,11-12H2,1-3H3,(H,24,25)
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n/an/an/an/a 200n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017283
PNG
(CHEMBL3287707 | US10099993, Compound 56)
Show SMILES CC(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C21H24O6/c1-13-12-16(21(24)25)6-8-18(13)26-10-4-5-11-27-19-9-7-17(15(3)22)20(23)14(19)2/h6-9,12,23H,4-5,10-11H2,1-3H3,(H,24,25)
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n/an/an/an/a 50n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017289
PNG
(CHEMBL3287715 | US10099993, Compound 64)
Show SMILES CC(C)C(=O)c1ccc(OCCCCOc2cccc(C(O)=O)c2C)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-14(2)21(24)18-10-11-20(16(4)22(18)25)29-13-6-5-12-28-19-9-7-8-17(15(19)3)23(26)27/h7-11,14,25H,5-6,12-13H2,1-4H3,(H,26,27)
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n/an/an/an/a 149n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017271
PNG
(CHEMBL3287726 | US10099993, Compound 75)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C
Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29)
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n/an/an/an/a 208n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017211
PNG
(CHEMBL3287695 | US10099993, Compound 44)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-21-9-7-17(24(27)28)14-22(21)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 148n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR2 receptor expressed in HEK293 cells assessed as thallium flux incubated for 2.5 mins prior to thallium buffer addition ...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017248
PNG
(CHEMBL3287689 | US10099993, Compound 38)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2cc(ccc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C24H30O6/c1-15(2)13-20(25)19-9-10-21(17(4)23(19)26)29-11-5-6-12-30-22-14-18(24(27)28)8-7-16(22)3/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017255
PNG
(CHEMBL3287697 | US10099993, Compound 46)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2Cl)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H27ClO6/c1-14(2)12-19(25)17-7-9-20(15(3)22(17)26)29-10-4-5-11-30-21-8-6-16(23(27)28)13-18(21)24/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 1.14E+3n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017259
PNG
(CHEMBL3287701 | US10099993, Compound 50)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-22-14-17(24(27)28)7-9-21(22)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 737n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017270
PNG
(CHEMBL3287725 | US10099993, Compound 74)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1cccc(C(O)=O)c1C)C(=O)CC(C)(C)C
Show InChI InChI=1S/C25H32O6/c1-16-18(24(28)29)9-8-10-21(16)30-13-6-7-14-31-22-12-11-19(23(27)17(22)2)20(26)15-25(3,4)5/h8-12,27H,6-7,13-15H2,1-5H3,(H,28,29)
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n/an/an/an/a 300n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50017271
PNG
(CHEMBL3287726 | US10099993, Compound 75)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C
Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29)
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n/an/an/an/a 258n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017227
PNG
(CHEMBL3287675 | US10099993, Compound 24)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2cccc(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-15(2)13-20(24)19-9-10-21(16(3)22(19)25)29-12-5-4-11-28-18-8-6-7-17(14-18)23(26)27/h6-10,14-15,25H,4-5,11-13H2,1-3H3,(H,26,27)
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n/an/an/an/a 222n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017243
PNG
(CHEMBL3287683 | US10099993, Compound 32)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(C(O)=O)c(Cl)c2)c(C)c1O
Show InChI InChI=1S/C23H27ClO6/c1-14(2)12-20(25)18-8-9-21(15(3)22(18)26)30-11-5-4-10-29-16-6-7-17(23(27)28)19(24)13-16/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 151n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017247
PNG
(CHEMBL3287688 | US10099993, Compound 37)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC1CCCC1
Show InChI InChI=1S/C25H29FO6/c1-16-23(11-9-19(24(16)28)22(27)14-17-6-2-3-7-17)32-13-5-4-12-31-18-8-10-21(26)20(15-18)25(29)30/h8-11,15,17,28H,2-7,12-14H2,1H3,(H,29,30)
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n/an/an/an/a 699n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017255
PNG
(CHEMBL3287697 | US10099993, Compound 46)
Show SMILES CC(C)CC(=O)c1ccc(OCCCCOc2ccc(cc2Cl)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H27ClO6/c1-14(2)12-19(25)17-7-9-20(15(3)22(17)26)29-10-4-5-11-30-21-8-6-16(23(27)28)13-18(21)24/h6-9,13-14,26H,4-5,10-12H2,1-3H3,(H,27,28)
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n/an/an/an/a 96n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017258
PNG
(CHEMBL3287700 | US10099993, Compound 49)
Show SMILES Cc1cc(OCCCCOc2ccc(C(=O)CC3CCCC3)c(O)c2C)ccc1C(O)=O
Show InChI InChI=1S/C26H32O6/c1-17-15-20(9-10-21(17)26(29)30)31-13-5-6-14-32-24-12-11-22(25(28)18(24)2)23(27)16-19-7-3-4-8-19/h9-12,15,19,28H,3-8,13-14,16H2,1-2H3,(H,29,30)
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n/an/an/an/a 564n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017284
PNG
(CHEMBL3287708 | US10099993, Compound 57)
Show SMILES CCC(=O)c1ccc(OCCCCOc2ccc(cc2OC)C(O)=O)c(C)c1O
Show InChI InChI=1S/C22H26O7/c1-4-17(23)16-8-10-18(14(2)21(16)24)28-11-5-6-12-29-19-9-7-15(22(25)26)13-20(19)27-3/h7-10,13,24H,4-6,11-12H2,1-3H3,(H,25,26)
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n/an/an/an/a 114n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017286
PNG
(CHEMBL3287711 | US10099993, Compound 60)
Show SMILES CCC(=O)c1ccc(OCCCCOc2ccc(F)c(c2)C(O)=O)c(C)c1O
Show InChI InChI=1S/C21H23FO6/c1-3-18(23)15-7-9-19(13(2)20(15)24)28-11-5-4-10-27-14-6-8-17(22)16(12-14)21(25)26/h6-9,12,24H,3-5,10-11H2,1-2H3,(H,25,26)
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n/an/an/an/a 124n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017207
PNG
(CHEMBL3287722 | US10099993, Compound 71)
Show SMILES CCCC(=O)c1ccc(OCCCCOc2ccc(cc2C)C(O)=O)c(C)c1O
Show InChI InChI=1S/C23H28O6/c1-4-7-19(24)18-9-11-21(16(3)22(18)25)29-13-6-5-12-28-20-10-8-17(23(26)27)14-15(20)2/h8-11,14,25H,4-7,12-13H2,1-3H3,(H,26,27)
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n/an/an/an/a 104n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017268
PNG
(CHEMBL3287723 | US10099993, Compound 96)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-22-14-17(24(28)29)8-10-21(22)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/an/an/a 184n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017269
PNG
(CHEMBL3287724 | US10099993, Compound 73)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-21-10-8-17(24(28)29)14-22(21)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)
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n/an/an/an/a 47n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50017270
PNG
(CHEMBL3287725 | US10099993, Compound 74)
Show SMILES Cc1c(O)c(ccc1OCCCCOc1cccc(C(O)=O)c1C)C(=O)CC(C)(C)C
Show InChI InChI=1S/C25H32O6/c1-16-18(24(28)29)9-8-10-21(16)30-13-6-7-14-31-22-12-11-19(23(27)17(22)2)20(26)15-25(3,4)5/h8-12,27H,6-7,13-15H2,1-5H3,(H,28,29)
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n/an/an/an/a 136n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...


J Med Chem 57: 4154-72 (2014)


Article DOI: 10.1021/jm5000563
BindingDB Entry DOI: 10.7270/Q2GH9KH9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%