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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk2 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of CHK2 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of mTOR (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of PI3K alpha (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of FGFR1 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of EGFR (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of IGF-1R (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of FLT3 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of CHK1 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of Cdk1/cyclin B (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of C-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of Kit (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human ERG after 60 mins by competitive binding assay | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of VEGFR2 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of B-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of MET (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Aurora kinase B (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of aurora B (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of PI3K beta (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of PDGFR-beta (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase Nek2 (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of Nek2 (unknown origin) | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM50015314 (CHEMBL3263869) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Development Center for Biotechnology Curated by ChEMBL | Assay Description Inhibition of aurora A (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis | J Med Chem 57: 4098-110 (2014) Article DOI: 10.1021/jm401990s BindingDB Entry DOI: 10.7270/Q23J3FH9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
