Affinity Data by PubMed id=24782313

PubMed code 24782313

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM50379156 (CHEMBL2012958 \| Genz-669178) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM28817 (5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]tria...) Show SMILES Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM231630 (GSK3) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM231628 (IDI-6253) Show SMILES Cc1nnc2c3ccccc3c(nn12)N1CCc2ccccc2C1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM231628 (IDI-6253) Show SMILES Cc1nnc2c3ccccc3c(nn12)N1CCc2ccccc2C1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM231629 (IDI-6273) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50379156 (CHEMBL2012958 \| Genz-669178) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM231629 (IDI-6273) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM28817 (5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]tria...) Show SMILES Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM231630 (GSK3) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard School of Public Health					Assay Description Substrate-dependent inhibition of recombinant PfDHODH protein was assessed in an in vitro assay in 384-well clear plates (Corning 3702) as described ...				J Biol Chem 289: 17980-95 (2014) Article DOI: 10.1074/jbc.M114.558353 BindingDB Entry DOI: 10.7270/Q27P8X8G
Harvard School of Public Health					More data for this Ligand-Target Pair

* indicates data uncertainty>20%