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PubMed code 24793884

Compile data set for download or QSAR
Found 151 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 3.80n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016165
PNG
(CHEMBL3261516)
Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 6n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 6.80n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 2 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 1 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 13n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 6 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016148
PNG
(CHEMBL3261500)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C15H9Cl2N3OS/c16-9-1-2-10(11(17)7-9)12-13(14(18)21)22-15(20-12)8-3-5-19-6-4-8/h1-7H,(H2,18,21)
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n/an/a 14n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.667 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 17n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.012 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016161
PNG
(CHEMBL3261512)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1C(F)(F)F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H10F3N5OS/c16-15(17,18)8-4-2-1-3-7(8)10-11(12(19)24)25-13(23-10)9-5-6-21-14(20)22-9/h1-6H,(H2,19,24)(H2,20,21,22)
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 9 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016160
PNG
(CHEMBL3261511)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H10FN5OS/c15-8-4-2-1-3-7(8)10-11(12(16)21)22-13(20-10)9-5-6-18-14(17)19-9/h1-6H,(H2,16,21)(H2,17,18,19)
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.333 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016167
PNG
(CHEMBL3261518)
Show SMILES CN(C)c1nc(sc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H12N6OS/c1-16(2)8-6(7(11)17)18-9(15-8)5-3-4-13-10(12)14-5/h3-4H,1-2H3,(H2,11,17)(H2,12,13,14)
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n/an/a 21n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 23n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 18 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.111 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016162
PNG
(CHEMBL3261513)
Show SMILES NC(=O)c1sc(nc1-c1cc(F)ccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9F2N5OS/c15-6-1-2-8(16)7(5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 33n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 35n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.222 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 40n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.025 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016153
PNG
(CHEMBL3261505)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H10N4O3S/c1-2-17-9(16)6-7(15)14-8(18-6)5-3-4-12-10(11)13-5/h3-4,15H,2H2,1H3,(H2,11,12,13)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 27 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016164
PNG
(CHEMBL3261515)
Show SMILES NC(=O)c1sc(nc1-c1cc(Cl)cc(Cl)c1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-7-3-6(4-8(16)5-7)10-11(12(17)22)23-13(21-10)9-1-2-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.037 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.074 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta (unknown origin) by TR-FRET assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 54 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016147
PNG
(CHEMBL3261499)
Show SMILES COc1nc(sc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016137
PNG
(CHEMBL3261489)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H11N3OS/c16-14(19)13-12(10-4-2-1-3-5-10)18-15(20-13)11-6-8-17-9-7-11/h1-9H,(H2,16,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta (unknown origin) by TR-FRET assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016146
PNG
(CHEMBL3261498)
Show SMILES O=C1Nc2ccccc2Nc2nc(sc12)-c1ccncc1
Show InChI InChI=1S/C15H10N4OS/c20-14-12-13(17-10-3-1-2-4-11(10)18-14)19-15(21-12)9-5-7-16-8-6-9/h1-8,17H,(H,18,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016136
PNG
(CHEMBL3261488)
Show SMILES NC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016135
PNG
(CHEMBL3261245)
Show SMILES OC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H10N2O2S/c18-15(19)13-12(10-4-2-1-3-5-10)17-14(20-13)11-6-8-16-9-7-11/h1-9H,(H,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.023 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.75 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 1.5 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.047 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 3 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016129
PNG
(CHEMBL3261240)
Show SMILES CCOC(=O)c1sc(nc1-c1cccc(Cl)c1Cl)-c1ccncc1
Show InChI InChI=1S/C17H12Cl2N2O2S/c1-2-23-17(22)15-14(11-4-3-5-12(18)13(11)19)21-16(24-15)10-6-8-20-9-7-10/h3-9H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016144
PNG
(CHEMBL3261496)
Show SMILES c1ccc(cc1)-c1nc(sc1-c1nn[nH]n1)-c1ccncc1
Show InChI InChI=1S/C15H10N6S/c1-2-4-10(5-3-1)12-13(14-18-20-21-19-14)22-15(17-12)11-6-8-16-9-7-11/h1-9H,(H,18,19,20,21)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016141
PNG
(CHEMBL3261493)
Show SMILES NNC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4OS/c16-19-14(20)13-12(10-4-2-1-3-5-10)18-15(21-13)11-6-8-17-9-7-11/h1-9H,16H2,(H,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 528n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.094 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016127
PNG
(CHEMBL3261238)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1Cl)-c1ccncc1
Show InChI InChI=1S/C17H13ClN2O2S/c1-2-22-17(21)15-14(12-5-3-4-6-13(12)18)20-16(23-15)11-7-9-19-10-8-11/h3-10H,2H2,1H3
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n/an/a 529n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 545n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha (unknown origin) by TR-FRET assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 546n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.375 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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n/an/a 547n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin) using 0.188 uM of ATP as substrate by AlphaScreen assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016122
PNG
(CHEMBL3261234)
Show SMILES CCOC(=O)c1sc(nc1N(C)C)-c1ccncc1
Show InChI InChI=1S/C13H15N3O2S/c1-4-18-13(17)10-11(16(2)3)15-12(19-10)9-5-7-14-8-6-9/h5-8H,4H2,1-3H3
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n/an/a 669n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 694n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha (unknown origin) by TR-FRET assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016148
PNG
(CHEMBL3261500)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C15H9Cl2N3OS/c16-9-1-2-10(11(17)7-9)12-13(14(18)21)22-15(20-12)8-3-5-19-6-4-8/h1-7H,(H2,18,21)
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n/an/a 700n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 729n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/Cyclin-T1 (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 749n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK9/Cyclin-T1 (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016131
PNG
(CHEMBL3261242)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc(OC)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C18H15ClN2O3S/c1-3-24-18(22)16-15(13-5-4-12(23-2)10-14(13)19)21-17(25-16)11-6-8-20-9-7-11/h4-10H,3H2,1-2H3
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n/an/a 855n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 862n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016130
PNG
(CHEMBL3261241)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C17H12Cl2N2O2S/c1-2-23-17(22)15-14(12-4-3-11(18)9-13(12)19)21-16(24-15)10-5-7-20-8-6-10/h3-9H,2H2,1H3
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n/an/a 973n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016128
PNG
(CHEMBL3261239)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc(F)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C17H12ClFN2O2S/c1-2-23-17(22)15-14(12-4-3-11(19)9-13(12)18)21-16(24-15)10-5-7-20-8-6-10/h3-9H,2H2,1H3
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n/an/a 1.02E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016160
PNG
(CHEMBL3261511)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H10FN5OS/c15-8-4-2-1-3-7(8)10-11(12(16)21)22-13(20-10)9-5-6-18-14(17)19-9/h1-6H,(H2,16,21)(H2,17,18,19)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016146
PNG
(CHEMBL3261498)
Show SMILES O=C1Nc2ccccc2Nc2nc(sc12)-c1ccncc1
Show InChI InChI=1S/C15H10N4OS/c20-14-12-13(17-10-3-1-2-4-11(10)18-14)19-15(21-12)9-5-7-16-8-6-9/h1-8,17H,(H,18,20)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016165
PNG
(CHEMBL3261516)
Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016142
PNG
(CHEMBL3261494)
Show SMILES ONC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H11N3O2S/c19-14(18-20)13-12(10-4-2-1-3-5-10)17-15(21-13)11-6-8-16-9-7-11/h1-9,20H,(H,18,19)
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n/an/a 1.69E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 1.82E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016167
PNG
(CHEMBL3261518)
Show SMILES CN(C)c1nc(sc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H12N6OS/c1-16(2)8-6(7(11)17)18-9(15-8)5-3-4-13-10(12)14-5/h3-4H,1-2H3,(H2,11,17)(H2,12,13,14)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016161
PNG
(CHEMBL3261512)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1C(F)(F)F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H10F3N5OS/c16-15(17,18)8-4-2-1-3-7(8)10-11(12(19)24)25-13(23-10)9-5-6-21-14(20)22-9/h1-6H,(H2,19,24)(H2,20,21,22)
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n/an/a 2.04E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016126
PNG
(CHEMBL3261237)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1O)-c1ccncc1
Show InChI InChI=1S/C17H14N2O3S/c1-2-22-17(21)15-14(12-5-3-4-6-13(12)20)19-16(23-15)11-7-9-18-10-8-11/h3-10,20H,2H2,1H3
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n/an/a 3.22E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016162
PNG
(CHEMBL3261513)
Show SMILES NC(=O)c1sc(nc1-c1cc(F)ccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9F2N5OS/c15-6-1-2-8(16)7(5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 3.62E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016145
PNG
(CHEMBL3261497)
Show SMILES c1nnc(o1)-c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H10N4OS/c1-2-4-11(5-3-1)13-14(15-20-18-10-21-15)22-16(19-13)12-6-8-17-9-7-12/h1-10H
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n/an/a 3.87E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016118
PNG
(CHEMBL3261230)
Show SMILES CCOC(=O)c1sc(nc1N)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-2-16-11(15)8-9(12)14-10(17-8)7-3-5-13-6-4-7/h3-6H,2,12H2,1H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016147
PNG
(CHEMBL3261499)
Show SMILES COc1nc(sc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14)
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n/an/a 5.71E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016134
PNG
(CHEMBL3261244)
Show SMILES Cl.OC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H6N2O3S.ClH/c12-7-6(9(13)14)15-8(11-7)5-1-3-10-4-2-5;/h1-4,12H,(H,13,14);1H
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n/an/a 6.13E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016165
PNG
(CHEMBL3261516)
Show SMILES Cc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5OS/c1-7-2-3-8(9(16)6-7)11-12(13(17)22)23-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 7.03E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016119
PNG
(CHEMBL3261231)
Show SMILES CCOC(=O)c1sc(nc1NC)-c1ccncc1
Show InChI InChI=1S/C12H13N3O2S/c1-3-17-12(16)9-10(13-2)15-11(18-9)8-4-6-14-7-5-8/h4-7,13H,3H2,1-2H3
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n/an/a 7.35E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016151
PNG
(CHEMBL3261503)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccnc(CC)c1
Show InChI InChI=1S/C13H14N2O3S/c1-3-9-7-8(5-6-14-9)12-15-11(16)10(19-12)13(17)18-4-2/h5-7,16H,3-4H2,1-2H3
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n/an/a 7.50E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016132
PNG
(CHEMBL3261243)
Show SMILES CCOC(=O)c1sc(nc1-c1cccnc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O2S/c1-2-21-16(20)14-13(12-4-3-7-18-10-12)19-15(22-14)11-5-8-17-9-6-11/h3-10H,2H2,1H3
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n/an/a 8.29E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016164
PNG
(CHEMBL3261515)
Show SMILES NC(=O)c1sc(nc1-c1cc(Cl)cc(Cl)c1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-7-3-6(4-8(16)5-7)10-11(12(17)22)23-13(21-10)9-1-2-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016138
PNG
(CHEMBL3261490)
Show SMILES CNC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-11-8(14)7-9(15)13-10(16-7)6-2-4-12-5-3-6/h2-5,15H,1H3,(H,11,14)
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n/an/a 8.98E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016147
PNG
(CHEMBL3261499)
Show SMILES COc1nc(sc1C(N)=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-15-9-7(8(11)14)16-10(13-9)6-2-4-12-5-3-6/h2-5H,1H3,(H2,11,14)
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n/an/a 9.93E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016143
PNG
(CHEMBL3261495)
Show SMILES N#Cc1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H9N3S/c16-10-13-14(11-4-2-1-3-5-11)18-15(19-13)12-6-8-17-9-7-12/h1-9H
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n/an/a 1.03E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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n/an/a 1.06E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016148
PNG
(CHEMBL3261500)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C15H9Cl2N3OS/c16-9-1-2-10(11(17)7-9)12-13(14(18)21)22-15(20-12)8-3-5-19-6-4-8/h1-7H,(H2,18,21)
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n/an/a 1.15E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016139
PNG
(CHEMBL3261491)
Show SMILES Oc1nc(sc1C(=O)NCc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O2S/c20-14(18-10-11-4-2-1-3-5-11)13-15(21)19-16(22-13)12-6-8-17-9-7-12/h1-9,21H,10H2,(H,18,20)
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n/an/a 1.16E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016117
PNG
(CHEMBL3261229)
Show SMILES CCOC(=O)c1sc(nc1OC)-c1ccncc1
Show InChI InChI=1S/C12H12N2O3S/c1-3-17-12(15)9-10(16-2)14-11(18-9)8-4-6-13-7-5-8/h4-7H,3H2,1-2H3
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n/an/a 1.72E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016167
PNG
(CHEMBL3261518)
Show SMILES CN(C)c1nc(sc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H12N6OS/c1-16(2)8-6(7(11)17)18-9(15-8)5-3-4-13-10(12)14-5/h3-4H,1-2H3,(H2,11,17)(H2,12,13,14)
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n/an/a 1.82E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016152
PNG
(CHEMBL3261504)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1)-c1ccnc(N)c1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)15-14(11-6-4-3-5-7-11)20-16(23-15)12-8-9-19-13(18)10-12/h3-10H,2H2,1H3,(H2,18,19)
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n/an/a 1.99E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016125
PNG
(CHEMBL172094)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H14N2O2S/c1-2-21-17(20)15-14(12-6-4-3-5-7-12)19-16(22-15)13-8-10-18-11-9-13/h3-11H,2H2,1H3
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n/an/a 2.05E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016137
PNG
(CHEMBL3261489)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H11N3OS/c16-14(19)13-12(10-4-2-1-3-5-10)18-15(20-13)11-6-8-17-9-7-11/h1-9H,(H2,16,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016123
PNG
(CHEMBL3261235)
Show SMILES CCOC(=O)c1cnc(s1)-c1ccncc1
Show InChI InChI=1S/C11H10N2O2S/c1-2-15-11(14)9-7-13-10(16-9)8-3-5-12-6-4-8/h3-7H,2H2,1H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016140
PNG
(CHEMBL3261492)
Show SMILES CN(C)C(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-14(2)11(16)8-9(15)13-10(17-8)7-3-5-12-6-4-7/h3-6,15H,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016124
PNG
(CHEMBL3261236)
Show SMILES CCOC(=O)c1sc(nc1C)-c1ccncc1
Show InChI InChI=1S/C12H12N2O2S/c1-3-16-12(15)10-8(2)14-11(17-10)9-4-6-13-7-5-9/h4-7H,3H2,1-2H3
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n/an/a 2.51E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016155
PNG
(CHEMBL3261507)
Show SMILES CCOC(=O)c1sc(nc1O)-c1cnccn1
Show InChI InChI=1S/C10H9N3O3S/c1-2-16-10(15)7-8(14)13-9(17-7)6-5-11-3-4-12-6/h3-5,14H,2H2,1H3
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n/an/a 2.65E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016158
PNG
(CHEMBL3261509)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccsc1
Show InChI InChI=1S/C10H9NO3S2/c1-2-14-10(13)7-8(12)11-9(16-7)6-3-4-15-5-6/h3-5,12H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016149
PNG
(CHEMBL3261501)
Show SMILES OC(=O)C(F)(F)F.CCOC(=O)c1sc(nc1O)-c1cccnc1
Show InChI InChI=1S/C11H10N2O3S.C2HF3O2/c1-2-16-11(15)8-9(14)13-10(17-8)7-4-3-5-12-6-7;3-2(4,5)1(6)7/h3-6,14H,2H2,1H3;(H,6,7)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016137
PNG
(CHEMBL3261489)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H11N3OS/c16-14(19)13-12(10-4-2-1-3-5-10)18-15(20-13)11-6-8-17-9-7-11/h1-9H,(H2,16,19)
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n/an/a 3.42E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016162
PNG
(CHEMBL3261513)
Show SMILES NC(=O)c1sc(nc1-c1cc(F)ccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9F2N5OS/c15-6-1-2-8(16)7(5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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n/an/a 3.48E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016161
PNG
(CHEMBL3261512)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1C(F)(F)F)-c1ccnc(N)n1
Show InChI InChI=1S/C15H10F3N5OS/c16-15(17,18)8-4-2-1-3-7(8)10-11(12(19)24)25-13(23-10)9-5-6-21-14(20)22-9/h1-6H,(H2,19,24)(H2,20,21,22)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016120
PNG
(CHEMBL3261232)
Show SMILES CCOC(=O)c1sc(nc1NCc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C18H17N3O2S/c1-2-23-18(22)15-16(20-12-13-6-4-3-5-7-13)21-17(24-15)14-8-10-19-11-9-14/h3-11,20H,2,12H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016156
PNG
(CHEMBL65312)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccc1
Show InChI InChI=1S/C12H11NO3S/c1-2-16-12(15)9-10(14)13-11(17-9)8-6-4-3-5-7-8/h3-7,14H,2H2,1H3
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n/an/a 4.67E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016136
PNG
(CHEMBL3261488)
Show SMILES NC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 in human HCT116 cells assessed as reduction of MCM2 phosphorylation after 14 hrs


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin-D1 (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin-D1 (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50016163
PNG
(CHEMBL3261514)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-6-1-2-7(8(16)5-6)10-11(12(17)22)23-13(21-10)9-3-4-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin-B (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM50016166
PNG
(CHEMBL3261517)
Show SMILES COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1
Show InChI InChI=1S/C15H12ClN5O2S/c1-23-7-2-3-8(9(16)6-7)11-12(13(17)22)24-14(21-11)10-4-5-19-15(18)20-10/h2-6H,1H3,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin-B (unknown origin) by homogeneous time-resolved fluorescence assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016139
PNG
(CHEMBL3261491)
Show SMILES Oc1nc(sc1C(=O)NCc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O2S/c20-14(18-10-11-4-2-1-3-5-11)13-15(21)19-16(22-13)12-6-8-17-9-7-12/h1-9,21H,10H2,(H,18,20)
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n/an/a 5.21E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016153
PNG
(CHEMBL3261505)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccnc(N)n1
Show InChI InChI=1S/C10H10N4O3S/c1-2-17-9(16)6-7(15)14-8(18-6)5-3-4-12-10(11)13-5/h3-4,15H,2H2,1H3,(H2,11,12,13)
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n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016150
PNG
(CHEMBL3261502)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccn1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-5-3-4-6-12-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016120
PNG
(CHEMBL3261232)
Show SMILES CCOC(=O)c1sc(nc1NCc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C18H17N3O2S/c1-2-23-18(22)15-16(20-12-13-6-4-3-5-7-13)21-17(24-15)14-8-10-19-11-9-14/h3-11,20H,2,12H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016121
PNG
(CHEMBL3261233)
Show SMILES CCOC(=O)c1sc(nc1Nc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)14-15(19-13-6-4-3-5-7-13)20-16(23-14)12-8-10-18-11-9-12/h3-11,19H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016136
PNG
(CHEMBL3261488)
Show SMILES NC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H7N3O2S/c10-7(13)6-8(14)12-9(15-6)5-1-3-11-4-2-5/h1-4,14H,(H2,10,13)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016149
PNG
(CHEMBL3261501)
Show SMILES OC(=O)C(F)(F)F.CCOC(=O)c1sc(nc1O)-c1cccnc1
Show InChI InChI=1S/C11H10N2O3S.C2HF3O2/c1-2-16-11(15)8-9(14)13-10(17-8)7-4-3-5-12-6-7;3-2(4,5)1(6)7/h3-6,14H,2H2,1H3;(H,6,7)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016152
PNG
(CHEMBL3261504)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1)-c1ccnc(N)c1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)15-14(11-6-4-3-5-7-11)20-16(23-15)12-8-9-19-13(18)10-12/h3-10H,2H2,1H3,(H2,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016160
PNG
(CHEMBL3261511)
Show SMILES NC(=O)c1sc(nc1-c1ccccc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C14H10FN5OS/c15-8-4-2-1-3-7(8)10-11(12(16)21)22-13(20-10)9-5-6-18-14(17)19-9/h1-6H,(H2,16,21)(H2,17,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016154
PNG
(CHEMBL3261506)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1)-c1cc(N)ncn1
Show InChI InChI=1S/C16H14N4O2S/c1-2-22-16(21)14-13(10-6-4-3-5-7-10)20-15(23-14)11-8-12(17)19-9-18-11/h3-9H,2H2,1H3,(H2,17,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016119
PNG
(CHEMBL3261231)
Show SMILES CCOC(=O)c1sc(nc1NC)-c1ccncc1
Show InChI InChI=1S/C12H13N3O2S/c1-3-17-12(16)9-10(13-2)15-11(18-9)8-4-6-14-7-5-8/h4-7,13H,3H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016129
PNG
(CHEMBL3261240)
Show SMILES CCOC(=O)c1sc(nc1-c1cccc(Cl)c1Cl)-c1ccncc1
Show InChI InChI=1S/C17H12Cl2N2O2S/c1-2-23-17(22)15-14(11-4-3-5-12(18)13(11)19)21-16(24-15)10-6-8-20-9-7-10/h3-9H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016134
PNG
(CHEMBL3261244)
Show SMILES Cl.OC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C9H6N2O3S.ClH/c12-7-6(9(13)14)15-8(11-7)5-1-3-10-4-2-5;/h1-4,12H,(H,13,14);1H
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016156
PNG
(CHEMBL65312)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccc1
Show InChI InChI=1S/C12H11NO3S/c1-2-16-12(15)9-10(14)13-11(17-9)8-6-4-3-5-7-8/h3-7,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016133
PNG
(CHEMBL3259834)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc2ccccc2c1)-c1ccncc1
Show InChI InChI=1S/C21H16N2O2S/c1-2-25-21(24)19-18(23-20(26-19)15-9-11-22-12-10-15)17-8-7-14-5-3-4-6-16(14)13-17/h3-13H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016157
PNG
(CHEMBL3261508)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccc(OC)cc1
Show InChI InChI=1S/C13H13NO4S/c1-3-18-13(16)10-11(15)14-12(19-10)8-4-6-9(17-2)7-5-8/h4-7,15H,3H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016128
PNG
(CHEMBL3261239)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc(F)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C17H12ClFN2O2S/c1-2-23-17(22)15-14(12-4-3-11(19)9-13(12)18)21-16(24-15)10-5-7-20-8-6-10/h3-9H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016131
PNG
(CHEMBL3261242)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc(OC)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C18H15ClN2O3S/c1-3-24-18(22)16-15(13-5-4-12(23-2)10-14(13)19)21-17(25-16)11-6-8-20-9-7-11/h4-10H,3H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016145
PNG
(CHEMBL3261497)
Show SMILES c1nnc(o1)-c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C16H10N4OS/c1-2-4-11(5-3-1)13-14(15-20-18-10-21-15)22-16(19-13)12-6-8-17-9-7-12/h1-10H
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016159
PNG
(CHEMBL3261510)
Show SMILES CCOC(=O)c1sc(nc1O)C(C)(C)C
Show InChI InChI=1S/C10H15NO3S/c1-5-14-8(13)6-7(12)11-9(15-6)10(2,3)4/h12H,5H2,1-4H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016123
PNG
(CHEMBL3261235)
Show SMILES CCOC(=O)c1cnc(s1)-c1ccncc1
Show InChI InChI=1S/C11H10N2O2S/c1-2-15-11(14)9-7-13-10(16-9)8-3-5-12-6-4-8/h3-7H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016124
PNG
(CHEMBL3261236)
Show SMILES CCOC(=O)c1sc(nc1C)-c1ccncc1
Show InChI InChI=1S/C12H12N2O2S/c1-3-16-12(15)10-8(2)14-11(17-10)9-4-6-13-7-5-9/h4-7H,3H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016127
PNG
(CHEMBL3261238)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1Cl)-c1ccncc1
Show InChI InChI=1S/C17H13ClN2O2S/c1-2-22-17(21)15-14(12-5-3-4-6-13(12)18)20-16(23-15)11-7-9-19-10-8-11/h3-10H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016135
PNG
(CHEMBL3261245)
Show SMILES OC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H10N2O2S/c18-15(19)13-12(10-4-2-1-3-5-10)17-14(20-13)11-6-8-16-9-7-11/h1-9H,(H,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016143
PNG
(CHEMBL3261495)
Show SMILES N#Cc1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H9N3S/c16-10-13-14(11-4-2-1-3-5-11)18-15(19-13)12-6-8-17-9-7-12/h1-9H
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016154
PNG
(CHEMBL3261506)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1)-c1cc(N)ncn1
Show InChI InChI=1S/C16H14N4O2S/c1-2-22-16(21)14-13(10-6-4-3-5-7-10)20-15(23-14)11-8-12(17)19-9-18-11/h3-9H,2H2,1H3,(H2,17,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016164
PNG
(CHEMBL3261515)
Show SMILES NC(=O)c1sc(nc1-c1cc(Cl)cc(Cl)c1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H9Cl2N5OS/c15-7-3-6(4-8(16)5-7)10-11(12(17)22)23-13(21-10)9-1-2-19-14(18)20-9/h1-5H,(H2,17,22)(H2,18,19,20)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016125
PNG
(CHEMBL172094)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H14N2O2S/c1-2-21-17(20)15-14(12-6-4-3-5-7-12)19-16(22-15)13-8-10-18-11-9-13/h3-11H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016132
PNG
(CHEMBL3261243)
Show SMILES CCOC(=O)c1sc(nc1-c1cccnc1)-c1ccncc1
Show InChI InChI=1S/C16H13N3O2S/c1-2-21-16(20)14-13(12-4-3-7-18-10-12)19-15(22-14)11-5-8-17-9-6-11/h3-10H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016142
PNG
(CHEMBL3261494)
Show SMILES ONC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H11N3O2S/c19-14(18-20)13-12(10-4-2-1-3-5-10)17-15(21-13)11-6-8-16-9-7-11/h1-9,20H,(H,18,19)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016157
PNG
(CHEMBL3261508)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccc(OC)cc1
Show InChI InChI=1S/C13H13NO4S/c1-3-18-13(16)10-11(15)14-12(19-10)8-4-6-9(17-2)7-5-8/h4-7,15H,3H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016158
PNG
(CHEMBL3261509)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccsc1
Show InChI InChI=1S/C10H9NO3S2/c1-2-14-10(13)7-8(12)11-9(16-7)6-3-4-15-5-6/h3-5,12H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016121
PNG
(CHEMBL3261233)
Show SMILES CCOC(=O)c1sc(nc1Nc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C17H15N3O2S/c1-2-22-17(21)14-15(19-13-6-4-3-5-7-13)20-16(23-14)12-8-10-18-11-9-12/h3-11,19H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016116
PNG
(CHEMBL3261228)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016133
PNG
(CHEMBL3259834)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc2ccccc2c1)-c1ccncc1
Show InChI InChI=1S/C21H16N2O2S/c1-2-25-21(24)19-18(23-20(26-19)15-9-11-22-12-10-15)17-8-7-14-5-3-4-6-16(14)13-17/h3-13H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016140
PNG
(CHEMBL3261492)
Show SMILES CN(C)C(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-14(2)11(16)8-9(15)13-10(17-8)7-3-5-12-6-4-7/h3-6,15H,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016144
PNG
(CHEMBL3261496)
Show SMILES c1ccc(cc1)-c1nc(sc1-c1nn[nH]n1)-c1ccncc1
Show InChI InChI=1S/C15H10N6S/c1-2-4-10(5-3-1)12-13(14-18-20-21-19-14)22-15(17-12)11-6-8-16-9-7-11/h1-9H,(H,18,19,20,21)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016151
PNG
(CHEMBL3261503)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccnc(CC)c1
Show InChI InChI=1S/C13H14N2O3S/c1-3-9-7-8(5-6-14-9)12-15-11(16)10(19-12)13(17)18-4-2/h5-7,16H,3-4H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016155
PNG
(CHEMBL3261507)
Show SMILES CCOC(=O)c1sc(nc1O)-c1cnccn1
Show InChI InChI=1S/C10H9N3O3S/c1-2-16-10(15)7-8(14)13-9(17-7)6-5-11-3-4-12-6/h3-5,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016122
PNG
(CHEMBL3261234)
Show SMILES CCOC(=O)c1sc(nc1N(C)C)-c1ccncc1
Show InChI InChI=1S/C13H15N3O2S/c1-4-18-13(17)10-11(16(2)3)15-12(19-10)9-5-7-14-8-6-9/h5-8H,4H2,1-3H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016130
PNG
(CHEMBL3261241)
Show SMILES CCOC(=O)c1sc(nc1-c1ccc(Cl)cc1Cl)-c1ccncc1
Show InChI InChI=1S/C17H12Cl2N2O2S/c1-2-23-17(22)15-14(12-4-3-11(18)9-13(12)19)21-16(24-15)10-5-7-20-8-6-10/h3-9H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016150
PNG
(CHEMBL3261502)
Show SMILES CCOC(=O)c1sc(nc1O)-c1ccccn1
Show InChI InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-5-3-4-6-12-7/h3-6,14H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase


(Homo sapiens (Human))
BDBM50016159
PNG
(CHEMBL3261510)
Show SMILES CCOC(=O)c1sc(nc1O)C(C)(C)C
Show InChI InChI=1S/C10H15NO3S/c1-5-14-8(13)6-7(12)11-9(15-6)10(2,3)4/h12H,5H2,1-4H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Cdc7/Dbf4 (unknown origin)-mediated phosphorylation of MCM2 by protein-A luminescent proximity homogenous assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016117
PNG
(CHEMBL3261229)
Show SMILES CCOC(=O)c1sc(nc1OC)-c1ccncc1
Show InChI InChI=1S/C12H12N2O3S/c1-3-17-12(15)9-10(16-2)14-11(18-9)8-4-6-13-7-5-8/h4-7H,3H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016118
PNG
(CHEMBL3261230)
Show SMILES CCOC(=O)c1sc(nc1N)-c1ccncc1
Show InChI InChI=1S/C11H11N3O2S/c1-2-16-11(15)8-9(12)14-10(17-8)7-3-5-13-6-4-7/h3-6H,2,12H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016126
PNG
(CHEMBL3261237)
Show SMILES CCOC(=O)c1sc(nc1-c1ccccc1O)-c1ccncc1
Show InChI InChI=1S/C17H14N2O3S/c1-2-22-17(21)15-14(12-5-3-4-6-13(12)20)19-16(23-15)11-7-9-18-10-8-11/h3-10,20H,2H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016138
PNG
(CHEMBL3261490)
Show SMILES CNC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O2S/c1-11-8(14)7-9(15)13-10(16-7)6-2-4-12-5-3-6/h2-5,15H,1H3,(H,11,14)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50016141
PNG
(CHEMBL3261493)
Show SMILES NNC(=O)c1sc(nc1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C15H12N4OS/c16-19-14(20)13-12(10-4-2-1-3-5-10)18-15(21-13)11-6-8-17-9-7-11/h1-9H,16H2,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin-E (unknown origin) using maltose binding protein as substrate by HTRF assay


Eur J Med Chem 80: 364-82 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.013
BindingDB Entry DOI: 10.7270/Q2NC62R8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%