Found 17 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018543
(CHEMBL3290677)Show SMILES CC(C)Oc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F |r,t:23| Show InChI InChI=1S/C36H32BrF3N2O3/c1-22(2)45-30-20-28(36(38,39)40)17-14-27(30)21-42-33(25-15-18-29(37)19-16-25)31(34(43)26-12-8-5-9-13-26)32(35(42)44)41-23(3)24-10-6-4-7-11-24/h4-20,22-23,33,41H,21H2,1-3H3/t23-,33?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018554
(CHEMBL3290682)Show SMILES C[C@@H](NC1=C(C(N(Cc2cccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C31H26BrN3O2/c1-21(23-10-4-2-5-11-23)34-28-27(30(36)25-12-6-3-7-13-25)29(24-14-16-26(32)17-15-24)35(31(28)37)20-22-9-8-18-33-19-22/h2-19,21,29,34H,20H2,1H3/t21-,29?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50229787
((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6| Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018555
(CHEMBL3290683)Show SMILES C[C@@H](NC1=C(C(N(CCCn2ccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C31H29BrN4O2/c1-22(23-9-4-2-5-10-23)34-28-27(30(37)25-11-6-3-7-12-25)29(24-13-15-26(32)16-14-24)36(31(28)38)19-8-18-35-20-17-33-21-35/h2-7,9-17,20-22,29,34H,8,18-19H2,1H3/t22-,29?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018541
(CHEMBL2180122)Show SMILES CC(C)OC1=C(C(N(CCCn2ccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C26H26BrN3O3/c1-18(2)33-25-22(24(31)20-7-4-3-5-8-20)23(19-9-11-21(27)12-10-19)30(26(25)32)15-6-14-29-16-13-28-17-29/h3-5,7-13,16-18,23H,6,14-15H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018540
(CHEMBL3290675)Show SMILES CC(C)OC1=C(C(N(Cc2cccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C26H23BrN2O3/c1-17(2)32-25-22(24(30)20-8-4-3-5-9-20)23(19-10-12-21(27)13-11-19)29(26(25)31)16-18-7-6-14-28-15-18/h3-15,17,23H,16H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018537
(CHEMBL3290672)Show SMILES COc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(OC(C)C)C1=O)c1ccc(Br)cc1)C(F)(F)F |t:21| Show InChI InChI=1S/C29H25BrF3NO4/c1-17(2)38-27-24(26(35)19-7-5-4-6-8-19)25(18-10-13-22(30)14-11-18)34(28(27)36)16-20-9-12-21(29(31,32)33)15-23(20)37-3/h4-15,17,25H,16H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018536
(CHEMBL3290671)Show SMILES CCOc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(OC(C)C)C1=O)c1ccc(Br)cc1)C(F)(F)F |t:22| Show InChI InChI=1S/C30H27BrF3NO4/c1-4-38-24-16-22(30(32,33)34)13-10-21(24)17-35-26(19-11-14-23(31)15-12-19)25(28(29(35)37)39-18(2)3)27(36)20-8-6-5-7-9-20/h5-16,18,26H,4,17H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018534
(CHEMBL3290670)Show SMILES CC(C)OC1=C(C(N(Cc2ccc(cc2OC(C)(C)C)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C32H31BrF3NO4/c1-19(2)40-29-26(28(38)21-9-7-6-8-10-21)27(20-12-15-24(33)16-13-20)37(30(29)39)18-22-11-14-23(32(34,35)36)17-25(22)41-31(3,4)5/h6-17,19,27H,18H2,1-5H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018539
(CHEMBL3290674)Show SMILES CC(C)OC1=C(C(N(Cc2ccc(cc2)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C28H23BrF3NO3/c1-17(2)36-26-23(25(34)20-6-4-3-5-7-20)24(19-10-14-22(29)15-11-19)33(27(26)35)16-18-8-12-21(13-9-18)28(30,31)32/h3-15,17,24H,16H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018547
(CHEMBL3290678)Show SMILES CCOc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F |r,t:22| Show InChI InChI=1S/C35H30BrF3N2O3/c1-3-44-29-20-27(35(37,38)39)17-14-26(29)21-41-32(24-15-18-28(36)19-16-24)30(33(42)25-12-8-5-9-13-25)31(34(41)43)40-22(2)23-10-6-4-7-11-23/h4-20,22,32,40H,3,21H2,1-2H3/t22-,32?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018542
(CHEMBL3290676)Show SMILES C[C@@H](NC1=C(C(N(Cc2ccc(cc2OC(C)(C)C)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C37H34BrF3N2O3/c1-23(24-11-7-5-8-12-24)42-32-31(34(44)26-13-9-6-10-14-26)33(25-16-19-29(38)20-17-25)43(35(32)45)22-27-15-18-28(37(39,40)41)21-30(27)46-36(2,3)4/h5-21,23,33,42H,22H2,1-4H3/t23-,33?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018552
(CHEMBL3290681)Show SMILES C[C@@H](NC1=C(C(N(Cc2ccc(cc2)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C33H26BrF3N2O2/c1-21(23-8-4-2-5-9-23)38-29-28(31(40)25-10-6-3-7-11-25)30(24-14-18-27(34)19-15-24)39(32(29)41)20-22-12-16-26(17-13-22)33(35,36)37/h2-19,21,30,38H,20H2,1H3/t21-,30?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018548
(CHEMBL3290679)Show SMILES COc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F |r,t:21| Show InChI InChI=1S/C34H28BrF3N2O3/c1-21(22-9-5-3-6-10-22)39-30-29(32(41)24-11-7-4-8-12-24)31(23-14-17-27(35)18-15-23)40(33(30)42)20-25-13-16-26(34(36,37)38)19-28(25)43-2/h3-19,21,31,39H,20H2,1-2H3/t21-,31?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018538
(CHEMBL3290673)Show SMILES CC(C)OC1=C(C(N(Cc2ccc(cc2F)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C28H22BrF4NO3/c1-16(2)37-26-23(25(35)18-6-4-3-5-7-18)24(17-9-12-21(29)13-10-17)34(27(26)36)15-19-8-11-20(14-22(19)30)28(31,32)33/h3-14,16,24H,15H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018535
(CHEMBL3290669)Show SMILES CC(C)OC1=C(C(N(Cc2ccc(cc2OC(C)C)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C31H29BrF3NO4/c1-18(2)39-25-16-23(31(33,34)35)13-10-22(25)17-36-27(20-11-14-24(32)15-12-20)26(29(30(36)38)40-19(3)4)28(37)21-8-6-5-7-9-21/h5-16,18-19,27H,17H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50018549
(CHEMBL3290680)Show SMILES C[C@@H](NC1=C(C(N(Cc2ccc(cc2F)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C33H25BrF4N2O2/c1-20(21-8-4-2-5-9-21)39-29-28(31(41)23-10-6-3-7-11-23)30(22-13-16-26(34)17-14-22)40(32(29)42)19-24-12-15-25(18-27(24)35)33(36,37)38/h2-18,20,30,39H,19H2,1H3/t20-,30?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay |
Bioorg Med Chem Lett 24: 2648-50 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.063
BindingDB Entry DOI: 10.7270/Q2QV3P22 |
More data for this
Ligand-Target Pair | |
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