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PubMed code 24837154

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019121
PNG
(CHEMBL3288416)
Show SMILES COc1ccc2n(c(CCn3c4ncccc4n(C)c3=O)nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O2/c1-26-20-9-6-13-24-22(20)27(23(26)29)14-12-21-25-18-15-17(30-2)10-11-19(18)28(21)16-7-4-3-5-8-16/h3-11,13,15H,12,14H2,1-2H3
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n/an/a 6.30n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019126
PNG
(CHEMBL3288421)
Show SMILES COc1cccc2n(c(CCn3c4ncccc4n(C)c3=O)nc12)-c1ccccc1
Show InChI InChI=1S/C23H21N5O2/c1-26-18-11-7-14-24-22(18)27(23(26)29)15-13-20-25-21-17(10-6-12-19(21)30-2)28(20)16-8-4-3-5-9-16/h3-12,14H,13,15H2,1-2H3
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n/an/a 7.30n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019118
PNG
(CHEMBL3288413)
Show SMILES Cc1nn(CCc2nc3cc(C)ccc3n2-c2ccccc2)c2ncccc12
Show InChI InChI=1S/C23H21N5/c1-16-10-11-21-20(15-16)25-22(28(21)18-7-4-3-5-8-18)12-14-27-23-19(17(2)26-27)9-6-13-24-23/h3-11,13,15H,12,14H2,1-2H3
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n/an/a 8.30n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019117
PNG
(CHEMBL3288412)
Show SMILES Cc1nc(CCc2nc3cc(C)ccc3n2-c2ccccc2)n2ncccc12
Show InChI InChI=1S/C23H21N5/c1-16-10-11-21-19(15-16)26-22(27(21)18-7-4-3-5-8-18)12-13-23-25-17(2)20-9-6-14-24-28(20)23/h3-11,14-15H,12-13H2,1-2H3
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n/an/a 9.10n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019119
PNG
(CHEMBL3288414)
Show SMILES Cc1ccc2n(c(CCn3c4ncccc4n(C)c3=O)nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O/c1-16-10-11-19-18(15-16)25-21(28(19)17-7-4-3-5-8-17)12-14-27-22-20(9-6-13-24-22)26(2)23(27)29/h3-11,13,15H,12,14H2,1-2H3
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n/an/a 9.20n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019129
PNG
(CHEMBL3288424)
Show SMILES COc1ccnc2n(c(CCn3c4nccc(C)c4n(C)c3=O)nc12)-c1ccccc1
Show InChI InChI=1S/C23H22N6O2/c1-15-9-12-25-22-20(15)27(2)23(30)28(22)14-11-18-26-19-17(31-3)10-13-24-21(19)29(18)16-7-5-4-6-8-16/h4-10,12-13H,11,14H2,1-3H3
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n/an/a 9.5n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019120
PNG
(CHEMBL3288415)
Show SMILES Cc1ccc2n(c(CCn3c4ncccc4nc(C)c3=O)nc2c1)-c1ccccc1
Show InChI InChI=1S/C24H21N5O/c1-16-10-11-21-20(15-16)27-22(29(21)18-7-4-3-5-8-18)12-14-28-23-19(9-6-13-25-23)26-17(2)24(28)30/h3-11,13,15H,12,14H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019127
PNG
(CHEMBL3288422)
Show SMILES COc1ccnc2n(c(CCn3c4ncccc4n(C)c3=O)nc12)-c1ccccc1
Show InChI InChI=1S/C22H20N6O2/c1-26-16-9-6-12-23-20(16)27(22(26)29)14-11-18-25-19-17(30-2)10-13-24-21(19)28(18)15-7-4-3-5-8-15/h3-10,12-13H,11,14H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019123
PNG
(CHEMBL3288418)
Show SMILES COc1ccc2n(c(CCn3c4ncccc4n(C)c3=O)nc2c1)-c1cccnc1
Show InChI InChI=1S/C22H20N6O2/c1-26-19-6-4-11-24-21(19)27(22(26)29)12-9-20-25-17-13-16(30-2)7-8-18(17)28(20)15-5-3-10-23-14-15/h3-8,10-11,13-14H,9,12H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019116
PNG
(CHEMBL3288411)
Show SMILES Cc1ccc2n(c(CCc3ncc4cccnn34)nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H19N5/c1-16-9-10-20-19(14-16)25-22(26(20)17-6-3-2-4-7-17)12-11-21-23-15-18-8-5-13-24-27(18)21/h2-10,13-15H,11-12H2,1H3
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n/an/a 92n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019124
PNG
(CHEMBL3288419)
Show SMILES COc1ccc2n(c(CCn3c4ncccc4n(C)c3=O)nc2c1)-c1ccncc1
Show InChI InChI=1S/C22H20N6O2/c1-26-19-4-3-10-24-21(19)27(22(26)29)13-9-20-25-17-14-16(30-2)5-6-18(17)28(20)15-7-11-23-12-8-15/h3-8,10-12,14H,9,13H2,1-2H3
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n/an/a 97n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019128
PNG
(CHEMBL3288423)
Show SMILES COc1ccnc2n(c(CCn3c4nccnc4n(C)c3=O)nc12)-c1ccccc1
Show InChI InChI=1S/C21H19N7O2/c1-26-19-20(24-12-11-23-19)27(21(26)29)13-9-16-25-17-15(30-2)8-10-22-18(17)28(16)14-6-4-3-5-7-14/h3-8,10-12H,9,13H2,1-2H3
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n/an/a 111n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019125
PNG
(CHEMBL3288420)
Show SMILES Cc1cnc2n(c(CCn3c4ncccc4n(C)c3=O)nc2c1)-c1ccccc1
Show InChI InChI=1S/C22H20N6O/c1-15-13-17-20(24-14-15)28(16-7-4-3-5-8-16)19(25-17)10-12-27-21-18(9-6-11-23-21)26(2)22(27)29/h3-9,11,13-14H,10,12H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019115
PNG
(CHEMBL3288410)
Show SMILES Cc1nc(CCc2nc3cc(C)ccc3n2-c2ccccc2)n2cccnc12
Show InChI InChI=1S/C23H21N5/c1-16-9-10-20-19(15-16)26-22(28(20)18-7-4-3-5-8-18)12-11-21-25-17(2)23-24-13-6-14-27(21)23/h3-10,13-15H,11-12H2,1-2H3
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n/an/a 210n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019122
PNG
(CHEMBL3288417)
Show SMILES COc1ccc2n(c(CCn3c4ncccc4n(C)c3=O)nc2c1)-c1ccccn1
Show InChI InChI=1S/C22H20N6O2/c1-26-18-6-5-12-24-21(18)27(22(26)29)13-10-20-25-16-14-15(30-2)8-9-17(16)28(20)19-7-3-4-11-23-19/h3-9,11-12,14H,10,13H2,1-2H3
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n/an/a 220n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019113
PNG
(CHEMBL3288408)
Show SMILES Cc1nc(CCc2nc3cc(C)ccc3n2-c2ccccc2)n2ccccc12
Show InChI InChI=1S/C24H22N4/c1-17-11-12-22-20(16-17)26-24(28(22)19-8-4-3-5-9-19)14-13-23-25-18(2)21-10-6-7-15-27(21)23/h3-12,15-16H,13-14H2,1-2H3
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n/an/a 590n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019130
PNG
(CHEMBL3288425)
Show SMILES COc1ccc2[nH]c(CCc3nc(C)c4ccccn34)nc2c1
Show InChI InChI=1S/C18H18N4O/c1-12-16-5-3-4-10-22(16)18(19-12)9-8-17-20-14-7-6-13(23-2)11-15(14)21-17/h3-7,10-11H,8-9H2,1-2H3,(H,20,21)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50019114
PNG
(CHEMBL3288409)
Show SMILES Cc1ccc2n(c(CCc3ncc4ccccn34)nc2c1)-c1ccccc1
Show InChI InChI=1S/C23H20N4/c1-17-10-11-21-20(15-17)25-23(27(21)18-7-3-2-4-8-18)13-12-22-24-16-19-9-5-6-14-26(19)22/h2-11,14-16H,12-13H2,1H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A expressed in Sf9 insect cell system assessed as inhibition of cAMP hydrolysis preincubated for 30 mins before ...


Bioorg Med Chem 22: 3515-26 (2014)


Article DOI: 10.1016/j.bmc.2014.04.023
BindingDB Entry DOI: 10.7270/Q2RN39D7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%