Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044955
(CHEMBL3309402)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
(FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044959
(CHEMBL3309566)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCCC1 Show InChI InChI=1S/C39H35F2N5O5/c1-49-35-23-30-32(24-36(35)50-21-7-20-45-18-5-2-6-19-45)42-17-16-33(30)51-34-15-12-26(22-31(34)41)43-38(47)37-28-8-3-4-9-29(28)39(48)46(44-37)27-13-10-25(40)11-14-27/h3-4,8-17,22-24H,2,5-7,18-21H2,1H3,(H,43,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044958
(CHEMBL3309410)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C39H36F2N6O5/c1-45-17-19-46(20-18-45)16-5-21-51-36-24-32-30(23-35(36)50-2)33(14-15-42-32)52-34-13-10-26(22-31(34)41)43-38(48)37-28-6-3-4-7-29(28)39(49)47(44-37)27-11-8-25(40)9-12-27/h3-4,6-15,22-24H,5,16-21H2,1-2H3,(H,43,48) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50044955
(CHEMBL3309402)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50044955
(CHEMBL3309402)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044957
(CHEMBL3309404)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-27-30(23-35(34)49-20-8-19-44-17-6-7-18-44)41-16-15-32(27)50-33-14-13-24(21-29(33)40)42-37(46)36-25-9-2-3-10-26(25)38(47)45(43-36)31-12-5-4-11-28(31)39/h2-5,9-16,21-23H,6-8,17-20H2,1H3,(H,42,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044956
(CHEMBL3309403)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(F)c5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-19-7-18-44-16-4-5-17-44)41-15-14-32(29)50-33-13-12-25(21-30(33)40)42-37(46)36-27-10-2-3-11-28(27)38(47)45(43-36)26-9-6-8-24(39)20-26/h2-3,6,8-15,20-23H,4-5,7,16-19H2,1H3,(H,42,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50044954
(CHEMBL3309401)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H34FN5O5/c1-47-34-23-29-31(24-35(34)48-21-9-20-43-18-7-8-19-43)40-17-16-32(29)49-33-15-14-25(22-30(33)39)41-37(45)36-27-12-5-6-13-28(27)38(46)44(42-36)26-10-3-2-4-11-26/h2-6,10-17,22-24H,7-9,18-21H2,1H3,(H,41,45) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50044955
(CHEMBL3309402)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of PDGFRalpha (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50044955
(CHEMBL3309402)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50044955
(CHEMBL3309402)Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 Show InChI InChI=1S/C38H33F2N5O5/c1-48-34-22-29-31(23-35(34)49-20-6-19-44-17-4-5-18-44)41-16-15-32(29)50-33-14-11-25(21-30(33)40)42-37(46)36-27-7-2-3-8-28(27)38(47)45(43-36)26-12-9-24(39)10-13-26/h2-3,7-16,21-23H,4-6,17-20H2,1H3,(H,42,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of EGFR (unknown origin) after 30 mins using poly (Glu,Tyr)4:1 substrate |
Bioorg Med Chem 22: 3642-53 (2014)
Article DOI: 10.1016/j.bmc.2014.05.013
BindingDB Entry DOI: 10.7270/Q23T9JV2 |
More data for this
Ligand-Target Pair | |
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