Found 38 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
Reactome pathway
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PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to dopamine D2 receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
UniProtKB/SwissProt
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| 1.26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to dopamine D3 receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
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| 3.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to 5HT2A receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to dopamine D3 receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to dopamine D2 receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to 5HT2A receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human ERG |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50347783
(CHEMBL1223753)Show InChI InChI=1S/C18H24FN3O2/c1-12-10-17-16(11-15(12)19)20-18(23)22(17)14-2-6-21(7-3-14)13-4-8-24-9-5-13/h10-11,13-14H,2-9H2,1H3,(H,20,23) | PDB
MMDB
Reactome pathway
KEGG
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UniProtKB/TrEMBL
B.MOAD
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CHEMBL
PC cid
PC sid
UniChem
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Similars
| Article
PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human ERG |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50391741
(CHEMBL2146599)Show InChI InChI=1S/C18H25N3O2/c1-13-2-3-16-17(12-13)21(18(22)19-16)15-4-8-20(9-5-15)14-6-10-23-11-7-14/h2-3,12,14-15H,4-11H2,1H3,(H,19,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human ERG |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50391742
(CHEMBL2146598)Show InChI InChI=1S/C17H23N3O2/c21-17-18-15-3-1-2-4-16(15)20(17)14-5-9-19(10-6-14)13-7-11-22-12-8-13/h1-4,13-14H,5-12H2,(H,18,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human ERG |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human ERG |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | >2.51E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M4 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50391741
(CHEMBL2146599)Show InChI InChI=1S/C18H25N3O2/c1-13-2-3-16-17(12-13)21(18(22)19-16)15-4-8-20(9-5-15)14-6-10-23-11-7-14/h2-3,12,14-15H,4-11H2,1H3,(H,19,22) | PDB
Reactome pathway
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human)) | BDBM50391742
(CHEMBL2146598)Show InChI InChI=1S/C17H23N3O2/c21-17-18-15-3-1-2-4-16(15)20(17)14-5-9-19(10-6-14)13-7-11-22-12-8-13/h1-4,13-14H,5-12H2,(H,18,21) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50391741
(CHEMBL2146599)Show InChI InChI=1S/C18H25N3O2/c1-13-2-3-16-17(12-13)21(18(22)19-16)15-4-8-20(9-5-15)14-6-10-23-11-7-14/h2-3,12,14-15H,4-11H2,1H3,(H,19,22) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50347783
(CHEMBL1223753)Show InChI InChI=1S/C18H24FN3O2/c1-12-10-17-16(11-15(12)19)20-18(23)22(17)14-2-6-21(7-3-14)13-4-8-24-9-5-13/h10-11,13-14H,2-9H2,1H3,(H,20,23) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
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Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.94 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50347783
(CHEMBL1223753)Show InChI InChI=1S/C18H24FN3O2/c1-12-10-17-16(11-15(12)19)20-18(23)22(17)14-2-6-21(7-3-14)13-4-8-24-9-5-13/h10-11,13-14H,2-9H2,1H3,(H,20,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19.9 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M4 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50391741
(CHEMBL2146599)Show InChI InChI=1S/C18H25N3O2/c1-13-2-3-16-17(12-13)21(18(22)19-16)15-4-8-20(9-5-15)14-6-10-23-11-7-14/h2-3,12,14-15H,4-11H2,1H3,(H,19,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 79.4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50347783
(CHEMBL1223753)Show InChI InChI=1S/C18H24FN3O2/c1-12-10-17-16(11-15(12)19)20-18(23)22(17)14-2-6-21(7-3-14)13-4-8-24-9-5-13/h10-11,13-14H,2-9H2,1H3,(H,20,23) | PDB
Reactome pathway
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| n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M4 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50347783
(CHEMBL1223753)Show InChI InChI=1S/C18H24FN3O2/c1-12-10-17-16(11-15(12)19)20-18(23)22(17)14-2-6-21(7-3-14)13-4-8-24-9-5-13/h10-11,13-14H,2-9H2,1H3,(H,20,23) | PDB
Reactome pathway
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| n/a | n/a | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50391742
(CHEMBL2146598)Show InChI InChI=1S/C17H23N3O2/c21-17-18-15-3-1-2-4-16(15)20(17)14-5-9-19(10-6-14)13-7-11-22-12-8-13/h1-4,13-14H,5-12H2,(H,18,21) | PDB
Reactome pathway
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| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M4 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | >2.51E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | Reactome pathway
KEGG
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| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50391742
(CHEMBL2146598)Show InChI InChI=1S/C17H23N3O2/c21-17-18-15-3-1-2-4-16(15)20(17)14-5-9-19(10-6-14)13-7-11-22-12-8-13/h1-4,13-14H,5-12H2,(H,18,21) | UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
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PubMed
| n/a | n/a | n/a | n/a | 63.1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
Reactome pathway
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| n/a | n/a | n/a | n/a | >2.51E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50391743
(CHEMBL2146597)Show InChI InChI=1S/C18H25N3O/c22-18-19-16-8-4-5-9-17(16)21(18)15-10-12-20(13-11-15)14-6-2-1-3-7-14/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,19,22) | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| n/a | n/a | n/a | n/a | >3.16E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activity at 5HT1A receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human)) | BDBM50391741
(CHEMBL2146599)Show InChI InChI=1S/C18H25N3O2/c1-13-2-3-16-17(12-13)21(18(22)19-16)15-4-8-20(9-5-15)14-6-10-23-11-7-14/h2-3,12,14-15H,4-11H2,1H3,(H,19,22) | Reactome pathway
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PC cid
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| n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50391742
(CHEMBL2146598)Show InChI InChI=1S/C17H23N3O2/c21-17-18-15-3-1-2-4-16(15)20(17)14-5-9-19(10-6-14)13-7-11-22-12-8-13/h1-4,13-14H,5-12H2,(H,18,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | Reactome pathway
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| n/a | n/a | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | UniProtKB/SwissProt
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PC cid
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| n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50391742
(CHEMBL2146598)Show InChI InChI=1S/C17H23N3O2/c21-17-18-15-3-1-2-4-16(15)20(17)14-5-9-19(10-6-14)13-7-11-22-12-8-13/h1-4,13-14H,5-12H2,(H,18,21) | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50391741
(CHEMBL2146599)Show InChI InChI=1S/C18H25N3O2/c1-13-2-3-16-17(12-13)21(18(22)19-16)15-4-8-20(9-5-15)14-6-10-23-11-7-14/h2-3,12,14-15H,4-11H2,1H3,(H,19,22) | PDB
Reactome pathway
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| n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M4 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization ... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human)) | BDBM50347783
(CHEMBL1223753)Show InChI InChI=1S/C18H24FN3O2/c1-12-10-17-16(11-15(12)19)20-18(23)22(17)14-2-6-21(7-3-14)13-4-8-24-9-5-13/h10-11,13-14H,2-9H2,1H3,(H,20,23) | Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
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PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR a... |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50347782
(CHEMBL1802360)Show SMILES Fc1ccc(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 Show InChI InChI=1S/C21H24FN3O2/c22-16-6-8-18(9-7-16)27-15-3-12-24-13-10-17(11-14-24)25-20-5-2-1-4-19(20)23-21(25)26/h1-2,4-9,17H,3,10-15H2,(H,23,26) | PDB
UniProtKB/SwissProt
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CHEMBL
PC cid
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| n/a | n/a | n/a | n/a | 50.1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Activity at 5HT1A receptor |
ACS Med Chem Lett 1: 244-248 (2010)
Article DOI: 10.1021/ml100105x
BindingDB Entry DOI: 10.7270/Q20R9QGK |
More data for this
Ligand-Target Pair | |
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