new BindingDB logo
myBDB logout

PubMed code 24900278

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50382930
PNG
(CHEMBL115097)
Show SMILES CCCCCCOc1cc2c(cc1N(C)c1ncc(cn1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H37N3O3/c1-7-8-9-10-13-32-22-15-20-19(25(2,3)11-12-26(20,4)5)14-21(22)29(6)24-27-16-18(17-28-24)23(30)31/h14-17H,7-13H2,1-6H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 77.6n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at RXRalpha expressed in COS1 cells assessed as inhibition of NEt-TMN-induced luciferase activity after 18 hrs by reporter gene a...


ACS Med Chem Lett 2: 896-900 (2011)


Article DOI: 10.1021/ml200197e
BindingDB Entry DOI: 10.7270/Q2DR2WJM
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50382931
PNG
(CHEMBL2029403)
Show SMILES CCN(c1ccc(cn1)C(O)=O)c1cc(OCC(C)C)c(cc1\C=C\c1ccccc1)C(C)C
Show InChI InChI=1S/C29H34N2O3/c1-6-31(28-15-14-24(18-30-28)29(32)33)26-17-27(34-19-20(2)3)25(21(4)5)16-23(26)13-12-22-10-8-7-9-11-22/h7-18,20-21H,6,19H2,1-5H3,(H,32,33)/b13-12+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 5.89n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at RXRalpha expressed in COS1 cells assessed as inhibition of NEt-TMN-induced luciferase activity after 18 hrs by reporter gene a...


ACS Med Chem Lett 2: 896-900 (2011)


Article DOI: 10.1021/ml200197e
BindingDB Entry DOI: 10.7270/Q2DR2WJM
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM50382931
PNG
(CHEMBL2029403)
Show SMILES CCN(c1ccc(cn1)C(O)=O)c1cc(OCC(C)C)c(cc1\C=C\c1ccccc1)C(C)C
Show InChI InChI=1S/C29H34N2O3/c1-6-31(28-15-14-24(18-30-28)29(32)33)26-17-27(34-19-20(2)3)25(21(4)5)16-23(26)13-12-22-10-8-7-9-11-22/h7-18,20-21H,6,19H2,1-5H3,(H,32,33)/b13-12+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 5.5n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at RXRalpha expressed in COS1 cells assessed as inhibition of NEt-3IP-induced luciferase activity after 18 hrs by reporter gene a...


ACS Med Chem Lett 2: 896-900 (2011)


Article DOI: 10.1021/ml200197e
BindingDB Entry DOI: 10.7270/Q2DR2WJM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%