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PubMed code 24900886

Compile data set for download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 0.900n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020166
PNG
(CHEMBL3288505)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C25H20N4O/c1-15-8-11-18(12-9-15)27-25(30)21-6-2-4-16-14-17(10-13-19(16)21)20-5-3-7-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 1.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020169
PNG
(CHEMBL3288506)
Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020167
PNG
(CHEMBL3288518)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c12
Show InChI InChI=1S/C24H16Cl2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020193
PNG
(CHEMBL3288515)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(F)cc(F)c3)c12
Show InChI InChI=1S/C24H16F2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 1.60n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020170
PNG
(CHEMBL3288502)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H18N4O/c25-23-22-19(9-5-11-21(22)27-28-23)16-12-13-18-15(14-16)6-4-10-20(18)24(29)26-17-7-2-1-3-8-17/h1-14H,(H,26,29)(H3,25,27,28)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020166
PNG
(CHEMBL3288505)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C25H20N4O/c1-15-8-11-18(12-9-15)27-25(30)21-6-2-4-16-14-17(10-13-19(16)21)20-5-3-7-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 1.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020194
PNG
(CHEMBL3288504)
Show SMILES Cc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C25H20N4O/c1-15-5-2-7-18(13-15)27-25(30)21-9-3-6-16-14-17(11-12-19(16)21)20-8-4-10-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020195
PNG
(CHEMBL3288512)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c12
Show InChI InChI=1S/C24H17FN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020210
PNG
(CHEMBL3288519)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Br)cc(Br)c3)c12
Show InChI InChI=1S/C24H16Br2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020223
PNG
(CHEMBL3288514)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3F)c12
Show InChI InChI=1S/C24H16F2N4O/c25-15-8-10-20(19(26)12-15)28-24(31)18-5-1-3-13-11-14(7-9-16(13)18)17-4-2-6-21-22(17)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 2.60n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020225
PNG
(CHEMBL3288523)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12
Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)
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n/an/a 2.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020227
PNG
(CHEMBL3288516)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C24H17ClN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 3.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020228
PNG
(CHEMBL3288509)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c(F)c1
Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-21(20(26)12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-22-23(18)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020170
PNG
(CHEMBL3288502)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H18N4O/c25-23-22-19(9-5-11-21(22)27-28-23)16-12-13-18-15(14-16)6-4-10-20(18)24(29)26-17-7-2-1-3-8-17/h1-14H,(H,26,29)(H3,25,27,28)
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n/an/a 3.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020229
PNG
(CHEMBL3288508)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-20(26)22(12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-21-23(18)24(27)30-29-21/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 3.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020230
PNG
(CHEMBL3288517)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C24H17BrN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 3.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020233
PNG
(CHEMBL3288510)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C25H19FN4O/c1-14-8-10-17(13-21(14)26)28-25(31)20-6-2-4-15-12-16(9-11-18(15)20)19-5-3-7-22-23(19)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 4.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020233
PNG
(CHEMBL3288510)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)cc1F
Show InChI InChI=1S/C25H19FN4O/c1-14-8-10-17(13-21(14)26)28-25(31)20-6-2-4-15-12-16(9-11-18(15)20)19-5-3-7-22-23(19)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 4.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 4.60n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDGFR-beta (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020234
PNG
(CHEMBL3288520)
Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1
Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)
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n/an/a 5.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020229
PNG
(CHEMBL3288508)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-20(26)22(12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-21-23(18)24(27)30-29-21/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 6.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020235
PNG
(CHEMBL3288511)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3F)c12
Show InChI InChI=1S/C24H17FN4O/c25-19-8-1-2-9-20(19)27-24(30)18-7-3-5-14-13-15(11-12-16(14)18)17-6-4-10-21-22(17)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 6.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 6.20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020236
PNG
(CHEMBL3288524)
Show SMILES Nc1nccc2occ(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17N3O2/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)
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n/an/a 7n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020238
PNG
(CHEMBL3288522)
Show SMILES CCNC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C20H18N4O/c1-2-22-20(25)16-7-3-5-12-11-13(9-10-14(12)16)15-6-4-8-17-18(15)19(21)24-23-17/h3-11H,2H2,1H3,(H,22,25)(H3,21,23,24)
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n/an/a 7n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020239
PNG
(CHEMBL3288525)
Show SMILES Nc1nccc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17N3OS/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)
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n/an/a 7.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020195
PNG
(CHEMBL3288512)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c12
Show InChI InChI=1S/C24H17FN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 7.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020194
PNG
(CHEMBL3288504)
Show SMILES Cc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C25H20N4O/c1-15-5-2-7-18(13-15)27-25(30)21-9-3-6-16-14-17(11-12-19(16)21)20-8-4-10-22-23(20)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 7.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020242
PNG
(CHEMBL3288507)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12
Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)
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n/an/a 7.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020228
PNG
(CHEMBL3288509)
Show SMILES Cc1ccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c(F)c1
Show InChI InChI=1S/C25H19FN4O/c1-14-8-11-21(20(26)12-14)28-25(31)19-6-2-4-15-13-16(9-10-17(15)19)18-5-3-7-22-23(18)24(27)30-29-22/h2-13H,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 7.60n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020245
PNG
(CHEMBL3288513)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C24H17FN4O/c25-16-8-10-17(11-9-16)27-24(30)20-5-1-3-14-13-15(7-12-18(14)20)19-4-2-6-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 9.20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020234
PNG
(CHEMBL3288520)
Show SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)no1
Show InChI InChI=1S/C22H17N5O2/c1-12-10-19(27-29-12)24-22(28)17-6-2-4-13-11-14(8-9-15(13)17)16-5-3-7-18-20(16)21(23)26-25-18/h2-11H,1H3,(H3,23,25,26)(H,24,27,28)
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n/an/a 9.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020193
PNG
(CHEMBL3288515)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(F)cc(F)c3)c12
Show InChI InChI=1S/C24H16F2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 11n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020249
PNG
(CHEMBL3288527)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4N(CCOc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C22H19N5O2/c23-21-20-16(7-4-8-17(20)25-26-21)14-9-10-18-19(13-14)29-12-11-27(18)22(28)24-15-5-2-1-3-6-15/h1-10,13H,11-12H2,(H,24,28)(H3,23,25,26)
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n/an/a 13n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020245
PNG
(CHEMBL3288513)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c12
Show InChI InChI=1S/C24H17FN4O/c25-16-8-10-17(11-9-16)27-24(30)20-5-1-3-14-13-15(7-12-18(14)20)19-4-2-6-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020169
PNG
(CHEMBL3288506)
Show SMILES CCc1cccc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C26H22N4O/c1-2-16-6-3-8-19(14-16)28-26(31)22-10-4-7-17-15-18(12-13-20(17)22)21-9-5-11-23-24(21)25(27)30-29-23/h3-15H,2H2,1H3,(H,28,31)(H3,27,29,30)
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n/an/a 18n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020235
PNG
(CHEMBL3288511)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3F)c12
Show InChI InChI=1S/C24H17FN4O/c25-19-8-1-2-9-20(19)27-24(30)18-7-3-5-14-13-15(11-12-16(14)18)17-6-4-10-21-22(17)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 19n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020239
PNG
(CHEMBL3288525)
Show SMILES Nc1nccc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17N3OS/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)
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n/an/a 20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant RET (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020246
PNG
(CHEMBL3288521)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c12
Show InChI InChI=1S/C23H17N5O/c24-22-21-18(6-2-8-20(21)27-28-22)15-9-10-17-14(12-15)4-1-7-19(17)23(29)26-16-5-3-11-25-13-16/h1-13H,(H,26,29)(H3,24,27,28)
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n/an/a 20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020236
PNG
(CHEMBL3288524)
Show SMILES Nc1nccc2occ(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C24H17N3O2/c25-23-22-20(14-29-21(22)11-12-26-23)16-9-10-18-15(13-16)5-4-8-19(18)24(28)27-17-6-2-1-3-7-17/h1-14H,(H2,25,26)(H,27,28)
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n/an/a 21n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020230
PNG
(CHEMBL3288517)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Br)c3)c12
Show InChI InChI=1S/C24H17BrN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 24n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020248
PNG
(CHEMBL3288503)
Show SMILES Cc1ccccc1NC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C25H20N4O/c1-15-6-2-3-10-21(15)27-25(30)20-9-4-7-16-14-17(12-13-18(16)20)19-8-5-11-22-23(19)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 27n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 35n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant VEGFR-1 (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020249
PNG
(CHEMBL3288527)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4N(CCOc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C22H19N5O2/c23-21-20-16(7-4-8-17(20)25-26-21)14-9-10-18-19(13-14)29-12-11-27(18)22(28)24-15-5-2-1-3-6-15/h1-10,13H,11-12H2,(H,24,28)(H3,23,25,26)
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n/an/a 41n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020227
PNG
(CHEMBL3288516)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C24H17ClN4O/c25-16-5-2-6-17(13-16)27-24(30)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(26)29-28-21/h1-13H,(H,27,30)(H3,26,28,29)
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n/an/a 48n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020248
PNG
(CHEMBL3288503)
Show SMILES Cc1ccccc1NC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C25H20N4O/c1-15-6-2-3-10-21(15)27-25(30)20-9-4-7-16-14-17(12-13-18(16)20)19-8-5-11-22-23(19)24(26)29-28-22/h2-14H,1H3,(H,27,30)(H3,26,28,29)
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n/an/a 86n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020223
PNG
(CHEMBL3288514)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3F)c12
Show InChI InChI=1S/C24H16F2N4O/c25-15-8-10-20(19(26)12-15)28-24(31)18-5-1-3-13-11-14(7-9-16(13)18)17-4-2-6-21-22(17)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a 93n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020225
PNG
(CHEMBL3288523)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)NC3CC3)c12
Show InChI InChI=1S/C21H18N4O/c22-20-19-16(4-2-6-18(19)24-25-20)13-7-10-15-12(11-13)3-1-5-17(15)21(26)23-14-8-9-14/h1-7,10-11,14H,8-9H2,(H,23,26)(H3,22,24,25)
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n/an/a 95n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020167
PNG
(CHEMBL3288518)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c12
Show InChI InChI=1S/C24H16Cl2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a>100n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020210
PNG
(CHEMBL3288519)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Br)cc(Br)c3)c12
Show InChI InChI=1S/C24H16Br2N4O/c25-15-10-16(26)12-17(11-15)28-24(31)20-5-1-3-13-9-14(7-8-18(13)20)19-4-2-6-21-22(19)23(27)30-29-21/h1-12H,(H,28,31)(H3,27,29,30)
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n/an/a>100n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020242
PNG
(CHEMBL3288507)
Show SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cccc(c3)C(F)(F)F)c12
Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)16-5-2-6-17(13-16)30-24(33)20-8-1-4-14-12-15(10-11-18(14)20)19-7-3-9-21-22(19)23(29)32-31-21/h1-13H,(H,30,33)(H3,29,31,32)
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n/an/a>100n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50020238
PNG
(CHEMBL3288522)
Show SMILES CCNC(=O)c1cccc2cc(ccc12)-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C20H18N4O/c1-2-22-20(25)16-7-3-5-12-11-13(9-10-14(12)16)15-6-4-8-17-18(15)19(21)24-23-17/h3-11H,2H2,1H3,(H,22,25)(H3,21,23,24)
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n/an/a 101n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 549n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDGFR-alpha (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a 644n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of FGFR-1 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human ErbB2 expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant EPH-A2 (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ErbB4 using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of IGF-1R (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant Flt-3 (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Src (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant Abl (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISA


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50020165
PNG
(CHEMBL3288526)
Show SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C23H16N4OS/c24-21-20-19(12-29-23(20)26-13-25-21)15-9-10-17-14(11-15)5-4-8-18(17)22(28)27-16-6-2-1-3-7-16/h1-13H,(H,27,28)(H2,24,25,26)
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of wild type EGFR kinase domain (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 ...


ACS Med Chem Lett 5: 592-7 (2014)


Article DOI: 10.1021/ml5000417
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%