Found 18 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021130
(CHEMBL3287658)Show SMILES COc1nc2cccnc2n1-c1ccc(Nc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C20H16N6O/c1-27-20-25-17-7-4-12-21-18(17)26(20)14-10-8-13(9-11-14)22-19-23-15-5-2-3-6-16(15)24-19/h2-12H,1H3,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021260
(CHEMBL3287907)Show SMILES COc1nc2cccnc2n1[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:11.12,wD:13.17,(17.3,-49.84,;18.06,-51.17,;17.29,-52.5,;15.76,-52.66,;15.43,-54.18,;14.1,-54.95,;14.1,-56.49,;15.44,-57.26,;16.77,-56.49,;16.77,-54.95,;17.92,-53.92,;19.42,-54.23,;20.71,-53.39,;21.55,-54.67,;20.27,-55.51,;23.06,-54.99,;24.09,-53.84,;23.77,-52.33,;25.11,-51.56,;25.42,-50.06,;26.88,-49.58,;28.03,-50.61,;27.71,-52.11,;26.25,-52.59,;25.63,-54,)| Show InChI InChI=1S/C18H17N5OS/c1-24-18-22-14-6-4-8-19-16(14)23(18)12-9-11(10-12)20-17-21-13-5-2-3-7-15(13)25-17/h2-8,11-12H,9-10H2,1H3,(H,20,21)/t11-,12- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021256
(CHEMBL3287905)Show SMILES COc1nc2cccnc2n1C1CC(C1)Nc1nc2ccccc2s1 |(18.03,-39.73,;18.8,-41.06,;18.02,-42.4,;16.49,-42.56,;16.16,-44.07,;14.83,-44.84,;14.83,-46.38,;16.17,-47.16,;17.51,-46.38,;17.5,-44.84,;18.65,-43.81,;20.15,-44.12,;21,-45.41,;22.28,-44.57,;21.44,-43.28,;23.79,-44.88,;24.82,-43.74,;24.51,-42.22,;25.84,-41.45,;26.15,-39.95,;27.61,-39.47,;28.76,-40.5,;28.44,-42.01,;26.98,-42.48,;26.36,-43.89,)| Show InChI InChI=1S/C18H17N5OS/c1-24-18-22-14-6-4-8-19-16(14)23(18)12-9-11(10-12)20-17-21-13-5-2-3-7-15(13)25-17/h2-8,11-12H,9-10H2,1H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021259
(CHEMBL3287906)Show SMILES COc1nc2cccnc2n1[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:11.12,13.17,(.72,-50.17,;1.49,-51.51,;.72,-52.84,;-.83,-53,;-1.15,-54.51,;-2.48,-55.28,;-2.48,-56.83,;-1.15,-57.6,;.2,-56.83,;.2,-55.29,;1.35,-54.25,;2.85,-54.57,;3.7,-55.85,;4.98,-55.01,;4.14,-53.73,;6.49,-55.33,;7.52,-54.18,;7.2,-52.67,;8.54,-51.9,;8.85,-50.4,;10.31,-49.91,;11.46,-50.94,;11.14,-52.45,;9.68,-52.93,;9.06,-54.33,)| Show InChI InChI=1S/C18H17N5OS/c1-24-18-22-14-6-4-8-19-16(14)23(18)12-9-11(10-12)20-17-21-13-5-2-3-7-15(13)25-17/h2-8,11-12H,9-10H2,1H3,(H,20,21)/t11-,12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021188
(CHEMBL3287662)Show InChI InChI=1S/C19H17N5O/c1-13-5-10-17(21-12-13)22-14-6-8-15(9-7-14)24-18-16(4-3-11-20-18)23-19(24)25-2/h3-12H,1-2H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021131
(CHEMBL3287659)Show InChI InChI=1S/C20H15N5OS/c1-26-20-24-16-6-4-12-21-18(16)25(20)14-10-8-13(9-11-14)22-19-23-15-5-2-3-7-17(15)27-19/h2-12H,1H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021251
(CHEMBL3287903)Show InChI InChI=1S/C21H21N5/c1-3-5-20-25-18-6-4-13-22-21(18)26(20)17-10-8-16(9-11-17)24-19-12-7-15(2)14-23-19/h4,6-14H,3,5H2,1-2H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021128
(CHEMBL3287657)Show SMILES COc1nc2cccnc2n1-c1ccc(cc1)C(=O)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C21H15N5O2/c1-28-21-25-17-7-4-12-22-20(17)26(21)14-10-8-13(9-11-14)18(27)19-23-15-5-2-3-6-16(15)24-19/h2-12H,1H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021250
(CHEMBL3287902)Show InChI InChI=1S/C22H19N5S/c1-2-6-20-25-18-8-5-14-23-21(18)27(20)16-12-10-15(11-13-16)24-22-26-17-7-3-4-9-19(17)28-22/h3-5,7-14H,2,6H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021194
(CHEMBL3287900)Show InChI InChI=1S/C21H17N5S/c1-2-19-24-17-7-5-13-22-20(17)26(19)15-11-9-14(10-12-15)23-21-25-16-6-3-4-8-18(16)27-21/h3-13H,2H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021192
(CHEMBL3287665)Show InChI InChI=1S/C20H15N5S/c1-13-22-17-6-4-12-21-19(17)25(13)15-10-8-14(9-11-15)23-20-24-16-5-2-3-7-18(16)26-20/h2-12H,1H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021168
(CHEMBL3287661)Show InChI InChI=1S/C18H14ClN5O/c1-25-18-23-15-3-2-10-20-17(15)24(18)14-7-5-13(6-8-14)22-16-9-4-12(19)11-21-16/h2-11H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021249
(CHEMBL3287901)Show InChI InChI=1S/C20H19N5/c1-3-19-24-17-5-4-12-21-20(17)25(19)16-9-7-15(8-10-16)23-18-11-6-14(2)13-22-18/h4-13H,3H2,1-2H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021193
(CHEMBL3287899)Show InChI InChI=1S/C19H17N5/c1-13-5-10-18(21-12-13)23-15-6-8-16(9-7-15)24-14(2)22-17-4-3-11-20-19(17)24/h3-12H,1-2H3,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021191
(CHEMBL3287664)Show InChI InChI=1S/C19H13N5S/c1-2-6-17-15(4-1)23-19(25-17)22-13-7-9-14(10-8-13)24-12-21-16-5-3-11-20-18(16)24/h1-12H,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021162
(CHEMBL3287660)Show InChI InChI=1S/C22H17N5O/c1-28-22-26-19-7-4-14-23-21(19)27(22)17-11-9-16(10-12-17)24-20-13-8-15-5-2-3-6-18(15)25-20/h2-14H,1H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021252
(CHEMBL3287904)Show SMILES COc1nc2cccnc2n1C1CCC(CC1)Nc1nc2ccccc2s1 |(2.39,-40.58,;3.16,-41.91,;2.38,-43.25,;.85,-43.41,;.52,-44.92,;-.81,-45.69,;-.81,-47.23,;.53,-48,;1.87,-47.23,;1.86,-45.69,;3.01,-44.66,;4.51,-44.97,;4.99,-46.44,;6.49,-46.76,;7.52,-45.62,;7.04,-44.15,;5.54,-43.83,;9.03,-45.94,;10.06,-44.79,;9.74,-43.28,;11.08,-42.51,;11.39,-41.01,;12.85,-40.53,;14,-41.56,;13.68,-43.06,;12.22,-43.54,;11.6,-44.95,)| Show InChI InChI=1S/C20H21N5OS/c1-26-20-24-16-6-4-12-21-18(16)25(20)14-10-8-13(9-11-14)22-19-23-15-5-2-3-7-17(15)27-19/h2-7,12-14H,8-11H2,1H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 271 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50021190
(CHEMBL3287663)Show InChI InChI=1S/C18H15N5S/c19-14-4-3-11-20-17(14)21-12-7-9-13(10-8-12)22-18-23-15-5-1-2-6-16(15)24-18/h1-11H,19H2,(H,20,21)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 404 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE10A using cAMP as substrate after 1 hr by IMAP-FRET assay |
ACS Med Chem Lett 5: 700-5 (2014)
Article DOI: 10.1021/ml5000993
BindingDB Entry DOI: 10.7270/Q2T43VPW |
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Ligand-Target Pair | |
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