Found 79 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50445235
(CHEMBL3102948)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C23H22N2O4/c1-26-19-7-5-14(10-21(19)28-3)16-9-17-18(13-25-23(17)24-12-16)15-6-8-20(27-2)22(11-15)29-4/h5-13H,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50391954
(CHEMBL2152262)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C21H19N3O2/c1-25-19-7-6-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-4-3-5-16(22)8-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054444
(CHEMBL3319467)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C(=O)N2CCOCC2)c(N)c1 Show InChI InChI=1S/C26H26N4O4/c1-32-23-6-4-17(13-24(23)33-2)21-15-29-25-20(21)11-18(14-28-25)16-3-5-19(22(27)12-16)26(31)30-7-9-34-10-8-30/h3-6,11-15H,7-10,27H2,1-2H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054443
(CHEMBL3319468)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C24H24N2O5/c1-27-19-7-6-14(9-20(19)28-2)18-13-26-24-17(18)8-16(12-25-24)15-10-21(29-3)23(31-5)22(11-15)30-4/h6-13H,1-5H3,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054417
(CHEMBL3319472)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(N)cc1 Show InChI InChI=1S/C21H19N3O2/c1-25-19-8-5-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-3-6-16(22)7-4-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50332019
(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(N)c1 Show InChI InChI=1S/C20H18N4O2/c1-25-18-4-3-12(7-19(18)26-2)17-11-24-20-16(17)6-14(9-23-20)13-5-15(21)10-22-8-13/h3-11H,21H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50332012
(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C26H22N4O4S/c1-33-24-9-8-17(12-25(24)34-2)23-16-29-26-22(23)11-19(14-28-26)18-10-20(15-27-13-18)30-35(31,32)21-6-4-3-5-7-21/h3-16,30H,1-2H3,(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055056
(CHEMBL3319475)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(OCCN2CCOCC2)c(N)c1 Show InChI InChI=1S/C27H30N4O4/c1-32-25-6-4-19(15-26(25)33-2)22-17-30-27-21(22)13-20(16-29-27)18-3-5-24(23(28)14-18)35-12-9-31-7-10-34-11-8-31/h3-6,13-17H,7-12,28H2,1-2H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054442
(CHEMBL3319469)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C)c(N)c1 Show InChI InChI=1S/C22H21N3O2/c1-13-4-5-14(9-19(13)23)16-8-17-18(12-25-22(17)24-11-16)15-6-7-20(26-2)21(10-15)27-3/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055055
(CHEMBL3319474)Show SMILES COc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H21N3O3/c1-26-17-7-14(6-16(23)10-17)15-8-18-19(12-25-22(18)24-11-15)13-4-5-20(27-2)21(9-13)28-3/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054441
(CHEMBL3319470)Show SMILES COc1ccc(cc1N)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H21N3O3/c1-26-19-6-4-13(9-18(19)23)15-8-16-17(12-25-22(16)24-11-15)14-5-7-20(27-2)21(10-14)28-3/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50445237
(CHEMBL3102946)Show SMILES COc1ccc(c(OC)c1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C23H22N2O4/c1-26-16-6-7-17(21(11-16)28-3)15-9-18-19(13-25-23(18)24-12-15)14-5-8-20(27-2)22(10-14)29-4/h5-13H,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054414
(CHEMBL3319394)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(c1)N(C)C Show InChI InChI=1S/C23H23N3O2/c1-26(2)18-7-5-6-15(10-18)17-11-19-20(14-25-23(19)24-13-17)16-8-9-21(27-3)22(12-16)28-4/h5-14H,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055054
(CHEMBL3319476)Show SMILES COc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H20N2O3/c1-25-17-6-4-5-14(9-17)16-10-18-19(13-24-22(18)23-12-16)15-7-8-20(26-2)21(11-15)27-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054410
(CHEMBL3319447)Show InChI InChI=1S/C20H17N3O2/c1-24-18-4-3-14(10-19(18)25-2)17-12-23-20-16(17)9-15(11-22-20)13-5-7-21-8-6-13/h3-12H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055048
(CHEMBL3319455)Show SMILES COc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H20N2O3/c1-25-17-7-4-14(5-8-17)16-10-18-19(13-24-22(18)23-12-16)15-6-9-20(26-2)21(11-15)27-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054424
(CHEMBL3319471)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C22H18N2O4/c1-25-18-5-4-14(9-20(18)26-2)17-11-24-22-16(17)7-15(10-23-22)13-3-6-19-21(8-13)28-12-27-19/h3-11H,12H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054417
(CHEMBL3319472)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(N)cc1 Show InChI InChI=1S/C21H19N3O2/c1-25-19-8-5-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-3-6-16(22)7-4-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054409
(CHEMBL3319448)Show InChI InChI=1S/C20H17N3O2/c1-24-18-6-5-13(9-19(18)25-2)17-12-23-20-16(17)8-15(11-22-20)14-4-3-7-21-10-14/h3-12H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054415
(CHEMBL2152263)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C22H17N3O2/c1-26-20-7-6-16(10-21(20)27-2)19-13-25-22-18(19)9-17(12-24-22)15-5-3-4-14(8-15)11-23/h3-10,12-13H,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054445
(CHEMBL3319466)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NC(C)=O)c1 Show InChI InChI=1S/C23H21N3O3/c1-14(27)26-18-6-4-5-15(9-18)17-10-19-20(13-25-23(19)24-12-17)16-7-8-21(28-2)22(11-16)29-3/h4-13H,1-3H3,(H,24,25)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054416
(CHEMBL3319473)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cnc(N)nc1 Show InChI InChI=1S/C19H17N5O2/c1-25-16-4-3-11(6-17(16)26-2)15-10-22-18-14(15)5-12(7-21-18)13-8-23-19(20)24-9-13/h3-10H,1-2H3,(H,21,22)(H2,20,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055051
(CHEMBL3319452)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C21H17FN2O2/c1-25-19-8-5-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-3-6-16(22)7-4-13/h3-12H,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054447
(CHEMBL3319464)Show InChI InChI=1S/C19H16N4/c20-15-5-1-3-12(7-15)14-9-17-18(11-23-19(17)22-10-14)13-4-2-6-16(21)8-13/h1-11H,20-21H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054455
(CHEMBL3319457)Show SMILES COc1cc(cc(OC)c1OC)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C22H21N3O3/c1-26-19-9-14(10-20(27-2)21(19)28-3)18-12-25-22-17(18)8-15(11-24-22)13-5-4-6-16(23)7-13/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055047
(CHEMBL3319456)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cc(F)cc(F)c1 Show InChI InChI=1S/C21H16F2N2O2/c1-26-19-4-3-12(8-20(19)27-2)18-11-25-21-17(18)7-14(10-24-21)13-5-15(22)9-16(23)6-13/h3-11H,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054454
(CHEMBL3319458)Show SMILES COc1ccc(cc1F)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C20H16FN3O/c1-25-19-6-5-13(9-18(19)21)17-11-24-20-16(17)8-14(10-23-20)12-3-2-4-15(22)7-12/h2-11H,22H2,1H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50332020
(CHEMBL1289468 | N-(3-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C27H23N3O4S/c1-33-25-12-11-19(15-26(25)34-2)24-17-29-27-23(24)14-20(16-28-27)18-7-6-8-21(13-18)30-35(31,32)22-9-4-3-5-10-22/h3-17,30H,1-2H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054411
(CHEMBL3319446)Show InChI InChI=1S/C21H18N2O2/c1-24-19-9-8-15(11-20(19)25-2)18-13-23-21-17(18)10-16(12-22-21)14-6-4-3-5-7-14/h3-13H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50445235
(CHEMBL3102948)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C23H22N2O4/c1-26-19-7-5-14(10-21(19)28-3)16-9-17-18(13-25-23(17)24-12-16)15-6-8-20(27-2)22(11-15)29-4/h5-13H,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054413
(CHEMBL3319395)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(C)c1 Show InChI InChI=1S/C22H20N2O2/c1-14-5-4-6-15(9-14)17-10-18-19(13-24-22(18)23-12-17)16-7-8-20(25-2)21(11-16)26-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 261 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054448
(CHEMBL3319463)Show SMILES COc1cc(OC)cc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C21H19N3O2/c1-25-17-7-14(8-18(10-17)26-2)20-12-24-21-19(20)9-15(11-23-21)13-4-3-5-16(22)6-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50332012
(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C26H22N4O4S/c1-33-24-9-8-17(12-25(24)34-2)23-16-29-26-22(23)11-19(14-28-26)18-10-20(15-27-13-18)30-35(31,32)21-6-4-3-5-7-21/h3-16,30H,1-2H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055048
(CHEMBL3319455)Show SMILES COc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H20N2O3/c1-25-17-7-4-14(5-8-17)16-10-18-19(13-24-22(18)23-12-16)15-6-9-20(26-2)21(11-15)27-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 371 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054450
(CHEMBL3319461)Show SMILES COc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C20H17N3O/c1-24-17-7-5-13(6-8-17)19-12-23-20-18(19)10-15(11-22-20)14-3-2-4-16(21)9-14/h2-12H,21H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055052
(CHEMBL3319451)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C22H17N3O2/c1-26-20-8-7-16(10-21(20)27-2)19-13-25-22-18(19)9-17(12-24-22)15-5-3-14(11-23)4-6-15/h3-10,12-13H,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 426 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055050
(CHEMBL3319453)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H17ClN2O2/c1-25-19-8-5-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-3-6-16(22)7-4-13/h3-12H,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 457 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054412
(CHEMBL3319445)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(F)c1 Show InChI InChI=1S/C21H17FN2O2/c1-25-19-7-6-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-4-3-5-16(22)8-13/h3-12H,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055049
(CHEMBL3319454)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C)cc1 Show InChI InChI=1S/C22H20N2O2/c1-14-4-6-15(7-5-14)17-10-18-19(13-24-22(18)23-12-17)16-8-9-20(25-2)21(11-16)26-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 571 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054449
(CHEMBL3319462)Show SMILES COc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C20H17N3O/c1-24-17-7-3-5-14(9-17)19-12-23-20-18(19)10-15(11-22-20)13-4-2-6-16(21)8-13/h2-12H,21H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054408
(CHEMBL3319449)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccccc1C Show InChI InChI=1S/C22H20N2O2/c1-14-6-4-5-7-17(14)16-10-18-19(13-24-22(18)23-12-16)15-8-9-20(25-2)21(11-15)26-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 785 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50391954
(CHEMBL2152262)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C21H19N3O2/c1-25-19-7-6-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-4-3-5-16(22)8-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054445
(CHEMBL3319466)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NC(C)=O)c1 Show InChI InChI=1S/C23H21N3O3/c1-14(27)26-18-6-4-5-15(9-18)17-10-19-20(13-25-23(19)24-12-17)16-7-8-21(28-2)22(11-16)29-3/h4-13H,1-3H3,(H,24,25)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054416
(CHEMBL3319473)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cnc(N)nc1 Show InChI InChI=1S/C19H17N5O2/c1-25-16-4-3-11(6-17(16)26-2)15-10-22-18-14(15)5-12(7-21-18)13-8-23-19(20)24-9-13/h3-10H,1-2H3,(H,21,22)(H2,20,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055053
(CHEMBL3319450)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccccc1N Show InChI InChI=1S/C21H19N3O2/c1-25-19-8-7-13(10-20(19)26-2)17-12-24-21-16(17)9-14(11-23-21)15-5-3-4-6-18(15)22/h3-12H,22H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054453
(CHEMBL3319459)Show InChI InChI=1S/C19H16N4/c20-14-5-3-4-12(8-14)13-9-16-17(11-23-19(16)22-10-13)15-6-1-2-7-18(15)21/h1-11H,20-21H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50332019
(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(N)c1 Show InChI InChI=1S/C20H18N4O2/c1-25-18-4-3-12(7-19(18)26-2)17-11-24-20-16(17)6-14(9-23-20)13-5-15(21)10-22-8-13/h3-11H,21H2,1-2H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055054
(CHEMBL3319476)Show SMILES COc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H20N2O3/c1-25-17-6-4-5-14(9-17)16-10-18-19(13-24-22(18)23-12-16)15-7-8-20(26-2)21(11-15)27-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50332020
(CHEMBL1289468 | N-(3-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C27H23N3O4S/c1-33-25-12-11-19(15-26(25)34-2)24-17-29-27-23(24)14-20(16-28-27)18-7-6-8-21(13-18)30-35(31,32)22-9-4-3-5-10-22/h3-17,30H,1-2H3,(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054446
(CHEMBL3319465)Show SMILES Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C19H14ClN3/c20-15-6-4-12(5-7-15)18-11-23-19-17(18)9-14(10-22-19)13-2-1-3-16(21)8-13/h1-11H,21H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054443
(CHEMBL3319468)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C24H24N2O5/c1-27-19-7-6-14(9-20(19)28-2)18-13-26-24-17(18)8-16(12-25-24)15-10-21(29-3)23(31-5)22(11-15)30-4/h6-13H,1-5H3,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054409
(CHEMBL3319448)Show InChI InChI=1S/C20H17N3O2/c1-24-18-6-5-13(9-19(18)25-2)17-12-23-20-16(17)8-15(11-22-20)14-4-3-7-21-10-14/h3-12H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50445237
(CHEMBL3102946)Show SMILES COc1ccc(c(OC)c1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C23H22N2O4/c1-26-16-6-7-17(21(11-16)28-3)15-9-18-19(13-25-23(18)24-12-15)14-5-8-20(27-2)22(10-14)29-4/h5-13H,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055056
(CHEMBL3319475)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(OCCN2CCOCC2)c(N)c1 Show InChI InChI=1S/C27H30N4O4/c1-32-25-6-4-19(15-26(25)33-2)22-17-30-27-21(22)13-20(16-29-27)18-3-5-24(23(28)14-18)35-12-9-31-7-10-34-11-8-31/h3-6,13-17H,7-12,28H2,1-2H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054444
(CHEMBL3319467)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C(=O)N2CCOCC2)c(N)c1 Show InChI InChI=1S/C26H26N4O4/c1-32-23-6-4-17(13-24(23)33-2)21-15-29-25-20(21)11-18(14-28-25)16-3-5-19(22(27)12-16)26(31)30-7-9-34-10-8-30/h3-6,11-15H,7-10,27H2,1-2H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054410
(CHEMBL3319447)Show InChI InChI=1S/C20H17N3O2/c1-24-18-4-3-14(10-19(18)25-2)17-12-23-20-16(17)9-15(11-22-20)13-5-7-21-8-6-13/h3-12H,1-2H3,(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055052
(CHEMBL3319451)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C22H17N3O2/c1-26-20-8-7-16(10-21(20)27-2)19-13-25-22-18(19)9-17(12-24-22)15-5-3-14(11-23)4-6-15/h3-10,12-13H,1-2H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055048
(CHEMBL3319455)Show SMILES COc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H20N2O3/c1-25-17-7-4-14(5-8-17)16-10-18-19(13-24-22(18)23-12-16)15-6-9-20(26-2)21(11-15)27-3/h4-13H,1-3H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054415
(CHEMBL2152263)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C22H17N3O2/c1-26-20-7-6-16(10-21(20)27-2)19-13-25-22-18(19)9-17(12-24-22)15-5-3-4-14(8-15)11-23/h3-10,12-13H,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055051
(CHEMBL3319452)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C21H17FN2O2/c1-25-19-8-5-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-3-6-16(22)7-4-13/h3-12H,1-2H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055053
(CHEMBL3319450)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccccc1N Show InChI InChI=1S/C21H19N3O2/c1-25-19-8-7-13(10-20(19)26-2)17-12-24-21-16(17)9-14(11-23-21)15-5-3-4-6-18(15)22/h3-12H,22H2,1-2H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054412
(CHEMBL3319445)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(F)c1 Show InChI InChI=1S/C21H17FN2O2/c1-25-19-7-6-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-4-3-5-16(22)8-13/h3-12H,1-2H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055050
(CHEMBL3319453)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H17ClN2O2/c1-25-19-8-5-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-3-6-16(22)7-4-13/h3-12H,1-2H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054411
(CHEMBL3319446)Show InChI InChI=1S/C21H18N2O2/c1-24-19-9-8-15(11-20(19)25-2)18-13-23-21-17(18)10-16(12-22-21)14-6-4-3-5-7-14/h3-13H,1-2H3,(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50445235
(CHEMBL3102948)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C23H22N2O4/c1-26-19-7-5-14(10-21(19)28-3)16-9-17-18(13-25-23(17)24-12-16)15-6-8-20(27-2)22(11-15)29-4/h5-13H,1-4H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055049
(CHEMBL3319454)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C)cc1 Show InChI InChI=1S/C22H20N2O2/c1-14-4-6-15(7-5-14)17-10-18-19(13-24-22(18)23-12-17)16-8-9-20(25-2)21(11-16)26-3/h4-13H,1-3H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054413
(CHEMBL3319395)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(C)c1 Show InChI InChI=1S/C22H20N2O2/c1-14-5-4-6-15(9-14)17-10-18-19(13-24-22(18)23-12-17)16-7-8-20(25-2)21(11-16)26-3/h4-13H,1-3H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055049
(CHEMBL3319454)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C)cc1 Show InChI InChI=1S/C22H20N2O2/c1-14-4-6-15(7-5-14)17-10-18-19(13-24-22(18)23-12-17)16-8-9-20(25-2)21(11-16)26-3/h4-13H,1-3H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054409
(CHEMBL3319448)Show InChI InChI=1S/C20H17N3O2/c1-24-18-6-5-13(9-19(18)25-2)17-12-23-20-16(17)8-15(11-22-20)14-4-3-7-21-10-14/h3-12H,1-2H3,(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055055
(CHEMBL3319474)Show SMILES COc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H21N3O3/c1-26-17-7-14(6-16(23)10-17)15-8-18-19(12-25-22(18)24-11-15)13-4-5-20(27-2)21(9-13)28-3/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054441
(CHEMBL3319470)Show SMILES COc1ccc(cc1N)-c1cnc2[nH]cc(-c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C22H21N3O3/c1-26-19-6-4-13(9-18(19)23)15-8-16-17(12-25-22(16)24-11-15)14-5-7-20(27-2)21(10-14)28-3/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055047
(CHEMBL3319456)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cc(F)cc(F)c1 Show InChI InChI=1S/C21H16F2N2O2/c1-26-19-4-3-12(8-20(19)27-2)18-11-25-21-17(18)7-14(10-24-21)13-5-15(22)9-16(23)6-13/h3-11H,1-2H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054415
(CHEMBL2152263)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C22H17N3O2/c1-26-20-7-6-16(10-21(20)27-2)19-13-25-22-18(19)9-17(12-24-22)15-5-3-4-14(8-15)11-23/h3-10,12-13H,1-2H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054408
(CHEMBL3319449)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccccc1C Show InChI InChI=1S/C22H20N2O2/c1-14-6-4-5-7-17(14)16-10-18-19(13-24-22(18)23-12-16)15-8-9-20(25-2)21(11-15)26-3/h4-13H,1-3H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50054414
(CHEMBL3319394)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(c1)N(C)C Show InChI InChI=1S/C23H23N3O2/c1-26(2)18-7-5-6-15(10-18)17-11-19-20(14-25-23(19)24-13-17)16-8-9-21(27-3)22(12-16)28-4/h5-14H,1-4H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054442
(CHEMBL3319469)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc(C)c(N)c1 Show InChI InChI=1S/C22H21N3O2/c1-13-4-5-14(9-19(13)23)16-8-17-18(12-25-22(17)24-11-16)15-6-7-20(26-2)21(10-15)27-3/h4-12H,23H2,1-3H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054451
(CHEMBL3319460)Show InChI InChI=1S/C20H17N3/c1-13-5-7-14(8-6-13)19-12-23-20-18(19)10-16(11-22-20)15-3-2-4-17(21)9-15/h2-12H,21H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of c-KIT D816V mutant (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50391954
(CHEMBL2152262)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C21H19N3O2/c1-25-19-7-6-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-4-3-5-16(22)8-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50054424
(CHEMBL3319471)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C22H18N2O4/c1-25-18-5-4-14(9-20(18)26-2)17-11-24-22-16(17)7-15(10-23-22)13-3-6-19-21(8-13)28-12-27-19/h3-11H,12H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description
Inhibition of wild type c-KIT (unknown origin) |
J Med Chem 57: 6428-43 (2014)
Article DOI: 10.1021/jm500413g
BindingDB Entry DOI: 10.7270/Q2QR4ZS4 |
More data for this
Ligand-Target Pair | |
Search and Browse
