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PubMed code 25017033

Compile data set for download or QSAR
Found 148 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050546
PNG
(CHEMBL3182699)
Show SMILES CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O4/c1-15(2)32-20-12-5-3-10-18(20)22(30)28-16-8-7-9-17(14-16)29-23(31)19-11-4-6-13-21(19)33-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 1n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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n/an/a 2n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050542
PNG
(CHEMBL3183497)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C23H22N2O4/c1-3-29-21-14-7-5-12-19(21)23(27)25-17-10-8-9-16(15-17)24-22(26)18-11-4-6-13-20(18)28-2/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 2n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050541
PNG
(CHEMBL3188749)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O4/c1-30-18-11-4-2-9-16(18)20(28)26-14-7-6-8-15(13-14)27-21(29)17-10-3-5-12-19(17)31-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050538
PNG
(CHEMBL3182091)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccs2)c1
Show InChI InChI=1S/C19H16N2O2S/c1-13-5-2-6-14(11-13)18(22)20-15-7-3-8-16(12-15)21-19(23)17-9-4-10-24-17/h2-12H,1H3,(H,20,22)(H,21,23)
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n/an/a 5n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50123519
PNG
(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Show SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
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n/an/a 7n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050544
PNG
(CHEMBL3187764)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(C)C)c1
Show InChI InChI=1S/C24H24N2O3/c1-16(2)19-11-4-5-12-20(19)23(27)25-17-9-8-10-18(15-17)26-24(28)21-13-6-7-14-22(21)29-3/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 7n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 9n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 10n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 10n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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n/an/a 10n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050545
PNG
(CHEMBL3186000)
Show SMILES CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O3/c1-15(2)18-10-3-4-11-19(18)22(30)28-16-8-7-9-17(14-16)29-23(31)20-12-5-6-13-21(20)32-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 11n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 11n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 14n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 16n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050433
PNG
(CHEMBL3186489)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccccc1
Show InChI InChI=1S/C20H16N2O2/c23-19(15-8-3-1-4-9-15)21-17-12-7-13-18(14-17)22-20(24)16-10-5-2-6-11-16/h1-14H,(H,21,23)(H,22,24)
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n/an/a 21n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050508
PNG
(CHEMBL3186695)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-6-4-7-15(12-14)20(25)23-16-8-5-9-17(13-16)24-21(26)18-10-2-3-11-19(18)22/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 23n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050522
PNG
(CHEMBL3182551)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(F)c2)c1
Show InChI InChI=1S/C21H17FN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 25n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 27n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050504
PNG
(CHEMBL3182725)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O3/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)30-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 29n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050451
PNG
(CHEMBL3182777)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1cccs1
Show InChI InChI=1S/C18H14N2O2S/c21-17(13-6-2-1-3-7-13)19-14-8-4-9-15(12-14)20-18(22)16-10-5-11-23-16/h1-12H,(H,19,21)(H,20,22)
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n/an/a 29n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 30n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050495
PNG
(CHEMBL3185736)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-6-3-8-17(12-15)21(25)23-19-10-5-11-20(14-19)24-22(26)18-9-4-7-16(2)13-18/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 30n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050498
PNG
(CHEMBL3187806)
Show SMILES COc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-6-3-7-16(12-15)21(25)23-18-9-5-10-19(14-18)24-22(26)17-8-4-11-20(13-17)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 31n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050447
PNG
(CHEMBL1716797)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccco1
Show InChI InChI=1S/C18H14N2O3/c21-17(13-6-2-1-3-7-13)19-14-8-4-9-15(12-14)20-18(22)16-10-5-11-23-16/h1-12H,(H,19,21)(H,20,22)
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n/an/a 37n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 38n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050437
PNG
(CHEMBL1532914)
Show SMILES Fc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15FN2O2/c21-16-9-4-8-15(12-16)20(25)23-18-11-5-10-17(13-18)22-19(24)14-6-2-1-3-7-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 45n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050440
PNG
(CHEMBL3184966)
Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-16-9-4-8-15(12-16)20(25)23-18-11-5-10-17(13-18)22-19(24)14-6-2-1-3-7-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 52n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050504
PNG
(CHEMBL3182725)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O3/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)30-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 60n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050542
PNG
(CHEMBL3183497)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C23H22N2O4/c1-3-29-21-14-7-5-12-19(21)23(27)25-17-10-8-9-16(15-17)24-22(26)18-11-4-6-13-20(18)28-2/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 66n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050543
PNG
(CHEMBL1480257)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-8-3-4-11-18(15)21(25)23-16-9-7-10-17(14-16)24-22(26)19-12-5-6-13-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 73n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 75n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050493
PNG
(CHEMBL3184095)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)C1CCCCC1
Show InChI InChI=1S/C20H22N2O2/c23-19(15-8-3-1-4-9-15)21-17-12-7-13-18(14-17)22-20(24)16-10-5-2-6-11-16/h1,3-4,7-9,12-14,16H,2,5-6,10-11H2,(H,21,23)(H,22,24)
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n/an/a 79n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050453
PNG
(CHEMBL3182370)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccn2)c1)c1ccccc1
Show InChI InChI=1S/C19H15N3O2/c23-18(14-7-2-1-3-8-14)21-15-9-6-10-16(13-15)22-19(24)17-11-4-5-12-20-17/h1-13H,(H,21,23)(H,22,24)
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n/an/a 86n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050494
PNG
(CHEMBL3181939)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-7-5-9-17(13-15)21(25)23-18-10-6-11-19(14-18)24-22(26)20-12-4-3-8-16(20)2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 91n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a 95n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050161
PNG
(CHEMBL3186207)
Show SMILES Cc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-8-5-6-13-19(15)21(25)23-18-12-7-11-17(14-18)22-20(24)16-9-3-2-4-10-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 100n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050546
PNG
(CHEMBL3182699)
Show SMILES CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O4/c1-15(2)32-20-12-5-3-10-18(20)22(30)28-16-8-7-9-17(14-16)29-23(31)19-11-4-6-13-21(19)33-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 110n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050442
PNG
(CHEMBL3186206)
Show SMILES FC(F)(F)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)18-12-5-4-11-17(18)20(28)26-16-10-6-9-15(13-16)25-19(27)14-7-2-1-3-8-14/h1-13H,(H,25,27)(H,26,28)
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n/an/a 130n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050537
PNG
(CHEMBL3182773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C19H16N2O3/c1-13-5-2-6-14(11-13)18(22)20-15-7-3-8-16(12-15)21-19(23)17-9-4-10-24-17/h2-12H,1H3,(H,20,22)(H,21,23)
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n/an/a 140n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050502
PNG
(CHEMBL3317851)
Show SMILES COc1ccc(OC)c(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O4/c1-15-6-4-7-16(12-15)22(26)24-17-8-5-9-18(13-17)25-23(27)20-14-19(28-2)10-11-21(20)29-3/h4-14H,1-3H3,(H,24,26)(H,25,27)
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n/an/a 150n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050495
PNG
(CHEMBL3185736)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-6-3-8-17(12-15)21(25)23-19-10-5-11-20(14-19)24-22(26)18-9-4-7-16(2)13-18/h3-14H,1-2H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050518
PNG
(CHEMBL3186471)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-4-2-5-16(12-14)21(26)24-19-7-3-6-18(13-19)23-20(25)15-8-10-17(22)11-9-15/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 150n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050536
PNG
(CHEMBL3188463)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H23N3O2/c1-16-6-4-7-18(14-16)23(28)25-20-9-5-8-19(15-20)24-22(27)17-10-12-21(13-11-17)26(2)3/h4-15H,1-3H3,(H,24,27)(H,25,28)
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n/an/a 150n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050443
PNG
(CHEMBL3186946)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)16-9-4-8-15(12-16)20(28)26-18-11-5-10-17(13-18)25-19(27)14-6-2-1-3-7-14/h1-13H,(H,25,27)(H,26,28)
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n/an/a 160n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050452
PNG
(CHEMBL3183945)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccsc1
Show InChI InChI=1S/C18H14N2O2S/c21-17(13-5-2-1-3-6-13)19-15-7-4-8-16(11-15)20-18(22)14-9-10-23-12-14/h1-12H,(H,19,21)(H,20,22)
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n/an/a 160n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050548
PNG
(CHEMBL3317854)
Show SMILES COc1cc(ccn1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C21H19N3O3/c1-14-5-3-6-15(11-14)20(25)23-17-7-4-8-18(13-17)24-21(26)16-9-10-22-19(12-16)27-2/h3-13H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 180n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050497
PNG
(CHEMBL3181946)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(cc2)C(C)(C)C)c1
Show InChI InChI=1S/C25H26N2O2/c1-17-7-5-8-19(15-17)24(29)27-22-10-6-9-21(16-22)26-23(28)18-11-13-20(14-12-18)25(2,3)4/h5-16H,1-4H3,(H,26,28)(H,27,29)
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n/an/a 190n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050505
PNG
(CHEMBL3317852)
Show SMILES CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C24H24N2O3/c1-16(2)29-22-13-5-4-12-21(22)24(28)26-20-11-7-10-19(15-20)25-23(27)18-9-6-8-17(3)14-18/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 210n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050434
PNG
(CHEMBL3188343)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O3/c1-26-19-13-6-5-12-18(19)21(25)23-17-11-7-10-16(14-17)22-20(24)15-8-3-2-4-9-15/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050433
PNG
(CHEMBL3186489)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccccc1
Show InChI InChI=1S/C20H16N2O2/c23-19(15-8-3-1-4-9-15)21-17-12-7-13-18(14-17)22-20(24)16-10-5-2-6-11-16/h1-14H,(H,21,23)(H,22,24)
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n/an/a 240n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) by parental cell based thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050457
PNG
(CHEMBL3188245)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccncc2)c1)c1ccccc1
Show InChI InChI=1S/C19H15N3O2/c23-18(14-5-2-1-3-6-14)21-16-7-4-8-17(13-16)22-19(24)15-9-11-20-12-10-15/h1-13H,(H,21,23)(H,22,24)
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n/an/a 250n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050446
PNG
(CHEMBL3184653)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C22H21N3O2/c1-25(2)20-13-11-17(12-14-20)22(27)24-19-10-6-9-18(15-19)23-21(26)16-7-4-3-5-8-16/h3-15H,1-2H3,(H,23,26)(H,24,27)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50426570
PNG
(CHEMBL2324344)
Show SMILES CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050438
PNG
(CHEMBL3184075)
Show SMILES Fc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15FN2O2/c21-16-11-9-15(10-12-16)20(25)23-18-8-4-7-17(13-18)22-19(24)14-5-2-1-3-6-14/h1-13H,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050538
PNG
(CHEMBL3182091)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccs2)c1
Show InChI InChI=1S/C19H16N2O2S/c1-13-5-2-6-14(11-13)18(22)20-15-7-3-8-16(12-15)21-19(23)17-9-4-10-24-17/h2-12H,1H3,(H,20,22)(H,21,23)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050435
PNG
(CHEMBL3183938)
Show SMILES COc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O3/c1-26-19-12-5-9-16(13-19)21(25)23-18-11-6-10-17(14-18)22-20(24)15-7-3-2-4-8-15/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050496
PNG
(CHEMBL3184438)
Show SMILES CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C24H24N2O2/c1-16(2)21-12-4-5-13-22(21)24(28)26-20-11-7-10-19(15-20)25-23(27)18-9-6-8-17(3)14-18/h4-16H,1-3H3,(H,25,27)(H,26,28)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050541
PNG
(CHEMBL3188749)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O4/c1-30-18-11-4-2-9-16(18)20(28)26-14-7-6-8-15(13-14)27-21(29)17-10-3-5-12-19(17)31-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 480n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 500n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050439
PNG
(CHEMBL3182809)
Show SMILES Clc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-18-12-5-4-11-17(18)20(25)23-16-10-6-9-15(13-16)22-19(24)14-7-2-1-3-8-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 500n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050522
PNG
(CHEMBL3182551)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(F)c2)c1
Show InChI InChI=1S/C21H17FN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 600n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 690n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 710n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050545
PNG
(CHEMBL3186000)
Show SMILES CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O3/c1-15(2)18-10-3-4-11-19(18)22(30)28-16-8-7-9-17(14-16)29-23(31)20-12-5-6-13-21(20)32-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 730n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050504
PNG
(CHEMBL3182725)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O3/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)30-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 750n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050448
PNG
(CHEMBL3188024)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccoc1
Show InChI InChI=1S/C18H14N2O3/c21-17(13-5-2-1-3-6-13)19-15-7-4-8-16(11-15)20-18(22)14-9-10-23-12-14/h1-12H,(H,19,21)(H,20,22)
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n/an/a 800n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050494
PNG
(CHEMBL3181939)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-7-5-9-17(13-15)21(25)23-18-10-6-11-19(14-18)24-22(26)20-12-4-3-8-16(20)2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 960n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050451
PNG
(CHEMBL3182777)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1cccs1
Show InChI InChI=1S/C18H14N2O2S/c21-17(13-6-2-1-3-7-13)19-14-8-4-9-15(12-14)20-18(22)16-10-5-11-23-16/h1-12H,(H,19,21)(H,20,22)
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n/an/a 970n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 990n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050504
PNG
(CHEMBL3182725)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O3/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)30-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 990n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050544
PNG
(CHEMBL3187764)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(C)C)c1
Show InChI InChI=1S/C24H24N2O3/c1-16(2)19-11-4-5-12-20(19)23(27)25-17-9-8-10-18(15-17)26-24(28)21-13-6-7-14-22(21)29-3/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM58520
PNG
(MLS001035529 | N-(3-benzamidophenyl)-3-pyridinecar...)
Show SMILES O=C(Nc1cccc(NC(=O)c2cccnc2)c1)c1ccccc1
Show InChI InChI=1S/C19H15N3O2/c23-18(14-6-2-1-3-7-14)21-16-9-4-10-17(12-16)22-19(24)15-8-5-11-20-13-15/h1-13H,(H,21,23)(H,22,24)
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n/an/a 1.29E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050499
PNG
(CHEMBL3188671)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-5-3-6-17(13-15)22(26)24-19-8-4-7-18(14-19)23-21(25)16-9-11-20(27-2)12-10-16/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050508
PNG
(CHEMBL3186695)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-6-4-7-15(12-14)20(25)23-16-8-5-9-17(13-16)24-21(26)18-10-2-3-11-19(18)22/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 1.34E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050434
PNG
(CHEMBL3188343)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O3/c1-26-19-13-6-5-12-18(19)21(25)23-17-11-7-10-16(14-17)22-20(24)15-8-3-2-4-9-15/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050496
PNG
(CHEMBL3184438)
Show SMILES CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C24H24N2O2/c1-16(2)21-12-4-5-13-22(21)24(28)26-20-11-7-10-19(15-20)25-23(27)18-9-6-8-17(3)14-18/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 1.88E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050436
PNG
(CHEMBL3186030)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O3/c1-26-19-12-10-16(11-13-19)21(25)23-18-9-5-8-17(14-18)22-20(24)15-6-3-2-4-7-15/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a 2.14E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050543
PNG
(CHEMBL1480257)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-8-3-4-11-18(15)21(25)23-16-9-7-10-17(14-16)24-22(26)19-12-5-6-13-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050498
PNG
(CHEMBL3187806)
Show SMILES COc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-6-3-7-16(12-15)21(25)23-18-9-5-10-19(14-18)24-22(26)17-8-4-11-20(13-17)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050502
PNG
(CHEMBL3317851)
Show SMILES COc1ccc(OC)c(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O4/c1-15-6-4-7-16(12-15)22(26)24-17-8-5-9-18(13-17)25-23(27)20-14-19(28-2)10-11-21(20)29-3/h4-14H,1-3H3,(H,24,26)(H,25,27)
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050440
PNG
(CHEMBL3184966)
Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-16-9-4-8-15(12-16)20(25)23-18-11-5-10-17(13-18)22-19(24)14-6-2-1-3-7-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050548
PNG
(CHEMBL3317854)
Show SMILES COc1cc(ccn1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C21H19N3O3/c1-14-5-3-6-15(11-14)20(25)23-17-7-4-8-18(13-17)24-21(26)16-9-10-22-19(12-16)27-2/h3-13H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 2.43E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050442
PNG
(CHEMBL3186206)
Show SMILES FC(F)(F)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)18-12-5-4-11-17(18)20(28)26-16-10-6-9-15(13-16)25-19(27)14-7-2-1-3-8-14/h1-13H,(H,25,27)(H,26,28)
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050453
PNG
(CHEMBL3182370)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccn2)c1)c1ccccc1
Show InChI InChI=1S/C19H15N3O2/c23-18(14-7-2-1-3-8-14)21-15-9-6-10-16(13-15)22-19(24)17-11-4-5-12-20-17/h1-13H,(H,21,23)(H,22,24)
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050505
PNG
(CHEMBL3317852)
Show SMILES CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C24H24N2O3/c1-16(2)29-22-13-5-4-12-21(22)24(28)26-20-11-7-10-19(15-20)25-23(27)18-9-6-8-17(3)14-18/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050537
PNG
(CHEMBL3182773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C19H16N2O3/c1-13-5-2-6-14(11-13)18(22)20-15-7-3-8-16(12-15)21-19(23)17-9-4-10-24-17/h2-12H,1H3,(H,20,22)(H,21,23)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050535
PNG
(CHEMBL3317853)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-4-2-5-16(12-14)21(29)27-19-7-3-6-18(13-19)26-20(28)15-8-10-17(11-9-15)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050436
PNG
(CHEMBL3186030)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O3/c1-26-19-12-10-16(11-13-19)21(25)23-18-9-5-8-17(14-18)22-20(24)15-6-3-2-4-7-15/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050432
PNG
(CHEMBL3317848)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-10-12-17(13-11-15)21(25)23-19-9-5-8-18(14-19)22-20(24)16-6-3-2-4-7-16/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050441
PNG
(CHEMBL3317822)
Show SMILES Clc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-16-11-9-15(10-12-16)20(25)23-18-8-4-7-17(13-18)22-19(24)14-5-2-1-3-6-14/h1-13H,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050445
PNG
(CHEMBL3317850)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C24H24N2O2/c1-24(2,3)19-14-12-18(13-15-19)23(28)26-21-11-7-10-20(16-21)25-22(27)17-8-5-4-6-9-17/h4-16H,1-3H3,(H,25,27)(H,26,28)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM50050444
PNG
(CHEMBL3317849)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)16-11-9-15(10-12-16)20(28)26-18-8-4-7-17(13-18)25-19(27)14-5-2-1-3-6-14/h1-13H,(H,25,27)(H,26,28)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050445
PNG
(CHEMBL3317850)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C24H24N2O2/c1-24(2,3)19-14-12-18(13-15-19)23(28)26-21-11-7-10-20(16-21)25-22(27)17-8-5-4-6-9-17/h4-16H,1-3H3,(H,25,27)(H,26,28)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 3.94E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050435
PNG
(CHEMBL3183938)
Show SMILES COc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O3/c1-26-19-12-5-9-16(13-19)21(25)23-18-11-6-10-17(14-18)22-20(24)15-7-3-2-4-8-15/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050493
PNG
(CHEMBL3184095)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)C1CCCCC1
Show InChI InChI=1S/C20H22N2O2/c23-19(15-8-3-1-4-9-15)21-17-12-7-13-18(14-17)22-20(24)16-10-5-2-6-11-16/h1,3-4,7-9,12-14,16H,2,5-6,10-11H2,(H,21,23)(H,22,24)
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n/an/a 5.48E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050452
PNG
(CHEMBL3183945)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccsc1
Show InChI InChI=1S/C18H14N2O2S/c21-17(13-5-2-1-3-6-13)19-15-7-4-8-16(11-15)20-18(22)14-9-10-23-12-14/h1-12H,(H,19,21)(H,20,22)
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n/an/a 5.60E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050447
PNG
(CHEMBL1716797)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccco1
Show InChI InChI=1S/C18H14N2O3/c21-17(13-6-2-1-3-7-13)19-14-8-4-9-15(12-14)20-18(22)16-10-5-11-23-16/h1-12H,(H,19,21)(H,20,22)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050161
PNG
(CHEMBL3186207)
Show SMILES Cc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-8-5-6-13-19(15)21(25)23-18-12-7-11-17(14-18)22-20(24)16-9-3-2-4-10-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050439
PNG
(CHEMBL3182809)
Show SMILES Clc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-18-12-5-4-11-17(18)20(25)23-16-10-6-9-15(13-16)22-19(24)14-7-2-1-3-8-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 7.10E+3n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50050495
PNG
(CHEMBL3185736)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-6-3-8-17(12-15)21(25)23-19-10-5-11-20(14-19)24-22(26)18-9-4-7-16(2)13-18/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 1.24E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a 1.25E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050438
PNG
(CHEMBL3184075)
Show SMILES Fc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15FN2O2/c21-16-11-9-15(10-12-16)20(25)23-18-8-4-7-17(13-18)22-19(24)14-5-2-1-3-6-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050433
PNG
(CHEMBL3186489)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccccc1
Show InChI InChI=1S/C20H16N2O2/c23-19(15-8-3-1-4-9-15)21-17-12-7-13-18(14-17)22-20(24)16-10-5-2-6-11-16/h1-14H,(H,21,23)(H,22,24)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050448
PNG
(CHEMBL3188024)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccccc2)c1)c1ccoc1
Show InChI InChI=1S/C18H14N2O3/c21-17(13-5-2-1-3-6-13)19-15-7-4-8-16(11-15)20-18(22)14-9-10-23-12-14/h1-12H,(H,19,21)(H,20,22)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050535
PNG
(CHEMBL3317853)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-4-2-5-16(12-14)21(29)27-19-7-3-6-18(13-19)26-20(28)15-8-10-17(11-9-15)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 2


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of Kir2.1 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 2


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of Kir2.1 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050437
PNG
(CHEMBL1532914)
Show SMILES Fc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15FN2O2/c21-16-9-4-8-15(12-16)20(25)23-18-11-5-10-17(13-18)22-19(24)14-6-2-1-3-7-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050497
PNG
(CHEMBL3181946)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(cc2)C(C)(C)C)c1
Show InChI InChI=1S/C25H26N2O2/c1-17-7-5-8-19(15-17)24(29)27-22-10-6-9-21(16-22)26-23(28)18-11-13-20(14-12-18)25(2,3)4/h5-16H,1-4H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM58520
PNG
(MLS001035529 | N-(3-benzamidophenyl)-3-pyridinecar...)
Show SMILES O=C(Nc1cccc(NC(=O)c2cccnc2)c1)c1ccccc1
Show InChI InChI=1S/C19H15N3O2/c23-18(14-6-2-1-3-7-14)21-16-9-4-10-17(12-16)22-19(24)15-8-5-11-20-13-15/h1-13H,(H,21,23)(H,22,24)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050446
PNG
(CHEMBL3184653)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C22H21N3O2/c1-25(2)20-13-11-17(12-14-20)22(27)24-19-10-6-9-18(15-19)23-21(26)16-7-4-3-5-8-16/h3-15H,1-2H3,(H,23,26)(H,24,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050536
PNG
(CHEMBL3188463)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H23N3O2/c1-16-6-4-7-18(14-16)23(28)25-20-9-5-8-19(15-20)24-22(27)17-10-12-21(13-11-17)26(2)3/h4-15H,1-3H3,(H,24,27)(H,25,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 2


(Homo sapiens (Human))
BDBM50050539
PNG
(CHEMBL3187891)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of Kir2.1 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050441
PNG
(CHEMBL3317822)
Show SMILES Clc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN2O2/c21-16-11-9-15(10-12-16)20(25)23-18-8-4-7-17(13-18)22-19(24)14-5-2-1-3-6-14/h1-13H,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050457
PNG
(CHEMBL3188245)
Show SMILES O=C(Nc1cccc(NC(=O)c2ccncc2)c1)c1ccccc1
Show InChI InChI=1S/C19H15N3O2/c23-18(14-5-2-1-3-6-14)21-16-7-4-8-17(13-16)22-19(24)15-9-11-20-12-10-15/h1-13H,(H,21,23)(H,22,24)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050443
PNG
(CHEMBL3186946)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)16-9-4-8-15(12-16)20(28)26-18-11-5-10-17(13-18)25-19(27)14-6-2-1-3-7-14/h1-13H,(H,25,27)(H,26,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 2


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of Kir2.1 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Inward rectifier potassium channel 2


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of Kir2.1 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050518
PNG
(CHEMBL3186471)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-4-2-5-16(12-14)21(26)24-19-7-3-6-18(13-19)23-20(25)15-8-10-17(22)11-9-15/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050499
PNG
(CHEMBL3188671)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-5-3-6-17(13-15)22(26)24-19-8-4-7-18(14-19)23-21(25)16-9-11-20(27-2)12-10-16/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050432
PNG
(CHEMBL3317848)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-10-12-17(13-11-15)21(25)23-19-9-5-8-18(14-19)22-20(24)16-6-3-2-4-7-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050534
PNG
(CHEMBL3183773)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050444
PNG
(CHEMBL3317849)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H15F3N2O2/c22-21(23,24)16-11-9-15(10-12-16)20(28)26-18-8-4-7-17(13-18)25-19(27)14-5-2-1-3-6-14/h1-13H,(H,25,27)(H,26,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50050530
PNG
(CHEMBL3188857)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of KCNQ2 (unknown origin)


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%