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PubMed code 25022204

Compile data set for download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a 30n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050860
PNG
(CHEMBL3318034)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)NCc3ccccc3)ccnc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-24-26)15-9-18-19(22-11-15)17(7-8-21-18)25-20(27)23-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,21,23,25,27)
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n/an/a 66n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050861
PNG
(CHEMBL3318035)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)NCCc3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-25-27)16-11-19-20(24-12-16)18(8-10-22-19)26-21(28)23-9-7-15-5-3-2-4-6-15/h2-6,8,10-14H,7,9H2,1H3,(H2,22,23,26,28)
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n/an/a 86n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050858
PNG
(CHEMBL3318032)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)NC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-13-5-6-18-14-7-11(8-19-15(13)14)12-9-20-23(4)10-12/h5-10H,1-4H3,(H2,18,21,22,24)
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n/an/a 112n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050855
PNG
(CHEMBL3318008)
Show SMILES CCNC(=O)Nc1ccnc2cc(cnc12)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-14-7-8-21-15-9-13(11-22-18(14)15)12-5-6-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,21,23,24)
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n/an/a 136n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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n/an/a 171n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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n/an/a 191n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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n/an/a 227n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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n/an/a 260n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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n/an/a 429n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a 579n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a 624n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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n/an/a 702n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050856
PNG
(CHEMBL3318009)
Show SMILES COc1ccc(cc1OC)-c1cnc2c(NC(=O)NC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-15-8-9-22-16-10-14(12-23-19(15)16)13-6-7-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,22,24,25,26)
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n/an/a 714n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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n/an/a 733n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a 742n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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n/an/a 805n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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n/an/a 1.13E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050859
PNG
(CHEMBL3318033)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)Nc3ccccc3)ccnc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-22-25)13-9-17-18(21-10-13)16(7-8-20-17)24-19(26)23-15-5-3-2-4-6-15/h2-12H,1H3,(H2,20,23,24,26)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050857
PNG
(CHEMBL3318031)
Show SMILES COc1cc(ccc1O)-c1cnc2c(NC(=O)NC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-14-7-8-21-15-9-13(11-22-18(14)15)12-5-6-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,21,23,24,26)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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n/an/a 1.72E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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n/an/a 2.23E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of Aurora B (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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n/an/a 6.05E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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n/an/a 7.95E+3n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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n/an/a 1.27E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a 1.36E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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n/an/a 2.08E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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n/an/a 2.69E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050858
PNG
(CHEMBL3318032)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)NC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-13-5-6-18-14-7-11(8-19-15(13)14)12-9-20-23(4)10-12/h5-10H,1-4H3,(H2,18,21,22,24)
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n/an/a 3.16E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a>3.16E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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n/an/a 3.25E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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n/an/a 3.71E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a 4.18E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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n/an/a 4.29E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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n/an/a 8.06E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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n/an/a 8.55E+4n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050855
PNG
(CHEMBL3318008)
Show SMILES CCNC(=O)Nc1ccnc2cc(cnc12)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-14-7-8-21-15-9-13(11-22-18(14)15)12-5-6-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,21,23,24)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050854
PNG
(CHEMBL3318028)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)Nc3ccccc3)nc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-21-25)13-9-17-16(20-10-13)7-8-18(23-17)24-19(26)22-15-5-3-2-4-6-15/h2-12H,1H3,(H2,22,23,24,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050861
PNG
(CHEMBL3318035)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)NCCc3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-25-27)16-11-19-20(24-12-16)18(8-10-22-19)26-21(28)23-9-7-15-5-3-2-4-6-15/h2-6,8,10-14H,7,9H2,1H3,(H2,22,23,26,28)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050856
PNG
(CHEMBL3318009)
Show SMILES COc1ccc(cc1OC)-c1cnc2c(NC(=O)NC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-15-8-9-22-16-10-14(12-23-19(15)16)13-6-7-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,22,24,25,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050859
PNG
(CHEMBL3318033)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)Nc3ccccc3)ccnc2c1
Show InChI InChI=1S/C19H16N6O/c1-25-12-14(11-22-25)13-9-17-18(21-10-13)16(7-8-20-17)24-19(26)23-15-5-3-2-4-6-15/h2-12H,1H3,(H2,20,23,24,26)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050860
PNG
(CHEMBL3318034)
Show SMILES Cn1cc(cn1)-c1cnc2c(NC(=O)NCc3ccccc3)ccnc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-24-26)15-9-18-19(22-11-15)17(7-8-21-18)25-20(27)23-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,21,23,25,27)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050852
PNG
(CHEMBL3318030)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCc3ccccc3)nc2c1
Show InChI InChI=1S/C21H20N6O/c1-27-14-17(13-24-27)16-11-19-18(23-12-16)7-8-20(25-19)26-21(28)22-10-9-15-5-3-2-4-6-15/h2-8,11-14H,9-10H2,1H3,(H2,22,25,26,28)
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Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of YES (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50050849
PNG
(CHEMBL3318025)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C21H24N4O3/c1-21(2,3)25-20(26)24-19-9-7-15-16(23-19)10-14(12-22-15)13-6-8-17(27-4)18(11-13)28-5/h6-12H,1-5H3,(H2,23,24,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50050847
PNG
(CHEMBL3318027)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C17H20N6O/c1-17(2,3)22-16(24)21-15-6-5-13-14(20-15)7-11(8-18-13)12-9-19-23(4)10-12/h5-10H,1-4H3,(H2,20,21,22,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050851
PNG
(CHEMBL3318023)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H18N4O2/c1-3-19-18(23)22-17-9-8-15-16(21-17)10-13(11-20-15)12-4-6-14(24-2)7-5-12/h4-11H,3H2,1-2H3,(H2,19,21,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050848
PNG
(CHEMBL3318026)
Show SMILES COc1cc(ccc1O)-c1cnc2ccc(NC(=O)NC(C)(C)C)nc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,22,23,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of c-Abl (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 1


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of HIPK1 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50050857
PNG
(CHEMBL3318031)
Show SMILES COc1cc(ccc1O)-c1cnc2c(NC(=O)NC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C20H22N4O3/c1-20(2,3)24-19(26)23-14-7-8-21-15-9-13(11-22-18(14)15)12-5-6-16(25)17(10-12)27-4/h5-11,25H,1-4H3,(H2,21,23,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050853
PNG
(CHEMBL3318029)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCc3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6O/c1-26-13-16(12-23-26)15-9-18-17(21-11-15)7-8-19(24-18)25-20(27)22-10-14-5-3-2-4-6-14/h2-9,11-13H,10H2,1H3,(H2,22,24,25,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50050850
PNG
(CHEMBL3318024)
Show SMILES CCNC(=O)Nc1ccc2ncc(cc2n1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H20N4O3/c1-4-20-19(24)23-18-8-6-14-15(22-18)9-13(11-21-14)12-5-7-16(25-2)17(10-12)26-3/h5-11H,4H2,1-3H3,(H2,20,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Nantes

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin)


Bioorg Med Chem Lett 24: 3748-52 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.078
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%