Affinity Data by PubMed id=25078315

PubMed code 25078315

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM50100516 (CHEMBL3326315) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50100516 (CHEMBL3326315) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50100515 (CHEMBL3326305) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50100515 (CHEMBL3326305) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50100517 (CHEMBL3356478) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50047362 (CHEMBL3314616) Show SMILES Oc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst...				Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%