Affinity Data by PubMed id=25116076

PubMed code 25116076

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057418 (CHEMBL3326435) Show SMILES On1ccc(cc1=S)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057411 (CHEMBL3326430) Show SMILES Cc1ccn(O)c(=S)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057412 (CHEMBL3326429) Show SMILES Cc1cccn(O)c1=S Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057406 (CHEMBL3326434) Show SMILES On1cccc(c1=S)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	6.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057410 (CHEMBL3326431) Show SMILES Cc1ccc(=S)n(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057417 (CHEMBL3326436) Show SMILES On1cc(ccc1=S)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	2.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM60985 (1-hydroxy-2-pyridinethione \| 1-hydroxypyridine-2-t...) Show SMILES On1ccccc1=S Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	5.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057414 (CHEMBL3326439) Show SMILES On1c2ccccc2ccc1=S Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057408 (CHEMBL3326433) Show SMILES Cc1cc(C)n(O)c(=S)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	9.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057415 (CHEMBL3326438) Show SMILES On1ccc2ccccc2c1=S Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	2.30E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057409 (CHEMBL3326432) Show SMILES Cc1cccc(=S)n1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	2.30E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50057416 (CHEMBL3326437) Show SMILES On1c(cccc1=S)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Lethal factor (Bacillus anthracis)	BDBM50057413 (CHEMBL81398) Show SMILES On1ccccc1=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to anthrax lethal factor				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Lethal factor (Bacillus anthracis)	BDBM60985 (1-hydroxy-2-pyridinethione \| 1-hydroxypyridine-2-t...) Show SMILES On1ccccc1=S Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Binding affinity to anthrax lethal factor				J Med Chem 57: 7126-35 (2014) Article DOI: 10.1021/jm500984b BindingDB Entry DOI: 10.7270/Q20V8FD1
University of California Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%