Affinity Data by PubMed id=25127154

PubMed code 25127154

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50345949 (3-(4-Methoxy-phenyl)-9-prop-2-ynylamino-3H-pyrido[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058042 (CHEMBL3330823) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058048 (CHEMBL3330811) Show SMILES COc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058044 (CHEMBL3330817) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058056 (CHEMBL3330801) Show SMILES Fc1cccc(c1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058055 (CHEMBL3330802) Show SMILES Fc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058047 (CHEMBL3330812 \| US9260448, 29) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058049 (CHEMBL3330808 \| US9260448, 18) Show SMILES Cc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058045 (CHEMBL3330813) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058059 (CHEMBL3330800) Show SMILES O=c1n(cnc2c(csc12)-c1ccccc1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058052 (CHEMBL3330805 \| US9260448, 7) Show SMILES Clc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058050 (CHEMBL3330807) Show SMILES Cc1cccc(c1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058043 (CHEMBL3330820) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	221	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058041 (CHEMBL3330824) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	221	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058039 (CHEMBL3330827) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	257	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058053 (CHEMBL3330804 \| US9260448, 6) Show SMILES Clc1cccc(c1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	374	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058054 (CHEMBL3330803) Show SMILES Clc1ccccc1-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	407	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058051 (CHEMBL3330806) Show SMILES Cc1ccccc1-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058057 (CHEMBL3329236 \| US9260448, 2) Show SMILES Fc1ccccc1-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	677	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50058040 (CHEMBL3330826) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	747	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50058042 (CHEMBL3330823) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO-K1 cells by whole cell patch-clamp assay				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50058048 (CHEMBL3330811) Show SMILES COc1ccc(cc1)-n1cnc2c(csc2c1=O)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO-K1 cells by whole cell patch-clamp assay				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50345949 (3-(4-Methoxy-phenyl)-9-prop-2-ynylamino-3H-pyrido[...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO-K1 cells by whole cell patch-clamp assay				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50058044 (CHEMBL3330817) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO-K1 cells by whole cell patch-clamp assay				Eur J Med Chem 85: 629-37 (2014) Article DOI: 10.1016/j.ejmech.2014.08.027 BindingDB Entry DOI: 10.7270/Q2B56MDJ
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%