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PubMed code 25155387

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus)		BDBM50142916
PNG
((1S,4R,6S,14S,18R)-14-Cyclopentyloxycarbonylamino-...)
Show SMILES COc1ccc2c(O[C@@H]3C[C@@H]4N(C3)C(=O)[C@H](CCCCC\C=C/[C@@H]3C[C@]3(NC4=O)C(O)=O)NC(=O)OC3CCCC3)cc(nc2c1)-c1csc(NC(C)C)n1 |r,c:22|
Show InChI InChI=1S/C40H50N6O8S/c1-23(2)41-38-43-32(22-55-38)31-19-34(28-16-15-26(52-3)17-30(28)42-31)53-27-18-33-35(47)45-40(37(49)50)20-24(40)11-7-5-4-6-8-14-29(36(48)46(33)21-27)44-39(51)54-25-12-9-10-13-25/h7,11,15-17,19,22-25,27,29,33H,4-6,8-10,12-14,18,20-21H2,1-3H3,(H,41,43)(H,44,51)(H,45,47)(H,49,50)/b11-7-/t24-,27-,29+,33+,40-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023510
PNG
(CHEMBL3326826)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4cc(OC)ccc34)-c3nc(cs3)C(C)C)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:47,@:7|
Show InChI InChI=1S/C37H46N6O7S2/c1-22(2)29-21-51-32(39-29)28-18-31(26-12-11-25(49-5)17-27(26)38-28)50-20-24-16-30-33(44)42(4)15-9-7-6-8-10-23-19-37(23,40-35(46)43(24)30)34(45)41-52(47,48)36(3)13-14-36/h8,10-12,17-18,21-24,30H,6-7,9,13-16,19-20H2,1-5H3,(H,40,46)(H,41,45)/b10-8-/t23-,24-,30-,37-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023579
PNG
(CHEMBL3326830)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4c(Cl)c(OC)ccc34)-c3nc(cs3)C(C)C)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:48,@:7|
Show InChI InChI=1S/C37H45ClN6O7S2/c1-21(2)26-20-52-32(40-26)25-17-29(24-11-12-28(50-5)30(38)31(24)39-25)51-19-23-16-27-33(45)43(4)15-9-7-6-8-10-22-18-37(22,41-35(47)44(23)27)34(46)42-53(48,49)36(3)13-14-36/h8,10-12,17,20-23,27H,6-7,9,13-16,18-19H2,1-5H3,(H,41,47)(H,42,46)/b10-8-/t22-,23-,27-,37-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023508
PNG
(CHEMBL3326539)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@@H](COc3cc(nc4cc(OC)ccc34)-c3ccccc3)C[C@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1CC1 |r,c:45,@:7|
Show InChI InChI=1S/C36H41N5O7S/c1-40-17-9-4-3-8-12-24-21-36(24,34(43)39-49(45,46)27-14-15-27)38-35(44)41-25(18-31(41)33(40)42)22-48-32-20-29(23-10-6-5-7-11-23)37-30-19-26(47-2)13-16-28(30)32/h5-8,10-13,16,19-20,24-25,27,31H,3-4,9,14-15,17-18,21-22H2,1-2H3,(H,38,44)(H,39,43)/b12-8-/t24-,25+,31+,36-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023578
PNG
(CHEMBL3326829)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4c(C)c(OC)ccc34)-c3nc(cs3)C(C)C)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:48,@:7|
Show InChI InChI=1S/C38H48N6O7S2/c1-22(2)28-21-52-33(40-28)27-18-31(26-12-13-30(50-6)23(3)32(26)39-27)51-20-25-17-29-34(45)43(5)16-10-8-7-9-11-24-19-38(24,41-36(47)44(25)29)35(46)42-53(48,49)37(4)14-15-37/h9,11-13,18,21-22,24-25,29H,7-8,10,14-17,19-20H2,1-6H3,(H,41,47)(H,42,46)/b11-9-/t24-,25-,29-,38-/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023509
PNG
(CHEMBL3326540)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4c(F)c(OC)ccc34)-c3nc(cs3)C(C)C)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:48,@:7|
Show InChI InChI=1S/C37H45FN6O7S2/c1-21(2)26-20-52-32(40-26)25-17-29(24-11-12-28(50-5)30(38)31(24)39-25)51-19-23-16-27-33(45)43(4)15-9-7-6-8-10-22-18-37(22,41-35(47)44(23)27)34(46)42-53(48,49)36(3)13-14-36/h8,10-12,17,20-23,27H,6-7,9,13-16,18-19H2,1-5H3,(H,41,47)(H,42,46)/b10-8-/t22-,23-,27-,37-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023507
PNG
(CHEMBL3326538)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4cc(OC)ccc34)-c3ccccc3)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1CC1 |r,c:45,@:7|
Show InChI InChI=1S/C36H41N5O7S/c1-40-17-9-4-3-8-12-24-21-36(24,34(43)39-49(45,46)27-14-15-27)38-35(44)41-25(18-31(41)33(40)42)22-48-32-20-29(23-10-6-5-7-11-23)37-30-19-26(47-2)13-16-28(30)32/h5-8,10-13,16,19-20,24-25,27,31H,3-4,9,14-15,17-18,21-22H2,1-2H3,(H,38,44)(H,39,43)/b12-8-/t24-,25-,31-,36-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023581
PNG
(CHEMBL3326537)
Show SMILES [H][C@]12C[C@@]1(NC(=O)[C@@]1([H])C[C@H](COc3cc(nc4cc(OC)ccc34)-c3ccccc3)N1C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1CC1 |r,c:45|
Show InChI InChI=1S/C36H41N5O7S/c1-40-17-9-4-3-8-12-24-21-36(24,34(43)39-49(45,46)27-14-15-27)38-33(42)31-18-25(41(31)35(40)44)22-48-32-20-29(23-10-6-5-7-11-23)37-30-19-26(47-2)13-16-28(30)32/h5-8,10-13,16,19-20,24-25,27,31H,3-4,9,14-15,17-18,21-22H2,1-2H3,(H,38,42)(H,39,43)/b12-8-/t24-,25+,31+,36-/m0/s1
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IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023577
PNG
(CHEMBL3326828)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4c(Cl)c(OC)ccc34)-c3nc(cs3)C(C)C)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1CC1 |r,c:48,@:7|
Show InChI InChI=1S/C36H43ClN6O7S2/c1-20(2)26-19-51-32(39-26)25-16-29(24-12-13-28(49-4)30(37)31(24)38-25)50-18-22-15-27-33(44)42(3)14-8-6-5-7-9-21-17-36(21,40-35(46)43(22)27)34(45)41-52(47,48)23-10-11-23/h7,9,12-13,16,19-23,27H,5-6,8,10-11,14-15,17-18H2,1-4H3,(H,40,46)(H,41,45)/b9-7-/t21-,22-,27-,36-/m0/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023576
PNG
(CHEMBL3326827)
Show SMILES [H][C@]12C[C@@]1(NC(=O)N1[C@H](COc3cc(nc4c(C)c(OC)ccc34)-c3nc(cs3)C(C)C)C[C@@]1([H])C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1CC1 |r,c:48,@:7|
Show InChI InChI=1S/C37H46N6O7S2/c1-21(2)28-20-51-33(39-28)27-17-31(26-13-14-30(49-5)22(3)32(26)38-27)50-19-24-16-29-34(44)42(4)15-9-7-6-8-10-23-18-37(23,40-36(46)43(24)29)35(45)41-52(47,48)25-11-12-25/h8,10,13-14,17,20-21,23-25,29H,6-7,9,11-12,15-16,18-19H2,1-5H3,(H,40,46)(H,41,45)/b10-8-/t23-,24-,29-,37-/m0/s1
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IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus)		BDBM50023580
PNG
(CHEMBL3326536)
Show SMILES [H][C@]12C[C@@]1(NC(=O)[C@]1([H])C[C@@H](COc3cc(nc4cc(OC)ccc34)-c3ccccc3)N1C(=O)N(C)CCCC\C=C/2)C(=O)NS(=O)(=O)C1CC1 |r,c:45|
Show InChI InChI=1S/C36H41N5O7S/c1-40-17-9-4-3-8-12-24-21-36(24,34(43)39-49(45,46)27-14-15-27)38-33(42)31-18-25(41(31)35(40)44)22-48-32-20-29(23-10-6-5-7-11-23)37-30-19-26(47-2)13-16-28(30)32/h5-8,10-13,16,19-20,24-25,27,31H,3-4,9,14-15,17-18,21-22H2,1-2H3,(H,38,42)(H,39,43)/b12-8-/t24-,25-,31-,36-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



IDENIX Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay

Bioorg Med Chem Lett 24: 4444-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.002
BindingDB Entry DOI: 10.7270/Q20C4XBK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%