Affinity Data by PubMed id=25157640

PubMed code 25157640

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neurotensin receptor type 1 (Rattus norvegicus)	BDBM50130880 (CHEMBL407196 \| NT(1-13) \| neurotensin \| pGlu-Leu-T...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Rattus norvegicus)	BDBM85050 (CAS_184162-64-9 \| SR 142948A \| SR142948 \| SR142948...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM85050 (CAS_184162-64-9 \| SR 142948A \| SR142948 \| SR142948...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM50130880 (CHEMBL407196 \| NT(1-13) \| neurotensin \| pGlu-Leu-T...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM50023628 (CHEMBL3326831) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	202	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM50023627 (CHEMBL3326832) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Rattus norvegicus)	BDBM50023628 (CHEMBL3326831) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Rattus norvegicus)	BDBM50023627 (CHEMBL3326832) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM50023628 (CHEMBL3326831) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM50130880 (CHEMBL407196 \| NT(1-13) \| neurotensin \| pGlu-Leu-T...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM50023627 (CHEMBL3326832) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 2 (Rattus norvegicus)	BDBM85050 (CAS_184162-64-9 \| SR 142948A \| SR142948 \| SR142948...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Agonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as calcium mobilization by FLIPR assay				J Med Chem 57: 7472-7 (2014) Article DOI: 10.1021/jm500857r BindingDB Entry DOI: 10.7270/Q2BP04C6
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%