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PubMed code 25254640

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50203012
PNG
(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)
Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
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n/an/a 30n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50203012
PNG
(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)
Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CVCL8-induced [35S]GTPgammaS binding after 60 mins


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150966
PNG
(US8981106, 155)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(Cc1ccccn1)c1ccc(F)cc1
Show InChI InChI=1S/C25H21BFN3O3S/c27-20-9-11-22(12-10-20)30(16-21-6-3-4-14-28-21)25(31)18-8-13-24(29-15-18)34-17-19-5-1-2-7-23(19)26(32)33/h1-15,32-33H,16-17H2
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150973
PNG
(US8981106, 163)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C19H17BN2O4S/c23-16-8-6-15(7-9-16)22-19(24)13-5-10-18(21-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,23,25-26H,12H2,(H,22,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150837
PNG
(US8981106, 26)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccccc3-c3nn[nH]n3)nc2)cc1
Show InChI InChI=1S/C20H15FN6OS/c21-15-6-8-16(9-7-15)23-20(28)13-5-10-18(22-11-13)29-12-14-3-1-2-4-17(14)19-24-26-27-25-19/h1-11H,12H2,(H,23,28)(H,24,25,26,27)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150827
PNG
(US8981106, 16)
Show SMILES CC1(C)OB(OC1(C)C)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C25H26BFN2O3S/c1-24(2)25(3,4)32-26(31-24)21-8-6-5-7-18(21)16-33-22-14-9-17(15-28-22)23(30)29-20-12-10-19(27)11-13-20/h5-15H,16H2,1-4H3,(H,29,30)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150822
PNG
(US8981106, 13 (SX-578))
Show SMILES Oc1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H15FN2O2S/c20-15-6-8-16(9-7-15)22-19(24)13-5-10-18(21-11-13)25-12-14-3-1-2-4-17(14)23/h1-11,23H,12H2,(H,22,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150969
PNG
(US8981106, 159)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H16BF3N2O4S/c22-20(23,24)30-16-8-6-15(7-9-16)26-19(27)13-5-10-18(25-11-13)31-12-14-3-1-2-4-17(14)21(28)29/h1-11,28-29H,12H2,(H,26,27)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150974
PNG
(US8981106, 164)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C18H15BFN3O3S/c20-14-6-7-16(21-10-14)23-18(24)12-5-8-17(22-9-12)27-11-13-3-1-2-4-15(13)19(25)26/h1-10,25-26H,11H2,(H,21,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150821
PNG
(US8981106, 12)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccccc3)nc2)cc1
Show InChI InChI=1S/C19H15FN2OS/c20-16-7-9-17(10-8-16)22-19(23)15-6-11-18(21-12-15)24-13-14-4-2-1-3-5-14/h1-12H,13H2,(H,22,23)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150972
PNG
(US8981106, 162)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C18H16BN3O3S/c23-18(22-15-7-9-20-10-8-15)13-5-6-17(21-11-13)26-12-14-3-1-2-4-16(14)19(24)25/h1-11,24-25H,12H2,(H,20,22,23)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150887
PNG
(US8981106, 76)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCC3CCCO3)nc2)cc1
Show InChI InChI=1/C17H17FN2O2S/c18-13-4-6-14(7-5-13)20-17(21)12-3-8-16(19-10-12)23-11-15-2-1-9-22-15/h3-8,10,15H,1-2,9,11H2,(H,20,21)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150832
PNG
(US8981106, 21)
Show SMILES COC(=O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O3S/c1-27-21(26)18-5-3-2-4-15(18)13-28-19-11-6-14(12-23-19)20(25)24-17-9-7-16(22)8-10-17/h2-12H,13H2,1H3,(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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B.MOAD
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at human CXCR1 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150977
PNG
(US8981106, 157)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(Cc1ccncc1)c1ccc(F)cc1
Show InChI InChI=1S/C25H21BFN3O3S/c27-21-6-8-22(9-7-21)30(16-18-11-13-28-14-12-18)25(31)19-5-10-24(29-15-19)34-17-20-3-1-2-4-23(20)26(32)33/h1-15,32-33H,16-17H2
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150835
PNG
(US8981106, 24)
Show SMILES OC(=O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15FN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150838
PNG
(US8981106, 27)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccc(Cl)c(Cl)c3)nc2)cc1
Show InChI InChI=1S/C19H13Cl2FN2OS/c20-16-7-1-12(9-17(16)21)11-26-18-8-2-13(10-23-18)19(25)24-15-5-3-14(22)4-6-15/h1-10H,11H2,(H,24,25)
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n/an/a 1.61E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150968
PNG
(US8981106, 158)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(CC(O)=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H18BFN2O5S/c23-16-6-8-17(9-7-16)25(12-20(26)27)21(28)14-5-10-19(24-11-14)31-13-15-3-1-2-4-18(15)22(29)30/h1-11,29-30H,12-13H2,(H,26,27)
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n/an/a 1.99E+3n/an/an/an/an/an/a



Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150836
PNG
(US8981106, 25)
Show SMILES OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H15FN2O3S/c21-16-5-7-17(8-6-16)23-19(24)15-4-9-18(22-11-15)27-12-13-2-1-3-14(10-13)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150860
PNG
(US8981106, 49)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3nn[nH]n3)nc2)cc1
Show InChI InChI=1S/C14H11FN6OS/c15-10-2-4-11(5-3-10)17-14(22)9-1-6-13(16-7-9)23-8-12-18-20-21-19-12/h1-7H,8H2,(H,17,22)(H,18,19,20,21)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028389
PNG
(CHEMBL3342284)
Show SMILES [O-][N+](=O)c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)o1
Show InChI InChI=1S/C17H12FN3O4S/c18-12-2-4-13(5-3-12)20-17(22)11-1-7-15(19-9-11)26-10-14-6-8-16(25-14)21(23)24/h1-9H,10H2,(H,20,22)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028405
PNG
(CHEMBL3354644)
Show SMILES Fc1ccc(NC(=O)c2ccc(SC3CCOC3=O)nc2)cc1
Show InChI InChI=1/C16H13FN2O3S/c17-11-2-4-12(5-3-11)19-15(20)10-1-6-14(18-9-10)23-13-7-8-22-16(13)21/h1-6,9,13H,7-8H2,(H,19,20)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150888
PNG
(US8981106, 77)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCC3CCOCC3)nc2)cc1
Show InChI InChI=1S/C18H19FN2O2S/c19-15-2-4-16(5-3-15)21-18(22)14-1-6-17(20-11-14)24-12-13-7-9-23-10-8-13/h1-6,11,13H,7-10,12H2,(H,21,22)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150967
PNG
(US8981106, 156)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(CC1CCCCN1)c1ccc(F)cc1
Show InChI InChI=1/C25H27BFN3O3S/c27-20-9-11-22(12-10-20)30(16-21-6-3-4-14-28-21)25(31)18-8-13-24(29-15-18)34-17-19-5-1-2-7-23(19)26(32)33/h1-2,5,7-13,15,21,28,32-33H,3-4,6,14,16-17H2
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at platelet-activating factor receptor in human PMNs assessed as inhibition of PAF-induced intracellular Ca2+ release by fluoresc...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150848
PNG
(US8981106, 37)
Show SMILES Cc1nc(cs1)-c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C23H18FN3OS2/c1-15-26-21(14-29-15)17-4-2-3-16(11-17)13-30-22-10-5-18(12-25-22)23(28)27-20-8-6-19(24)7-9-20/h2-12,14H,13H2,1H3,(H,27,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150845
PNG
(US8981106, 34)
Show SMILES Cc1nc(no1)-c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H17FN4O2S/c1-14-25-21(27-29-14)16-4-2-15(3-5-16)13-30-20-11-6-17(12-24-20)22(28)26-19-9-7-18(23)8-10-19/h2-12H,13H2,1H3,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150854
PNG
(US8981106, 43)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccncc3)nc2)cc1
Show InChI InChI=1S/C18H14FN3OS/c19-15-2-4-16(5-3-15)22-18(23)14-1-6-17(21-11-14)24-12-13-7-9-20-10-8-13/h1-11H,12H2,(H,22,23)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150841
PNG
(US8981106, 30)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccccc3-c3cccs3)nc2)cc1
Show InChI InChI=1S/C23H17FN2OS2/c24-18-8-10-19(11-9-18)26-23(27)16-7-12-22(25-14-16)29-15-17-4-1-2-5-20(17)21-6-3-13-28-21/h1-14H,15H2,(H,26,27)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028387
PNG
(CHEMBL3342292)
Show SMILES [O-][N+](=O)c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H14FN3O3S/c20-15-4-6-16(7-5-15)22-19(24)14-3-10-18(21-11-14)27-12-13-1-8-17(9-2-13)23(25)26/h1-11H,12H2,(H,22,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150855
PNG
(US8981106, 44)
Show SMILES Cc1cc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)no1
Show InChI InChI=1S/C17H14FN3O2S/c1-11-8-15(21-23-11)10-24-16-7-2-12(9-19-16)17(22)20-14-5-3-13(18)4-6-14/h2-9H,10H2,1H3,(H,20,22)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150858
PNG
(US8981106, 47)
Show SMILES Cc1n[nH]c(C)c1CCSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H19FN4OS/c1-12-17(13(2)24-23-12)9-10-26-18-8-3-14(11-21-18)19(25)22-16-6-4-15(20)5-7-16/h3-8,11H,9-10H2,1-2H3,(H,22,25)(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150885
PNG
(US8981106, 74)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccc(o3)C(F)(F)F)nc2)cc1
Show InChI InChI=1S/C18H12F4N2O2S/c19-12-2-4-13(5-3-12)24-17(25)11-1-8-16(23-9-11)27-10-14-6-7-15(26-14)18(20,21)22/h1-9H,10H2,(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150856
PNG
(US8981106, 45)
Show SMILES Cc1onc(c1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C23H18FN3O2S/c1-15-20(22(27-29-15)16-5-3-2-4-6-16)14-30-21-12-7-17(13-25-21)23(28)26-19-10-8-18(24)9-11-19/h2-13H,14H2,1H3,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150889
PNG
(US8981106, 78)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCC3CCCCO3)nc2)cc1
Show InChI InChI=1/C18H19FN2O2S/c19-14-5-7-15(8-6-14)21-18(22)13-4-9-17(20-11-13)24-12-16-3-1-2-10-23-16/h4-9,11,16H,1-3,10,12H2,(H,21,22)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028388
PNG
(CHEMBL3342286)
Show SMILES Cc1nn(nc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C22H18FN5OS/c1-15-20(27-28(26-15)19-5-3-2-4-6-19)14-30-21-12-7-16(13-24-21)22(29)25-18-10-8-17(23)9-11-18/h2-13H,14H2,1H3,(H,25,29)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150833
PNG
(US8981106, 22)
Show SMILES COC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H17FN2O3S/c1-27-21(26)15-4-2-3-14(11-15)13-28-19-10-5-16(12-23-19)20(25)24-18-8-6-17(22)7-9-18/h2-12H,13H2,1H3,(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at C5a receptor in human PMNs assessed as inhibition of C5a-induced intracellular Ca2+ release by fluorescence based calcium flux...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517))
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at fMLF receptor in human PMNs assessed as inhibition of fMLF-induced intracellular Ca2+ release by fluorescence based calcium fl...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50113636
PNG
(CHEMBL39835 | [5-(4-Fluoro-phenylcarbamoyl)-pyridi...)
Show SMILES OC(=O)CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O3S/c15-10-2-4-11(5-3-10)17-14(20)9-1-6-12(16-7-9)21-8-13(18)19/h1-7H,8H2,(H,17,20)(H,18,19)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150894
PNG
(US8981106, 83)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCS(=O)(=O)c3ccccc3)nc2)cc1
Show InChI InChI=1S/C19H15FN2O3S2/c20-15-7-9-16(10-8-15)22-19(23)14-6-11-18(21-12-14)26-13-27(24,25)17-4-2-1-3-5-17/h1-12H,13H2,(H,22,23)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150881
PNG
(US8981106, 70)
Show SMILES Cc1nc(sc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C23H18FN3OS2/c1-15-20(30-23(26-15)16-5-3-2-4-6-16)14-29-21-12-7-17(13-25-21)22(28)27-19-10-8-18(24)9-11-19/h2-13H,14H2,1H3,(H,27,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150846
PNG
(US8981106, 35)
Show SMILES Cc1nc(no1)-c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H17FN4O2S/c1-14-25-21(27-29-14)16-4-2-3-15(11-16)13-30-20-10-5-17(12-24-20)22(28)26-19-8-6-18(23)7-9-19/h2-12H,13H2,1H3,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150893
PNG
(US8981106, 82)
Show SMILES CCOP(=O)(CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)OCC
Show InChI InChI=1S/C17H20FN2O4PS/c1-3-23-25(22,24-4-2)12-26-16-10-5-13(11-19-16)17(21)20-15-8-6-14(18)7-9-15/h5-11H,3-4,12H2,1-2H3,(H,20,21)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028406
PNG
(CHEMBL3342273)
Show SMILES [O-][N+](=O)CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C13H10FN3O3S/c14-10-2-4-11(5-3-10)16-13(18)9-1-6-12(15-7-9)21-8-17(19)20/h1-7H,8H2,(H,16,18)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150847
PNG
(US8981106, 36)
Show SMILES Cc1nc(cs1)-c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H18FN3OS2/c1-15-26-21(14-29-15)17-4-2-16(3-5-17)13-30-22-11-6-18(12-25-22)23(28)27-20-9-7-19(24)8-10-20/h2-12,14H,13H2,1H3,(H,27,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150852
PNG
(US8981106, 41)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccc(OC(F)(F)F)cc3)nc2)cc1
Show InChI InChI=1S/C20H14F4N2O2S/c21-15-4-6-16(7-5-15)26-19(27)14-3-10-18(25-11-14)29-12-13-1-8-17(9-2-13)28-20(22,23)24/h1-11H,12H2,(H,26,27)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150853
PNG
(US8981106, 42)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3cccc(OC(F)(F)F)c3)nc2)cc1
Show InChI InChI=1S/C20H14F4N2O2S/c21-15-5-7-16(8-6-15)26-19(27)14-4-9-18(25-11-14)29-12-13-2-1-3-17(10-13)28-20(22,23)24/h1-11H,12H2,(H,26,27)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150891
PNG
(US8981106, 80)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCC3CCN(CC3)C(=O)OCc3ccccc3)nc2)cc1
Show InChI InChI=1S/C26H26FN3O3S/c27-22-7-9-23(10-8-22)29-25(31)21-6-11-24(28-16-21)34-18-20-12-14-30(15-13-20)26(32)33-17-19-4-2-1-3-5-19/h1-11,16,20H,12-15,17-18H2,(H,29,31)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150844
PNG
(US8981106, 33)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccc(cc3)-n3cncn3)nc2)cc1
Show InChI InChI=1S/C21H16FN5OS/c22-17-4-6-18(7-5-17)26-21(28)16-3-10-20(24-11-16)29-12-15-1-8-19(9-2-15)27-14-23-13-25-27/h1-11,13-14H,12H2,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150839
PNG
(US8981106, 28)
Show SMILES Cc1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1F
Show InChI InChI=1S/C20H16F2N2OS/c1-13-3-2-4-15(19(13)22)12-26-18-10-5-14(11-23-18)20(25)24-17-8-6-16(21)7-9-17/h2-11H,12H2,1H3,(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028386
PNG
(CHEMBL3342305)
Show SMILES Fc1ccc(NC(=O)c2ccc(Sc3ccccc3)nc2)cc1
Show InChI InChI=1S/C18H13FN2OS/c19-14-7-9-15(10-8-14)21-18(22)13-6-11-17(20-12-13)23-16-4-2-1-3-5-16/h1-12H,(H,21,22)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150857
PNG
(US8981106, 46)
Show SMILES Cc1noc(c1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C23H18FN3O2S/c1-15-20(22(29-27-15)16-5-3-2-4-6-16)14-30-21-12-7-17(13-25-21)23(28)26-19-10-8-18(24)9-11-19/h2-13H,14H2,1H3,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150849
PNG
(US8981106, 38)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3cccc(c3)-n3cccc3)nc2)cc1
Show InChI InChI=1S/C23H18FN3OS/c24-19-7-9-20(10-8-19)26-23(28)18-6-11-22(25-15-18)29-16-17-4-3-5-21(14-17)27-12-1-2-13-27/h1-15H,16H2,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150970
PNG
(US8981106, 160)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H17BN2O5S/c24-19(23-16-8-5-13(6-9-16)20(25)26)14-7-10-18(22-11-14)29-12-15-3-1-2-4-17(15)21(27)28/h1-11,27-28H,12H2,(H,23,24)(H,25,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150971
PNG
(US8981106, 161)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(cc1)-c1nn[nH]n1
Show InChI InChI=1S/C20H17BN6O3S/c28-20(23-16-8-5-13(6-9-16)19-24-26-27-25-19)14-7-10-18(22-11-14)31-12-15-3-1-2-4-17(15)21(29)30/h1-11,29-30H,12H2,(H,23,28)(H,24,25,26,27)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150843
PNG
(US8981106, 32)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccc(cc3)-n3cccn3)nc2)cc1
Show InChI InChI=1S/C22H17FN4OS/c23-18-5-7-19(8-6-18)26-22(28)17-4-11-21(24-14-17)29-15-16-2-9-20(10-3-16)27-13-1-12-25-27/h1-14H,15H2,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150842
PNG
(US8981106, 31)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccc(cc3)-n3cccc3)nc2)cc1
Show InChI InChI=1S/C23H18FN3OS/c24-19-6-8-20(9-7-19)26-23(28)18-5-12-22(25-15-18)29-16-17-3-10-21(11-4-17)27-13-1-2-14-27/h1-15H,16H2,(H,26,28)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50028385
PNG
(CHEMBL3342307)
Show SMILES OC(=O)c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H15FN2O3S/c21-16-6-8-17(9-7-16)23-19(24)15-5-10-18(22-11-15)27-12-13-1-3-14(4-2-13)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150882
PNG
(US8981106, 71)
Show SMILES Cc1nc(sc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H17F4N3OS2/c1-14-20(34-23(30-14)15-2-5-17(6-3-15)24(26,27)28)13-33-21-11-4-16(12-29-21)22(32)31-19-9-7-18(25)8-10-19/h2-12H,13H2,1H3,(H,31,32)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM150834
PNG
(US8981106, 23)
Show SMILES COC(=O)c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H17FN2O3S/c1-27-21(26)15-4-2-14(3-5-15)13-28-19-11-6-16(12-23-19)20(25)24-18-9-7-17(22)8-10-18/h2-12H,13H2,1H3,(H,24,25)
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Syntrix Biosystems

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...


J Med Chem 57: 8378-97 (2014)


Article DOI: 10.1021/jm500827t
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%