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PubMed code 2536438

Compile data set for download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50228047
PNG
(CHEMBL119237)
Show SMILES CC1CC(=O)NN=C1\C=C\c1ccc(cc1)-n1cnc2CCCCc12 |c:6|
Show InChI InChI=1S/C20H22N4O/c1-14-12-20(25)23-22-17(14)11-8-15-6-9-16(10-7-15)24-13-21-18-4-2-3-5-19(18)24/h6-11,13-14H,2-5,12H2,1H3,(H,23,25)/b11-8+
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n/an/a 18n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50228044
PNG
(CHEMBL544813)
Show SMILES Cl.CC1CC(=O)NN=C1\C=C\c1ccc(cc1)-n1ccnc1 |c:6|
Show InChI InChI=1S/C16H16N4O.ClH/c1-12-10-16(21)19-18-15(12)7-4-13-2-5-14(6-3-13)20-9-8-17-11-20;/h2-9,11-12H,10H2,1H3,(H,19,21);1H/b7-4+;
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n/an/a 77n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 3 from human platelets at 1*10e-7-1*10e-4 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50016839
PNG
(5-Methyl-6-[4-(4,5,6,7-tetrahydro-benzoimidazol-1-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1cnc2CCCCc12 |c:6|
Show InChI InChI=1S/C18H20N4O/c1-12-10-17(23)20-21-18(12)13-6-8-14(9-7-13)22-11-19-15-4-2-3-5-16(15)22/h6-9,11-12H,2-5,10H2,1H3,(H,20,23)
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n/an/a 110n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50225945
PNG
(CI-930)
Show SMILES CC1CC(O)=NN=C1c1ccc(cc1)-n1ccnc1 |c:4,6|
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
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n/an/a 400n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50228043
PNG
(CHEMBL333083)
Show SMILES O=C1CCC(\C=C\c2ccc(cc2)-n2ccnc2)=NN1 |c:19|
Show InChI InChI=1S/C15H14N4O/c20-15-8-5-13(17-18-15)4-1-12-2-6-14(7-3-12)19-10-9-16-11-19/h1-4,6-7,9-11H,5,8H2,(H,18,20)/b4-1+
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n/an/a 400n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50228045
PNG
(CHEMBL333598)
Show SMILES CC1CC(=O)NN=C1\C=C\c1ccc(NC(C)=O)cc1 |c:6|
Show InChI InChI=1S/C15H17N3O2/c1-10-9-15(20)18-17-14(10)8-5-12-3-6-13(7-4-12)16-11(2)19/h3-8,10H,9H2,1-2H3,(H,16,19)(H,18,20)/b8-5+
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n/an/a 870n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1 |c:4|
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM34651
PNG
(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Show SMILES Nc1cc(c[nH]c1=O)-c1ccncc1
Show InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50228046
PNG
(CHEMBL117783)
Show SMILES CC1CC(=O)NN=C1\C=C\c1ccc(cc1)-n1cnc(C)c1C |c:6|
Show InChI InChI=1S/C18H20N4O/c1-12-10-18(23)21-20-17(12)9-6-15-4-7-16(8-5-15)22-11-19-13(2)14(22)3/h4-9,11-12H,10H2,1-3H3,(H,21,23)/b9-6+
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n/an/a 8.70E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 M

J Med Chem 32: 342-50 (1989)


BindingDB Entry DOI: 10.7270/Q27083P1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%