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PubMed code 25382253

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM150751
PNG
(CPR005231 (6))
Show SMILES COc1cc(ccc1O)-c1ccc2ccc(-c3cccc(c3)C(=O)NCCN(C)C)n2n1
Show InChI InChI=1S/C25H26N4O3/c1-28(2)14-13-26-25(31)19-6-4-5-18(15-19)22-11-9-20-8-10-21(27-29(20)22)17-7-12-23(30)24(16-17)32-3/h4-12,15-16,30H,13-14H2,1-3H3,(H,26,31)
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UniChem
Article
PubMed
n/an/a 150n/an/an/an/a7.525



University of Copenhagen



Assay Description
The reaction was started by adding a mix of ATP and Peptide 38 to assay plates containing DAPK1. Prior to mixing, all reagents are diluted in assay b...


Chembiochem 16: 59-63 (2015)


Article DOI: 10.1002/cbic.201402512
BindingDB Entry DOI: 10.7270/Q2XW4HHD
More data for this
Ligand-Target Pair
Death-associated protein kinase 1 (DAPK1)


(Homo sapiens (Human))
BDBM150751
PNG
(CPR005231 (6))
Show SMILES COc1cc(ccc1O)-c1ccc2ccc(-c3cccc(c3)C(=O)NCCN(C)C)n2n1
Show InChI InChI=1S/C25H26N4O3/c1-28(2)14-13-26-25(31)19-6-4-5-18(15-19)22-11-9-20-8-10-21(27-29(20)22)17-7-12-23(30)24(16-17)32-3/h4-12,15-16,30H,13-14H2,1-3H3,(H,26,31)
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UniChem
Article
PubMed
n/an/a 247n/an/an/an/a7.525



University of Copenhagen



Assay Description
The reaction was started by adding a mix of ATP and Peptide 38 to assay plates containing DAPK1. Prior to mixing, all reagents are diluted in assay b...


Chembiochem 16: 59-63 (2015)


Article DOI: 10.1002/cbic.201402512
BindingDB Entry DOI: 10.7270/Q2XW4HHD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM150751
PNG
(CPR005231 (6))
Show SMILES COc1cc(ccc1O)-c1ccc2ccc(-c3cccc(c3)C(=O)NCCN(C)C)n2n1
Show InChI InChI=1S/C25H26N4O3/c1-28(2)14-13-26-25(31)19-6-4-5-18(15-19)22-11-9-20-8-10-21(27-29(20)22)17-7-12-23(30)24(16-17)32-3/h4-12,15-16,30H,13-14H2,1-3H3,(H,26,31)
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UniChem
Article
PubMed
n/an/a 1.60E+3n/an/an/an/a7.525



University of Copenhagen



Assay Description
The reaction was started by adding a mix of ATP and Peptide 38 to assay plates containing DAPK1. Prior to mixing, all reagents are diluted in assay b...


Chembiochem 16: 59-63 (2015)


Article DOI: 10.1002/cbic.201402512
BindingDB Entry DOI: 10.7270/Q2XW4HHD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM150751
PNG
(CPR005231 (6))
Show SMILES COc1cc(ccc1O)-c1ccc2ccc(-c3cccc(c3)C(=O)NCCN(C)C)n2n1
Show InChI InChI=1S/C25H26N4O3/c1-28(2)14-13-26-25(31)19-6-4-5-18(15-19)22-11-9-20-8-10-21(27-29(20)22)17-7-12-23(30)24(16-17)32-3/h4-12,15-16,30H,13-14H2,1-3H3,(H,26,31)
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UniChem
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PubMed
n/an/a 1.80E+3n/an/an/an/a7.525



University of Copenhagen



Assay Description
The reaction was started by adding a mix of ATP and Peptide 38 to assay plates containing DAPK1. Prior to mixing, all reagents are diluted in assay b...


Chembiochem 16: 59-63 (2015)


Article DOI: 10.1002/cbic.201402512
BindingDB Entry DOI: 10.7270/Q2XW4HHD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PAK7


(Homo sapiens (Human))
BDBM150751
PNG
(CPR005231 (6))
Show SMILES COc1cc(ccc1O)-c1ccc2ccc(-c3cccc(c3)C(=O)NCCN(C)C)n2n1
Show InChI InChI=1S/C25H26N4O3/c1-28(2)14-13-26-25(31)19-6-4-5-18(15-19)22-11-9-20-8-10-21(27-29(20)22)17-7-12-23(30)24(16-17)32-3/h4-12,15-16,30H,13-14H2,1-3H3,(H,26,31)
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UniChem
Article
PubMed
n/an/a 5.60E+3n/an/an/an/a7.525



University of Copenhagen



Assay Description
The reaction was started by adding a mix of ATP and Peptide 38 to assay plates containing DAPK1. Prior to mixing, all reagents are diluted in assay b...


Chembiochem 16: 59-63 (2015)


Article DOI: 10.1002/cbic.201402512
BindingDB Entry DOI: 10.7270/Q2XW4HHD
More data for this
Ligand-Target Pair
Death-associated protein kinase 1 (DAPK1)


(Homo sapiens (Human))
BDBM150751
PNG
(CPR005231 (6))
Show SMILES COc1cc(ccc1O)-c1ccc2ccc(-c3cccc(c3)C(=O)NCCN(C)C)n2n1
Show InChI InChI=1S/C25H26N4O3/c1-28(2)14-13-26-25(31)19-6-4-5-18(15-19)22-11-9-20-8-10-21(27-29(20)22)17-7-12-23(30)24(16-17)32-3/h4-12,15-16,30H,13-14H2,1-3H3,(H,26,31)
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UniChem
Article
PubMed
n/an/an/a 240n/an/an/a7.5n/a



University of Copenhagen



Assay Description
40 ÁL of a solution containing 350-500 ÁM of CPR005231 (compound 6) were titrated into the 200 ÁL sample cell containing 25-55 ÁM DAPK1 (AA 1-285) or...


Chembiochem 16: 59-63 (2015)


Article DOI: 10.1002/cbic.201402512
BindingDB Entry DOI: 10.7270/Q2XW4HHD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%